DK338187A - 13beta-milbemycinderivater samt deres fremstillingog anvendelse - Google Patents
13beta-milbemycinderivater samt deres fremstillingog anvendelseInfo
- Publication number
- DK338187A DK338187A DK338187A DK338187A DK338187A DK 338187 A DK338187 A DK 338187A DK 338187 A DK338187 A DK 338187A DK 338187 A DK338187 A DK 338187A DK 338187 A DK338187 A DK 338187A
- Authority
- DK
- Denmark
- Prior art keywords
- unsubstituted
- substituted
- groups
- hydrogen
- milbemycine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 230000000361 pesticidal effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH266886 | 1986-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK338187D0 DK338187D0 (da) | 1987-07-01 |
| DK338187A true DK338187A (da) | 1988-01-03 |
Family
ID=4238883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK338187A DK338187A (da) | 1986-07-02 | 1987-07-01 | 13beta-milbemycinderivater samt deres fremstillingog anvendelse |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4859657A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0252879B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2528883B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR960001480B1 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE75745T1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE3778768D1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK338187A (cg-RX-API-DMAC10.html) |
| ES (1) | ES2039258T3 (cg-RX-API-DMAC10.html) |
| GR (1) | GR3004535T3 (cg-RX-API-DMAC10.html) |
| IL (1) | IL83031A0 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA874752B (cg-RX-API-DMAC10.html) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001822A (en) * | 1989-04-11 | 1999-12-14 | Pfizer Inc. | Antiparasitic formulations |
| TW202452B (cg-RX-API-DMAC10.html) * | 1989-12-01 | 1993-03-21 | Ciba Geigy Ag | |
| US6514951B1 (en) | 1989-12-15 | 2003-02-04 | American Cyanamid Company | Pour-on formulations effective for the control of internal and external parasites of homothermic animals |
| US5208222A (en) * | 1991-03-28 | 1993-05-04 | Merck & Co., Inc. | 4"-and 4'-alkylthio avermectin derivatives |
| US5229415A (en) * | 1992-03-24 | 1993-07-20 | Merck & Co., Inc. | Alkylthio alkyl avermectins are active antiparasitic agents |
| HU228617B1 (en) * | 1997-12-03 | 2013-04-29 | Merial Llc | Long acting injectable formulations containing hydrogenated castor oil |
| ES2359973T3 (es) * | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas. |
| EP1176869B1 (en) * | 1999-04-02 | 2005-01-12 | Kwang-Suk Chung | Multi purpose fish-hook case including fishline binding device |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| US20060205681A1 (en) * | 2002-06-21 | 2006-09-14 | Maryam Moaddeb | Homogenous paste formulations |
| US7001889B2 (en) * | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
| US7531186B2 (en) | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
| US20080027011A1 (en) * | 2005-12-20 | 2008-01-31 | Hassan Nached | Homogeneous paste and gel formulations |
| EP2035390B1 (en) | 2006-07-05 | 2015-12-09 | Merial, Inc. | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof |
| DK3428148T3 (da) | 2007-05-15 | 2020-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Aryloazol-2-yl-cyanoethylaminoforbindelser, fremgangsmåde til fremstilling og fremgangsmåde til anvendelse deraf |
| CN101909450B (zh) | 2007-11-26 | 2014-04-23 | 梅里亚有限公司 | 用于抗击寄生物的浇泼配制剂的溶剂系统 |
| EP2237774B1 (en) | 2007-12-21 | 2016-06-22 | Merial Limited | THE USE OF 6-HALOGENO-(1,2,4)-TRIAZOLO-(1,5-a)-PYRIMIDINE COMPOUNDS FOR COMBATING PESTS IN AND ON ANIMALS |
| WO2010008891A2 (en) * | 2008-06-24 | 2010-01-21 | Merial Limited | Anthelminthic formulations |
| BRPI0921546A8 (pt) | 2008-11-14 | 2022-08-16 | Merial Ltd | Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos |
| NZ592865A (en) | 2008-11-19 | 2013-08-30 | Merial Ltd | Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| ES2537424T3 (es) | 2008-12-04 | 2015-06-08 | Merial Limited | Derivados de dímeros de avermectina y de milbemicina |
| CN102596968B (zh) | 2009-07-30 | 2015-05-06 | 梅里亚有限公司 | 杀虫的4-氨基-噻吩并[2,3-d]-嘧啶化合物及其使用方法 |
| AU2010325827B2 (en) | 2009-12-04 | 2015-11-05 | Basf Se | Pesticidal bis-organosulfur compounds |
| MX336189B (es) | 2009-12-17 | 2016-01-11 | Merial Ltd | Compuesto de dihidroazol antiparasiticos y composiciones qe¡ue comprenden los mismos. |
| AU2010330844B2 (en) | 2009-12-17 | 2014-11-27 | Boehringer Ingelheim Animal Health USA Inc. | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| DK2568980T3 (en) | 2010-05-12 | 2015-11-30 | Merial Inc | INJECTABLE PARASITICIDE FORMULATIONS OF LEVAMISOL AND MACROCYCLIC LACTONS |
| EP2640728B1 (en) | 2010-11-16 | 2016-09-07 | Merial, Inc. | Novel monensin derivatives for the treatment and prevention of protozoal infections |
| WO2012078605A1 (en) | 2010-12-07 | 2012-06-14 | Merial Limited | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| WO2013003168A1 (en) | 2011-06-27 | 2013-01-03 | Merial Limited | Novel insect-repellent coumarin derivatives, syntheses, and methods of use |
| EP2723716B1 (en) | 2011-06-27 | 2017-01-11 | Merial, Inc. | Amido-pyridyl ether compounds and compositions and their use against parasites |
| CN106474120B (zh) | 2011-09-12 | 2020-07-28 | 勃林格殷格翰动物保健美国公司 | 包含异噁唑啉活性剂的杀寄生物组合物，其方法和用途 |
| US20130079394A1 (en) | 2011-09-23 | 2013-03-28 | Cnrs (Centre National Recherche Scientifique) | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
| CA2855954C (en) | 2011-11-17 | 2020-09-01 | Merial Limited | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof. |
| HUE067125T2 (hu) | 2011-12-02 | 2024-10-28 | Boehringer Ingelheim Vetmedica Gmbh | Hosszú hatású injektálható moxidektin formulációk |
| TR201909461T4 (tr) | 2012-02-06 | 2019-07-22 | Boehringer Ingelheim Animal Health Usa Inc | Si̇stemi̇k olarak etki̇ eden akti̇f maddeleri̇ i̇çeren parazi̇ti̇si̇dal oral veteri̇nerli̇ğe ai̇t bi̇leşi̇mler, bunlarin yöntemleri̇ ve kullanimlari |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| NZ701185A (en) | 2012-04-20 | 2015-08-28 | Merial Ltd | Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof |
| NZ716598A (en) | 2012-11-20 | 2017-02-24 | Merial Inc | Anthelmintic compounds and compositions and method of using thereof |
| LT2950795T (lt) | 2013-01-31 | 2018-06-25 | Merial, Inc. | Leišmaniozės gydymo ir naikinimo būdas naudojant feksinidazolą |
| EA030935B1 (ru) | 2013-11-01 | 2018-10-31 | Мериал, Инк. | Антипаразитарные и пестицидные изоксазолиновые соединения |
| CA2945766C (en) | 2014-04-17 | 2023-09-26 | Merial, Inc. | Use of malononitrile compounds for protecting animals from parasites |
| CA2949511A1 (en) | 2014-05-19 | 2015-11-26 | Merial, Inc. | Anthelmintic compounds |
| BR112016029888B1 (pt) | 2014-06-19 | 2021-05-18 | Merial, Inc | composições parasiticidas compreendendo derivados de indol, métodos e usos dos mesmos |
| AU2015339096B2 (en) | 2014-10-31 | 2018-08-02 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal composition comprising fipronil |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| WO2016164487A1 (en) | 2015-04-08 | 2016-10-13 | Merial, Inc. | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| WO2016187534A1 (en) | 2015-05-20 | 2016-11-24 | Merial, Inc. | Anthelmintic depsipeptide compounds |
| WO2016191389A2 (en) | 2015-05-27 | 2016-12-01 | Merial, Inc. | Compositions containing antimicrobial igy antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (ohc) microorganisms |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| AU2017344097A1 (en) | 2016-10-14 | 2019-05-02 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| WO2018093920A1 (en) | 2016-11-16 | 2018-05-24 | Merial, Inc. | Anthelmintic depsipeptide compounds |
