CL2019001366A1 - Formulaciones tamponadas exendina (9-39). - Google Patents
Formulaciones tamponadas exendina (9-39).Info
- Publication number
- CL2019001366A1 CL2019001366A1 CL2019001366A CL2019001366A CL2019001366A1 CL 2019001366 A1 CL2019001366 A1 CL 2019001366A1 CL 2019001366 A CL2019001366 A CL 2019001366A CL 2019001366 A CL2019001366 A CL 2019001366A CL 2019001366 A1 CL2019001366 A1 CL 2019001366A1
- Authority
- CL
- Chile
- Prior art keywords
- exendin
- approximately
- buffered
- buffer
- subject
- Prior art date
Links
- WSEVKKHALHSUMB-RYVRVIGHSA-N (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-5-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[2-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O WSEVKKHALHSUMB-RYVRVIGHSA-N 0.000 title abstract 3
- 108010024703 exendin (9-39) Proteins 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000012669 liquid formulation Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 239000008351 acetate buffer Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000007979 citrate buffer Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008181 tonicity modifier Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662424979P | 2016-11-21 | 2016-11-21 | |
| US201762517065P | 2017-06-08 | 2017-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019001366A1 true CL2019001366A1 (es) | 2019-11-08 |
Family
ID=62145888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019001366A CL2019001366A1 (es) | 2016-11-21 | 2019-05-20 | Formulaciones tamponadas exendina (9-39). |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11020484B2 (https=) |
| EP (2) | EP4591853A1 (https=) |
| JP (4) | JP7584894B2 (https=) |
| CN (1) | CN110267648A (https=) |
| AU (3) | AU2017361539B2 (https=) |
| CA (1) | CA3043899A1 (https=) |
| CL (1) | CL2019001366A1 (https=) |
| DK (1) | DK3541366T3 (https=) |
| ES (1) | ES3014024T3 (https=) |
| FI (1) | FI3541366T3 (https=) |
| HR (1) | HRP20250278T1 (https=) |
| HU (1) | HUE070730T2 (https=) |
| IL (1) | IL266568B2 (https=) |
| LT (1) | LT3541366T (https=) |
| PL (1) | PL3541366T3 (https=) |
| PT (1) | PT3541366T (https=) |
| RS (1) | RS66595B1 (https=) |
| SI (1) | SI3541366T1 (https=) |
| SM (1) | SMT202500120T1 (https=) |
| WO (1) | WO2018094404A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3456340T1 (sl) | 2007-01-08 | 2022-08-31 | The Trustees Of The University Of Pennsylvania | Antagonisti receptorja za GLP-1 za uporabo pri zdravljenju prirojenega hiperinsulinizma |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| LT3297653T (lt) | 2015-05-22 | 2022-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais |
| US10653753B2 (en) | 2016-03-04 | 2020-05-19 | Eiger Biopharmaceuticals, Inc. | Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives |
| LT3541366T (lt) * | 2016-11-21 | 2025-03-10 | Amylyx Pharmaceuticals, Inc. | Eksendino (9-39) buferiniai preparatai |
| IL299864B2 (en) | 2017-06-16 | 2024-06-01 | Zealand Pharma As | Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues |
| EP3628683A1 (en) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| CN112867730A (zh) * | 2018-10-15 | 2021-05-28 | 艾格尔峰生物制药有限公司 | 用于治疗高胰岛素低血糖症的阿维西特 |
| JP7702428B2 (ja) * | 2020-05-12 | 2025-07-03 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｇｌｐ１ｒアンタゴニスト抗体およびその使用方法 |
| WO2022271753A1 (en) | 2021-06-21 | 2022-12-29 | Eiger Biopharmaceuticals, Inc. | Treatment of congenital hyperinsulinism with avexitide |
| WO2023229987A1 (en) * | 2022-05-25 | 2023-11-30 | Neuvian LLC | Vaginal care compositions comprising exosomes and its uses for improving vaginal health |
| CN116606367A (zh) * | 2022-05-31 | 2023-08-18 | 南京盛德瑞尔医药科技有限公司 | 长效Exendin-9-39及其在低血糖治疗中的应用和作为治疗低血糖的药物 |
