DK3475417T3 - Sammensætninger og fremgangsmåder til fremstilling af benzylisoquinolin-alkaloider, morphinan-alkaloider, thebain og derivater deraf - Google Patents
Sammensætninger og fremgangsmåder til fremstilling af benzylisoquinolin-alkaloider, morphinan-alkaloider, thebain og derivater deraf Download PDFInfo
- Publication number
- DK3475417T3 DK3475417T3 DK17735761.3T DK17735761T DK3475417T3 DK 3475417 T3 DK3475417 T3 DK 3475417T3 DK 17735761 T DK17735761 T DK 17735761T DK 3475417 T3 DK3475417 T3 DK 3475417T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkaloids
- thebaine
- derivatives
- compositions
- processes
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
- C12Y114/16002—Tyrosine 3-monooxygenase (1.14.16.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01128—(RS)-Norcoclaurine 6-O-methyltransferase (2.1.1.128)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662355022P | 2016-06-27 | 2016-06-27 | |
| US201662433431P | 2016-12-13 | 2016-12-13 | |
| US201662438695P | 2016-12-23 | 2016-12-23 | |
| US201662438702P | 2016-12-23 | 2016-12-23 | |
| US201662438601P | 2016-12-23 | 2016-12-23 | |
| US201662438588P | 2016-12-23 | 2016-12-23 | |
| US201662438540P | 2016-12-23 | 2016-12-23 | |
| US201762469006P | 2017-03-09 | 2017-03-09 | |
| US201762514104P | 2017-06-02 | 2017-06-02 | |
| PCT/US2017/039589 WO2018005553A1 (en) | 2016-06-27 | 2017-06-27 | Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3475417T3 true DK3475417T3 (da) | 2023-07-24 |
Family
ID=59285401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17735761.3T DK3475417T3 (da) | 2016-06-27 | 2017-06-27 | Sammensætninger og fremgangsmåder til fremstilling af benzylisoquinolin-alkaloider, morphinan-alkaloider, thebain og derivater deraf |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11142780B2 (da) |
| EP (2) | EP3475417B1 (da) |
| AU (2) | AU2017290594B2 (da) |
| CA (1) | CA3029263A1 (da) |
| DK (1) | DK3475417T3 (da) |
| ES (1) | ES2952733T3 (da) |
| IL (1) | IL263947B2 (da) |
| WO (1) | WO2018005553A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2527254B (en) | 2013-03-15 | 2020-07-15 | Univ Leland Stanford Junior | Benzylisoquinoline alkaloids (BIA) Producing microbes, and methods of making and using the same |
| EP3066207A1 (en) | 2013-11-04 | 2016-09-14 | The Board Of Trustees Of The University Of the Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
| CN107614688B (zh) | 2015-05-04 | 2023-02-28 | 小利兰·斯坦福大学托管委员会 | 产生苄基异喹啉生物碱(bia)前体的微生物及其制备和使用方法 |
| WO2016183023A1 (en) | 2015-05-08 | 2016-11-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of producing epimerases and benzylisoquinoline alkaloids |
| ES2952733T3 (es) | 2016-06-27 | 2023-11-03 | Antheia Inc | Composiciones y métodos para preparar alcaloides de bencilisoquinolina, alcaloides de morfinano, tebaína y derivados de los mismos |
| WO2018000089A1 (en) | 2016-06-27 | 2018-01-04 | Serturner Corp. | Polynucleotides and polypeptides useful for making alkaloid compounds |
| CA3043591A1 (en) | 2016-10-18 | 2018-04-26 | Antheia, Inc. | Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids |
| GB2579940B (en) | 2017-08-03 | 2022-11-30 | Antheia Inc | Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids |
| CA3078818A1 (en) * | 2017-09-08 | 2019-03-14 | Intrexon Corporation | Microorganisms and methods in the fermentation of benzylisoquinoline alkaloids |
| AU2018379410A1 (en) | 2017-12-05 | 2020-07-23 | Willow Biosciences Inc. | Neopinone isomerase and methods of using |
| WO2019113710A1 (en) * | 2017-12-15 | 2019-06-20 | Serturner Corp. | Benzylisoquinoline uptake permeases and methods of using |
