DK409384D0 - Krystallinsk salt af en l- eller (s)-3-(3,4-dihydroxyphenyl)-2-methylalaninester og fremgangsmaade til fremstilling deraf - Google Patents

Krystallinsk salt af en l- eller (s)-3-(3,4-dihydroxyphenyl)-2-methylalaninester og fremgangsmaade til fremstilling deraf

Info

Publication number
DK409384D0
DK409384D0 DK409384A DK409384A DK409384D0 DK 409384 D0 DK409384 D0 DK 409384D0 DK 409384 A DK409384 A DK 409384A DK 409384 A DK409384 A DK 409384A DK 409384 D0 DK409384 D0 DK 409384D0
Authority
DK
Denmark
Prior art keywords
methylalanine
dihydroxyphenyl
salts
crystallinic
estes
Prior art date
Application number
DK409384A
Other languages
English (en)
Other versions
DK409384A (da
Inventor
John Budavari
Robert F Czaja
Edward J J Grabowski
William F Shukis
Arthur J Zambito
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK409384D0 publication Critical patent/DK409384D0/da
Publication of DK409384A publication Critical patent/DK409384A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK409384A 1983-08-29 1984-08-28 Krystallinsk salt af en l- eller (s)-3-(3,4-dihydroxyphenyl)-2-methylalaninester og fremgangsmaade til fremstilling deraf DK409384A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52752683A 1983-08-29 1983-08-29

Publications (2)

Publication Number Publication Date
DK409384D0 true DK409384D0 (da) 1984-08-28
DK409384A DK409384A (da) 1985-03-01

Family

ID=24101812

Family Applications (1)

Application Number Title Priority Date Filing Date
DK409384A DK409384A (da) 1983-08-29 1984-08-28 Krystallinsk salt af en l- eller (s)-3-(3,4-dihydroxyphenyl)-2-methylalaninester og fremgangsmaade til fremstilling deraf

Country Status (14)

Country Link
EP (1) EP0139983B1 (da)
JP (1) JPS6072848A (da)
KR (1) KR900003530B1 (da)
AT (1) ATE30318T1 (da)
AU (1) AU575067B2 (da)
CA (1) CA1232614A (da)
DE (1) DE3466877D1 (da)
DK (1) DK409384A (da)
ES (1) ES8700226A1 (da)
GR (1) GR80155B (da)
IL (1) IL72726A (da)
NZ (1) NZ209285A (da)
PT (1) PT79107B (da)
ZA (1) ZA846698B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005252220B2 (en) * 2004-06-04 2011-06-02 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
WO2008076458A1 (en) * 2006-12-21 2008-06-26 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983138A (en) * 1973-09-25 1976-09-28 Merck & Co., Inc. Amino acid esters
US4404392A (en) * 1981-11-16 1983-09-13 Merck & Co., Inc. Resolution of α-pivaloyloxyethyl-(S)-3-(3,4-dihydroxyphenyl)-2-methylalantinate into its α and β isomers
US4440942A (en) * 1982-03-01 1984-04-03 Merck & Co., Inc. Crystalline diastereomeric L-alpha-methyldopa POE ester and process for its preparation

Also Published As

Publication number Publication date
DK409384A (da) 1985-03-01
AU575067B2 (en) 1988-07-21
ATE30318T1 (de) 1987-11-15
AU3244884A (en) 1985-03-07
JPS6072848A (ja) 1985-04-24
PT79107A (en) 1984-09-01
DE3466877D1 (en) 1987-11-26
CA1232614A (en) 1988-02-09
ES8700226A1 (es) 1986-10-16
ES535444A0 (es) 1986-10-16
ZA846698B (en) 1986-04-30
IL72726A (en) 1988-02-29
NZ209285A (en) 1988-04-29
IL72726A0 (en) 1984-11-30
KR850001729A (ko) 1985-04-01
GR80155B (en) 1984-12-19
KR900003530B1 (ko) 1990-05-21
EP0139983B1 (en) 1987-10-21
PT79107B (en) 1986-11-14
EP0139983A1 (en) 1985-05-08

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