DK305184A - Hexahydropyrrolo(2,1-a)isoquinolin-derivater - Google Patents

Hexahydropyrrolo(2,1-a)isoquinolin-derivater Download PDF

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Publication number
DK305184A
DK305184A DK305184A DK305184A DK305184A DK 305184 A DK305184 A DK 305184A DK 305184 A DK305184 A DK 305184A DK 305184 A DK305184 A DK 305184A DK 305184 A DK305184 A DK 305184A
Authority
DK
Denmark
Prior art keywords
hexahydropyrrolo
derivatives
isoquinolin
isoquinolines
depression
Prior art date
Application number
DK305184A
Other languages
Danish (da)
English (en)
Other versions
DK305184D0 (da
Inventor
Bruce E Maryanoff
Original Assignee
Mcneil Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Pharmaceutical filed Critical Mcneil Pharmaceutical
Publication of DK305184D0 publication Critical patent/DK305184D0/da
Publication of DK305184A publication Critical patent/DK305184A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/402,5-Pyrrolidine-diones
    • C07D207/4042,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Fats And Perfumes (AREA)
DK305184A 1983-06-23 1984-06-22 Hexahydropyrrolo(2,1-a)isoquinolin-derivater DK305184A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50725083A 1983-06-23 1983-06-23

Publications (2)

Publication Number Publication Date
DK305184D0 DK305184D0 (da) 1984-06-22
DK305184A true DK305184A (da) 1984-12-24

Family

ID=24017860

Family Applications (1)

Application Number Title Priority Date Filing Date
DK305184A DK305184A (da) 1983-06-23 1984-06-22 Hexahydropyrrolo(2,1-a)isoquinolin-derivater

Country Status (16)

Country Link
EP (1) EP0130069B1 (es)
JP (1) JPS6069082A (es)
KR (1) KR910002564B1 (es)
AT (1) ATE59041T1 (es)
AU (1) AU563990B2 (es)
CA (1) CA1253155A (es)
DE (1) DE3483735D1 (es)
DK (1) DK305184A (es)
ES (1) ES8602676A1 (es)
FI (1) FI76798C (es)
HK (1) HK54891A (es)
HU (1) HU193937B (es)
NO (1) NO164474C (es)
NZ (1) NZ208480A (es)
SG (1) SG44391G (es)
ZA (1) ZA844402B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572911A (en) * 1984-08-02 1986-02-25 Mcneilab, Inc. Hexahydroindolinzine compounds, pharmaceutical compositions and methods and intermediates
DE3717395A1 (de) * 1987-05-23 1988-12-08 Basf Ag 5-phenyl-1,2,3a,4,5,9b-hexahydro-3h-benz(e) indole, ihre herstellung und verwendung als arzneimittel
GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
GB9326600D0 (en) * 1993-12-22 1994-03-02 Celltech Ltd Chemical compounds
WO2006138604A1 (en) * 2005-06-17 2006-12-28 Janssen Pharmaceutica N.V. Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE690792A (es) * 1966-12-07 1967-05-16
CH538477A (de) * 1970-01-06 1973-06-30 Hoffmann La Roche Verfahren zur Herstellung von Isochinolin-Derivaten

Also Published As

Publication number Publication date
HUT34478A (en) 1985-03-28
ES533657A0 (es) 1985-10-01
NO842345L (no) 1984-12-27
JPS6069082A (ja) 1985-04-19
ZA844402B (en) 1986-01-29
KR850000440A (ko) 1985-02-27
AU563990B2 (en) 1987-07-30
KR910002564B1 (ko) 1991-04-26
ES8602676A1 (es) 1985-10-01
AU2977784A (en) 1985-01-03
ATE59041T1 (de) 1990-12-15
NO164474C (no) 1990-10-10
DE3483735D1 (en) 1991-01-24
EP0130069B1 (en) 1990-12-12
SG44391G (en) 1991-07-26
NO164474B (no) 1990-07-02
FI842533A (fi) 1984-12-24
HU193937B (en) 1987-12-28
EP0130069A2 (en) 1985-01-02
CA1253155A (en) 1989-04-25
HK54891A (en) 1991-07-26
DK305184D0 (da) 1984-06-22
NZ208480A (en) 1986-08-08
FI76798B (fi) 1988-08-31
FI842533A0 (fi) 1984-06-21
EP0130069A3 (en) 1985-09-11
FI76798C (fi) 1988-12-12

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