DK3823990T3 - Tungkædeantistoffer, der binder til cd19 - Google Patents
Tungkædeantistoffer, der binder til cd19Info
- Publication number
- DK3823990T3 DK3823990T3 DK19749123.6T DK19749123T DK3823990T3 DK 3823990 T3 DK3823990 T3 DK 3823990T3 DK 19749123 T DK19749123 T DK 19749123T DK 3823990 T3 DK3823990 T3 DK 3823990T3
- Authority
- DK
- Denmark
- Prior art keywords
- binding
- heavy chain
- chain antibodies
- antibodies
- heavy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862701281P | 2018-07-20 | 2018-07-20 | |
| PCT/US2019/042633 WO2020018922A1 (en) | 2018-07-20 | 2019-07-19 | Heavy chain antibodies binding to cd19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3823990T3 true DK3823990T3 (da) | 2026-03-16 |
Family
ID=67515196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19749123.6T DK3823990T3 (da) | 2018-07-20 | 2019-07-19 | Tungkædeantistoffer, der binder til cd19 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US12202898B2 (enExample) |
| EP (2) | EP3823990B1 (enExample) |
| JP (2) | JP7439046B2 (enExample) |
| KR (2) | KR102930803B1 (enExample) |
| CN (2) | CN112351997B (enExample) |
| AU (1) | AU2019305663B2 (enExample) |
| BR (1) | BR112020024074A2 (enExample) |
| CA (1) | CA3101069A1 (enExample) |
| DK (1) | DK3823990T3 (enExample) |
| ES (1) | ES3064933T3 (enExample) |
| FI (1) | FI3823990T3 (enExample) |
| HR (1) | HRP20260372T1 (enExample) |
| IL (2) | IL326259A (enExample) |
| LT (1) | LT3823990T (enExample) |
| MX (1) | MX2021000708A (enExample) |
| PL (1) | PL3823990T3 (enExample) |
| PT (1) | PT3823990T (enExample) |
| RS (1) | RS67881B1 (enExample) |
| SG (1) | SG11202011597RA (enExample) |
| SM (1) | SMT202600121T1 (enExample) |
| WO (1) | WO2020018922A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109641049B (zh) | 2016-06-21 | 2023-07-07 | 特尼奥生物股份有限公司 | Cd3结合抗体 |
| RU2762835C2 (ru) | 2016-08-24 | 2021-12-23 | Тенеобио, Инк. | Трансгенные животные, отличные от человека, продуцирующие модифицированные антитела, содержащие только тяжелые цепи |
| MY200988A (en) | 2016-09-14 | 2024-01-27 | Teneobio Inc | CD3 Binding Antibodies |
| KR102745676B1 (ko) | 2016-12-21 | 2024-12-24 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
| WO2018237006A1 (en) | 2017-06-20 | 2018-12-27 | Teneoone, Inc. | Anti-bcma heavy chain-only antibodies |
| IL312322B2 (en) | 2017-06-20 | 2026-05-01 | Teneobio Inc | Antibodies against BCMA containing only heavy chains |
| WO2019126756A1 (en) | 2017-12-22 | 2019-06-27 | Teneobio, Inc. | Heavy chain antibodies binding to cd22 |
| BR112020024074A2 (pt) | 2018-07-20 | 2021-02-17 | Teneobio, Inc. | anticorpos de cadeia pesada com ligação a cd19 |
| WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CR20210500A (es) | 2019-04-05 | 2021-11-05 | Teneobio Inc | Anticuerpos de cadena pesada que se unen al psma |
| JP7665538B2 (ja) | 2019-06-14 | 2025-04-21 | テネオバイオ， インコーポレイテッド | Ｃｄ２２及びｃｄ３に結合する多重特異性重鎖抗体 |
| EP4592310A2 (en) * | 2020-03-16 | 2025-07-30 | Angeles Therapeutics, Inc. | Novel antigen binding domains and synthetic antigen receptors incorporating the same |
