DK376179A - Fremgangsmaade til fremstilling af en inhibitor for angiotensinkonverterende enzym (ace). - Google Patents

Fremgangsmaade til fremstilling af en inhibitor for angiotensinkonverterende enzym (ace).

Info

Publication number
DK376179A
DK376179A DK376179A DK376179A DK376179A DK 376179 A DK376179 A DK 376179A DK 376179 A DK376179 A DK 376179A DK 376179 A DK376179 A DK 376179A DK 376179 A DK376179 A DK 376179A
Authority
DK
Denmark
Prior art keywords
angiotens
enzym
conversing
ace
inhibitor
Prior art date
Application number
DK376179A
Other languages
Danish (da)
English (en)
Inventor
James W Ryan
Alfred Chung
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/064,900 external-priority patent/US4690939A/en
Priority claimed from US06/064,902 external-priority patent/US4690940A/en
Priority claimed from US06/064,897 external-priority patent/US4690937A/en
Priority claimed from US06/064,899 external-priority patent/US4698356A/en
Priority claimed from US06/064,898 external-priority patent/US4690938A/en
Priority claimed from US06/064,903 external-priority patent/US4698355A/en
Priority claimed from US06/064,901 external-priority patent/US4695577A/en
Application filed by Univ Miami filed Critical Univ Miami
Publication of DK376179A publication Critical patent/DK376179A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK376179A 1978-09-11 1979-09-10 Fremgangsmaade til fremstilling af en inhibitor for angiotensinkonverterende enzym (ace). DK376179A (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US94128978A 1978-09-11 1978-09-11
US95818078A 1978-11-06 1978-11-06
US06/064,900 US4690939A (en) 1979-08-14 1979-08-14 Anti-hypertensive agents
US06/064,902 US4690940A (en) 1979-08-14 1979-08-14 Anti-hypertensive agents
US06/064,897 US4690937A (en) 1979-08-14 1979-08-14 Anti-hypertensive agents
US06/064,899 US4698356A (en) 1979-08-14 1979-08-14 Anti-hypertensive agents
US06/064,898 US4690938A (en) 1979-08-14 1979-08-14 Anti-hypertensive agents
US06/064,903 US4698355A (en) 1979-08-14 1979-08-14 Anti-hypertensive agents
US06/064,901 US4695577A (en) 1979-08-14 1979-08-14 Anti-hypertensive agents

Publications (1)

Publication Number Publication Date
DK376179A true DK376179A (da) 1980-03-12

Family

ID=27578299

Family Applications (1)

Application Number Title Priority Date Filing Date
DK376179A DK376179A (da) 1978-09-11 1979-09-10 Fremgangsmaade til fremstilling af en inhibitor for angiotensinkonverterende enzym (ace).

Country Status (15)

Country Link
EP (1) EP0009898B1 (es)
AT (1) AT390795B (es)
AU (1) AU532424B2 (es)
BG (1) BG34463A3 (es)
CS (1) CS242857B2 (es)
DE (1) DE2965443D1 (es)
DK (1) DK376179A (es)
FI (1) FI71749C (es)
GR (1) GR73585B (es)
HU (1) HU187258B (es)
IL (1) IL58223A (es)
IT (1) IT1193214B (es)
NZ (1) NZ191524A (es)
PH (1) PH19104A (es)
PT (1) PT70158A (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
PT70158A1 (en) * 1980-03-03 1982-03-01 Univ Miami Process for preparing anti-hypertensive agents
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
US4734420A (en) * 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
DE3161915D1 (en) * 1980-03-05 1984-02-23 Univ Miami Angiotensin converting enzyme inhibitors
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
AT386603B (de) * 1981-06-19 1988-09-26 Chugai Pharmaceutical Co Ltd Verfahren zur herstellung von neuen prolinderivaten
JPS57209270A (en) * 1981-06-19 1982-12-22 Chugai Pharmaceut Co Ltd Proline derivative
HUT46044A (en) * 1986-11-21 1988-09-28 Richter Gedeon Vegyeszet Process for producing immunstimulant peptides inhibiting multiplication of leukaemic cells and pharmaceutics comprising same
CN1081650C (zh) * 1995-12-27 2002-03-27 罗纳-普朗克·维斯科苏希公司 缩聚物,尤其是聚酰胺6,6后冷凝的方法
EP2291545B1 (en) 2008-06-14 2013-05-08 Veredus Laboratories Pte Ltd Influenza sequences

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives

Also Published As

Publication number Publication date
AU5070579A (en) 1980-03-20
IT7925612A0 (it) 1979-09-11
HU187258B (en) 1985-12-28
AT390795B (de) 1990-06-25
IL58223A (en) 1984-01-31
DE2965443D1 (en) 1983-07-07
CS242857B2 (en) 1986-05-15
NZ191524A (en) 1982-12-07
PT70158A (en) 1979-09-30
FI792806A (fi) 1980-03-12
FI71749B (fi) 1986-10-31
CS615079A2 (en) 1985-08-15
BG34463A3 (en) 1983-09-15
EP0009898A1 (en) 1980-04-16
ATA596279A (de) 1989-12-15
IT1193214B (it) 1988-06-15
GR73585B (es) 1984-03-26
EP0009898B1 (en) 1983-05-18
FI71749C (fi) 1987-02-09
PH19104A (en) 1986-01-02
AU532424B2 (en) 1983-09-29

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