DK3585886T3 - Storskalasyntese af messenger-rna - Google Patents
Storskalasyntese af messenger-rna Download PDFInfo
- Publication number
- DK3585886T3 DK3585886T3 DK18713747.6T DK18713747T DK3585886T3 DK 3585886 T3 DK3585886 T3 DK 3585886T3 DK 18713747 T DK18713747 T DK 18713747T DK 3585886 T3 DK3585886 T3 DK 3585886T3
- Authority
- DK
- Denmark
- Prior art keywords
- messenger rna
- scale synthesis
- synthesis
- scale
- messenger
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 108020004999 messenger RNA Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07006—DNA-directed RNA polymerase (2.7.7.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
- G01N27/44778—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis on a common gel carrier, i.e. 2D gel electrophoresis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762464043P | 2017-02-27 | 2017-02-27 | |
| PCT/US2018/020008 WO2018157153A1 (en) | 2017-02-27 | 2018-02-27 | Large scale synthesis of messenger rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3585886T3 true DK3585886T3 (da) | 2024-02-19 |
Family
ID=61800667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18713747.6T DK3585886T3 (da) | 2017-02-27 | 2018-02-27 | Storskalasyntese af messenger-rna |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11560562B2 (da) |
| EP (2) | EP4105326A1 (da) |
| AU (1) | AU2018224325A1 (da) |
| CA (1) | CA3053814A1 (da) |
| DK (1) | DK3585886T3 (da) |
| IL (2) | IL268892B1 (da) |
| MA (1) | MA47607A (da) |
| WO (1) | WO2018157153A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103748078B (zh) | 2011-06-08 | 2016-11-09 | 夏尔人类遗传性治疗公司 | 可裂解脂质 |
| JP7423522B2 (ja) | 2017-11-22 | 2024-01-29 | モダーナティエックス・インコーポレイテッド | 尿素サイクル異常症の治療のためのオルニチントランスカルバミラーゼをコードするポリヌクレオチド |
| CN115461042A (zh) | 2019-12-20 | 2022-12-09 | 翻译生物公司 | 制备负载mrna的脂质纳米颗粒的改进方法 |
| US20230051811A1 (en) | 2019-12-20 | 2023-02-16 | Translate Bio, Inc | Rectal delivery of messenger rna |
| CN115443338A (zh) | 2020-02-10 | 2022-12-06 | 翻译生物公司 | 用于信使rna纯化的方法和组合物 |
| AU2021224892A1 (en) | 2020-02-18 | 2022-10-13 | Translate Bio, Inc. | Improved processes for in vitro transcription of messenger RNA |
| JP2023514450A (ja) | 2020-02-25 | 2023-04-05 | トランスレイト バイオ， インコーポレイテッド | Ｍｒｎａ担持脂質ナノ粒子を調製する改善された方法 |
| WO2021226463A1 (en) | 2020-05-07 | 2021-11-11 | Translate Bio, Inc. | Composition and methods for treatment of primary ciliary dyskinesia |
| CA3177940A1 (en) | 2020-05-07 | 2021-11-11 | Anusha DIAS | Optimized nucleotide sequences encoding sars-cov-2 antigens |
| AU2021273502A1 (en) | 2020-05-15 | 2023-02-02 | Translate Bio, Inc. | Lipid nanoparticle formulations for mRNA delivery |
| EP4225268A1 (en) | 2020-10-06 | 2023-08-16 | Translate Bio, Inc. | Improved process and formulation of lipid nanoparticles |
| JP2023545128A (ja) | 2020-10-12 | 2023-10-26 | トランスレイト バイオ， インコーポレイテッド | ｍＲＮＡ搭載脂質ナノ粒子を製造する改善された方法 |
| WO2022081548A1 (en) | 2020-10-12 | 2022-04-21 | Translate Bio, Inc. | Improved process of preparing ice-based lipid nanoparticles |
| WO2022082001A1 (en) * | 2020-10-15 | 2022-04-21 | Translate Bio, Inc. | Large scale synthesis of messenger rna |
| WO2022099003A1 (en) * | 2020-11-06 | 2022-05-12 | Sanofi | Lipid nanoparticles for delivering mrna vaccines |
| EP4313115A1 (en) | 2021-03-25 | 2024-02-07 | Translate Bio, Inc. | Optimized nucleotide sequences encoding the extracellular domain of human ace2 protein or a portion thereof |
| EP4326338A1 (en) | 2021-04-19 | 2024-02-28 | Translate Bio, Inc. | Improved compositions for delivery of mrna |
| WO2023278754A1 (en) | 2021-07-01 | 2023-01-05 | Translate Bio, Inc. | Compositions for delivery of mrna |
| WO2023086893A1 (en) | 2021-11-10 | 2023-05-19 | Translate Bio, Inc. | Composition and methods for treatment of primary ciliary dyskinesia |
| US20240043892A1 (en) * | 2022-07-01 | 2024-02-08 | Arcturus Therapeutics, Inc. | Methods for in vitro transcription |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2937245T3 (es) | 2005-08-23 | 2023-03-27 | Univ Pennsylvania | ARN que contiene nucleósidos modificados y métodos de uso del mismo |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| EP2459231B1 (de) | 2009-07-31 | 2016-06-08 | Ethris Gmbh | Rna mit einer kombination aus unmodifizierten und modifizierten nucleotiden zur proteinexpression |