| WO2021222578A1 (en) | 2020-04-29 | 2021-11-04 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
| IL297601A (en) | 2020-04-29 | 2022-12-01 | Teneobio Inc | Multispecific heavy chain antibodies with modified heavy chain constant regions |
| EP4182351A4 (en) * | 2020-07-16 | 2024-12-11 | Legend Biotech Ireland Limited | CD19-BINDING MOLECULES AND THEIR USES |
| WO2022012680A1 (en) | 2020-07-16 | 2022-01-20 | Nanjing Legend Biotech Co., Ltd. | Cd20 binding molecules and uses thereof |
| WO2022060901A1 (en) | 2020-09-16 | 2022-03-24 | Amgen Inc. | Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer |
| KR20230166090A (ko) * | 2021-04-06 | 2023-12-06 | 테네오바이오, 인코포레이티드 | 항-cd19 항체 및 car-t 구조체 |
| WO2024243093A2 (en) * | 2023-05-19 | 2024-11-28 | The Regents Of The University Of California | Multispecific antibodies targeting cd3 and cd22 |
| EP4566619A1 (en) | 2023-12-08 | 2025-06-11 | AvenCell Therapeutics Inc. | Targeting modules against cd19 and cd20 for use in a method for stimulating a reversed chimeric antigen receptor-mediated immune response in a mammal |
| WO2025222102A1 (en) * | 2024-04-19 | 2025-10-23 | TeneoTwo, Inc. | Therapeutic combinations of acalabrutinib and a multispecific antibody to treat b-cell malignancies |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| US6066721A (en) | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| ATE279947T1 (de) | 1996-03-18 | 2004-11-15 | Univ Texas | Immunglobulinähnliche domäne mit erhöhten halbwertszeiten |
| AU6232899A (en) | 1999-10-06 | 2001-05-10 | Campina Melkunie B.V. | Use of transforming growth factor beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| CA2438682A1 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| EP1578447A4 (en) | 2002-10-31 | 2009-06-03 | Genentech Inc | METHOD AND COMPOSITIONS FOR INCREASING ANTIBODY PRODUCTION |
| CA2513113A1 (en) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| US20060008548A1 (en) | 2003-11-19 | 2006-01-12 | Invista North America S.A R.L. | Spinneret plate for producing a bulked continuous filament having a three-sided exterior cross-section and a convex six-sided central void |
| EP1978032A3 (en) | 2004-07-22 | 2009-02-18 | Erasmus University Medical Center Rotterdam | Binding molecules |
| CN101218351A (zh) * | 2005-02-15 | 2008-07-09 | 杜克大学 | 抗cd19抗体及其在肿瘤学中的应用 |
| HUE025945T2 (en) * | 2005-02-15 | 2016-07-28 | Univ Duke | Anti-CD19 antibodies and their applications in oncology |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| CA2688834C (en) | 2007-06-01 | 2020-01-07 | Ronald Buelow | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
| US20100122358A1 (en) | 2008-06-06 | 2010-05-13 | Crescendo Biologics Limited | H-Chain-only antibodies |
| EA024492B1 (ru) * | 2008-07-17 | 2016-09-30 | Новартис Аг | Антитела, специфически связывающиеся с baffr, и их применение |
| KR101589785B1 (ko) | 2009-03-10 | 2016-01-28 | 바이오젠 엠에이 인코포레이티드 | 항-ｂｃｍａ 항체 |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| US9963513B2 (en) | 2013-02-05 | 2018-05-08 | Engmab Sàrl | Method for the selection of antibodies against BCMA |
