DK3045397T3

DK3045397T3 - Packaging device for pharmaceuticals

Info

Publication number: DK3045397T3
Application number: DK15151360.3T
Authority: DK
Inventors: Dietmar Gross
Original assignee: Becton Dickinson Rowa Germany Gmbh
Priority date: 2015-01-16
Filing date: 2015-01-16
Publication date: 2017-03-20
Also published as: CN107428424B; CA2985677C; EP3045397B1; EP3045397A1; MX364420B; JP2018502019A; JP6856531B2; KR20170102866A; AU2016208113A1; CN107428424A; PT3045397T; MX2017009240A; BR112017011839A2; KR102423996B1; CA2985677A1; ES2618062T3; BR112017011839B1; AU2016208113B2; WO2016113291A1

Description

Packaging device for pharmaceuticals

The present invention relates to a packaging device for pharmaceuticals and in particular to a packaging device for use in a blister machine.

Corresponding blister machines are known from the prior art. For example, WO 2013/034504 A1 describes a blister machine that can be used in chemists and hospitals or, with corresponding dimensioning, even in blister centres, which puts together pharmaceuticals in a patient-individualised manner in accordance with medically prescribed intake times. The packaging device of the blister machine packs the pharmaceutical combinations (which can contains only one pharmaceutical or a plurality of individual pharmaceuticals) in a bag formed from an endless packaging material web, so-called blister bags, wherein these bags leave the packaging device for further use as a "blister tube" (blister bags filled in a row that have not yet been separated are designated as a blister tube). One blister bag often corresponds to one intake time of a patient, i.e. it contains all pharmaceuticals which a patient has to take e.g. in the morning.

The blister machine according to the aforementioned WO publication comprises a plurality of storage and dispensing devices for pharmaceuticals which interact with a plurality of circumferential guiding devices which also supply the pharmaceuticals to circumferential collection devices via which the pharmaceutical combinations are supplied to a packaging device. The blister machine can provide a plurality of pharmaceutical combinations in a short period of time due to the particular construction which places particular requirements on the packaging device.

In known packaging devices, the prepared pharmaceutical combinations are supplied to the device itself via corresponding transport devices and are packaged in the packaging device in blister bags (this process is also designated as blistering). In the case of a predefined position, the pharmaceutical combination is transferred to the packaging device. This occurs, for example by the transport device being temporarily opened, whereupon the pharmaceutical combination falls on an impact plate provided for such purpose. In packaging devices according to the prior art, the impact plate simultaneously serves as a moulder/folding aid for a packaging material web (from which the packaging device forms the individual blister bags) guided past said impact plate. The packaging material web is in this case usually folded along the longitudinal axis such that the folding region is arranged "below". The individual pharmaceuticals of the pharmaceutical combination slide from the impact plate into the folding region, where a stop is often formed by the vertical welding of the previous bag.

Due to the alignment of the impact plate and the folded packaging material web, the movement direction of the packaging material web and the design of the impact plate means that the pharmaceuticals to be packaged often lie one behind the other in the pre-folded packaging material web. Depending on the number of pharmaceuticals, relatively long bags can thus develop which leads to material wastage and increase of the duration of packaging.

Depending on the shape of the pharmaceuticals to be packaged, the geometry of the impact plate means that pharmaceuticals are unfavourably supplied partially to the pre-folded section of the packaging material web (for example tablets in the form of a flat circular cylinder on a front face) such that there may be problems closing the pre-folded filled section of the packaging material web and its further transport through the packaging device.

The object of the present invention is to provide a packaging device for pharmaceuticals in which the supply of pharmaceuticals into the pre-folded packaging material web is improved such that shorter pharmaceutical bags can be produced.

The object is achieved according to the invention by a packaging device for pharmaceuticals according to claim 1. The packaging device according to the invention exhibits a packaging material supply for supplying a flexible, oblong packaging material web from a storage roll as well as a folding and guiding device that is situated downstream from the packaging material supply (the designation "downstream" is in this case based on the movement direction of the packaging material web, proceeding from the storage roll through the packaging device).

The folding and guiding device exhibits a packaging material web receiving region and two packaging material web folding regions, which converge in a folding section which is arranged counter to the receiving region of the folding and guiding device. The folding and guiding device of the packaging device according to the invention folds the packaging material web in the longitudinal direction by guiding the edges of the packaging material web along the packaging material web folding regions and the folding section fixing a folding region in the packaging material web, whereby a folded packaging material web develops with a cross-section that is U-shaped to some extent.