| CN121219002A (zh) * | 2023-04-21 | 2025-12-26 | 小利兰斯坦福大学董事会 | Glp-1r拮抗作用改善胃肠外科手术后的营养 |
Family Cites Families (55)
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| EP0969016A2 (en) | 1992-06-15 | 2000-01-05 | Scios Inc. | Glucagon-like peptide and insulinotropin derivates |
| US5424286A (en) * | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US20040092443A1 (en) | 1996-08-06 | 2004-05-13 | Yeda Research And Development Co., Ltd | Long-acting exendins and exendin agonists |
| ATE493998T1 (de) | 1996-08-08 | 2011-01-15 | Amylin Pharmaceuticals Inc | Pharmazeutische zusammensetzung mit einem exendin-4-peptid |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| DE122007000044I2 (de) | 1997-01-07 | 2011-05-05 | Amylin Pharmaceuticals Inc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
| ATE197408T1 (de) | 1998-01-30 | 2000-11-11 | Novo Nordisk As | Eine injektionsspritze |
| ATE288268T1 (de) | 1998-12-10 | 2005-02-15 | Agouron Pharma | Nichtpeptidische antagonisten des glp-1 rezeptors und verwendungsmethoden |
| US6902744B1 (en) | 1999-01-14 | 2005-06-07 | Amylin Pharmaceuticals, Inc. | Exendin agonist formulations and methods of administration thereof |
| ES2278589T3 (es) | 1999-01-14 | 2007-08-16 | Amylin Pharmaceuticals, Inc. | Excendinas destinadas a la inhibicion de glucagon. |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6903074B1 (en) | 1999-06-04 | 2005-06-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Neuromedin b and somatostatin receptor agonists |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| US6479065B2 (en) | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| SE0004462D0 (sv) | 2000-12-04 | 2000-12-04 | Pharmacia Ab | Novel method and use |
| WO2002066062A2 (en) | 2001-02-01 | 2002-08-29 | Drucker Daniel J | Enhancement of glp-2 activity |
| WO2002081649A2 (en) | 2001-04-06 | 2002-10-17 | The Trustees Of The University Of Pennsylvania | ErbB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF |
| GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| EP1432430A4 (en) * | 2001-08-28 | 2006-05-10 | Lilly Co Eli | PREMIXTURES OF GLP-1 AND BASALINSULIN |
| US7378385B2 (en) | 2002-08-08 | 2008-05-27 | University Of Cincinnati | Role for GLP-1 to mediate responses to disparate stressors |
| DK3300721T4 (da) | 2003-11-20 | 2025-03-03 | Novo Nordisk As | Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
| US8617613B2 (en) | 2004-04-15 | 2013-12-31 | Alkermes Pharma Ireland Limited | Polymer-based sustained release device |
| DE102004043153B4 (de) | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
| EP1888031B1 (en) | 2005-06-06 | 2013-01-23 | Camurus Ab | Glp-1 analogue formulations |
| PL1971362T3 (pl) | 2005-08-19 | 2015-05-29 | Amylin Pharmaceuticals Llc | Eksendyna do leczenia cukrzycy i zmniejszania masy ciała |
| AR060487A1 (es) * | 2006-04-21 | 2008-06-18 | Xoma Technology Ltd | Composiciones farmaceuticas de antagonistas del anticuerpo anti- cd40 |
| WO2007139941A2 (en) * | 2006-05-26 | 2007-12-06 | Amylin Pharmaceuticals, Inc. | Composition and methods for treatment of congestive heart failure |
| SI3456340T1 (sl) | 2007-01-08 | 2022-08-31 | The Trustees Of The University Of Pennsylvania | Antagonisti receptorja za GLP-1 za uporabo pri zdravljenju prirojenega hiperinsulinizma |
| EP2144649B1 (de) | 2007-04-05 | 2011-07-20 | Tecpharma Licensing AG | Verabreichungsvorrichtung mit funktionalem antriebsglied |
| DE102007016811A1 (de) | 2007-04-05 | 2008-10-09 | Tecpharma Licensing Ag | Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle |
| WO2008133908A2 (en) | 2007-04-23 | 2008-11-06 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
| US20110046053A1 (en) | 2008-05-05 | 2011-02-24 | Oramed Ltd. | Methods and compositions for oral administration of exenatide |
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| EP2303226B1 (en) | 2008-06-25 | 2016-03-23 | Endo Pharmaceuticals Solutions Inc. | Sustained delivery of exenatide and other polypeptides |
| WO2010003939A1 (en) | 2008-07-08 | 2010-01-14 | Novartis Ag | Use of pasireotide for the treatment of endogenous hyperinsulinemic hypoglycemia |
| SI2341905T2 (sl) | 2008-09-04 | 2024-02-29 | Amylin Pharmaceuticals, Llc | Formulacije s podaljšanim sproščanjem z uporabo brezvodnih nosilcev |
| SG174355A1 (en) | 2009-04-03 | 2011-10-28 | Nestec Sa | Improvement in promotion of healthy catch-up growth |
| WO2010144508A1 (en) | 2009-06-08 | 2010-12-16 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
| WO2011109787A1 (en) * | 2010-03-05 | 2011-09-09 | Conjuchem, Llc | Methods of administering insulinotropic peptides |
| WO2012012352A2 (en) | 2010-07-19 | 2012-01-26 | Amidebio, Llc | Modified peptides and proteins |
| US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US20140256626A1 (en) | 2011-10-18 | 2014-09-11 | Prolynx Llc | Peg conjugates of exenatide |
| WO2013120022A2 (en) | 2012-02-08 | 2013-08-15 | Seneb Biosciences, Inc. | Treatment of hypoglycemia |
| EP4527855A3 (en) * | 2012-03-26 | 2025-06-11 | Sanofi | Stable igg4 based binding agent formulations |
| US20160185837A1 (en) | 2013-08-16 | 2016-06-30 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| LT3297653T (lt) | 2015-05-22 | 2022-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais |
| US10653753B2 (en) | 2016-03-04 | 2020-05-19 | Eiger Biopharmaceuticals, Inc. | Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives |
| LT3541366T (lt) * | 2016-11-21 | 2025-03-10 | Amylyx Pharmaceuticals, Inc. | Eksendino (9-39) buferiniai preparatai |
-
2017
- 2017-11-21 LT LTEPPCT/US2017/062838T patent/LT3541366T/lt unknown
- 2017-11-21 DK DK17871296.4T patent/DK3541366T3/da active
- 2017-11-21 HU HUE17871296A patent/HUE070730T2/hu unknown
- 2017-11-21 AU AU2017361539A patent/AU2017361539B2/en active Active
- 2017-11-21 CN CN201780078743.2A patent/CN110267648A/zh active Pending
- 2017-11-21 EP EP24222303.0A patent/EP4591853A1/en active Pending
- 2017-11-21 WO PCT/US2017/062838 patent/WO2018094404A1/en not_active Ceased
- 2017-11-21 EP EP17871296.4A patent/EP3541366B1/en active Active
- 2017-11-21 CA CA3043899A patent/CA3043899A1/en active Pending
- 2017-11-21 PL PL17871296.4T patent/PL3541366T3/pl unknown
- 2017-11-21 RS RS20250225A patent/RS66595B1/sr unknown
- 2017-11-21 HR HRP20250278TT patent/HRP20250278T1/hr unknown
- 2017-11-21 JP JP2019527188A patent/JP7584894B2/ja active Active
- 2017-11-21 US US16/461,329 patent/US11020484B2/en active Active
- 2017-11-21 IL IL266568A patent/IL266568B2/en unknown
- 2017-11-21 SM SM20250120T patent/SMT202500120T1/it unknown
- 2017-11-21 PT PT178712964T patent/PT3541366T/pt unknown
- 2017-11-21 FI FIEP17871296.4T patent/FI3541366T3/fi active
- 2017-11-21 SI SI201731598T patent/SI3541366T1/sl unknown
- 2017-11-21 ES ES17871296T patent/ES3014024T3/es active Active
-
2019
- 2019-05-20 CL CL2019001366A patent/CL2019001366A1/es unknown
-
2021
- 2021-05-03 US US17/306,782 patent/US11738086B2/en active Active
-
2022
- 2022-08-03 JP JP2022123899A patent/JP2022153624A/ja not_active Withdrawn
-
2023
- 2023-06-22 US US18/339,305 patent/US20240042035A1/en active Pending
- 2023-09-28 AU AU2023237119A patent/AU2023237119B2/en active Active
-
2024
- 2024-06-21 JP JP2024100740A patent/JP2024150450A/ja active Pending
-
2025
- 2025-07-08 AU AU2025205195A patent/AU2025205195A1/en active Pending
- 2025-10-09 US US19/353,711 patent/US20260034221A1/en active Pending
- 2025-11-04 JP JP2025185576A patent/JP2026048629A/ja active Pending
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