| BR112020016083A2 (pt) * | 2018-02-08 | 2020-12-15 | Antheia, Inc. | Métodos de produção de alcaloides morfinanos e derivados |
| WO2019165551A1 (en) * | 2018-02-28 | 2019-09-06 | Serturner Corp. | Alkaloid biosynthesis facilitating proteins and methods of use |
| WO2019243624A1 (en) | 2018-06-22 | 2019-12-26 | Valorbec, Limited Partnership | Production of benzylisoquinoline alkaloids in recombinant hosts |
| EP3908654A1 (en) | 2019-01-11 | 2021-11-17 | River Stone Biotech ApS | Recombinant host cells with improved production of l-dopa, dopamine, (s)-norcoclaurine or derivatives thereof |
| WO2024100063A1 (en) | 2022-11-08 | 2024-05-16 | River Stone Biotech Aps | Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268463A (en) | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5543508A (en) | 1987-12-15 | 1996-08-06 | Gene Shears Pty. Limited | Ribozymes |
| US5658772A (en) | 1989-12-22 | 1997-08-19 | E. I. Du Pont De Nemours And Company | Site-specific recombination of DNA in plant cells |
| US6067749A (en) | 1996-07-11 | 2000-05-30 | Tasmanian Alkaloids Pty. Ltd. | Papaver somniferum strain with high concentration of thebaine and oripavine |
| AU2000280409A1 (en) * | 1999-10-20 | 2004-02-12 | Board Of Trustees Of The University Of Illinois | Soybean promoter expressed preferentially in pods |
| AU2002211669A1 (en) | 2000-10-12 | 2002-04-22 | Robert Corcoran | Purification of substance by reaction affinity chromatography |
| US8975063B2 (en) | 2006-10-19 | 2015-03-10 | California Institute Of Technology | Compositions and methods for producing benzylisoquinoline alkaloids |
| US7671204B2 (en) | 2007-12-17 | 2010-03-02 | Mallinckrodt Inc. | N-demethylation of N-methyl morphinans |
| WO2011058446A2 (en) | 2009-11-12 | 2011-05-19 | Uti Limited Partnership | Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum |
| RU2729065C2 (ru) | 2013-12-04 | 2020-08-04 | Эпимерон Инк. | Композиции и способы получения (R)-ретикулина и его предшественников |
| AU2015261278C1 (en) | 2014-05-16 | 2021-06-03 | Sun Pharmaceutical Industries (Australia) Pty Limited | Novel cytochrome P450 fusion protein |
| ES2952733T3 (es) | 2016-06-27 | 2023-11-03 | Antheia Inc | Composiciones y métodos para preparar alcaloides de bencilisoquinolina, alcaloides de morfinano, tebaína y derivados de los mismos |
-
2017
- 2017-06-27 ES ES17735761T patent/ES2952733T3/es active Active
- 2017-06-27 EP EP17735761.3A patent/EP3475417B1/en active Active
- 2017-06-27 DK DK17735761.3T patent/DK3475417T3/da active
- 2017-06-27 AU AU2017290594A patent/AU2017290594B2/en active Active
- 2017-06-27 EP EP23174662.9A patent/EP4253531A3/en active Pending
- 2017-06-27 WO PCT/US2017/039589 patent/WO2018005553A1/en unknown
- 2017-06-27 US US16/312,776 patent/US11142780B2/en active Active
- 2017-06-27 CA CA3029263A patent/CA3029263A1/en active Pending
-
2018
- 2018-12-24 IL IL263947A patent/IL263947B2/en unknown
-
2021
- 2021-10-07 US US17/496,540 patent/US20220205004A1/en active Pending
-
2022
- 2022-05-17 AU AU2022203287A patent/AU2022203287A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022203287A1 (en) | 2022-06-02 |
| ES2952733T3 (es) | 2023-11-03 |
| IL263947B2 (en) | 2023-02-01 |
| EP3475417A1 (en) | 2019-05-01 |
| US11142780B2 (en) | 2021-10-12 |
| IL263947A (en) | 2019-02-28 |
| AU2017290594B2 (en) | 2022-02-17 |
| IL263947B (en) | 2022-10-01 |
| EP4253531A3 (en) | 2023-10-25 |
| EP4253531A2 (en) | 2023-10-04 |
| AU2017290594A1 (en) | 2019-01-24 |
| CA3029263A1 (en) | 2018-01-04 |
| US20200140906A1 (en) | 2020-05-07 |
| US20220205004A1 (en) | 2022-06-30 |
| EP3475417B1 (en) | 2023-05-24 |
| WO2018005553A1 (en) | 2018-01-04 |
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