DK3327141T3 - Fremgangsmåde til identificering af den cellulære sammensætning i en biologisk prøve - Google Patents
Fremgangsmåde til identificering af den cellulære sammensætning i en biologisk prøve Download PDFInfo
- Publication number
- DK3327141T3 DK3327141T3 DK17200612.4T DK17200612T DK3327141T3 DK 3327141 T3 DK3327141 T3 DK 3327141T3 DK 17200612 T DK17200612 T DK 17200612T DK 3327141 T3 DK3327141 T3 DK 3327141T3
- Authority
- DK
- Denmark
- Prior art keywords
- identifying
- biological sample
- cellular composition
- cellular
- composition
- Prior art date
Links
- 239000012472 biological sample Substances 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361813802P | 2013-04-19 | 2013-04-19 | |
| EP13173442 | 2013-06-24 | ||
| EP14721278.1A EP2986735B1 (en) | 2013-04-19 | 2014-04-22 | Method for identifying the quantitative composition of blood cells in a sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3327141T3 true DK3327141T3 (da) | 2020-05-04 |
Family
ID=48672462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17200612.4T DK3327141T3 (da) | 2013-04-19 | 2014-04-22 | Fremgangsmåde til identificering af den cellulære sammensætning i en biologisk prøve |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10208346B2 (https=) |
| EP (3) | EP3561074B1 (https=) |
| JP (2) | JP6590790B2 (https=) |
| CN (2) | CN105189783B (https=) |
| CA (1) | CA2904658C (https=) |
| DK (1) | DK3327141T3 (https=) |
| PL (2) | PL2986735T3 (https=) |
| WO (1) | WO2014170497A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3029150T3 (pl) * | 2014-12-05 | 2019-03-29 | Epiontis Gmbh | Epigenetyczny sposób identyfikacji folikularnych pomocniczych limfocytów T (TFH) |
| GB201516972D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells |
| GB201516975D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | PARK2 as epigenetic marker for the identification of immune cells, in particular monocytes |
| JP6100867B1 (ja) * | 2015-11-06 | 2017-03-22 | 振武 曽 | 免疫状態の分析のための検査方法 |
| CN106520693B (zh) * | 2016-10-20 | 2019-11-22 | 清华大学 | 记忆b细胞前体细胞及其用途 |
| EP3360971A1 (en) * | 2017-02-09 | 2018-08-15 | Epiontis GmbH | Improved method for epigenetic immune cell counting |
| EP3382033B1 (en) * | 2017-03-30 | 2020-08-05 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Method for determining blood counts based on dna methylation |
| DE102017004108A1 (de) * | 2017-05-01 | 2018-11-08 | Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen | Verfahren zur Bestimmung der Zellzahl von eukaryotischen Zellen |
| DE102017125013B4 (de) * | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | MCC als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere basophiler Granulozyten |
| DE102017125019B4 (de) * | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | PDCD1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere PD1+ Zellen |
| DE102017125150B4 (de) * | 2017-10-26 | 2019-10-10 | Epiontis Gmbh | Endosialin (CD248) als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere naïver CD8+ T-Zellen |
| CN111526793A (zh) * | 2017-10-27 | 2020-08-11 | 朱诺诊断学公司 | 用于超低体积液体活检的设备、系统和方法 |
| DE102017125335B4 (de) * | 2017-10-27 | 2019-10-17 | Epiontis Gmbh | Amplikon-Region als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere nicht-klassischer Monozyten |
| DE102017126248B4 (de) * | 2017-11-09 | 2019-10-17 | Epiontis Gmbh | ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs) |
