DK495286A - Fremgangsmaade til fremstilling af 5r,6s-6-(1r-1-hydroxyethyl)-2-(1-oxo-3-thioanylthio)-2-penem-3-carboxylsyre eller farmaceutisk acceptable kationsalte eller pivaloyloxymethylesteren deraf samt forbindelser til anvendelse som mellemprodukter ved fremgangsmaaden - Google Patents
Fremgangsmaade til fremstilling af 5r,6s-6-(1r-1-hydroxyethyl)-2-(1-oxo-3-thioanylthio)-2-penem-3-carboxylsyre eller farmaceutisk acceptable kationsalte eller pivaloyloxymethylesteren deraf samt forbindelser til anvendelse som mellemprodukter ved fremgangsmaaden Download PDFInfo
- Publication number
- DK495286A DK495286A DK495286A DK495286A DK495286A DK 495286 A DK495286 A DK 495286A DK 495286 A DK495286 A DK 495286A DK 495286 A DK495286 A DK 495286A DK 495286 A DK495286 A DK 495286A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- oxo
- hydroxyethyl
- thioanylthio
- antylylyle
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- -1 pivaloyloxymethyl esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78827385A | 1985-10-17 | 1985-10-17 | |
| US87795786A | 1986-06-24 | 1986-06-24 | |
| US06/877,831 US4739047A (en) | 1985-10-17 | 1986-06-24 | Intermediates for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK495286D0 DK495286D0 (da) | 1986-10-16 |
| DK495286A true DK495286A (da) | 1987-04-18 |
Family
ID=27419851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK495286A DK495286A (da) | 1985-10-17 | 1986-10-16 | Fremgangsmaade til fremstilling af 5r,6s-6-(1r-1-hydroxyethyl)-2-(1-oxo-3-thioanylthio)-2-penem-3-carboxylsyre eller farmaceutisk acceptable kationsalte eller pivaloyloxymethylesteren deraf samt forbindelser til anvendelse som mellemprodukter ved fremgangsmaaden |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0223397B1 (el) |
| KR (1) | KR890004559B1 (el) |
| CN (1) | CN86106583B (el) |
| AT (1) | ATE66923T1 (el) |
| DE (1) | DE3681255D1 (el) |
| DK (1) | DK495286A (el) |
| EG (1) | EG18143A (el) |
| ES (1) | ES2029794T3 (el) |
| FI (1) | FI83654C (el) |
| GR (1) | GR3002766T3 (el) |
| HU (1) | HU198066B (el) |
| IE (1) | IE59260B1 (el) |
| IL (1) | IL80295A0 (el) |
| NO (1) | NO165839C (el) |
| NZ (1) | NZ217944A (el) |
| PL (1) | PL149240B1 (el) |
| PT (1) | PT83560B (el) |
| YU (1) | YU43956B (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013729A (en) * | 1987-05-11 | 1991-05-07 | Pfizer Inc. | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids |
| WO1990011284A1 (en) * | 1989-03-28 | 1990-10-04 | Pfizer Inc. | Antibacterial 2-carbapenem derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4347183A (en) * | 1981-02-02 | 1982-08-31 | Schering Corporation | Process for the synthesis of penems and carbapenems |
| DE3464610D1 (de) * | 1983-06-21 | 1987-08-13 | Pfizer | 2-alkylthiopenem derivatives |
-
1986
- 1986-10-10 EP EP86307840A patent/EP0223397B1/en not_active Expired - Lifetime
- 1986-10-10 ES ES198686307840T patent/ES2029794T3/es not_active Expired - Lifetime
- 1986-10-10 DE DE8686307840T patent/DE3681255D1/de not_active Expired - Fee Related
- 1986-10-10 AT AT86307840T patent/ATE66923T1/de not_active IP Right Cessation
- 1986-10-14 IL IL80295A patent/IL80295A0/xx not_active IP Right Cessation
- 1986-10-15 NZ NZ217944A patent/NZ217944A/xx unknown
- 1986-10-16 DK DK495286A patent/DK495286A/da not_active Application Discontinuation
- 1986-10-16 KR KR1019860008669A patent/KR890004559B1/ko not_active IP Right Cessation
- 1986-10-16 YU YU1762/86A patent/YU43956B/xx unknown
- 1986-10-16 PL PL1986261891A patent/PL149240B1/pl unknown
- 1986-10-16 IE IE273986A patent/IE59260B1/en not_active IP Right Cessation
- 1986-10-16 PT PT83560A patent/PT83560B/pt not_active IP Right Cessation
- 1986-10-16 FI FI864182A patent/FI83654C/fi not_active IP Right Cessation
- 1986-10-16 EG EG653/86A patent/EG18143A/xx active
- 1986-10-16 NO NO864125A patent/NO165839C/no unknown
- 1986-10-16 HU HU864320D patent/HU198066B/hu not_active IP Right Cessation
- 1986-10-16 CN CN86106583A patent/CN86106583B/zh not_active Expired
-
1991
- 1991-09-20 GR GR91401378T patent/GR3002766T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN86106583B (zh) | 1988-07-06 |
| PT83560A (en) | 1986-11-01 |
| EG18143A (en) | 1992-08-30 |
| YU176286A (en) | 1988-02-29 |
| EP0223397B1 (en) | 1991-09-04 |
| EP0223397A2 (en) | 1987-05-27 |
| KR870004039A (ko) | 1987-05-07 |
| FI864182A0 (fi) | 1986-10-16 |
| GR3002766T3 (en) | 1993-01-25 |
| PT83560B (pt) | 1989-05-31 |
| DE3681255D1 (de) | 1991-10-10 |
| DK495286D0 (da) | 1986-10-16 |
| NO165839C (no) | 1991-04-17 |
| NO864125L (no) | 1987-04-21 |
| NZ217944A (en) | 1989-06-28 |
| ATE66923T1 (de) | 1991-09-15 |
| FI83654C (fi) | 1991-08-12 |
| FI864182A (fi) | 1987-04-18 |
| HU198066B (en) | 1989-07-28 |
| IE862739L (en) | 1987-04-17 |
| PL261891A1 (en) | 1988-08-04 |
| HUT45065A (en) | 1988-05-30 |
| KR890004559B1 (ko) | 1989-11-15 |
| PL149240B1 (en) | 1990-01-31 |
| IL80295A0 (en) | 1987-01-30 |
| IE59260B1 (en) | 1994-01-26 |
| ES2029794T3 (es) | 1992-10-01 |
| NO165839B (no) | 1991-01-07 |
| YU43956B (en) | 1989-12-31 |
| NO864125D0 (no) | 1986-10-16 |
| FI83654B (fi) | 1991-04-30 |
| CN86106583A (zh) | 1987-04-22 |
| EP0223397A3 (en) | 1988-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |