DK444582A - Fremgangsmaade til fremstilling af peptider - Google Patents

Fremgangsmaade til fremstilling af peptider Download PDF

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Publication number
DK444582A
DK444582A DK444582A DK444582A DK444582A DK 444582 A DK444582 A DK 444582A DK 444582 A DK444582 A DK 444582A DK 444582 A DK444582 A DK 444582A DK 444582 A DK444582 A DK 444582A
Authority
DK
Denmark
Prior art keywords
procedure
renin
preparing peptides
peptides
hyperaldosteronism
Prior art date
Application number
DK444582A
Other languages
Danish (da)
English (en)
Inventor
Daniel F Veber
Daniel H Rich
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK444582A publication Critical patent/DK444582A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK444582A 1981-10-08 1982-10-07 Fremgangsmaade til fremstilling af peptider DK444582A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/309,854 US4384994A (en) 1981-10-08 1981-10-08 Renin inhibitory peptides

Publications (1)

Publication Number Publication Date
DK444582A true DK444582A (da) 1983-04-09

Family

ID=23199956

Family Applications (1)

Application Number Title Priority Date Filing Date
DK444582A DK444582A (da) 1981-10-08 1982-10-07 Fremgangsmaade til fremstilling af peptider

Country Status (9)

Country Link
US (1) US4384994A (de)
EP (1) EP0077029B1 (de)
JP (1) JPS5890536A (de)
AT (1) ATE15053T1 (de)
DE (1) DE3265634D1 (de)
DK (1) DK444582A (de)
ES (1) ES8401015A1 (de)
GR (1) GR77714B (de)
PT (1) PT75652B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4478826A (en) * 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
US5006511A (en) * 1981-10-14 1991-04-09 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
US4479941A (en) * 1981-12-10 1984-10-30 Merck & Co., Inc. Renin inhibitory peptides having PHE13 delection
US4650661A (en) * 1982-09-15 1987-03-17 Aktiebolaget Hassle Enzyme inhibitors
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
DE3381565D1 (de) * 1982-12-27 1990-06-21 Merck & Co Inc Reninhemmende tripeptide.
US4485099A (en) * 1983-06-15 1984-11-27 Merck & Co., Inc. Renin inhibitors containing a C-terminal amide cycle
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
US4665052A (en) * 1984-03-27 1987-05-12 Merck & Co., Inc. Renin inhibitors containing homophe8 and a C-terminal amide cycle
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
US4663310A (en) * 1984-04-04 1987-05-05 Merck & Co., Inc. Renin inhibitors containing 2-substituted statine
US4645759A (en) * 1984-06-22 1987-02-24 Abbott Laboratories Renin inhibiting compounds
US4652551A (en) * 1984-06-22 1987-03-24 Abbott Laboratories Renin inhibiting compounds
US4880781A (en) * 1984-08-06 1989-11-14 The Upjohn Company Renin inhibitory peptides containing an N-alkyl-histidine moiety
EP0181110A3 (de) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidinderivate als Renininhibitoren
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
US4609641A (en) * 1984-12-03 1986-09-02 Merck & Co., Inc. Renin-inhibitory peptide analogs
DE3512128A1 (de) 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
WO1986006379A1 (en) 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
US4665055A (en) * 1985-06-17 1987-05-12 Merck & Co., Inc. Peptide renin inhibitors
EP0206807A3 (de) * 1985-06-28 1988-01-20 Kissei Pharmaceutical Co. Ltd. Aminosäure-Derivate
US4853463A (en) * 1985-09-04 1989-08-01 Kissei Pharmaceutical Co., Ltd. Amino acid derivatives
US4906613A (en) * 1985-11-05 1990-03-06 Schering Corporation Antiglaucoma compositions and methods
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
DE3638425A1 (de) * 1986-11-11 1988-05-19 Merck Patent Gmbh Aminosaeurederivate
JPS6322081A (ja) * 1986-07-11 1988-01-29 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
US4743584A (en) * 1986-10-07 1988-05-10 Merck & Co., Inc. C-terminal amide cyclic renin inhibitors containing peptide isosteres
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
US5688770A (en) * 1989-12-14 1997-11-18 Schering Corporation Antiglaucoma compositions and methods
AU667995B2 (en) * 1993-02-15 1996-04-18 Bayer Aktiengesellschaft New pseudopeptides having an antiviral action
ATE301674T1 (de) * 1996-05-15 2005-08-15 Altana Pharma Ag Verfahren zur trennung und bestimmung von hydrophoben proteinen durch dünnschichtchromatographie
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902459D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873681A (en) * 1972-02-16 1975-03-25 Lilly Co Eli Determination of increased amounts of renin in body fluids
US3784686A (en) * 1972-02-16 1974-01-08 Lilly Co Eli Method of inhibiting the action of renin in hypertensive mammals
DE2506601C3 (de) * 1974-02-28 1980-12-11 Sanraku-Ocean Co., Ltd., Tokio Tetrapeptide und Verfahren zu ihrer Herstellung
FR2399409A1 (fr) * 1977-08-04 1979-03-02 Anvar Nouveaux derives de la pepstatine, leur preparation et les compositions pharmaceutiques qui les contiennent
US4269827A (en) * 1980-06-23 1981-05-26 The Massachusetts General Hospital Process and composition for reducing blood pressure

Also Published As

Publication number Publication date
US4384994A (en) 1983-05-24
EP0077029B1 (de) 1985-08-21
ATE15053T1 (de) 1985-09-15
ES516293A0 (es) 1983-11-16
GR77714B (de) 1984-09-25
JPS5890536A (ja) 1983-05-30
PT75652B (en) 1985-12-09
ES8401015A1 (es) 1983-11-16
EP0077029A2 (de) 1983-04-20
EP0077029A3 (en) 1984-03-21
DE3265634D1 (en) 1985-09-26
PT75652A (en) 1982-11-01

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