DK3426303T3 - Behandling af muskellidelser med kombinationer af rxr-agonister og thyroideahormoner - Google Patents
Behandling af muskellidelser med kombinationer af rxr-agonister og thyroideahormoner Download PDFInfo
- Publication number
- DK3426303T3 DK3426303T3 DK16893790.2T DK16893790T DK3426303T3 DK 3426303 T3 DK3426303 T3 DK 3426303T3 DK 16893790 T DK16893790 T DK 16893790T DK 3426303 T3 DK3426303 T3 DK 3426303T3
- Authority
- DK
- Denmark
- Prior art keywords
- combinations
- treatment
- thyroid hormones
- muscle disorders
- rxr agonists
- Prior art date
Links
- 208000029578 Muscle disease Diseases 0.000 title 1
- 208000021642 Muscular disease Diseases 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 239000005495 thyroid hormone Substances 0.000 title 1
- 229940036555 thyroid hormone Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662306472P | 2016-03-10 | 2016-03-10 | |
| PCT/US2016/059775 WO2017155578A1 (en) | 2016-03-10 | 2016-10-31 | Treatment of muscular disorders with combinations of rxr agonists and thyroid hormones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3426303T3 true DK3426303T3 (da) | 2022-09-19 |
Family
ID=59790702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16893790.2T DK3426303T3 (da) | 2016-03-10 | 2016-10-31 | Behandling af muskellidelser med kombinationer af rxr-agonister og thyroideahormoner |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10835507B2 (da) |
| EP (1) | EP3426303B1 (da) |
| JP (1) | JP7169647B2 (da) |
| KR (1) | KR20180121983A (da) |
| CN (1) | CN109069645A (da) |
| AU (1) | AU2016396659B2 (da) |
| CA (1) | CA3016878C (da) |
| DK (1) | DK3426303T3 (da) |
| ES (1) | ES2926961T3 (da) |
| IL (1) | IL261668B (da) |
| MX (1) | MX2018010863A (da) |
| NZ (1) | NZ745704A (da) |
| PL (1) | PL3426303T3 (da) |
| SG (1) | SG11201807250PA (da) |
| WO (1) | WO2017155578A1 (da) |
| ZA (1) | ZA201805940B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1937244T (pt) | 2005-09-30 | 2018-11-07 | Io Therapeutics Llc | Tratamento do cancro com agonistas específicos de rxr |
| CA2858882C (en) | 2011-12-13 | 2021-02-02 | Trustees Of Dartmouth College | Autoimmune disorder treatment using rxr agonists |
| US10092535B2 (en) | 2015-10-31 | 2018-10-09 | Io Therapeutics, Inc. | Treatment of nervous system disorders using combinations of RXR agonists and thyroid hormones |
| IL261669B2 (en) | 2016-03-10 | 2023-12-01 | Io Therapeutics Inc | A combination of thyroid hormones and an RXR agonist for the treatment of autoimmune diseases |
| US10835507B2 (en) * | 2016-03-10 | 2020-11-17 | Io Therapeutics, Inc. | Treatment of muscular disorders with combinations of RXR agonists and thyroid hormones |
| US11517549B2 (en) | 2017-09-20 | 2022-12-06 | Io Therapeutics, Inc. | Treatment of disease with esters of selective RXR agonists |
| IL304970A (en) | 2017-11-17 | 2023-10-01 | Io Therapeutics Inc | Processes for the preparation of retinoids specific for the retinoid X receptor |
| US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
| JP7514546B2 (ja) * | 2019-12-03 | 2024-07-11 | 学校法人自治医科大学 | 心筋細胞の成熟方法、心筋細胞の成熟度評価方法、成熟心筋細胞の純化方法、心筋細胞成熟度評価装置、心筋細胞成熟度評価プログラム、及び心筋細胞成熟キット |
| MX2024006978A (es) | 2021-12-07 | 2024-07-19 | Io Therapeutics Inc | Uso de un agonista de rxr y taxanos en el tratamiento de cáncer her2+. |
| CA3242047A1 (en) | 2021-12-07 | 2023-06-15 | Io Therapeutics, Inc. | Use of an rxr agonist in treating drug resistant her2+ cancers |
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-
2016
- 2016-10-31 US US16/083,619 patent/US10835507B2/en active Active
- 2016-10-31 ES ES16893790T patent/ES2926961T3/es active Active
- 2016-10-31 WO PCT/US2016/059775 patent/WO2017155578A1/en active Application Filing
- 2016-10-31 CA CA3016878A patent/CA3016878C/en active Active
- 2016-10-31 NZ NZ745704A patent/NZ745704A/en unknown
- 2016-10-31 CN CN201680083364.8A patent/CN109069645A/zh active Pending
- 2016-10-31 KR KR1020187029175A patent/KR20180121983A/ko not_active Application Discontinuation
- 2016-10-31 PL PL16893790.2T patent/PL3426303T3/pl unknown
- 2016-10-31 SG SG11201807250PA patent/SG11201807250PA/en unknown
- 2016-10-31 DK DK16893790.2T patent/DK3426303T3/da active
- 2016-10-31 AU AU2016396659A patent/AU2016396659B2/en active Active
- 2016-10-31 EP EP16893790.2A patent/EP3426303B1/en active Active
- 2016-10-31 JP JP2018547331A patent/JP7169647B2/ja active Active
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2018
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- 2018-09-06 IL IL261668A patent/IL261668B/en unknown
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2020
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| EP3426303B1 (en) | 2022-06-15 |
| AU2016396659B2 (en) | 2019-02-14 |
| AU2016396659A1 (en) | 2018-09-13 |
| US20210077445A1 (en) | 2021-03-18 |
| SG11201807250PA (en) | 2018-09-27 |
| US10835507B2 (en) | 2020-11-17 |
| KR20180121983A (ko) | 2018-11-09 |
| IL261668A (en) | 2018-10-31 |
| CA3016878C (en) | 2024-02-27 |
| ZA201805940B (en) | 2019-07-31 |
| JP2019511492A (ja) | 2019-04-25 |
| PL3426303T3 (pl) | 2022-10-03 |
| US20190298678A1 (en) | 2019-10-03 |
| CN109069645A (zh) | 2018-12-21 |
| ES2926961T3 (es) | 2022-10-31 |
| MX2018010863A (es) | 2019-01-10 |
| IL261668B (en) | 2022-05-01 |
| CA3016878A1 (en) | 2017-09-14 |
| EP3426303A4 (en) | 2019-10-30 |
| EP3426303A1 (en) | 2019-01-16 |
| NZ745704A (en) | 2019-04-26 |
| JP7169647B2 (ja) | 2022-11-11 |
| WO2017155578A1 (en) | 2017-09-14 |
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