DK3116569T3 - Inhalator til aktivt tørpulver - Google Patents

Inhalator til aktivt tørpulver Download PDF

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Publication number
DK3116569T3
DK3116569T3 DK15715459.2T DK15715459T DK3116569T3 DK 3116569 T3 DK3116569 T3 DK 3116569T3 DK 15715459 T DK15715459 T DK 15715459T DK 3116569 T3 DK3116569 T3 DK 3116569T3
Authority
DK
Denmark
Prior art keywords
capsule
gas
inhaler
needle
flow
Prior art date
Application number
DK15715459.2T
Other languages
English (en)
Inventor
Nimrod Kaufmann
Original Assignee
Inspiro Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspiro Medical Ltd filed Critical Inspiro Medical Ltd
Application granted granted Critical
Publication of DK3116569T3 publication Critical patent/DK3116569T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0003Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0035Piercing means
    • A61M15/0036Piercing means hollow piercing means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0041Details of the piercing or cutting means with movable piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/002Details of inhalators; Constructional features thereof with air flow regulating means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • A61M2205/3334Measuring or controlling the flow rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502User interfaces, e.g. screens or keyboards
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/20Blood composition characteristics
    • A61M2230/205Blood composition characteristics partial oxygen pressure (P-O2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/30Blood pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (4)

  1. hvor aktiveringsmekanismen er aktiverbar for at klargøre inhalatoren (1300) ved bevægelse af nålen (122) i forhold til kapselkammeret (1311) langs med en vej til indføring af en del af nålen (122) hen over en første begrænsningslokalitet for kapselfastholdelsesvolumenet (1311) og ind i kapselfastholdelsesvolumenets (1311) indre; og hvor aktiveringsmekanismen fortsætter aktiveret bevægelse af nålen (122) langs med vejen i forhold til kapselkammeret (1311) med henblik på at bevæge delen af nålen (122) fra det indre til en anden begrænsningslokalitet for kapselfastholdelsesvolumenet (1311) og derefter at placere delen af nålen (402) med henblik på at strække sig forbi den anden begrænsningslokalitet for at udtræde af kapselfastholdelsesvolumenet (404); kendetegnet ved, at: yderligere fortsat aktivering af aktiveringsmekanismen tilbagetrækker delen af nålen (122), der indbefatter det mindst ene gasudtag (304), i det indre og væk fra den anden begrænsningslokalitet; og hvor inhalatoren (1300) er konfigureret til at dispergere tørpulvermedikamentet fra en udtrædelsesåbning (310), som efterlades åben af den tilbagetrukne nål i kapslens (420) væg på den anden begrænsningslokalitet, mens delen af nålen (122), der indbefatter det mindst ene gasudtag (304), forbliver tilbagetrukket i det indre og, når inhalatoren (1300) er klargjort med kapslen (210), er placeret inde i kapselfastholdelsesvolumenet (1311).
  2. 13. Kit, der omfatter modulet (1302) ifølge krav 12 og mindst ti kapsler (210), som indeholder tørpulvermedikament.
  3. 14. Fremgangsmåde til fremstilling afen inhalatorkapsel (210), som indeholder tørpulvermedikament med et kapseludtag (310) til medikamentet, hvilken fremgangsmåde omfatter: indføring af en nål (122), der omfatter et gaslumen med mindst ét gasudtag (304), ind i kapslens (210) indre; og punktering af en væg i inhalatorkapslen (210) ved presning af nålen (122) mod væggen fra kapslens indre med henblik på at definere kapseludtaget (310); kendetegnet ved: tilbagetrækning af nålen (122) med henblik på at genåbne kapseludtaget (310), idet det mindst ene gasudtag (304) anbringes inde i kapslens indre; og styring af gas ind i det mindst ene gasudtag (304), mens den forbliver i det indre, og kapseludtaget (310) genåbnes, hvorved tørpulvermedikamentet frigives fra kapslen (210).
  4. 15. Fremgangsmåde ifølge krav 14, hvor ikke mere end 20 % af kapslens (210) væg, som forskubbes for at danne kapseludtaget (310), er inde i kapslens indre efter dannelse af kapseludtaget (310).
DK15715459.2T 2014-03-10 2015-03-10 Inhalator til aktivt tørpulver DK3116569T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461950256P 2014-03-10 2014-03-10
PCT/IL2015/050248 WO2015136529A1 (en) 2014-03-10 2015-03-10 Active dry powder inhaler

Publications (1)

Publication Number Publication Date
DK3116569T3 true DK3116569T3 (da) 2018-04-16

Family

ID=52823742

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15715459.2T DK3116569T3 (da) 2014-03-10 2015-03-10 Inhalator til aktivt tørpulver

Country Status (8)

Country Link
US (1) US10166350B2 (da)
EP (1) EP3116569B1 (da)
CN (1) CN106456914A (da)
DK (1) DK3116569T3 (da)
ES (1) ES2667518T3 (da)
NO (1) NO2709641T3 (da)
TW (1) TW201538187A (da)
WO (1) WO2015136529A1 (da)

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Also Published As

Publication number Publication date
CN106456914A (zh) 2017-02-22
WO2015136529A1 (en) 2015-09-17
TW201538187A (zh) 2015-10-16
NO2709641T3 (da) 2018-05-12
EP3116569B1 (en) 2018-02-28
EP3116569A1 (en) 2017-01-18
US20170165439A1 (en) 2017-06-15
ES2667518T3 (es) 2018-05-11
US10166350B2 (en) 2019-01-01

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