The pharmaceuticals are supplied to this pre-folded U-shaped region of the packaging material web during the packaging process, which is continuously "formed" when the packaging material web moves; this region is designated below as the "packaging region".

The folding and guiding device exhibits an impact region for pharmaceuticals to be packaged wherein the pharmaceuticals are guided from this impact region into the region of the folded packaging material web (packaging region).

The packaging device according to the invention exhibits a first joining device that is situated downstream from the folding and guiding device with which the folded packaging material web is joined together vertically to the longitudinal direction wherein two vertical joining regions are usually produced for each pharmaceutical bag or blister bag to be produced. Since the blister bags are not usually spaced apart in the device following packaging or production, a joining region often serves as the "end" of a preceding blister bag and the "start" of a new blister bag. However, depending on the precise configuration of the first joining device, two separate vertical joining regions can also be produced for each blister bag.

The packaging device further exhibits a second joining device that is situated downstream from the folding and guiding device with which the folded packaging material web is joined together parallel to the longitudinal direction and opposite or spaced apart from the folding region.

It is not essential for the present invention in which order the first and second joining device are arranged with regard to the movement direction of the packaging material web inside the package device and it depends on constructive details of the packaging device. However, it is common for the first joining device to be subordinate to the folding and guiding device.

According to the invention, the folding and guiding device exhibits a pharmaceutical supply section spaced apart from the folding section via which the pharmaceuticals to be packaged are guided vertically spaced apart from the folding region into the folded packaging material web (and joined together vertically downstream from the supply region) (the packaging region).

In packaging devices according to the prior art, flat impact plates are used by means of which the pharmaceuticals to be packaged are supplied to the packaging region in vertical proximity to the folding region which often leads to the pharmaceuticals, due to the advancing movement of the packaging material web during packaging, being arranged substantially behind each other such that the volume of the pharmaceutical bag produced during the course of the blistering is utilised inadequately and it turns out relatively "long" in relation to the longitudinal direction of the packaging material web.

Owing to the configuration of the folding and guiding device according to the invention, the pharmaceuticals are guided spaced vertically from the folding region into the packaging region such that the pharmaceuticals are initially, stopped by the vertical joining region of the preceding pharmaceutical bag, fall down on the folding region and subsequent pharmaceuticals are optionally arranged over pharmaceuticals already supplied. The pharmaceuticals to be supplied no longer impair each other such that in the case of constant speed (compared with known packaging devices) the same number of pharmaceuticals can be packaged more rapidly and in a "shorter" pharmaceutical bag since the pharmaceuticals are not only arranged in said pharmaceutical bag one after the other, but rather also on top of each other. When a folding and guiding device according to the invention is used, the supply of the individual pharmaceuticals to the pharmaceutical combination is therefore improved such that shorter pharmaceutical bags can be produced which leads, amongst other things, to material saving with regard to the packaging material. However, at the same time, more rapid blistering is also possible since the device can be operated more quickly owing to the shorter hindrance of the individual pharmaceuticals to each other during the supply.

When known impact plates are used, it is possible in unfavourable cases for circular cylindrical pharmaceuticals to be supplied on their front face to the folded packaging material web region. Insofar as pharmaceuticals are supposed to be packed with a relatively large radius, it may thus occur that they are (supposed to be) supplied and packaged vertically to the movement direction of the packaging material web, in relation to their radius, which, depending on the size of the pharmaceuticals and the filling of a folded packaging material web region to be closed may lead to problems in the subsequent joining regions. If for example the folded packaging material web is too strongly flattened, it may be too "flat" to be joined together in the second joining device parallel to the longitudinal direction since the packaging material web simply no longer reaches the actual joining region of the joining device.

In a preferred embodiment of the packaging device according to the invention, provision is thus made for the surface of the folding and guiding device that provides the impact region to have a concave design. This leads, on the one hand, to the impact region exhibiting a steeper angle of inclination (compared to a surface without a concave design) the pharmaceutical supply section arranged in the tip of the triangular folding and guiding device is, in contrast, designed flatter such that the surface of the folding and guiding device constitutes a kind of "ski jump" via which the pharmaceuticals are guided in a particularly effectively and directed manner (roughly in parallel to the joining region) into the pre-folded region of the packaging material web. A vertical joining region of a previous pharmaceutical bag forms a stop for the pharmaceuticals from which they fall to the folding region such that an arrangement of one on top of another is more probable.

