DE3681255D1 - Verfahren fuer 2-(1-oxo-3-thiolanyl)-2-penemantibiotika. - Google Patents

Verfahren fuer 2-(1-oxo-3-thiolanyl)-2-penemantibiotika.

Info

Publication number
DE3681255D1
DE3681255D1 DE8686307840T DE3681255T DE3681255D1 DE 3681255 D1 DE3681255 D1 DE 3681255D1 DE 8686307840 T DE8686307840 T DE 8686307840T DE 3681255 T DE3681255 T DE 3681255T DE 3681255 D1 DE3681255 D1 DE 3681255D1
Authority
DE
Germany
Prior art keywords
oxo
penemantibiotics
thiolanyl
thiolanylthio
azetidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686307840T
Other languages
English (en)
Inventor
Robert Louis Kaye
Robert Alfred Volkmann
David Louis Lindner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/877,831 external-priority patent/US4739047A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE3681255D1 publication Critical patent/DE3681255D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8686307840T 1985-10-17 1986-10-10 Verfahren fuer 2-(1-oxo-3-thiolanyl)-2-penemantibiotika. Expired - Fee Related DE3681255D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78827385A 1985-10-17 1985-10-17
US87795786A 1986-06-24 1986-06-24
US06/877,831 US4739047A (en) 1985-10-17 1986-06-24 Intermediates for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics

Publications (1)

Publication Number Publication Date
DE3681255D1 true DE3681255D1 (de) 1991-10-10

Family

ID=27419851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686307840T Expired - Fee Related DE3681255D1 (de) 1985-10-17 1986-10-10 Verfahren fuer 2-(1-oxo-3-thiolanyl)-2-penemantibiotika.

Country Status (18)

Country Link
EP (1) EP0223397B1 (de)
KR (1) KR890004559B1 (de)
CN (1) CN86106583B (de)
AT (1) ATE66923T1 (de)
DE (1) DE3681255D1 (de)
DK (1) DK495286A (de)
EG (1) EG18143A (de)
ES (1) ES2029794T3 (de)
FI (1) FI83654C (de)
GR (1) GR3002766T3 (de)
HU (1) HU198066B (de)
IE (1) IE59260B1 (de)
IL (1) IL80295A0 (de)
NO (1) NO165839C (de)
NZ (1) NZ217944A (de)
PL (1) PL149240B1 (de)
PT (1) PT83560B (de)
YU (1) YU43956B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008845A1 (en) * 1987-05-11 1988-11-17 Pfizer Inc. Diastereomeric 5r,6s-6-(1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
MX20084A (es) * 1989-03-28 1993-03-01 Pfizer Derivados de 2 -carbapenem antibacterianos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
EP0130025B1 (de) * 1983-06-21 1987-07-08 Pfizer Inc. 2-Alkylthiopenem-Derivate

Also Published As

Publication number Publication date
FI83654B (fi) 1991-04-30
YU43956B (en) 1989-12-31
CN86106583A (zh) 1987-04-22
GR3002766T3 (en) 1993-01-25
NO165839B (no) 1991-01-07
ES2029794T3 (es) 1992-10-01
CN86106583B (zh) 1988-07-06
EP0223397B1 (de) 1991-09-04
FI864182A (fi) 1987-04-18
HUT45065A (en) 1988-05-30
FI83654C (fi) 1991-08-12
KR870004039A (ko) 1987-05-07
IL80295A0 (en) 1987-01-30
IE862739L (en) 1987-04-17
NO864125L (no) 1987-04-21
PT83560A (en) 1986-11-01
KR890004559B1 (ko) 1989-11-15
NZ217944A (en) 1989-06-28
PL261891A1 (en) 1988-08-04
NO165839C (no) 1991-04-17
DK495286A (da) 1987-04-18
HU198066B (en) 1989-07-28
IE59260B1 (en) 1994-01-26
ATE66923T1 (de) 1991-09-15
EP0223397A3 (en) 1988-12-14
PL149240B1 (en) 1990-01-31
PT83560B (pt) 1989-05-31
EG18143A (en) 1992-08-30
NO864125D0 (no) 1986-10-16
EP0223397A2 (de) 1987-05-27
DK495286D0 (da) 1986-10-16
FI864182A0 (fi) 1986-10-16
YU176286A (en) 1988-02-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee