AU2019305663B2 - Heavy chain antibodies binding to cd19 - Google Patents

Heavy chain antibodies binding to cd19

Info

Publication number
AU2019305663B2
AU2019305663B2 AU2019305663A AU2019305663A AU2019305663B2 AU 2019305663 B2 AU2019305663 B2 AU 2019305663B2 AU 2019305663 A AU2019305663 A AU 2019305663A AU 2019305663 A AU2019305663 A AU 2019305663A AU 2019305663 B2 AU2019305663 B2 AU 2019305663B2
Authority
AU
Australia
Prior art keywords
antibody
heavy chain
binding
antibodies
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019305663A
Other languages
English (en)
Other versions
AU2019305663A1 (en
Inventor
Shelley Force Aldred
Katherine HARRIS
Udaya RANGASWAMY
Nathan Trinklein
Wim Van Schooten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TeneoTwo Inc
Original Assignee
TeneoTwo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TeneoTwo Inc filed Critical TeneoTwo Inc
Publication of AU2019305663A1 publication Critical patent/AU2019305663A1/en
Assigned to TeneoTwo, Inc reassignment TeneoTwo, Inc Request for Assignment Assignors: TENEOBIO, INC.
Application granted granted Critical
Publication of AU2019305663B2 publication Critical patent/AU2019305663B2/en
Priority to AU2026205247A priority Critical patent/AU2026205247A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019305663A 2018-07-20 2019-07-19 Heavy chain antibodies binding to cd19 Active AU2019305663B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2026205247A AU2026205247A1 (en) 2018-07-20 2026-07-02 Heavy chain antibodies binding to cd19

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862701281P 2018-07-20 2018-07-20
US62/701,281 2018-07-20
PCT/US2019/042633 WO2020018922A1 (en) 2018-07-20 2019-07-19 Heavy chain antibodies binding to cd19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2026205247A Division AU2026205247A1 (en) 2018-07-20 2026-07-02 Heavy chain antibodies binding to cd19

Publications (2)

Publication Number Publication Date
AU2019305663A1 AU2019305663A1 (en) 2021-03-11
AU2019305663B2 true AU2019305663B2 (en) 2026-04-02

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019305663A Active AU2019305663B2 (en) 2018-07-20 2019-07-19 Heavy chain antibodies binding to cd19
AU2026205247A Pending AU2026205247A1 (en) 2018-07-20 2026-07-02 Heavy chain antibodies binding to cd19

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2026205247A Pending AU2026205247A1 (en) 2018-07-20 2026-07-02 Heavy chain antibodies binding to cd19

Country Status (22)

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US (1) US12202898B2 (enExample)
EP (2) EP3823990B1 (enExample)
JP (2) JP7439046B2 (enExample)
KR (2) KR20260036383A (enExample)
CN (2) CN116769032A (enExample)
AU (2) AU2019305663B2 (enExample)
BR (1) BR112020024074A2 (enExample)
CA (1) CA3101069A1 (enExample)
DK (1) DK3823990T3 (enExample)
ES (1) ES3064933T3 (enExample)
FI (1) FI3823990T3 (enExample)
HR (1) HRP20260372T1 (enExample)
IL (2) IL326259A (enExample)
LT (1) LT3823990T (enExample)
MX (1) MX2021000708A (enExample)
PL (1) PL3823990T3 (enExample)
PT (1) PT3823990T (enExample)
RS (1) RS67881B1 (enExample)
SG (1) SG11202011597RA (enExample)
SI (1) SI3823990T1 (enExample)
SM (1) SMT202600121T1 (enExample)
WO (1) WO2020018922A1 (enExample)

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Publication number Publication date
US12202898B2 (en) 2025-01-21
DK3823990T3 (da) 2026-03-16
IL326259A (en) 2026-03-01
RS67881B1 (sr) 2026-04-30
BR112020024074A2 (pt) 2021-02-17
PT3823990T (pt) 2026-03-20
CN112351997B (zh) 2023-05-26
AU2019305663A1 (en) 2021-03-11
SI3823990T1 (sl) 2026-05-29
WO2020018922A1 (en) 2020-01-23
SMT202600121T1 (it) 2026-05-12
FI3823990T3 (fi) 2026-03-16
JP2021530236A (ja) 2021-11-11
KR102930803B1 (ko) 2026-02-26
LT3823990T (lt) 2026-04-10
HRP20260372T1 (hr) 2026-04-24
SG11202011597RA (en) 2020-12-30
CN116769032A (zh) 2023-09-19
EP3823990A1 (en) 2021-05-26
JP2024073430A (ja) 2024-05-29
IL279010B1 (en) 2026-03-01
IL279010A (en) 2021-01-31
KR20260036383A (ko) 2026-03-16
PL3823990T3 (pl) 2026-04-20
EP4714502A2 (en) 2026-03-25
JP7737488B2 (ja) 2025-09-10
US20210332133A1 (en) 2021-10-28
CA3101069A1 (en) 2020-01-23
KR20210032311A (ko) 2021-03-24
AU2026205247A1 (en) 2026-07-23
EP3823990B1 (en) 2025-12-17
MX2021000708A (es) 2021-03-25
CN112351997A (zh) 2021-02-09
ES3064933T3 (en) 2026-04-30
JP7439046B2 (ja) 2024-02-27
IL279010B2 (en) 2026-07-01

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