DK426682A - Fremgangsmaade til fremstilling af octahydronaphthalen-derivater eller salte deraf - Google Patents
Fremgangsmaade til fremstilling af octahydronaphthalen-derivater eller salte deraf Download PDFInfo
- Publication number
- DK426682A DK426682A DK426682A DK426682A DK426682A DK 426682 A DK426682 A DK 426682A DK 426682 A DK426682 A DK 426682A DK 426682 A DK426682 A DK 426682A DK 426682 A DK426682 A DK 426682A
- Authority
- DK
- Denmark
- Prior art keywords
- salts
- procedure
- preparation
- hydrogen atom
- group
- Prior art date
Links
- POPHMOPNVVKGRW-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7-octahydronaphthalene Chemical class C1CCC2CCCCC2=C1 POPHMOPNVVKGRW-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- -1 2-methylbutyryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- WWSNTLOVYSRDEL-DZSDEGEFSA-N compactin diol lactone Chemical compound C([C@@H]1[C@H]2[C@@H](O)CCC=C2C=C[C@@H]1C)C[C@@H]1C[C@@H](O)CC(=O)O1 WWSNTLOVYSRDEL-DZSDEGEFSA-N 0.000 abstract 1
- WWSNTLOVYSRDEL-UHFFFAOYSA-N desmethylmonacolin J Natural products CC1C=CC2=CCCC(O)C2C1CCC1CC(O)CC(=O)O1 WWSNTLOVYSRDEL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Artificial Filaments (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56151871A JPS5855443A (ja) | 1981-09-25 | 1981-09-25 | オクタヒドロナフタリン誘導体およびその製造法 |
| JP15187181 | 1981-09-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK426682A true DK426682A (da) | 1983-03-26 |
| DK171877B1 DK171877B1 (da) | 1997-07-28 |
Family
ID=15528032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK426682A DK171877B1 (da) | 1981-09-25 | 1982-09-24 | Analogifremgangsmåde til fremstilling af octahydronaphthalenderivater, de frie hydroxycarboxylsyrer,estere eller salte deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US4604472A (da) |
| EP (1) | EP0076601B1 (da) |
| JP (1) | JPS5855443A (da) |
| KR (1) | KR890000364B1 (da) |
| AT (1) | ATE19074T1 (da) |
| AU (1) | AU555242B2 (da) |
| CA (1) | CA1298845C (da) |
| DE (1) | DE3270445D1 (da) |
| DK (1) | DK171877B1 (da) |
| ES (1) | ES8308556A1 (da) |
| FI (1) | FI79706C (da) |
| IE (1) | IE53910B1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5855443A (ja) * | 1981-09-25 | 1983-04-01 | Sankyo Co Ltd | オクタヒドロナフタリン誘導体およびその製造法 |
| US4472426A (en) * | 1982-12-22 | 1984-09-18 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4719229A (en) * | 1987-05-13 | 1988-01-12 | Merck & Co., Inc. | Antihypercholesterolemic agents |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| JP2542429B2 (ja) * | 1987-10-27 | 1996-10-09 | 三共株式会社 | オクタヒドロナフタリン置換オキシム誘導体 |
| US4841074A (en) * | 1987-12-11 | 1989-06-20 | Merck & Co., Inc. | Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors |
| US5021453A (en) * | 1988-03-02 | 1991-06-04 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| US4857522A (en) * | 1988-03-21 | 1989-08-15 | E. R. Squibb & Sons, Inc. | Derivatives of pravastatin for inhibiting cholesterol biosynthesis |
| US4963538A (en) * | 1988-06-29 | 1990-10-16 | Merck & Co., Inc. | 5-oxygenated HMG-CoA reductase inhibitors |
| US4921974A (en) * | 1988-09-29 | 1990-05-01 | Merck & Co., Inc. | Intermediates and processes in the preparation of 5-oxygenated HMG-COA reductase inhibitors |
| JPH0233347U (da) * | 1988-08-27 | 1990-03-02 | ||
| US5166364A (en) * | 1989-02-27 | 1992-11-24 | E. R. Squibb & Sons, Inc. | Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
| US5099035A (en) * | 1989-02-27 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
| US4937259A (en) * | 1989-06-09 | 1990-06-26 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US5102911A (en) * | 1989-06-09 | 1992-04-07 | Merck & Co, Inc. | 4-Substituted HMG-CoA reductase inhibitors |
