DK3883689T3 - Anordning og fremgangsmåde til celledetektering i mikrodråber - Google Patents
Anordning og fremgangsmåde til celledetektering i mikrodråber Download PDFInfo
- Publication number
- DK3883689T3 DK3883689T3 DK19801405.2T DK19801405T DK3883689T3 DK 3883689 T3 DK3883689 T3 DK 3883689T3 DK 19801405 T DK19801405 T DK 19801405T DK 3883689 T3 DK3883689 T3 DK 3883689T3
- Authority
- DK
- Denmark
- Prior art keywords
- microdroplets
- cell detection
- cell
- detection
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/01—Drops
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- C—CHEMISTRY; METALLURGY
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- G—PHYSICS
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
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- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- B01L2200/0652—Sorting or classification of particles or molecules
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Fluid Mechanics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Thermal Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18207379.1A EP3656473A1 (en) | 2018-11-20 | 2018-11-20 | Microdroplet detection of cells |
EP18207377.5A EP3656472A1 (en) | 2018-11-20 | 2018-11-20 | Cell analyser |
GBGB1909514.0A GB201909514D0 (en) | 2018-11-20 | 2019-07-02 | Device and method for microdroplet detection of cells |
PCT/GB2019/053168 WO2020104769A1 (en) | 2018-11-20 | 2019-11-08 | Device and method for microdroplet detection of cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3883689T3 true DK3883689T3 (da) | 2024-04-08 |
Family
ID=67540110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19801405.2T DK3883689T3 (da) | 2018-11-20 | 2019-11-08 | Anordning og fremgangsmåde til celledetektering i mikrodråber |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220008927A1 (da) |
EP (2) | EP3883689B1 (da) |
JP (1) | JP7500560B2 (da) |
KR (1) | KR20210094583A (da) |
CN (2) | CN117586866A (da) |
AU (1) | AU2019385743A1 (da) |
BR (1) | BR112021009866A2 (da) |
CA (1) | CA3120239A1 (da) |
DK (1) | DK3883689T3 (da) |
GB (1) | GB201909514D0 (da) |
IL (1) | IL283266B1 (da) |
SG (1) | SG11202105140UA (da) |
WO (1) | WO2020104769A1 (da) |
ZA (1) | ZA202103400B (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB202012485D0 (en) * | 2020-08-11 | 2020-09-23 | Lightcast Discovery Ltd | Improvements in or relating to a method of maintaing a microdroplet |
JP2024506285A (ja) * | 2021-02-03 | 2024-02-13 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 高感度化学ルミネセンス検出システムおよび方法 |
GB202103609D0 (en) | 2021-03-16 | 2021-04-28 | Lightcast Discovery Ltd | Method of selecting cells |
WO2022241138A1 (en) * | 2021-05-13 | 2022-11-17 | Janssen Biotech, Inc. | Device and method for sorting biological cells |
GB202109967D0 (en) * | 2021-07-09 | 2021-08-25 | Lightcast Discovery Ltd | Improvements in or relating to imaging microdroplets in a microfluidic device |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US6565727B1 (en) | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
US6958132B2 (en) | 2002-05-31 | 2005-10-25 | The Regents Of The University Of California | Systems and methods for optical actuation of microfluidics based on opto-electrowetting |
US20060153745A1 (en) | 2005-01-11 | 2006-07-13 | Applera Corporation | Fluid processing device for oligonucleotide synthesis and analysis |
US20100120130A1 (en) | 2007-08-08 | 2010-05-13 | Advanced Liquid Logic, Inc. | Droplet Actuator with Droplet Retention Structures |
US8367370B2 (en) | 2008-02-11 | 2013-02-05 | Wheeler Aaron R | Droplet-based cell culture and cell assays using digital microfluidics |