| CN109897822B (zh) * | 2017-12-11 | 2023-04-04 | 复旦大学 | 一组人永生化b淋巴细胞系的建立和应用 |
| WO2020007951A1 (en) * | 2018-07-05 | 2020-01-09 | Epiontis Gmbh | Epigenetic method to detect and distinguish ipex and ipex-like syndromes, in particular in newborns |
| DE102018116353B4 (de) * | 2018-07-05 | 2020-06-10 | Epiontis Gmbh | Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening |
| CN109439626B (zh) * | 2018-11-09 | 2022-10-14 | 复旦大学附属中山医院 | 一种有助于体外获得Th22细胞的组合物及其用途 |
| CN109576350B (zh) * | 2019-01-18 | 2021-01-29 | 深圳恒特基因有限公司 | 一种dna与rna同时定量的试剂盒、方法及质控方法 |
| CN109988844B (zh) * | 2019-04-30 | 2022-10-04 | 上海奕谱生物科技有限公司 | 基于甲基化修饰的肿瘤标记物stamp-ep7及其应用 |
| DE102020108560B4 (de) | 2020-03-27 | 2022-03-03 | Precision For Medicine Gmbh | CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen |
| WO2022191293A1 (ja) * | 2021-03-12 | 2022-09-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 全単球及びｃｄ１６陽性単球の割合の測定方法 |
| CN113667673B (zh) * | 2021-07-15 | 2024-02-06 | 武汉血液中心 | 一种类孟买血型FUT1 236delG等位基因及其检测方法和应用 |
| CN115775624A (zh) * | 2021-09-03 | 2023-03-10 | 复旦大学 | 一种免疫衰老评估方法 |
| US20250003007A1 (en) * | 2021-10-04 | 2025-01-02 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Dna methylation signatures for predicting response to immunotherapy |
| KR102559496B1 (ko) * | 2022-04-26 | 2023-07-25 | 연세대학교 산학협력단 | 핵산의 메틸화 여부 확인용 조성물 및 핵산의 메틸화 여부를 확인하는 방법 |
| WO2024243375A1 (en) * | 2023-05-23 | 2024-11-28 | Yale University | Compositions and methods of determining lupus nephritis class |
| DE102023120207A1 (de) | 2023-07-28 | 2025-01-30 | Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts | Verbessertes Verfahren zur Quantifizierung der zellulären Zusammensetzung einer biologischen Probe |
| CN118067591B (zh) * | 2024-04-17 | 2024-07-12 | 南京佰抗生物科技有限公司 | 一种用于血液分析的耗材 |
| CN119372296B (zh) * | 2024-12-24 | 2025-06-13 | 北京致谱医学检验实验室有限公司 | 基于基因甲基化检测实现人b淋巴细胞计数的试剂盒 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5773290A (en) * | 1996-10-07 | 1998-06-30 | Wisconsin Alumni Research Foundation | Mammary gland-specific promoters |
| JP3783808B2 (ja) * | 1997-05-19 | 2006-06-07 | シスメックス株式会社 | 白血球分類計数用試薬 |
| BR0006019A (pt) * | 1999-04-06 | 2001-03-13 | Univ East Carolina | Oligonucleotìdeo de anti-sentido de adenosina baixo, composições, kit & método para tratamento de distúrbios de vias aéreas associados com broncoconstricção, inflamação pulmonar, alergia(s) & depleção de surfactante |
| JP4012339B2 (ja) * | 1999-05-24 | 2007-11-21 | 株式会社堀場製作所 | 血球分類マトリックス図表示装置、血球分類マトリックス図の表示方法および血球分類マトリックス図表示プログラムを記録した記録媒体 |
| WO2004050706A2 (en) | 2002-12-03 | 2004-06-17 | Medical Research Council | Regulatory t-cells |
| DE102004016437A1 (de) * | 2004-04-04 | 2005-10-20 | Oligene Gmbh | Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen |
| AU2005201935B2 (en) * | 2004-05-06 | 2012-04-26 | Veridex, Llc | Prognostic for hematological malignancy |
| US7851154B2 (en) * | 2005-07-22 | 2010-12-14 | Simon Daniel Spivack | GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra |
| WO2008073303A2 (en) * | 2006-12-07 | 2008-06-19 | Switchgear Genomics | Transcriptional regulatory elements of biological pathways, tools, and methods |
| EP2141245A1 (en) * | 2008-07-03 | 2010-01-06 | Ivana Türbachova | DNA methylation analysis of regulatory T cells through DNA-methylation analysis of the TSDR region of the gene foxP3 |
