DK3972603T3 - Fremgangsmåder til behandling af Sjögrens Syndrom ved brug af en Brutons Tyrosinkinasehæmmer - Google Patents

Fremgangsmåder til behandling af Sjögrens Syndrom ved brug af en Brutons Tyrosinkinasehæmmer Download PDF

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Publication number
DK3972603T3
DK3972603T3 DK20729203.8T DK20729203T DK3972603T3 DK 3972603 T3 DK3972603 T3 DK 3972603T3 DK 20729203 T DK20729203 T DK 20729203T DK 3972603 T3 DK3972603 T3 DK 3972603T3
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Denmark
Prior art keywords
bruton
syndrome
procedures
tyrosine kinase
kinase inhibitor
Prior art date
Application number
DK20729203.8T
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Danish (da)
English (en)
Inventor
Souvik Bhattacharya
Bruno Bieth
Maciej Cabanski
Bruno Cenni
Buck Stefan De
Martin Kaul
Arvind Kinhikar
Andrijana Radivojevic
Garami Alessandra Vitaliti
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
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Publication of DK3972603T3 publication Critical patent/DK3972603T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK20729203.8T 2019-05-23 2020-05-20 Fremgangsmåder til behandling af Sjögrens Syndrom ved brug af en Brutons Tyrosinkinasehæmmer DK3972603T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962851994P 2019-05-23 2019-05-23
PCT/IB2020/054754 WO2020234781A1 (en) 2019-05-23 2020-05-20 Methods of treating sjögren's syndrome using a bruton's tyrosine kinase inhibitor

Publications (1)

Publication Number Publication Date
DK3972603T3 true DK3972603T3 (da) 2024-12-02

Family

ID=70918750

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20729203.8T DK3972603T3 (da) 2019-05-23 2020-05-20 Fremgangsmåder til behandling af Sjögrens Syndrom ved brug af en Brutons Tyrosinkinasehæmmer

Country Status (23)

Country Link
US (2) US12383556B2 (https=)
EP (2) EP3972603B1 (https=)
JP (2) JP7765970B2 (https=)
KR (1) KR20220011652A (https=)
CN (1) CN113811301A (https=)
AU (2) AU2020278236C1 (https=)
BR (1) BR112021023110A2 (https=)
CA (1) CA3137271A1 (https=)
CL (1) CL2021003034A1 (https=)
DK (1) DK3972603T3 (https=)
ES (1) ES3004516T3 (https=)
FI (1) FI3972603T3 (https=)
HR (1) HRP20241584T1 (https=)
HU (1) HUE069020T2 (https=)
IL (1) IL287745B2 (https=)
LT (1) LT3972603T (https=)
MX (1) MX2021014161A (https=)
PL (1) PL3972603T3 (https=)
PT (1) PT3972603T (https=)
RS (1) RS66195B1 (https=)
SI (1) SI3972603T1 (https=)
TW (1) TWI857060B (https=)
WO (1) WO2020234781A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021023110A2 (pt) 2019-05-23 2022-04-12 Novartis Ag Métodos de tratamento de síndrome de sjögren com o uso de um inibidor de tirosina quinase de bruton
MX2023008671A (es) * 2021-01-26 2023-09-25 Novartis Ag Composicion farmaceutica.
CN116782888A (zh) * 2021-01-26 2023-09-19 诺华股份有限公司 药物组合物
JP7564347B2 (ja) 2021-09-03 2024-10-08 ノバルティス アーゲー 多発性硬化症を治療するためのlou064
US20250032488A1 (en) 2021-12-14 2025-01-30 Novartis Ag Methods of treatment using lou064
TW202342048A (zh) 2022-02-28 2023-11-01 瑞士商諾華公司 使用lou064治療化膿性汗腺炎之方法
KR102875105B1 (ko) 2023-04-03 2025-10-21 주식회사 사이알바이오 재조합 세마포린 4d 차단항체를 유효성분으로 포함하는 쇼그렌 증후군 예방 또는 치료용 약학 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ532310A (en) 2001-10-05 2007-02-23 Combinatorx Inc Combinations comprising a tetra-substituted pyrimidopyrimidine and a corticosteroid for the treatment of immunoinflammatory disorders
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
LT3390390T (lt) 2015-12-16 2021-11-25 Boehringer Ingelheim International Gmbh Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui
US10570118B2 (en) 2016-01-13 2020-02-25 Boehringer Ingelheim International Gmbh Isoquinolones as BTK inhibitors
US10874741B2 (en) 2017-08-28 2020-12-29 Spectrix Therapeutics, LLC Compound to treat Sjogren's syndrome
KR20200074993A (ko) 2017-11-03 2020-06-25 노파르티스 아게 쇼그렌 증후군 치료에 사용하기 위한 항-cd40 항체
TWI694995B (zh) * 2017-11-06 2020-06-01 美商美國禮來大藥廠 Btk抑制劑化合物
BR112021023110A2 (pt) 2019-05-23 2022-04-12 Novartis Ag Métodos de tratamento de síndrome de sjögren com o uso de um inibidor de tirosina quinase de bruton

Also Published As

Publication number Publication date
IL287745B1 (en) 2025-10-01
JP2025165957A (ja) 2025-11-05
IL287745B2 (en) 2026-02-01
TWI857060B (zh) 2024-10-01
EP3972603B1 (en) 2024-09-04
EP4442321A2 (en) 2024-10-09
AU2020278236A8 (en) 2022-04-28
AU2025263830A1 (en) 2025-11-27
US12383556B2 (en) 2025-08-12
ES3004516T3 (en) 2025-03-12
CN113811301A (zh) 2021-12-17
EP3972603A1 (en) 2022-03-30
EP4442321A3 (en) 2025-01-01
AU2020278236C1 (en) 2026-02-26
AU2020278236B2 (en) 2025-08-07
RS66195B1 (sr) 2024-12-31
TW202110451A (zh) 2021-03-16
US20220175772A1 (en) 2022-06-09
WO2020234781A1 (en) 2020-11-26
JP7765970B2 (ja) 2025-11-07
BR112021023110A2 (pt) 2022-04-12
LT3972603T (lt) 2024-12-10
PL3972603T3 (pl) 2025-02-03
FI3972603T3 (fi) 2024-12-04
CL2021003034A1 (es) 2022-09-09
PT3972603T (pt) 2024-11-26
US20250339428A1 (en) 2025-11-06
SI3972603T1 (sl) 2025-02-28
HRP20241584T1 (hr) 2025-01-31
HUE069020T2 (hu) 2025-02-28
JP2022533968A (ja) 2022-07-27
MX2021014161A (es) 2022-01-04
KR20220011652A (ko) 2022-01-28
AU2020278236A1 (en) 2022-01-06
CA3137271A1 (en) 2020-11-26
IL287745A (en) 2021-12-01

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