US8852952B2 (en) | 2008-05-03 | 2014-10-07 | Advanced Liquid Logic, Inc. | Method of loading a droplet actuator |
JP2011525811A (ja) * | 2008-06-27 | 2011-09-29 | マサチューセッツ インスティテュート オブ テクノロジー | 代謝工学および他の用途のためのマイクロ流体小滴 |
US8846414B2 (en) | 2009-09-29 | 2014-09-30 | Advanced Liquid Logic, Inc. | Detection of cardiac markers on a droplet actuator |
US20150306598A1 (en) | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus |
DE102015106870B3 (de) * | 2014-11-10 | 2016-02-25 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut | System zur Inkubation von mikrofluidischen Tropfen und Verfahren zur Bereitstellung von homogenen Inkubationsbedingungen in einer Tropfeninkubationseinheit |
EP3227025B1 (en) | 2014-12-05 | 2019-03-27 | The Regents of The University of California | Single-sided light-actuated microfluidic device with integrated mesh ground |
CN107206377B (zh) | 2014-12-09 | 2020-02-11 | 伯克利之光生命科技公司 | 微流体装置中测定阳性的区域的自动检测 |
US10267726B2 (en) | 2015-04-27 | 2019-04-23 | Illumina France Sarl | Systems and methods of identifying and/or tracking particles in a droplet, wherein the particle can be a cell |
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WO2017117567A1 (en) | 2015-12-30 | 2017-07-06 | Berkeley Lights, Inc. | Droplet generation in a microfluidic device having an optoelectrowetting configuration |
KR20240017985A (ko) | 2017-06-21 | 2024-02-08 | 베이스4 이노베이션 엘티디 | 마이크로 액적 조작 장치 |
BR112019027764A2 (pt) | 2017-06-21 | 2020-07-07 | Base4 Innovation Limited | método para manipular uma microgotícula e método para pirofosforizar um analito de ácido nucleico |
US10940477B2 (en) * | 2018-07-19 | 2021-03-09 | Micareo Taiwan Co., Ltd. | Fluid sample collection and retrieval apparatus and microfluidic chip |
-
2019
- 2019-07-02 GB GBGB1909514.0A patent/GB201909514D0/en not_active Ceased
- 2019-11-08 CN CN202311529990.3A patent/CN117586866A/zh active Pending
- 2019-11-08 WO PCT/GB2019/053168 patent/WO2020104769A1/en unknown
- 2019-11-08 CN CN201980076576.7A patent/CN113164952B/zh active Active
- 2019-11-08 BR BR112021009866-6A patent/BR112021009866A2/pt not_active Application Discontinuation
- 2019-11-08 JP JP2021528854A patent/JP7500560B2/ja active Active
- 2019-11-08 KR KR1020217018646A patent/KR20210094583A/ko unknown
- 2019-11-08 SG SG11202105140UA patent/SG11202105140UA/en unknown
- 2019-11-08 AU AU2019385743A patent/AU2019385743A1/en active Pending
- 2019-11-08 CA CA3120239A patent/CA3120239A1/en active Pending
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- 2019-11-08 US US17/295,654 patent/US20220008927A1/en active Pending
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2021
- 2021-05-19 IL IL283266A patent/IL283266B1/en unknown
- 2021-05-19 ZA ZA2021/03400A patent/ZA202103400B/en unknown
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IL283266B1 (en) | 2024-07-01 |
AU2019385743A1 (en) | 2021-06-17 |
CN117586866A (zh) | 2024-02-23 |
EP3883689B1 (en) | 2024-03-06 |
GB201909514D0 (en) | 2019-08-14 |
JP2022510140A (ja) | 2022-01-26 |
EP4336168A2 (en) | 2024-03-13 |
US20220008927A1 (en) | 2022-01-13 |
SG11202105140UA (en) | 2021-06-29 |
EP3883689A1 (en) | 2021-09-29 |
WO2020104769A1 (en) | 2020-05-28 |
BR112021009866A2 (pt) | 2021-09-14 |
IL283266A (en) | 2021-07-29 |
KR20210094583A (ko) | 2021-07-29 |
JP7500560B2 (ja) | 2024-06-17 |
CN113164952B (zh) | 2023-12-05 |
EP4336168A3 (en) | 2024-05-29 |
ZA202103400B (en) | 2022-10-26 |
CA3120239A1 (en) | 2020-05-28 |
CN113164952A (zh) | 2021-07-23 |
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