DK41590A - Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme - Google Patents

Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme Download PDF

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Publication number
DK41590A
DK41590A DK041590A DK41590A DK41590A DK 41590 A DK41590 A DK 41590A DK 041590 A DK041590 A DK 041590A DK 41590 A DK41590 A DK 41590A DK 41590 A DK41590 A DK 41590A
Authority
DK
Denmark
Prior art keywords
molecules
activation
procedures
preparation
same
Prior art date
Application number
DK041590A
Other languages
Danish (da)
English (en)
Other versions
DK41590D0 (da
Inventor
Robert M Wydro
Catherine L Oppenheimer
Debra A Barngrover
Dawn T Ferrara
William R Dackowski
Gregory M Landes
Nancy A Capalucci
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DK41590D0 publication Critical patent/DK41590D0/da
Publication of DK41590A publication Critical patent/DK41590A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK041590A 1987-05-18 1990-02-16 Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme DK41590A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5136687A 1987-05-18 1987-05-18
PCT/US1988/002083 WO1989012685A1 (en) 1987-05-18 1988-06-17 Improved protein c molecules and method for making and activating same

Publications (2)

Publication Number Publication Date
DK41590D0 DK41590D0 (da) 1990-02-16
DK41590A true DK41590A (da) 1990-04-11

Family

ID=22208746

Family Applications (1)

Application Number Title Priority Date Filing Date
DK041590A DK41590A (da) 1987-05-18 1990-02-16 Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme

Country Status (4)

Country Link
EP (1) EP0380508A4 (de)
JP (1) JPH03501921A (de)
DK (1) DK41590A (de)
WO (1) WO1989012685A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2024598A1 (en) * 1989-09-05 1991-03-06 Sau-Chi B. Yan Method for activating protein c
DE69032029T2 (de) * 1989-12-29 1998-08-20 Zymogenetics, Inc., Seattle, Wash. Hybrides protein c
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
ATE103982T1 (de) * 1990-01-26 1994-04-15 Immuno Ag Rekombinant hergestellte blutfaktoren, verfahren zur exprimierung besagter blutfaktoren sowie in besagtem prozess verwendeter rekombinanter vaccina-virus.
JP3043558B2 (ja) * 1993-10-29 2000-05-22 財団法人化学及血清療法研究所 ヒト活性化プロテインｃ調製物及びその製法
WO2004113385A1 (en) * 2003-06-20 2004-12-29 Maxygen Holdings Ltd. Protein c propeptide variants
EP2336360A1 (de) 2003-09-23 2011-06-22 University Of North Carolina At Chapel Hill Verfahren und Zusammensetzungen zur Korrelation von Einzelnukleotidpolymorphismen im Gen der Vitamin-K-Epoxidreduktase und der Dosierung von Warfarin
WO2006101474A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
EP1874928A1 (de) * 2005-04-13 2008-01-09 AstraZeneca AB Wirtszelle mit vektor zur herstellung von gamma-carboxylierung benötigenden proteinen
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
EP2869833B1 (de) 2012-07-04 2018-04-04 ZZ Biotech LLC. Aktiviertes protein c zur behandlung von hautentzündungserkrankungen
WO2015157791A1 (en) 2014-04-16 2015-10-22 The University Of Sydney Treatment of abnormal cutaneous scarring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189534A (en) * 1976-11-11 1980-02-19 Massachusetts Institute Of Technology Cell culture microcarriers
US4579821A (en) * 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4751084A (en) * 1986-02-26 1988-06-14 Monsanto Company Tissue plasminogen activator from normal human colon cells
EP0245949B1 (de) * 1986-04-09 1997-10-29 Eli Lilly And Company Verfahren zur Anwendung von den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren
IL82648A0 (en) * 1986-05-27 1987-11-30 Lilly Co Eli Human protein s,a plasma protein regulator of hemostasis
ZA889497B (en) * 1987-12-28 1990-08-29 Lilly Co Eli Vectors and compounds for expression of zymogen forms of human protein c

Also Published As

Publication number Publication date
DK41590D0 (da) 1990-02-16
JPH03501921A (ja) 1991-05-09
EP0380508A1 (de) 1990-08-08
EP0380508A4 (en) 1991-04-03
WO1989012685A1 (en) 1989-12-28

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