| UY37780A (es) | 2017-06-26 | 2019-01-31 | Merial Inc | Composiciones de gránulos parasiticidas con doble principio activo, sus métodos y usos |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| WO2019157241A1 (en) | 2018-02-08 | 2019-08-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| BR112021000257A2 (pt) | 2018-07-09 | 2021-04-06 | Boehringer Ingelheim Animal Health USA Inc. | Compostos heterocíclicos anti-helmínticos |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| NZ776819A (en) | 2019-01-16 | 2023-04-28 | Boehringer Ingelheim Animal Health Usa Inc | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| AU2020231319A1 (en) | 2019-03-01 | 2021-10-21 | Boehringer Ingelheim Animal Health USA Inc. | Injectable clorsulon compositions, methods and uses thereof |
| US11560388B2 (en) | 2019-03-19 | 2023-01-24 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| EP4003292A1 (en) | 2019-07-22 | 2022-06-01 | Intervet International B.V. | Soft chewable veterinary dosage form |
| EP4185589A1 (en) | 2020-05-29 | 2023-05-31 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic heterocyclic compounds |
| EP4262789A1 (en) | 2020-12-21 | 2023-10-25 | Boehringer Ingelheim Vetmedica GmbH | Parasiticidal collar comprising isoxazoline compounds |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093629A (en) * | 1977-04-11 | 1978-06-06 | Merck & Co., Inc. | Derivatives of antibiotic substance milbemycin and processes therefor |
| US4134973A (en) * | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4201861A (en) * | 1977-10-03 | 1980-05-06 | Merck & Co., Inc. | Acyl derivatives of C-076 compounds |
| US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4203976A (en) * | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4200581A (en) * | 1978-08-04 | 1980-04-29 | Merck & Co., Inc. | Alkyl derivatives of C-076 compounds |
| US4457920A (en) * | 1981-09-03 | 1984-07-03 | Merck & Co., Inc. | 4a-Substituted avermectin compounds |
| HUT39739A (en) * | 1984-12-04 | 1986-10-29 | Ciba Geigy Ag | Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof |
| GB2168345B (en) * | 1984-12-14 | 1988-05-25 | Ciba Geigy Ag | Pesticidal 13b-substituted milbemycin derivatives |
| US4778809A (en) * | 1985-08-23 | 1988-10-18 | Ciba-Geigy Corporation | 5-esters of milbemycins for controlling parasitic pests |
-
1987
- 1987-06-26 DE DE8787810369T patent/DE3778768D1/de not_active Expired - Lifetime
- 1987-06-26 EP EP87810369A patent/EP0252879B1/de not_active Expired - Lifetime
- 1987-06-26 ES ES198787810369T patent/ES2039258T3/es not_active Expired - Lifetime
- 1987-06-26 AT AT87810369T patent/ATE75745T1/de not_active IP Right Cessation
- 1987-06-30 IL IL83031A patent/IL83031A0/xx not_active IP Right Cessation
- 1987-06-30 US US07/068,692 patent/US4859657A/en not_active Expired - Fee Related
- 1987-07-01 DK DK338187A patent/DK338187A/da not_active Application Discontinuation
- 1987-07-01 ZA ZA874752A patent/ZA874752B/xx unknown
- 1987-07-02 KR KR1019870007115A patent/KR960001480B1/ko not_active Expired - Fee Related
- 1987-07-02 JP JP62164112A patent/JP2528883B2/ja not_active Expired - Lifetime
-
1992
- 1992-05-08 GR GR920400768T patent/GR3004535T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE75745T1 (de) | 1992-05-15 |
| ZA874752B (en) | 1988-01-04 |
| EP0252879A1 (de) | 1988-01-13 |
| DE3778768D1 (de) | 1992-06-11 |
| EP0252879B1 (de) | 1992-05-06 |
| KR880001661A (ko) | 1988-04-26 |
| IL83031A0 (en) | 1987-12-20 |
| GR3004535T3 (cg-RX-API-DMAC10.html) | 1993-04-28 |
| ES2039258T3 (es) | 1993-09-16 |
| KR960001480B1 (ko) | 1996-01-31 |
| JPS6333381A (ja) | 1988-02-13 |
| DK338187D0 (da) | 1987-07-01 |
| JP2528883B2 (ja) | 1996-08-28 |
| US4859657A (en) | 1989-08-22 |
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