DK3368657T3 - Fremgangsmåder til fremstilling af hepatocytter - Google Patents
Fremgangsmåder til fremstilling af hepatocytter Download PDFInfo
- Publication number
- DK3368657T3 DK3368657T3 DK16801292.0T DK16801292T DK3368657T3 DK 3368657 T3 DK3368657 T3 DK 3368657T3 DK 16801292 T DK16801292 T DK 16801292T DK 3368657 T3 DK3368657 T3 DK 3368657T3
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- DK
- Denmark
- Prior art keywords
- methods
- preparing hepatocytes
- hepatocytes
- preparing
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/38—Vitamins
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
- C12N2500/62—DMSO
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/237—Oncostatin M [OSM]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2513/00—3D culture
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/76—Agarose, agar-agar
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562248389P | 2015-10-30 | 2015-10-30 | |
PCT/IB2016/001617 WO2017072580A1 (en) | 2015-10-30 | 2016-10-29 | Methods for producing hepatocytes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3368657T3 true DK3368657T3 (da) | 2021-10-04 |
Family
ID=57394615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16801292.0T DK3368657T3 (da) | 2015-10-30 | 2016-10-29 | Fremgangsmåder til fremstilling af hepatocytter |
Country Status (8)
Country | Link |
---|---|
US (2) | US10683486B2 (da) |
EP (1) | EP3368657B1 (da) |
CN (1) | CN108884438B (da) |
AU (1) | AU2016344599B2 (da) |
CA (1) | CA3003566C (da) |
DK (1) | DK3368657T3 (da) |
ES (1) | ES2896548T3 (da) |
WO (1) | WO2017072580A1 (da) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210395679A1 (en) * | 2018-11-09 | 2021-12-23 | Children's Hospital Medical Center | In vitro cell culture system for producing hepatocyte-like cells and uses thereof |
CN111004770B (zh) * | 2019-09-25 | 2022-08-23 | 中国人民解放军军事科学院军事医学研究院 | 功能性肝细胞诱导方法及其专用三维诱导培养基和应用 |
CN115175986A (zh) * | 2020-02-10 | 2022-10-11 | 公立大学法人名古屋市立大学 | 用于诱导多能干细胞向脑毛细血管内皮样细胞分化的涂布剂及其利用 |
GB202214291D0 (en) * | 2022-09-29 | 2022-11-16 | Rinri Therapeutics Ltd | Laminin culture protocol |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080299077A1 (en) * | 2007-06-01 | 2008-12-04 | Nevada Cancer Institute | Isolation and growth of stem cells from hemangiomas |
RU2473684C2 (ru) * | 2007-11-27 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
JP5822287B2 (ja) * | 2008-05-14 | 2015-11-24 | 公立大学法人横浜市立大学 | ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法 |
MX356756B (es) * | 2008-11-20 | 2018-06-11 | Centocor Ortho Biotech Inc | Células madre pluripotentes en microportadores. |
US20120190059A1 (en) * | 2009-07-23 | 2012-07-26 | Beijing Huayuanbochuang Technology Co., Ltd. | Methods for obtaining hepatocytes, hepatic endoderm cells and hepatic progenitor cells by induced differentiation |
JP5936547B2 (ja) * | 2009-10-30 | 2016-06-22 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
US10138292B2 (en) * | 2010-12-17 | 2018-11-27 | Biolamina Ab | Cell culture medium |
US20130157368A1 (en) * | 2011-12-20 | 2013-06-20 | Advanced Technologies And Regenerative Medicine, Llc | Induced pluripotent stem cells prepared from human kidney-derived cells |
CN103374546B (zh) * | 2012-04-12 | 2018-05-18 | 北京大学 | 肝实质细胞及其制备、鉴定与应用方法 |
US20130330825A1 (en) * | 2012-06-07 | 2013-12-12 | City Of Hope | Attachment substrates for directed differentiation of human embryonic stem cells in culture |
CA2917743A1 (en) * | 2012-07-12 | 2014-01-16 | Isletone Ab | Derivation and self-renewal of isl1+ cells and uses thereof |
ES2742444T3 (es) * | 2013-07-02 | 2020-02-14 | Nat Univ Singapore | Diferenciación de células madre pluripotentes y células progenitoras cardíacas en fibras de cardiomiocito estriadas usando laminianas LN-15, LN-521 y LN-221 |
JP6278324B2 (ja) * | 2014-07-16 | 2018-02-21 | 国立大学法人大阪大学 | ラミニンフラグメントの細胞培養基質活性増強方法 |
HRP20182119T4 (hr) * | 2015-02-20 | 2022-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Upotreba laminina za diferencijaciju pluripotentnih stanica u stanice hepatocitne linije |
CN105647860A (zh) * | 2016-03-30 | 2016-06-08 | 王凌仪 | 临床治疗级人胎盘底蜕膜来源的间充质干细胞(PDB-MSCs)无血清体外提取制备方法 |
CN105713869A (zh) * | 2016-03-30 | 2016-06-29 | 王凌仪 | 回输临床治疗用人胎盘叶状绒毛膜来源的间充质干细胞体外三维分离培养保存方法 |
US11285174B2 (en) * | 2016-09-19 | 2022-03-29 | The University Court Of The University Of Edinburgh | Macrophage-based therapy for use in the treatment of liver injury |
-
2016
- 2016-10-29 DK DK16801292.0T patent/DK3368657T3/da active
- 2016-10-29 WO PCT/IB2016/001617 patent/WO2017072580A1/en active Application Filing
- 2016-10-29 ES ES16801292T patent/ES2896548T3/es active Active
- 2016-10-29 CN CN201680077299.8A patent/CN108884438B/zh active Active
- 2016-10-29 CA CA3003566A patent/CA3003566C/en active Active
- 2016-10-29 AU AU2016344599A patent/AU2016344599B2/en active Active
- 2016-10-29 EP EP16801292.0A patent/EP3368657B1/en active Active
- 2016-10-29 US US15/338,352 patent/US10683486B2/en active Active
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2020
- 2020-06-16 US US16/902,368 patent/US11713448B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA3003566A1 (en) | 2017-05-04 |
CN108884438B (zh) | 2022-12-23 |
WO2017072580A1 (en) | 2017-05-04 |
EP3368657A1 (en) | 2018-09-05 |
CN108884438A (zh) | 2018-11-23 |
EP3368657B1 (en) | 2021-06-30 |
US10683486B2 (en) | 2020-06-16 |
US11713448B2 (en) | 2023-08-01 |
US20170121686A1 (en) | 2017-05-04 |
AU2016344599B2 (en) | 2020-12-17 |
AU2016344599A1 (en) | 2018-05-10 |
CA3003566C (en) | 2024-01-02 |
ES2896548T3 (es) | 2022-02-24 |
US20200308551A1 (en) | 2020-10-01 |
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