When the pharmaceuticals impact in the impact region of the folding and guiding device, the smallest pharmaceutical particles often flake off and contaminate the surface of the folding and guiding device. Subsequent pharmaceuticals can drag the contaminating particles along such that increasing contamination of the pharmaceuticals in the pharmaceutical bags can occur over time. It is thus necessary for the folding and guiding device to be regularly replaced which is time-consuming and makes an undesired interruption of the blistering necessary.

In a preferred embodiment of the packaging device according to the invention, provision is thus made for the folding and guiding device to exhibit a detachable pharmaceutical supply component and the folding component wherein the supply section is part of the detachable pharmaceutical supply component and the folding section is part of the folding component. As soon as a certain level of contamination is reached, only the removable pharmaceutical supply component coming into contact with the pharmaceuticals has to be replaced owing to the configuration of the folding and guiding device according to the invention, the fold component, which ensures the guiding and folding of the packaging material web, can remain in the packaging device. The replacement can thus be carried out significantly more rapidly since it is no longer necessary to use the complete folding and guiding device in the guide path of the packaging material web.

As already described above, a significant advantage of the packaging device according to the invention is the pharmaceutical also being arranged one top of the other in the packaging region. An optimal arrangement of the pharmaceuticals in the folded region of the packaging material web is dependent on the distance of the supply section to the folding region of the packaging material web, more precisely on the distance of the top side of the supply section to the underside of the folding section. In order to be able to ideally adjust this distance, provision is made in a preferred embodiment for the removable pharmaceutical supply component to be swivel mounted.

As already mentioned, the contamination of the surface of the folding and guiding device is problematic and requires a cleaned surface to be regularly provided. This can for example occur by the folding and guiding device, or at least a component of this device, being replaced. In order to extend the intervals between providing a cleaned surface, in a preferred embodiment of the packaging device according to the invention, provision is made for the surface of the folding and guiding device providing the impact region to be provided at least in sections with a non-stick coating which makes the adherence of flaked off pharmaceutical particles more difficult. Any flaking-off pharmaceutical particles are guided with the pharmaceuticals into the folded packaging material web and do not remain on the surface.

Alternatively or additionally, in a further preferred embodiment, provision is made for a cleaning device to be allocated to the folding and guiding device with which contaminants adhering to the surface of the folding and guiding device can be removed. This can for example occur by a fluid being applied to the surface of the folding and guiding device which rinses the adhering contaminants into the packaging material web. The contaminated region of the packaging material web is as usual joined to form a bag and subsequently disposed of. A cleaning liquid can for example be used as the cleaning fluid. In the configuration of the cleaning device and the guiding of the cleaning fluid, it must be noted that the contaminant particles are not rinsed into other regions of the packaging device.

The packaging material web is provided to the folding and guiding device via the packaging material supply and namely usually from a storage roll which can be arranged in a special section of the packaging device. In particular in the case of large blister centres, large quantities of pharmaceuticals are blistered in sequences that are often repeated such that the storage roll can already exhibit completely printed or marked packaging material web regions. In such a case, a spontaneous change of the pharmaceuticals to be packaged is only possible when the storage roll with the already marked packaging material web is changed. In order to be flexible with regard to the pharmaceuticals to be packaged, provision is made in a preferred embodiment of the packaging device according to the invention for the packaging device to exhibit a marking device with which the packaging material web is marked corresponding to the pharmaceuticals to be packaged or already packaged. Corresponding markings are usually printed on the packaging material web such that it is preferred for the marking device to be situated upstream from the folding and guiding device so that a packaging material web that has not yet been folded can be printed.

An embodiment of the packaging device according to the invention is described in detail below with reference to the drawing in which

Fig. 1A shows an oblique view of the packaging device according to the invention with packaging material web guided through the device;

Fig. IB shows an oblique view of the packaging device according to the invention without the packaging material web;

Figs. 2A - 2F show detail views of the packaging device according to the invention in the region of the folding and guiding device.

