DK503082A - Fremgangsmaade til fremstilling af 3-(1-substitueret-4-piperidyl)-1,2-benzisoxazoler - Google Patents

Fremgangsmaade til fremstilling af 3-(1-substitueret-4-piperidyl)-1,2-benzisoxazoler Download PDF

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Publication number
DK503082A
DK503082A DK503082A DK503082A DK503082A DK 503082 A DK503082 A DK 503082A DK 503082 A DK503082 A DK 503082A DK 503082 A DK503082 A DK 503082A DK 503082 A DK503082 A DK 503082A
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DK
Denmark
Prior art keywords
benzisoxazoles
piperidyl
substituted
preparing
compositions
Prior art date
Application number
DK503082A
Other languages
Danish (da)
English (en)
Inventor
Joseph Thomas Strupczewski
Richard Charles Allen
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK503082A publication Critical patent/DK503082A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK503082A 1981-11-12 1982-11-11 Fremgangsmaade til fremstilling af 3-(1-substitueret-4-piperidyl)-1,2-benzisoxazoler DK503082A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/319,872 US4352811A (en) 1981-11-12 1981-11-12 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Publications (1)

Publication Number Publication Date
DK503082A true DK503082A (da) 1983-05-13

Family

ID=23243961

Family Applications (1)

Application Number Title Priority Date Filing Date
DK503082A DK503082A (da) 1981-11-12 1982-11-11 Fremgangsmaade til fremstilling af 3-(1-substitueret-4-piperidyl)-1,2-benzisoxazoler

Country Status (17)

Country Link
US (1) US4352811A (el)
EP (1) EP0079564B1 (el)
JP (1) JPS5890583A (el)
AT (1) ATE18669T1 (el)
AU (1) AU556307B2 (el)
CA (1) CA1196334A (el)
DE (1) DE3270015D1 (el)
DK (1) DK503082A (el)
ES (5) ES517249A0 (el)
FI (1) FI823860L (el)
GR (1) GR78402B (el)
HU (1) HU191366B (el)
IL (1) IL67235A (el)
NO (1) NO823775L (el)
NZ (1) NZ202457A (el)
PT (1) PT75848A (el)
ZA (1) ZA828278B (el)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US4469869A (en) * 1982-08-11 1984-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(4-Piperidinium)-1,2-benzisoxazoles
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4524074A (en) * 1983-05-31 1985-06-18 Hoechst-Roussel Pharmaceuticals Inc. 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4528292A (en) * 1984-04-23 1985-07-09 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive 1,2-benzisothiazole piperidines
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
JP3645906B2 (ja) * 1993-11-19 2005-05-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイクロカプセル封入された３−ピペリジニル−置換１，２−ベンズイソオキサゾール類及び１，２−ベンズイソチアゾール類
ES2074966B1 (es) * 1994-02-11 1996-06-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.
FR2749304B1 (fr) * 1996-06-04 1998-06-26 Adir Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
CA2320120C (en) * 1998-02-09 2009-08-11 Duphar International Research Bv Benzisoxazole derivatives having d4-antagonistic activity
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
JP4836797B2 (ja) 2003-10-23 2011-12-14 大塚製薬株式会社 放出制御性無菌注射アリピプラゾール製剤および方法
DK1856114T3 (en) * 2005-02-25 2014-11-17 Raqualia Pharma Inc Benzisoxazol-DERIVATIVES
AR067747A1 (es) * 2007-07-31 2009-10-21 Otsuka Pharma Co Ltd Metodos para producir suspension de aripiprazol y formulacion liofilizada
ATE530170T1 (de) * 2007-08-21 2011-11-15 Teva Pharma Paliperidonformulierung mit verzögerter freisetzung
CN101759693B (zh) * 2008-12-23 2011-09-14 江苏恩华药业股份有限公司 苯骈异恶唑哌啶衍生物及在制备镇痛、镇静药物中的应用
WO2016071723A1 (en) * 2014-11-03 2016-05-12 Sifavitor S.R.L. Process for the preparation of a fluspirilene intermediate
CN104829591B (zh) * 2015-04-27 2017-05-03 梯尔希（南京）药物研发有限公司 氘代匹莫齐特的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (el) * 1962-06-13
US3678062A (en) * 1970-09-08 1972-07-18 American Cyanamid Co Certain 4-/(indazol-3-yl)-pyridinium/compounds
JPS5545545B2 (el) * 1972-03-17 1980-11-18
US4217349A (en) * 1974-07-01 1980-08-12 Sumitomo Chemical Company, Limited Benzisoxazole derivatives
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Also Published As

Publication number Publication date
GR78402B (el) 1984-09-27
IL67235A0 (en) 1983-03-31
ES529314A0 (es) 1985-08-01
NO823775L (no) 1983-05-13
ES8506705A1 (es) 1985-08-01
ZA828278B (en) 1983-09-28
US4352811A (en) 1982-10-05
AU9039182A (en) 1983-05-19
JPS5890583A (ja) 1983-05-30
ATE18669T1 (de) 1986-04-15
IL67235A (en) 1987-03-31
ES8405396A1 (es) 1984-06-01
DE3270015D1 (en) 1986-04-24
ES529312A0 (es) 1985-07-01
FI823860A0 (fi) 1982-11-10
FI823860L (fi) 1983-05-13
ES8506293A1 (es) 1985-07-01
ES8506657A1 (es) 1985-07-16
ES8506658A1 (es) 1985-08-01
ES529315A0 (es) 1985-08-01
EP0079564A1 (en) 1983-05-25
EP0079564B1 (en) 1986-03-19
ES529313A0 (es) 1985-07-16
PT75848A (en) 1982-12-01
NZ202457A (en) 1986-05-09
AU556307B2 (en) 1986-10-30
HU191366B (en) 1987-02-27
CA1196334A (en) 1985-11-05
ES517249A0 (es) 1984-06-01

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