| US4970231A (en) * | 1989-06-09 | 1990-11-13 | Merck & Co., Inc. | 4-substituted HMG-CoA reductase inhibitors |
| US5041562A (en) * | 1989-06-09 | 1991-08-20 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| US5010105A (en) * | 1989-06-09 | 1991-04-23 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| ATE135352T1 (de) * | 1989-06-09 | 1996-03-15 | Merck & Co Inc | 3-keto-hmg-coa reduktase-inhibitoren |
| US5001241A (en) * | 1989-06-09 | 1991-03-19 | Merck & Co., Inc. | 3-KETO HMG-CoA reductase inhibitors |
| CA2036962C (en) * | 1990-02-26 | 1998-09-15 | Ann E. Decamp | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one |
| US5112857A (en) * | 1990-09-04 | 1992-05-12 | Merck & Co., Inc. | Hmg-coa reductase inhibitor metabolites |
| FI932188L (fi) | 1992-05-15 | 1993-11-16 | Sankyo Co | Oktahydronaftalenoximderivat foer inhibering av kolesterolbiosyntesen, deras framstaellning och anvaendning |
| WO2016161085A1 (en) | 2015-04-01 | 2016-10-06 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1354098A (en) * | 1970-04-24 | 1974-06-05 | Teikoku Hormone Mfg Co Ltd | 1-hydroxyiminonaphthalene derivatives |
| US4137322A (en) * | 1976-11-02 | 1979-01-30 | Sankyo Company Limited | ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents |
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| US4246277A (en) * | 1979-06-22 | 1981-01-20 | Albert Rolland S.A. | Lowering the concentration of plasma triglycerides |
| JPS56142236A (en) * | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
| JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
| JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Ｍｂ−５３０ｂ誘導体およびその製造法 |
| JPS5855443A (ja) * | 1981-09-25 | 1983-04-01 | Sankyo Co Ltd | オクタヒドロナフタリン誘導体およびその製造法 |
| US4503072A (en) * | 1982-12-22 | 1985-03-05 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
-
1981
- 1981-09-25 JP JP56151871A patent/JPS5855443A/ja active Granted
-
1982
- 1982-09-21 CA CA000411825A patent/CA1298845C/en not_active Expired - Fee Related
- 1982-09-23 AT AT82305015T patent/ATE19074T1/de not_active IP Right Cessation
- 1982-09-23 DE DE8282305015T patent/DE3270445D1/de not_active Expired
- 1982-09-23 EP EP82305015A patent/EP0076601B1/en not_active Expired
- 1982-09-24 DK DK426682A patent/DK171877B1/da active
- 1982-09-24 IE IE2319/82A patent/IE53910B1/en not_active IP Right Cessation
- 1982-09-24 AU AU88666/82A patent/AU555242B2/en not_active Expired
- 1982-09-24 FI FI823282A patent/FI79706C/fi not_active IP Right Cessation
- 1982-09-24 ES ES515954A patent/ES8308556A1/es not_active Expired
-
1985
- 1985-07-09 US US06/753,254 patent/US4604472A/en not_active Expired - Lifetime
-
1986
- 1986-05-06 US US06/860,185 patent/US4733003A/en not_active Expired - Lifetime
-
1988
- 1988-09-22 KR KR1019880012273A patent/KR890000364B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES515954A0 (es) | 1983-09-16 |
| AU555242B2 (en) | 1986-09-18 |
| DK171877B1 (da) | 1997-07-28 |
| CA1298845C (en) | 1992-04-14 |
| US4733003A (en) | 1988-03-22 |
| FI79706C (fi) | 1990-02-12 |
| EP0076601B1 (en) | 1986-04-09 |
| FI823282L (fi) | 1983-03-26 |
| AU8866682A (en) | 1983-03-31 |
| EP0076601A1 (en) | 1983-04-13 |
| US4604472A (en) | 1986-08-05 |
| IE53910B1 (en) | 1989-04-12 |
| JPH0153662B2 (da) | 1989-11-15 |
| IE822319L (en) | 1983-03-25 |
| JPS5855443A (ja) | 1983-04-01 |
| ATE19074T1 (de) | 1986-04-15 |
| FI79706B (fi) | 1989-10-31 |
| DE3270445D1 (en) | 1986-05-15 |
| KR890000364B1 (ko) | 1989-03-15 |
| FI823282A0 (fi) | 1982-09-24 |
| ES8308556A1 (es) | 1983-09-16 |
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