Figs. 3A and 3B show side views of the packaging device according to the invention in the region of the folding and guiding device;

Figs. 4A - 4C and 5A - 5C show schematic depictions of the supply of pharmaceuticals into the folded packaging material web when a common impact plate and a folding and guiding device according to the invention are used; and

Figs. 6A - 6F show different views of an embodiment of the folding and guiding device.

Figs. 1A and IB show oblique views of an embodiment of the packaging device according to the invention. Fig. 1A depicts in the upper region a packaging material web 2 guided through the device which leaves the device as a blister tube 2d (merely indicated). The blister tube is formed when passing through the device; how this precisely occurs is explained with reference to the following figures. In Fig. IB, the packaging material web and the blister tube is omitted, otherwise the figures are identical.

The depicted embodiment of the packaging device according to the invention exhibits a storage roll 11 on which a packaging material web 2 is mounted which is formed into bags when passing through the packaging device and is filled with pharmaceuticals. The packaging material web 2 with a packaging material supply 10 is guided from the storage roll 11 to a folding and guiding device 20 wherein a marking device 60 is still arranged between the storage roll and the folding and guiding device 20 in the embodiment shown, with which information can be applied to the packaging material web.

With the aid of a folding and guiding device 20 that is triangular in this embodiment and a subsequent first joining device 40, the packaging material web 2 is folded in the longitudinal direction to form a U-shaped double web wherein the two "legs" of the double web are uniformly equally ready or high. How exactly the actual folding process of the packaging material web and the filling of the folded packaging material web occurring in the same section of the packaging device is carried out, is described in greater detail with reference to the following figures.

With the first joining device 40 arranged downstream from the folding and guiding device 20, the folded packaging material web filled with pharmaceuticals is joined vertically to the longitudinal direction or movement direction X of the packaging material web (see Fig. 1), wherein a joining region also constitutes the start of a new (not yet closed) blister bag and the end of the preceding blister bag. In the embodiment shown, the first joining device 40 is implemented by a welding device with which the folded double web is welded vertically to the longitudinal direction. A cleaning device 29 is attached to the first joining device 40 with which a cleaning fluid can be applied to the surface of the folding and guiding device 20 in order to remove contaminants from the surface. A second joining device 50 is arranged downstream from the first joining device 40 with which the folded double web, which is filled with pharmaceutics and already provided with vertical joining regions, is joined parallel to the longitudinal direction and spaced apart from the folding of the packaging material web wherein it is implemented in the embodiment shown again by a weld. The finished blister tube 2d is guided out from the blister machine and supplied for inspection and (for example patient-related) separation.

Figs. 2A - 2E show detail views of an embodiment of the packaging device according to the invention in the region of the folding and guiding device 20. As can already be discerned in Fig. 2A, the packaging material web 2 is folded with the aid of the folding and guiding device 20 and the first joining device 40 to form a double web 2c.

In addition, the unfolded packaging material web 2 in the case of a packaging material web receiving region 21 is guided under the triangular folding and guiding device 20. Sections 2a, 2b of the packaging material web 2 emerge at the side regions of the folding and guiding device. The folding region is fixed at the tip of the folding and guiding device 20 (not discernible in Fig. 2A), i.e. the region in which the actual folding of the packaging material web occurs. The folding of the double web is in this case maintained by the first joining device 40 subordinate to the folding and guiding device 20.

Fig. 2A also shows some details of the first joining device 40 and namely two weld rollers 41, 42 aligned vertically to the longitudinal direction or movement direction of the packaging material web (or double web) by means of which weld regions or joining regions directed vertically to the longitudinal direction of the packaging material web are formed.

When blistering, the weld rollers 41, 42 rotate wherein the rotational speed is or will be adapted to the bag length and the movement speed of the packaging material web. In the embodiment depicted, each weld roller exhibits two opposing weld sections 41a, 41b, 42a, 42b (see Fig. 2B) and only in these regions do the weld rollers have contact with the double web carried out between them during the rotation. The weld sections are matched to each other such that when the double web advances and the weld rollers rotate, they come into contact with the double web every X cm and form a joining region 4. The path of the "non-contact" between weld sections and double web defines the length of the blister bag.

The depiction according to Fig. 2B serves merely to show the rollers/contact regions. As is visible, the joining region in the movement direction of the packaging material web is at the height of the shafts of the weld rollers, i.e. the joining region 4 was introduced "straight"; the rollers had to be depicted rotated by 90° to reproduce this welding that was just carried out. For reasons of clarity, however, this depiction is selected.