| DK2199411T3 (en) * | 2008-12-16 | 2015-08-03 | Epiontis Gmbh | Epigenetic markers for the identification of CD3-positive T lymphocytes |
| WO2010120526A2 (en) * | 2009-03-31 | 2010-10-21 | Emory University | Methods and systems for screening for and diagnosing dna methylation associated with autism spectrum disorders |
| EP2248913B1 (en) * | 2009-04-28 | 2016-10-05 | Epiontis GmbH | GNLY as epigenetic marker for the identification of CD56-expressing natural killer cells |
| WO2010144634A1 (en) * | 2009-06-09 | 2010-12-16 | Banner Sun Health Research Institute | Method and system to detect, diagnose, and monitor the progression of alzheimer's disease |
| EP2354242A1 (en) * | 2010-02-03 | 2011-08-10 | Epiontis GmbH | Assay for determining the type and/or status of a cell based on the epigenetic pattern and the chromatin structure |
| WO2011135088A1 (en) | 2010-04-29 | 2011-11-03 | Epiontis Gmbh | Detection of immune cells, in particular t cells through dna-methylation analysis of the genes ccr6 and blr1 |
| EP2596132A4 (en) * | 2010-07-23 | 2013-12-18 | Harvard College | METHOD FOR DETECTING SIGNS FOR ILLNESS OR SUFFERING IN BODY FLUIDS |
| JP5583629B2 (ja) * | 2011-04-28 | 2014-09-03 | シスメックス株式会社 | 白血球の分類計数方法、白血球分類試薬キット及び白血球分類試薬 |
| EP2518160A1 (en) * | 2011-04-29 | 2012-10-31 | Universitätsklinikum Freiburg | Mitochondrial nucleic acid as a marker for autoimmune and autoinflammatory diseases |
| GB201112586D0 (en) * | 2011-07-22 | 2011-09-07 | Epiontis Gmbh | Epigenetic marker for the identification of natural killer cells |
-
2014
- 2014-04-22 US US14/771,496 patent/US10208346B2/en active Active
- 2014-04-22 WO PCT/EP2014/058087 patent/WO2014170497A2/en not_active Ceased
- 2014-04-22 PL PL14721278T patent/PL2986735T3/pl unknown
- 2014-04-22 EP EP19160756.3A patent/EP3561074B1/en active Active
- 2014-04-22 CN CN201480016515.9A patent/CN105189783B/zh active Active
- 2014-04-22 EP EP14721278.1A patent/EP2986735B1/en active Active
- 2014-04-22 CA CA2904658A patent/CA2904658C/en active Active
- 2014-04-22 CN CN201711262337.XA patent/CN107941681B/zh active Active
- 2014-04-22 PL PL17200612T patent/PL3327141T3/pl unknown
- 2014-04-22 DK DK17200612.4T patent/DK3327141T3/da active
- 2014-04-22 JP JP2016508191A patent/JP6590790B2/ja not_active Expired - Fee Related
- 2014-04-22 EP EP17200612.4A patent/EP3327141B1/en active Active
-
2017
- 2017-11-28 JP JP2017227763A patent/JP6577005B2/ja not_active Expired - Fee Related
-
2018
- 2018-03-30 US US15/941,863 patent/US10894984B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3561074A1 (en) | 2019-10-30 |
| CN105189783B (zh) | 2020-08-07 |
| WO2014170497A2 (en) | 2014-10-23 |
| EP3327141A1 (en) | 2018-05-30 |
| CA2904658A1 (en) | 2014-10-23 |
| JP6590790B2 (ja) | 2019-10-16 |
| EP2986735A2 (en) | 2016-02-24 |
| JP2016515397A (ja) | 2016-05-30 |
| CN107941681A (zh) | 2018-04-20 |
| US20160024578A1 (en) | 2016-01-28 |
| US10208346B2 (en) | 2019-02-19 |
| PL3327141T3 (pl) | 2020-07-27 |
| CN105189783A (zh) | 2015-12-23 |
| US20180291447A1 (en) | 2018-10-11 |
| EP2986735B1 (en) | 2019-03-06 |
| PL2986735T3 (pl) | 2019-08-30 |
| CA2904658C (en) | 2023-10-17 |
| US10894984B2 (en) | 2021-01-19 |
| EP3561074B1 (en) | 2024-03-20 |
| JP6577005B2 (ja) | 2019-09-18 |
| JP2018064570A (ja) | 2018-04-26 |
| EP3327141B1 (en) | 2020-01-29 |
| CN107941681B (zh) | 2021-07-30 |
| WO2014170497A3 (en) | 2014-12-11 |
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