| AP2017009823A0 (en) * | 2014-09-26 | 2017-03-31 | Macrogenics Inc | Bi-specific monovalent diabodies that are capable of binding cd19 and cd3, and uses thereof |
| CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| US9914683B2 (en) * | 2016-05-26 | 2018-03-13 | X Development Llc | Fuel synthesis from an aqueous solution |
| CN109641049B (zh) | 2016-06-21 | 2023-07-07 | 特尼奥生物股份有限公司 | Cd3结合抗体 |
| RU2762835C2 (ru) | 2016-08-24 | 2021-12-23 | Тенеобио, Инк. | Трансгенные животные, отличные от человека, продуцирующие модифицированные антитела, содержащие только тяжелые цепи |
| MY200988A (en) | 2016-09-14 | 2024-01-27 | Teneobio Inc | CD3 Binding Antibodies |
| KR102745676B1 (ko) | 2016-12-21 | 2024-12-24 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
| WO2018237006A1 (en) | 2017-06-20 | 2018-12-27 | Teneoone, Inc. | Anti-bcma heavy chain-only antibodies |
| IL312322B2 (en) | 2017-06-20 | 2026-05-01 | Teneobio Inc | Antibodies against BCMA containing only heavy chains |
| KR102757010B1 (ko) | 2017-06-30 | 2025-01-23 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 인간 도메인을 갖는 항-b 세포 성숙화 항원 키메라성 항원 수용체 |
| BR112020013086A2 (pt) | 2017-12-27 | 2020-12-08 | Teneobio, Inc. | Anticorpos específicos de heterodímero de cd3-delta/épsilon |
| CA3101340A1 (en) | 2018-05-24 | 2019-11-28 | Ayala Pharmaceuticals Inc. | Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds and immunotherapeutics and methods of use thereof |
| BR112020024074A2 (pt) | 2018-07-20 | 2021-02-17 | Teneobio, Inc. | anticorpos de cadeia pesada com ligação a cd19 |
| JP7665538B2 (ja) | 2019-06-14 | 2025-04-21 | テネオバイオ， インコーポレイテッド | Ｃｄ２２及びｃｄ３に結合する多重特異性重鎖抗体 |
| IL297601A (en) | 2020-04-29 | 2022-12-01 | Teneobio Inc | Multispecific heavy chain antibodies with modified heavy chain constant regions |
-
2019
- 2019-07-19 BR BR112020024074-5A patent/BR112020024074A2/pt unknown
- 2019-07-19 FI FIEP19749123.6T patent/FI3823990T3/fi active
- 2019-07-19 KR KR1020207034987A patent/KR102930803B1/ko active Active
- 2019-07-19 PL PL19749123.6T patent/PL3823990T3/pl unknown
- 2019-07-19 CN CN201980035712.8A patent/CN112351997B/zh active Active
- 2019-07-19 PT PT197491236T patent/PT3823990T/pt unknown
- 2019-07-19 CN CN202310539593.8A patent/CN116769032A/zh active Pending
- 2019-07-19 MX MX2021000708A patent/MX2021000708A/es unknown
- 2019-07-19 IL IL326259A patent/IL326259A/en unknown
- 2019-07-19 SG SG11202011597RA patent/SG11202011597RA/en unknown
- 2019-07-19 KR KR1020267005215A patent/KR20260036383A/ko active Pending
- 2019-07-19 SM SM20260121T patent/SMT202600121T1/it unknown
- 2019-07-19 EP EP19749123.6A patent/EP3823990B1/en active Active
- 2019-07-19 US US17/260,213 patent/US12202898B2/en active Active
- 2019-07-19 RS RS20260319A patent/RS67881B1/sr unknown
- 2019-07-19 JP JP2021502833A patent/JP7439046B2/ja active Active
- 2019-07-19 CA CA3101069A patent/CA3101069A1/en active Pending
- 2019-07-19 LT LTEPPCT/US2019/042633T patent/LT3823990T/lt unknown