As already indicated, the folding and guiding device 20 can be configured in multiple parts and exhibit a removable pharmaceutical supply component and a folding component. The removable pharmaceutical supply component 26 is omitted in Fig. 2C and only the flatly designed, triangular folding component 27 can be discerned. It can also be discerned in this figure that the packaging material web 2, after it has been guided below the folding and guiding device 20 in the packaging material receiving region 21, emerge at the two other side regions of the folding and guiding device, the so-called packaging material web folding regions of which only the packaging material web folding region 22a on the "right" in the movement direction can be discerned.

The complete folding and guiding device 20 is shown in Fig. 2D, however, the packaging material web 2 is omitted and in this depiction, the "left" packaging material web folding region 22b can be discerned.

In Fig. 2E, the first joining device is omitted to illustrate the folding in order to illustrate the region in which the folded packaging material web regions 2a, 2b meet each other wherein this region 6 is merely schematically depicted. For example, it is indicated that the packaging material web regions 2a, 2b converge sharply in the region 6 which is not entirely correct in practice since the region is constantly filled with pharmaceuticals which deform the region.

The packaging material web/double web is moved in the case of blistering through the packaging device and the joining region (in the direction of the arrow) also moves further with the web. The folded packaging material web and the folding and guiding device 20 form a kind of funnel and pharmaceuticals to be blistered are guided into this funnel via the folding and guiding device (see also Fig. 3B).

In the depiction shown in Fig. 2F, both the first joining device and the packaging material web / double web are omitted and the folding and guiding device 20 designed according to the invention can be discerned. In the embodiment shown, the folding and guiding device 20 is built in two parts with a lower folding component 27 and an upper pharmaceutical supply component 26 wherein the pharmaceutical supply component is attached removeably to the folding component. In the embodiment shown, the pharmaceutical supply component 26 provides an impact region 24 from which pharmaceuticals to be packaged are supplied to the packaging region.

As can be discerned in Fig. 2F, the two packaging material web folding regions 22a, 22b, which are provided in the present case by the folding component 27, converge in the folding section 23 which defines the folding region of the packaging material web. The pharmaceutical supply component 26 exhibits the pharmaceutical supply section 25 in the region of the tip which is designed vertically spaced apart (upwards) from the folding section 23. It can also already be surmised in Fig. 2F that the surface of the pharmaceutical supply component 26 has a concave design.

Figs. 3A and 3B show side views of the packaging device according to the invention in the region of the folding and guiding device 20. The first joining device is omitted in Fig. 3A in order to illustrate the course of the folding of the packaging material web 2 from the side. It can be discerned in this depiction that the folding and guiding device is itself arranged inclined in the packaging device and the folded packaging material web 2c is also guided inclined further through the device following folding.

Fig. 3B shows a further side view of the packaging device according to the invention wherein in this depiction a part of the folded packaging material web, the region 2b from Fig. 3A, is omitted such that the folding and guiding device 20 can be discerned. In this depiction according to Fig. 3B, a plurality of pharmaceuticals 7 are further depicted in order to illustrate, on the one hand, the supply of pharmaceuticals 7 into the packaging region 6 and the arrangement of individual pharmaceuticals in a blister bag (that is still to be finished) (delimited by joining regions 4a, 4b).

The provided pharmaceutical combination is suppled via a supply 5 to the folding and guiding device 20 on which they impinge in the impact region 24. The concave configuration of the surface of the folding and guiding device 20, which is formed by the pharmaceutical supply component 26 and the folding component 27 in the embodiment shown, causes the angle in the impact region to be steeper in comparison to a surface that does not have a concave design such that the pharmaceuticals are accelerated more rapidly. The pharmaceutical supply section 25 is designed in the region of the tip of the folding and guiding device 20 and namely vertically spaced apart from the folding section 23. The configuration according to the invention of the folding and guiding device causes the pharmaceuticals 7 to not be supplied in the region of the folding 3 to the packaging region 6, but rather in relation to the movement direction of the packaging material web, vertically spaced apart from the folding region 3. The folding and guiding device according to the invention forms a kind of ski jump (this effect is enhanced by the concave configuration of the surface) which results in the pharmaceuticals 7 not simply being deposited one behind the other in the folding region 3, but rather "jumping" into the packaging region 6. In the packaging region, they impact, in the case of the "snapshot" depicted, against the vertical joining region 4a and then fall in the direction of the folding region 3. Pharmaceuticals can thereby not only be arranged one behind the other (in the movement direction of the packaging material web), but also on top of each other which leads to the same number of pharmaceuticals being able to be packaged in a smaller blister bag. A correspondingly produced blister bag is depicted in Fig. 3B "left" of the joining region 4a. It can also be discerned that a joining region 4a for the blister bag that was just produced constitutes the "start" and for the preceding blister bag, the bag end.

