DK515982A - Fremgangsmaade til fremstilling af hexahydronaphth(1,2-b)-1,4-oxaziner - Google Patents

Fremgangsmaade til fremstilling af hexahydronaphth(1,2-b)-1,4-oxaziner Download PDF

Info

Publication number
DK515982A
DK515982A DK515982A DK515982A DK515982A DK 515982 A DK515982 A DK 515982A DK 515982 A DK515982 A DK 515982A DK 515982 A DK515982 A DK 515982A DK 515982 A DK515982 A DK 515982A
Authority
DK
Denmark
Prior art keywords
hexahydronaphth
oxazines
preparing
chloroacetamidotetrahydronaphthalen
parkinsonism
Prior art date
Application number
DK515982A
Other languages
Danish (da)
English (en)
Inventor
James H Jones
David E Mcclure
Victor J Grenda
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK515982A publication Critical patent/DK515982A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Luminescent Compositions (AREA)
DK515982A 1981-11-20 1982-11-19 Fremgangsmaade til fremstilling af hexahydronaphth(1,2-b)-1,4-oxaziner DK515982A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32334981A 1981-11-20 1981-11-20

Publications (1)

Publication Number Publication Date
DK515982A true DK515982A (da) 1983-05-21

Family

ID=23258834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK515982A DK515982A (da) 1981-11-20 1982-11-19 Fremgangsmaade til fremstilling af hexahydronaphth(1,2-b)-1,4-oxaziner

Country Status (12)

Country Link
EP (1) EP0080115B1 (es)
JP (1) JPS5892670A (es)
AT (1) ATE27155T1 (es)
AU (1) AU556908B2 (es)
CA (1) CA1204745A (es)
DE (1) DE3276312D1 (es)
DK (1) DK515982A (es)
ES (1) ES8401048A1 (es)
GR (1) GR77041B (es)
HK (1) HK66090A (es)
IE (1) IE54157B1 (es)
PT (1) PT75859B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540691A (en) * 1984-04-13 1985-09-10 Nelson Research & Development Co. Dopamine agonists and use thereof
HU193979B (en) * 1984-06-12 1987-12-28 Sandoz Ag Process for producing naphtoxazine derivatives and pharmaceutical compositions containing them
US4774243A (en) * 1985-12-24 1988-09-27 Merck & Co., Inc. Dopamine agonists for treating elevated intraocular pressure
US4758661A (en) * 1986-06-24 1988-07-19 Merck & Co., Inc. Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine
GB8616669D0 (en) * 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions
US4743601A (en) * 1987-07-13 1988-05-10 Hoechst-Roussel Pharmaceuticals Inc. Dihydro-1,4-oxazino(2,3-C)quinolines
US4942037A (en) * 1988-06-02 1990-07-17 Merck & Co., Inc. Transdermal delivery systems
FR2721027B1 (fr) * 1994-06-08 1996-07-19 Adir Nouveaux dérivés tétracycliques de la 1,4-oxazine, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR2767825A1 (fr) * 1997-09-01 1999-02-26 Adir Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1853572A4 (en) * 2005-02-14 2009-11-11 Clera Inc FLUORINATED PHNO AND ANALOGS OF SAID SUBSTANCE
FR2906249B1 (fr) * 2006-09-26 2008-12-19 Servier Lab Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2098511A1 (en) 2008-03-07 2009-09-09 Solvias AG Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
GB0821432D0 (en) * 2008-11-24 2008-12-31 Gen Electric Imaging ligands
CN102898397B (zh) * 2012-09-26 2014-12-10 江苏华益科技有限公司 (4aR,10bR)-3,4,4a,5,6,10b-六氢-2H-萘并[1,2-b][1,4]噁嗪-9-醇类物质及其盐酸盐合成方法
WO2017109095A1 (en) * 2015-12-22 2017-06-29 AbbVie Deutschland GmbH & Co. KG Fused (hetero)cyclic compounds as s1p modulators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642789A (en) * 1970-02-13 1972-02-15 Dow Chemical Co Indeno(1 2-b)-1 4-oxazines
US4238486A (en) * 1979-11-23 1980-12-09 Merck & Co., Inc. Indolobenzoxazines