| US8326547B2 (en) | 2009-10-07 | 2012-12-04 | Nanjingjinsirui Science & Technology Biology Corp. | Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm |
| PL3338765T3 (pl) | 2009-12-01 | 2019-06-28 | Translate Bio, Inc. | Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych |
| WO2012075040A2 (en) | 2010-11-30 | 2012-06-07 | Shire Human Genetic Therapies, Inc. | mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES |
| EP4043025A1 (en) | 2011-06-08 | 2022-08-17 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| ES2680595T3 (es) | 2013-03-14 | 2018-09-10 | Translate Bio, Inc. | Evaluación cuantitativa para eficacia de ARN mensajero para tapar |
| EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
| SG11201608725YA (en) | 2014-04-25 | 2016-11-29 | Shire Human Genetic Therapies | Methods for purification of messenger rna |
| MX2016016170A (es) * | 2014-06-10 | 2017-03-28 | Curevac Ag | Metodos y medios para aumentar la produccion de arn. |
| AU2016233135B2 (en) * | 2015-03-19 | 2021-07-08 | Translate Bio, Inc. | mRNA therapy for pompe disease |
| EP3294885B1 (en) * | 2015-05-08 | 2020-07-01 | CureVac Real Estate GmbH | Method for producing rna |
-
2018
- 2018-02-27 DK DK18713747.6T patent/DK3585886T3/da active
- 2018-02-27 EP EP22169158.7A patent/EP4105326A1/en active Pending
- 2018-02-27 CA CA3053814A patent/CA3053814A1/en active Pending
- 2018-02-27 EP EP18713747.6A patent/EP3585886B1/en active Active
- 2018-02-27 IL IL268892A patent/IL268892B1/en unknown
- 2018-02-27 IL IL310939A patent/IL310939A/en unknown
- 2018-02-27 AU AU2018224325A patent/AU2018224325A1/en active Pending
- 2018-02-27 MA MA047607A patent/MA47607A/fr unknown
- 2018-02-27 WO PCT/US2018/020008 patent/WO2018157153A1/en unknown
- 2018-02-27 US US15/907,163 patent/US11560562B2/en active Active
-
2022
- 2022-12-14 US US18/065,952 patent/US20240018514A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018157153A1 (en) | 2018-08-30 |
| US20180258423A1 (en) | 2018-09-13 |
| IL268892B1 (en) | 2024-03-01 |
| MA47607A (fr) | 2020-01-01 |
| IL268892A (en) | 2019-10-31 |
| US11560562B2 (en) | 2023-01-24 |
| IL310939A (en) | 2024-04-01 |
| EP4105326A1 (en) | 2022-12-21 |
| EP3585886A1 (en) | 2020-01-01 |
| CA3053814A1 (en) | 2018-08-30 |
| EP3585886B1 (en) | 2023-11-22 |
| US20240018514A1 (en) | 2024-01-18 |
| AU2018224325A1 (en) | 2019-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3585886T3 (da) | Storskalasyntese af messenger-rna | |
| DK3585892T3 (da) | Fremgangsmåder til oprensning af messenger-rna | |
| DK3585891T3 (da) | Fremgangsmåder til oprensning af messenger-rna | |
| DK4140491T3 (da) | Fremgangsmåde til syntetisering af RNA'er med 5'-kappe | |
| DK3430141T3 (da) | Oligonukleotider til reduktion af PD-L1-ekspression | |
| IL247973A0 (en) | Methods for purifying messenger RNA | |
| DK3377059T3 (da) | Hæmmere af cxcr2 | |
| DK3463483T3 (da) | Behandling af primær ciliedyskinesi med syntetisk messenger-RNA | |
| DK3180331T3 (da) | Polymorfer af selinexor | |
| DK3448846T3 (da) | Syntese af indazoler | |
| DK3448849T3 (da) | Syntese af indazoler | |
| DK3607068T3 (da) | RNA-interferensmedieret inhibering af TMPRSS6 | |
| DK3325621T3 (da) | Kloning af en-strenget nucleinsyre | |
| DK3380453T3 (da) | Syntese af beta-mercaptoethanol | |
| DK3284267T3 (da) | Ophængning af en række højttalere | |
| DK3558920T3 (da) | Forbedret syntese af lysinacetylsalicylat-glycin-partikler | |
| DK3515454T3 (da) | Krystallinsk polymorf form af 3-hydroxy-4,5-bis-benzyloxy-6-benzyloxymethyl-2-phenyl-2-oxo-2lambda5-[1,2]oxaphosphinan | |
| DK3191464T3 (da) | Syntese af isoflavaner og intermediater deraf | |
| DK3320102T3 (da) | Fremgangsmåde til syntese af pentostatin | |
| UA34689S (uk) | Комплект етикеток | |
| UA35215S (uk) | Комплект етикеток | |
| UA35195S (uk) | Комплект етикеток | |
| UA35279S (uk) | Комплект етикеток | |
| UA35281S (uk) | Комплект етикеток | |
| UA35280S (uk) | Комплект етикеток |