The exact type of deposition of the pharmaceuticals in the packaging region depends on the pharmaceuticals themselves and the length of the blister bag. In the state shown, the pharmaceuticals impact on the joining region and then fall down. When the packaging material web advances, in the case of which the joining region 4a moves further left, it may also happen that the pharmaceuticals no longer impact the joining region, but rather simply land in the movement direction spaced apart in the packaging region.

Figs. 4A - 4C and 5A - 5C schematically show the difference when producing blister bags with a known impact plate and a folding and guiding device according to the invention wherein Figs. 4A - 4C show the production with a known impact plate 20'.

Figs. 6A - 6D show different views of an embodiment of a folding and guiding device 20 wherein the embodiment shown exhibits a pharmaceutical supply component 26 and a folding component 27.

In the embodiment shown, the folding component 27 is designed as a flat triangular plate. However, the underside of the folding component can in particular also be designed completely differently in the case of other embodiments.

In the figures, in particular Fig. 6C, the concave configuration of the surface of the pharmaceutical supply component 26 can be easily discerned. The packaging material web receiving region 21 and the packaging material web folding regions 22a, 22b can also be discerned which are provided by the folding component 27 in the embodiment shown.

It can be discerned in Figs. 6E and 6F that the pharmaceutical supply component can be designed so as to be swivelable towards the folding component, whereby an adaptation of the folding and guiding device to the pharmaceuticals to be packaged or to be blistered is possible.

Claims

A packing device (1) for medicaments exhibiting a packing material supply (10) for supplying a flexible elongated packing material network (2) from a supply roll (11), a folding and guide device (20) located downstream of the packing material supply (10). ), and has the wrapping material mesh receiving area (21) and two wrapping material mesh folding regions (22a, 22b) that coincide with a folding section (23), wherein the folding and guide device (20) folds the wrapping material mesh (2) longitudinally as the edges of the the wrapping material mesh is guided along the wrapping material mesh folding regions (22a, 22b), and the folding section (23) attaches a folding region (3) to the wrapping material mesh (2), and wherein the folding and guide device (20) exhibits impact zone (24) for the drugs to be wrapped; first joining device (40) located downstream of the folding and guide device (20), d the folded wrapping material (2) is joined vertically to the longitudinal direction, another joining device (50) located downstream of the folding and guide device (20), whereby the folded wrapping material (2) is joined parallel to the longitudinal direction, where the folding and guide device (20) a drug delivery portion (25) spaced apart from the folding portion (23) used to guide drugs spaced vertically from the folding region (3) to the folded wrapper material (2).

Pharmaceutical packaging device (1) according to claim 1, characterized in that the surface of the folding and controlling device (20) providing the impact zone (24) has a concave configuration.

Pharmaceutical packaging device (1) according to claim 1 or 2, characterized in that the folding and controlling device (20) has a removable pharmaceutical supply component (25) and a folding component (27), the supply section (25) being part of the removable pharmaceutical product. supply component (26) and the folding section (23) is part of the folding component (27).

Pharmaceutical packing device (1) according to claim 3, characterized in that the removable pharmaceutical supply component (26) is rotatably mounted in such a way that the supply section (25) of the pharmaceutical supply component (26) can be adjusted in height relative to the folding area ( 3).

Pharmaceutical packaging device (1) according to one of claims 1-4, characterized in that the surface of the folding and guiding device (20) which provides the impact zone (24) is provided at least sectionally with an adhesive preventive coating (28).

Pharmaceutical packaging device (1) according to one of claims 1 to 5, characterized in that the folding and controlling device (20) has a cleaning device (29) by which pollutants adhering to the surface of the folding and controlling device (20) can be removed. .

Pharmaceutical packaging device (1) according to one of claims 1-6, characterized in that the packaging device (1) comprises a labeling device (60) which is preferably located upstream of the folding and control device (20).