Also Published As

Publication number Publication date
JPH0347270B2 (es) 1991-07-18
EP0080115B1 (en) 1987-05-13
EP0080115A3 (en) 1984-07-18
HK66090A (en) 1990-08-31
IE822755L (en) 1983-05-20
ES517233A0 (es) 1983-12-01
AU556908B2 (en) 1986-11-27
ATE27155T1 (de) 1987-05-15
GR77041B (es) 1984-09-04
ES8401048A1 (es) 1983-12-01
IE54157B1 (en) 1989-07-05
DE3276312D1 (en) 1987-06-19
JPS5892670A (ja) 1983-06-02
EP0080115A2 (en) 1983-06-01
PT75859B (en) 1986-01-21
AU1444883A (en) 1984-11-15
PT75859A (en) 1982-12-01
CA1204745A (en) 1986-05-20

Similar Documents

Publication Publication Date Title
DK515982A (da) Fremgangsmaade til fremstilling af hexahydronaphth(1,2-b)-1,4-oxaziner
DE59006880D1 (de) Gerät zur Herstellung von Formkörpern und Verwendung desselben zur Herstellung von Inlays, Onlays, und Kronen in der Zahnmedizin.
MY108496A (en) Hypoglycemic thiazolidine diones.
ES2104883T3 (es) Cilindro de utilizacion temporal.
DE3783783D1 (de) Plastikumhuellter chiptraeger und verfahren zu dessen herstellung.
DK0714392T3 (da) Heterocykliske neurokinin-antagonister
DE3782201D1 (de) Halbleiterphotosensor und verfahren zu dessen herstellung.
IT8721365A0 (it) Dentiere. composizioni resinose per base di
DE3750887D1 (de) Verfahren zur Herstellung von Oxymethylencopolymeren und Harzzusammensetzung.
DE3769683D1 (de) Farblose ketimine, ihre herstellung und ihre verwendung als vernetzungsmittel.
NO891151D0 (no) Arylpiperazinylalkoksyderivater av cykliske imider, samt fremgangsmaate for fremstilling derav.
DK287A (da) Optisk rent s-(-)-1-propyl-2',6'-pipecoloxylidid- hydroklorid og fremgangsmaade til fremstilling der-af
DK8386D0 (da) Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme
DK123987A (da) N- (2-hydroxyphenyl)methylen 2-aminoethyl acetamidderivater, fremgangsmaade til fremstilling af saadanne derivater samt laegemiddel indeholdende disse
DE3877124D1 (de) Imidazol-derivate, verfahren zu deren herstellung und deren anwendung als alpha-2-adrenoceptor-antagonisten.
DE69030980D1 (de) Halbleiteranordnung mit CCD und dessen peripheren Bipolartransistoren und Verfahren zu dessen Herstellung
DE3787413D1 (de) Zyklische Ether-Derivate, Verfahren zu deren Herstellung und deren Anwendung.
PT70545A (de) Verfahren zur herstellung und verwendung von 7,8,9,10-tetrahydrothieno/3,2-e/pyrido/4,3-b/ indole als arzneimittel
FI905992A0 (fi) Menetelmä metyleeni-pristinamysiini-IA- tai metyleeni-virginiamysiinijohdannaisten valmistamiseksi
DK381983D0 (da) Fremgangsmade til fremstilling af spiro (2h-1,4-benzodioxepin-3(5h)4'-piperidin-og-3'-pyrrolidinforbindelser
AT348517B (de) Verfahren zur herstellung von reinem 3-methoxy- 4- (4'-aminobenzolsulfonamido) -1,2,5-thiadiazol
ATE65248T1 (de) 2-(benzhydrylsulfonyl) acetamid, verfahren zu dessen herstellung und dessen verwendung in der therapie.
NO158020C (no) Fremgangsmaate for fremstilling av optisk rent s-3-morfolino-4-(3'-tertbutylamino-2'-hydroxypropoxy)-1,2,5-thiadiazol
DE3680540D1 (de) Vorrichtung zur herstellung und zur verabreichung von getraenken.
PT66533A (de) 2-(dimethylcarbamoylimino)-1,3,4-thiadiazolin-3-carbons#ure-ester,verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel