DK3541366T3 - Bufferformuleringer af exendin (9-39) - Google Patents

Bufferformuleringer af exendin (9-39) Download PDF

Info

Publication number
DK3541366T3
DK3541366T3 DK17871296.4T DK17871296T DK3541366T3 DK 3541366 T3 DK3541366 T3 DK 3541366T3 DK 17871296 T DK17871296 T DK 17871296T DK 3541366 T3 DK3541366 T3 DK 3541366T3
Authority
DK
Denmark
Prior art keywords
exendin
buffer formulations
formulations
buffer
Prior art date
Application number
DK17871296.4T
Other languages
Danish (da)
English (en)
Inventor
Xiaofeng Xiong
Debra Odink
Colleen M Craig
Christine M N Smith
Tracey L Mclaughlin
Original Assignee
Amylyx Pharmaceuticals Inc
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amylyx Pharmaceuticals Inc, Univ Leland Stanford Junior filed Critical Amylyx Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3541366T3 publication Critical patent/DK3541366T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK17871296.4T 2016-11-21 2017-11-21 Bufferformuleringer af exendin (9-39) DK3541366T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662424979P 2016-11-21 2016-11-21
US201762517065P 2017-06-08 2017-06-08
PCT/US2017/062838 WO2018094404A1 (en) 2016-11-21 2017-11-21 Buffered formulations of exendin (9-39)

Publications (1)

Publication Number Publication Date
DK3541366T3 true DK3541366T3 (da) 2025-03-03

Family

ID=62145888

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17871296.4T DK3541366T3 (da) 2016-11-21 2017-11-21 Bufferformuleringer af exendin (9-39)

Country Status (20)

Country Link
US (4) US11020484B2 (https=)
EP (2) EP4591853A1 (https=)
JP (4) JP7584894B2 (https=)
CN (1) CN110267648A (https=)
AU (3) AU2017361539B2 (https=)
CA (1) CA3043899A1 (https=)
CL (1) CL2019001366A1 (https=)
DK (1) DK3541366T3 (https=)
ES (1) ES3014024T3 (https=)
FI (1) FI3541366T3 (https=)
HR (1) HRP20250278T1 (https=)
HU (1) HUE070730T2 (https=)
IL (1) IL266568B2 (https=)
LT (1) LT3541366T (https=)
PL (1) PL3541366T3 (https=)
PT (1) PT3541366T (https=)
RS (1) RS66595B1 (https=)
SI (1) SI3541366T1 (https=)
SM (1) SMT202500120T1 (https=)
WO (1) WO2018094404A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3456340T1 (sl) 2007-01-08 2022-08-31 The Trustees Of The University Of Pennsylvania Antagonisti receptorja za GLP-1 za uporabo pri zdravljenju prirojenega hiperinsulinizma
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
LT3297653T (lt) 2015-05-22 2022-01-10 The Board Of Trustees Of The Leland Stanford Junior University Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais
US10653753B2 (en) 2016-03-04 2020-05-19 Eiger Biopharmaceuticals, Inc. Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
LT3541366T (lt) * 2016-11-21 2025-03-10 Amylyx Pharmaceuticals, Inc. Eksendino (9-39) buferiniai preparatai
IL299864B2 (en) 2017-06-16 2024-06-01 Zealand Pharma As Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues
EP3628683A1 (en) * 2018-09-28 2020-04-01 Zealand Pharma A/S Formulations of glucagon-like-peptide-2 (glp-2) analogues
CN112867730A (zh) * 2018-10-15 2021-05-28 艾格尔峰生物制药有限公司 用于治疗高胰岛素低血糖症的阿维西特
JP7702428B2 (ja) * 2020-05-12 2025-07-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗glp1rアンタゴニスト抗体およびその使用方法
WO2022271753A1 (en) 2021-06-21 2022-12-29 Eiger Biopharmaceuticals, Inc. Treatment of congenital hyperinsulinism with avexitide
WO2023229987A1 (en) * 2022-05-25 2023-11-30 Neuvian LLC Vaginal care compositions comprising exosomes and its uses for improving vaginal health
CN116606367A (zh) * 2022-05-31 2023-08-18 南京盛德瑞尔医药科技有限公司 长效Exendin-9-39及其在低血糖治疗中的应用和作为治疗低血糖的药物
CN121219002A (zh) * 2023-04-21 2025-12-26 小利兰斯坦福大学董事会 Glp-1r拮抗作用改善胃肠外科手术后的营养

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0969016A2 (en) 1992-06-15 2000-01-05 Scios Inc. Glucagon-like peptide and insulinotropin derivates
US5424286A (en) * 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US20040092443A1 (en) 1996-08-06 2004-05-13 Yeda Research And Development Co., Ltd Long-acting exendins and exendin agonists
ATE493998T1 (de) 1996-08-08 2011-01-15 Amylin Pharmaceuticals Inc Pharmazeutische zusammensetzung mit einem exendin-4-peptid
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US7235627B2 (en) 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
DE122007000044I2 (de) 1997-01-07 2011-05-05 Amylin Pharmaceuticals Inc Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme
ATE197408T1 (de) 1998-01-30 2000-11-11 Novo Nordisk As Eine injektionsspritze
ATE288268T1 (de) 1998-12-10 2005-02-15 Agouron Pharma Nichtpeptidische antagonisten des glp-1 rezeptors und verwendungsmethoden
US6902744B1 (en) 1999-01-14 2005-06-07 Amylin Pharmaceuticals, Inc. Exendin agonist formulations and methods of administration thereof
ES2278589T3 (es) 1999-01-14 2007-08-16 Amylin Pharmaceuticals, Inc. Excendinas destinadas a la inhibicion de glucagon.
US6924264B1 (en) 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
US6903074B1 (en) 1999-06-04 2005-06-07 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Neuromedin b and somatostatin receptor agonists
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6479065B2 (en) 2000-08-10 2002-11-12 Alkermes Controlled Therapeutics, Inc. Process for the preparation of polymer-based sustained release compositions
US6824822B2 (en) 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
SE0004462D0 (sv) 2000-12-04 2000-12-04 Pharmacia Ab Novel method and use
WO2002066062A2 (en) 2001-02-01 2002-08-29 Drucker Daniel J Enhancement of glp-2 activity
WO2002081649A2 (en) 2001-04-06 2002-10-17 The Trustees Of The University Of Pennsylvania ErbB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF
GB0113179D0 (en) * 2001-05-31 2001-07-25 Novartis Ag Organic compounds
EP1432430A4 (en) * 2001-08-28 2006-05-10 Lilly Co Eli PREMIXTURES OF GLP-1 AND BASALINSULIN
US7378385B2 (en) 2002-08-08 2008-05-27 University Of Cincinnati Role for GLP-1 to mediate responses to disparate stressors
DK3300721T4 (da) 2003-11-20 2025-03-03 Novo Nordisk As Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
US7456254B2 (en) 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US8617613B2 (en) 2004-04-15 2013-12-31 Alkermes Pharma Ireland Limited Polymer-based sustained release device
DE102004043153B4 (de) 2004-09-03 2013-11-21 Philipps-Universität Marburg Erfindung betreffend GLP-1 und Exendin
EP1888031B1 (en) 2005-06-06 2013-01-23 Camurus Ab Glp-1 analogue formulations
PL1971362T3 (pl) 2005-08-19 2015-05-29 Amylin Pharmaceuticals Llc Eksendyna do leczenia cukrzycy i zmniejszania masy ciała
AR060487A1 (es) * 2006-04-21 2008-06-18 Xoma Technology Ltd Composiciones farmaceuticas de antagonistas del anticuerpo anti- cd40
WO2007139941A2 (en) * 2006-05-26 2007-12-06 Amylin Pharmaceuticals, Inc. Composition and methods for treatment of congestive heart failure
SI3456340T1 (sl) 2007-01-08 2022-08-31 The Trustees Of The University Of Pennsylvania Antagonisti receptorja za GLP-1 za uporabo pri zdravljenju prirojenega hiperinsulinizma
EP2144649B1 (de) 2007-04-05 2011-07-20 Tecpharma Licensing AG Verabreichungsvorrichtung mit funktionalem antriebsglied
DE102007016811A1 (de) 2007-04-05 2008-10-09 Tecpharma Licensing Ag Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
US20110046053A1 (en) 2008-05-05 2011-02-24 Oramed Ltd. Methods and compositions for oral administration of exenatide
WO2009143285A2 (en) 2008-05-21 2009-11-26 Amylin Pharmaceuticals, Inc. Exendins to lower cholestrol and triglycerides
EP2303226B1 (en) 2008-06-25 2016-03-23 Endo Pharmaceuticals Solutions Inc. Sustained delivery of exenatide and other polypeptides
WO2010003939A1 (en) 2008-07-08 2010-01-14 Novartis Ag Use of pasireotide for the treatment of endogenous hyperinsulinemic hypoglycemia
SI2341905T2 (sl) 2008-09-04 2024-02-29 Amylin Pharmaceuticals, Llc Formulacije s podaljšanim sproščanjem z uporabo brezvodnih nosilcev
SG174355A1 (en) 2009-04-03 2011-10-28 Nestec Sa Improvement in promotion of healthy catch-up growth
WO2010144508A1 (en) 2009-06-08 2010-12-16 Amunix Operating Inc. Glucose-regulating polypeptides and methods of making and using same
WO2011109787A1 (en) * 2010-03-05 2011-09-09 Conjuchem, Llc Methods of administering insulinotropic peptides
WO2012012352A2 (en) 2010-07-19 2012-01-26 Amidebio, Llc Modified peptides and proteins
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US20140256626A1 (en) 2011-10-18 2014-09-11 Prolynx Llc Peg conjugates of exenatide
WO2013120022A2 (en) 2012-02-08 2013-08-15 Seneb Biosciences, Inc. Treatment of hypoglycemia
EP4527855A3 (en) * 2012-03-26 2025-06-11 Sanofi Stable igg4 based binding agent formulations
US20160185837A1 (en) 2013-08-16 2016-06-30 Medimmune Limited Gip and glp-1 receptor dual-agonists for the treatment of diabetes
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
LT3297653T (lt) 2015-05-22 2022-01-10 The Board Of Trustees Of The Leland Stanford Junior University Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais
US10653753B2 (en) 2016-03-04 2020-05-19 Eiger Biopharmaceuticals, Inc. Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
LT3541366T (lt) * 2016-11-21 2025-03-10 Amylyx Pharmaceuticals, Inc. Eksendino (9-39) buferiniai preparatai

Also Published As

Publication number Publication date
JP2026048629A (ja) 2026-03-17
SI3541366T1 (sl) 2025-05-30
CN110267648A (zh) 2019-09-20
AU2025205195A1 (en) 2025-07-24
JP7584894B2 (ja) 2024-11-18
WO2018094404A1 (en) 2018-05-24
CL2019001366A1 (es) 2019-11-08
IL266568B1 (en) 2024-05-01
US20260034221A1 (en) 2026-02-05
EP3541366A4 (en) 2020-08-05
EP3541366B1 (en) 2024-12-25
SMT202500120T1 (it) 2025-05-12
BR112019010236A2 (pt) 2019-08-20
AU2023237119A1 (en) 2023-10-19
US20200069802A1 (en) 2020-03-05
PL3541366T3 (pl) 2025-04-28
EP3541366A1 (en) 2019-09-25
JP2024150450A (ja) 2024-10-23
ES3014024T3 (en) 2025-04-16
AU2017361539A1 (en) 2019-07-04
US11020484B2 (en) 2021-06-01
CA3043899A1 (en) 2018-05-24
IL266568B2 (en) 2024-09-01
EP4591853A1 (en) 2025-07-30
FI3541366T3 (fi) 2025-03-06
US11738086B2 (en) 2023-08-29
HRP20250278T1 (hr) 2025-04-25
JP2022153624A (ja) 2022-10-12
AU2017361539B2 (en) 2023-06-29
AU2023237119B2 (en) 2025-04-10
HUE070730T2 (hu) 2025-06-28
JP2019535734A (ja) 2019-12-12
US20240042035A1 (en) 2024-02-08
RS66595B1 (sr) 2025-04-30
US20210315995A1 (en) 2021-10-14
PT3541366T (pt) 2025-03-14
LT3541366T (lt) 2025-03-10
IL266568A (en) 2019-07-31

Similar Documents

Publication Publication Date Title
DK3541366T3 (da) Bufferformuleringer af exendin (9-39)
IL268697A (en) Formulations
DK3509581T3 (da) Formuleringer af (r)-2-amino-3-phenylpropylcarbamat
DK3688162T3 (da) Formuleringer
DK3595653T3 (da) Sammensætninger af plinabulin og anvendelse heraf
DK3827845T3 (da) Subkutane formuleringer af anti-cd38-antistoffer og anvendelser deraf
DK3495023T3 (da) Semifluorerede forbindelser og sammensætninger deraf
DK3302437T3 (da) Stabile cannabinoidformuleringer
DK3484469T3 (da) Sammensætninger og fremgangsmåder til potentiering af antimikrober
DK3394259T3 (da) Sammensætninger og fremgangsmåder til reducering af tau-ekspression
DK3102555T3 (da) Sammensætninger af forbindelser og anvendelser deraf
EP3536302A4 (en) HARDENING COMPOSITION
DK3393655T3 (da) Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme
DK3297654T3 (da) Behandling af post-bariatrisk hypoglykæmi med exendin(9-39)
DK3494119T3 (da) Forbindelser og sammensætninger og anvendelser deraf
EP3273950A4 (en) ADJUVANE COMPOSITIONS AND RELATED METHODS
DK3474822T3 (da) Formuleringer af brincidofovir
DK3512857T3 (da) Spiro-bicykliske inhibitorer af menin-mll-interaktion
DK3943070T3 (da) Langtidsvirkende formuleringer af bedaquilin
EP3364945C0 (en) SOLID FORMULATION
DK3697418T3 (da) Forbedrede formuleringer af bromocriptin
DK3678644T3 (da) Formuleringer af copanlisib
DK3576719T3 (da) Misbrugsafskrækkende formuleringer på basis af amfetamin
IL272167A (en) Hemopexin formulations
DK3512495T3 (da) Formuleringer af prostacyklinanaloger