- 2019-07-19 WO PCT/US2019/042633 patent/WO2020018922A1/en not_active Ceased
- 2019-07-19 DK DK19749123.6T patent/DK3823990T3/da active
- 2019-07-19 ES ES19749123T patent/ES3064933T3/es active Active
- 2019-07-19 AU AU2019305663A patent/AU2019305663B2/en active Active
- 2019-07-19 HR HRP20260372TT patent/HRP20260372T1/hr unknown
- 2019-07-19 EP EP25219867.6A patent/EP4714502A2/en active Pending
-
2020
- 2020-11-26 IL IL279010A patent/IL279010B1/en unknown
-
2024
- 2024-02-14 JP JP2024020312A patent/JP7737488B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RS67881B1 (sr) | 2026-04-30 |
| IL279010B1 (en) | 2026-03-01 |
| JP7737488B2 (ja) | 2025-09-10 |
| JP2024073430A (ja) | 2024-05-29 |
| LT3823990T (lt) | 2026-04-10 |
| US20210332133A1 (en) | 2021-10-28 |
| EP4714502A2 (en) | 2026-03-25 |
| MX2021000708A (es) | 2021-03-25 |
| KR20260036383A (ko) | 2026-03-16 |
| BR112020024074A2 (pt) | 2021-02-17 |
| SG11202011597RA (en) | 2020-12-30 |
| PL3823990T3 (pl) | 2026-04-20 |
| CN116769032A (zh) | 2023-09-19 |
| EP3823990B1 (en) | 2025-12-17 |
| IL326259A (en) | 2026-03-01 |
| CN112351997B (zh) | 2023-05-26 |
| KR102930803B1 (ko) | 2026-02-26 |
| PT3823990T (pt) | 2026-03-20 |
| JP2021530236A (ja) | 2021-11-11 |
| AU2019305663B2 (en) | 2026-04-02 |
| SMT202600121T1 (it) | 2026-05-12 |
| IL279010A (en) | 2021-01-31 |
| KR20210032311A (ko) | 2021-03-24 |
| HRP20260372T1 (hr) | 2026-04-24 |
| EP3823990A1 (en) | 2021-05-26 |
| CA3101069A1 (en) | 2020-01-23 |
| AU2019305663A1 (en) | 2021-03-11 |
| FI3823990T3 (fi) | 2026-03-16 |
| US12202898B2 (en) | 2025-01-21 |
| WO2020018922A1 (en) | 2020-01-23 |
| ES3064933T3 (en) | 2026-04-30 |
| JP7439046B2 (ja) | 2024-02-27 |
| CN112351997A (zh) | 2021-02-09 |
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| SG11202102859TA (en) | Antibodies binding to cd3 | |
| IL265321B1 (en) | Cd3 binding antibodies | |
| DK3122781T3 (da) | Bispecifikke antistoffer, der binder til cd38 og cd3 | |
| IL263840A (en) | Cd3 binding antibodies | |
| DK3328889T3 (da) | Bispecifikke antistofkonstruktioner, der binder dll3 og cd3 | |
| DK3328892T3 (da) | Bispecifikke antistofkonstruktioner, der binder egfrviii og cd3 | |
| DK3558369T3 (da) | Antistoffer, der specifikt binder til humant il-15, og anvendelse heraf | |
| DK3223845T3 (da) | Heterodimere antistoffer, der binder cd3 og cd20 | |
| DK3370768T3 (da) | Antistoffer som specifikt binder pd-1 og anvendelser deraf | |
| DK3328893T5 (da) | Bispecifikke antistofkonstruktioner, der binder mesothelin og cd3 | |
| DK3665198T3 (da) | Antistoffer, der binder egfr og cmet | |
| DK3328888T5 (da) | ANTI-PSMA-antistoffer, bispecifikke antigenbindingsmolekyler, der binder PSMA AND og CD3, samt anvendelser deraf | |
| IL282590A (en) | Heavy chain antibodies that bind to CD38 | |
| DK2992100T3 (da) | Agrokemiske sammensætninger omfattende antistoffer, der binder til sphingolipider | |
| IL275498A (en) | Heavy chain antibodies that bind CD22 | |
| DK2964258T3 (da) | Antistoffer, der binder IL-23 | |
| IL273235A (en) | Heavy chain antibodies that bind to ectoenzymes |