DK521489D0 - Desacetoxycephalosporin c synthase i oprenset form og fremgangsmaade til fremstilling af dette enzym - Google Patents

Desacetoxycephalosporin c synthase i oprenset form og fremgangsmaade til fremstilling af dette enzym

Info

Publication number
DK521489D0
DK521489D0 DK521489A DK521489A DK521489D0 DK 521489 D0 DK521489 D0 DK 521489D0 DK 521489 A DK521489 A DK 521489A DK 521489 A DK521489 A DK 521489A DK 521489 D0 DK521489 D0 DK 521489D0
Authority
DK
Denmark
Prior art keywords
desacetoxycephalosporin
enzym
synthase
preparing
procedure
Prior art date
Application number
DK521489A
Other languages
English (en)
Other versions
DK521489A (da
Inventor
Joe Edward Dotzlaf
Wu-Kuang Yeh
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK521489D0 publication Critical patent/DK521489D0/da
Publication of DK521489A publication Critical patent/DK521489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK521489A 1988-10-24 1989-10-20 Desacetoxycephalosporin c synthase i oprenset form og fremgangsmaade til fremstilling af dette enzym DK521489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/261,437 US5082772A (en) 1988-10-24 1988-10-24 Process for preparing deacetylcephalosporin c

Publications (2)

Publication Number Publication Date
DK521489D0 true DK521489D0 (da) 1989-10-20
DK521489A DK521489A (da) 1990-04-25

Family

ID=22993294

Family Applications (1)

Application Number Title Priority Date Filing Date
DK521489A DK521489A (da) 1988-10-24 1989-10-20 Desacetoxycephalosporin c synthase i oprenset form og fremgangsmaade til fremstilling af dette enzym

Country Status (8)

Country Link
US (1) US5082772A (da)
EP (1) EP0366354B1 (da)
JP (1) JPH02242675A (da)
DE (1) DE68925338T2 (da)
DK (1) DK521489A (da)
ES (1) ES2082787T3 (da)
GR (1) GR3018596T3 (da)
IL (1) IL92079A (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709859B1 (en) * 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
HU219370B (en) * 1991-10-15 2001-03-28 Gist Brocades Bv Novel bioprocesses for preparing 7-aca and 7-adac
DE69434023D1 (de) * 1993-07-30 2004-10-28 Dsm Ip Assets Bv Verfahren zur effizienten Herstellung von 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA und 3-(carboxymethylthio)propionyl-7-ADCA
JP3574453B2 (ja) * 1993-07-30 2004-10-06 ギスト ブロカデス ベスローテン フェンノートシャップ ３‐（カルボキシエチルチオ）プロピオニル‐７‐ａｄｃａを経由した７‐ａｄｃａの効果的な製造法
US5571910A (en) * 1994-12-09 1996-11-05 Schering Corporation Process for the preparation of intermediates useful in the synthesis of cephalosporins
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
WO1997020053A2 (en) * 1995-11-27 1997-06-05 Gist-Brocades B.V. Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g
WO1998002551A2 (en) * 1996-07-16 1998-01-22 Gist-Brocades B.V. Process for the production of adipoyl cephalosporins
CA2316401A1 (en) * 1997-12-24 1999-07-08 Isis Innovation Limited Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure
US6383773B2 (en) * 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
ID27054A (id) 1998-05-19 2001-02-22 Dsm Nv Perbaikan produksi sepalosporin di dalam organisme yang hidup
DE10051628B4 (de) * 2000-10-18 2007-06-06 Fresenius Hemocare Beteiligungs Gmbh Einzelsträngiges Oligonukleotid und dessen Verwendung
US6699699B2 (en) 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
CN113234093A (zh) * 2021-04-13 2021-08-10 伊犁川宁生物技术股份有限公司 一种3-去乙酰氧基头孢菌素c钠盐及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847742A (en) * 1972-04-26 1974-11-12 C Higgens Process for deacetoxycephalosporin c
JPS5539735A (en) * 1978-09-11 1980-03-19 Takeda Chem Ind Ltd Preparation of deacetyl cephalosporin c
US4414328A (en) * 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C
US4693977A (en) * 1982-08-23 1987-09-15 Queen's University At Kingston Enzyme immobilization for producing cephalosporin antibiotics
US4510246A (en) * 1982-08-23 1985-04-09 Queen's University At Kingston Isolation of cyclase, epimerase and a ring expansion enzyme for producing unnatural cephalosporins
US4536476A (en) * 1982-08-23 1985-08-20 Queen's University At Kingston Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.

Also Published As

Publication number Publication date
DE68925338T2 (de) 1996-06-05
US5082772A (en) 1992-01-21
DK521489A (da) 1990-04-25
EP0366354B1 (en) 1996-01-03
ES2082787T3 (es) 1996-04-01
JPH02242675A (ja) 1990-09-27
IL92079A (en) 1994-08-26
EP0366354A3 (en) 1991-03-20
DE68925338D1 (de) 1996-02-15
EP0366354A2 (en) 1990-05-02
GR3018596T3 (en) 1996-04-30

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