AU2016208113B2

AU2016208113B2 - Packaging device for drugs

Info

Publication number: AU2016208113B2
Application number: AU2016208113A
Authority: AU
Inventors: Dietmar Gross
Original assignee: Becton Dickinson Rowa Germany GmbH
Current assignee: Becton Dickinson Rowa Germany GmbH
Priority date: 2015-01-16
Filing date: 2016-01-13
Publication date: 2019-09-26
Anticipated expiration: 2036-01-13
Also published as: BR112017011839A2; CA2985677C; CA2985677A1; KR20170102866A; JP2018502019A; PT3045397T; CN107428424B; DK3045397T3; MX364420B; ES2618062T3; BR112017011839B1; EP3045397A1; CN107428424A; MX2017009240A; JP6856531B2; EP3045397B1; WO2016113291A1; KR102423996B1; AU2016208113A1

Abstract

The invention relates to a packaging device for drugs. The problem addressed by the invention is the fact that drugs cannot be optimally arranged in the packaging in the case of known packaging devices. This problem is solved in that the packaging device according to the invention comprises a packaging-material feed (10) and a folding and guiding device (20), wherein the folding and guiding device (20) folds a packaging-material web (2) in the longitudinal direction in that the edges of the packaging-material web are guided along packing-material-web folding regions (22a, 22b) and a folding segment (23) defines a folding region (3) in the packaging-material web (2), and wherein the folding and guiding device (20) has an impact region (24) for drugs to be packaged, a first joining device (40), and a second joining device (50), wherein the folding and guiding device (20) has a drug-feeding segment (25), which is spaced apart from the folding segment (23) and by means of which drugs can be guided into the folded packaging-material web (2) at a vertical distance from the folding region (3).

Description

Packaging device for medications

The present invention relates to a packaging device for medications and in particular a packaging device for use in an automatic blister packaging machine.

Corresponding automatic blister packaging machines are known from the prior art. For example, WO 2013/034504 Al describes an automatic blister packaging machine, which is usable in pharmacies and hospitals or, with corresponding dimensioning, also in blister packaging centers, which compiles the medications individually by patient in accordance with the times for taking them ordered by the physician. The packaging device of the automatic blister packaging machine packages the medication sets (which can contain only one medication or a plurality of individual medications) into a pouch formed from an endless packaging material web, a so-called blister pack, wherein this pouch leaves the packaging device for further use as a blister tube (the concatenated filled blister packs, which are not yet separated, are referred to as a blister tube). A blister pack generally corresponds to a time for taking a medication of a patient, i.e., it contains all medications which a patient must take in the morning, for example.

The automatic blister packaging machine according to the above-mentioned WO specification comprises a plurality of storage and discharge units for medications, which interact with a plurality of revolving guiding units, which supply the medications to collecting units, which also revolve, and via which the medication sets are supplied to a packaging device. Because of the special design, the automatic blister packaging machine can provide a plurality of medication sets in a short time, which places special demands on the packaging device.

In known packaging devices, the provided medication sets are supplied to the device itself via corresponding transport units and packaged in the packaging device into blister packs (this procedure is also referred to as blister packaging). The

C 578WO medication set is transferred to the packaging device at a predefined position. This takes place, for example, in that the transport unit is temporarily opened, upon which the medication set falls onto an impact plate provided for this purpose. In packaging devices according to the prior art, the impact plate is simultaneously used as a shaper/folding aid for a packaging material web guided past it (from which the packaging device shapes the individual blister packs). The packaging material web is typically folded in this case along the longitudinal axis such that the folding region is arranged below. The individual medications of the medication set slip down from the impact plate into the folding region, where a stop is generally formed by the vertical welding of the preceding pouch.

Because of the alignment of the impact plate and the folded packaging material web, the movement direction of the packaging material web and the construction of the impact plate generally cause the medications to be packaged to lie one behind another in the pre-folded packaging material web. In dependence on the number of the medications, relatively long pouches can thus result, which leads to material wastage and lengthening of the duration in time of the packaging.

In dependence on the shape of the medication to be packaged, the geometry of the impact plate causes the medication to be disadvantageously supplied to the pre-folded section of the packaging material web such that (for example, tablets in the form of a flat circular cylinder on an end face) problems can occur during the closing of the pre-folded filled section of the packaging material web and its further transport through the packaging device.

It is the object of the present invention to provide a packaging device for medications, in which the supply of medications into the pre-folded packaging material web is improved such that shorter medication packs can be created.

The object is achieved according to the invention by a packaging device for medications according to Claim 1. The packaging device according to the invention comprises a packaging material supply for supplying a flexible, elongated

C 578WO packaging material web from a storage roll and a folding and guiding unit arranged downstream of the packaging material supply (the term downstream relates in this case to the movement direction of the packaging material web, originating from the storage roll, through the packaging device).

The folding and guiding unit comprises a packaging material web receiving region and two packaging material web folding regions, which run together in a folding section, which is arranged opposite to the receiving region of the folding and guiding unit. The folding and guiding unit of the packaging device according to the invention folds the packaging material web in the longitudinal direction, in that the edges of the packaging material web are guided along the packaging material web folding regions and the folding section establishes a folded region in the packaging material web, whereby a folded packaging material web having a U-shaped cross section results to some extent.

During the packaging operation, the medication is supplied to this pre-folded U-shaped region of the packaging material web, which is continuously formed during movement of the packaging material web; this region is thereafter referred to as the packaging region.

The folding and guiding unit comprises an impact region for medication to be packaged, wherein the medication is guided by this impact region into the region of the folded packaging material web (packaging region).

The packaging device according to the invention comprises a first joining unit arranged downstream of the folding and guiding unit, using which the folded packaging material web is joined together vertically in relation to the longitudinal direction, wherein typically two vertical joining regions are produced per pharmaceutical pack or blister pack to be produced. Since the blister pack is typically not separated in the device after the packaging or production, a joining region is generally used as one end of a preceding blister pack and a beginning of a new blister pack. However, two separate vertical joining

C 578WO regions can also be created per blister pack in dependence on the precise embodiment of the first joining unit.

The packaging device furthermore comprises a second joining unit arranged downstream of the folding and guiding unit, using which the folded packaging material web is joined together in parallel to the longitudinal direction and opposite to or spaced apart from the folded region.

The sequence in which the first and second joining units are arranged in relation to the movement direction of the packaging material web inside the packaging device is not essential for the present invention and is dependent on design details of the packaging device. However, it is typical to arrange the first joining unit after the folding and guiding unit.

According to the invention, the folding and guiding unit comprises a medication supply section, which is spaced apart from the folding section, and via which the medication to be packaged is guided vertically spaced apart from the folding region into the folded packaging material web (which is joined together vertically downstream of the supply region) (the packaging region).

In packaging devices according to the prior art, flat impact plates are used, by means of which the medication to be packaged is supplied, in vertical proximity to the folded region, to the packaging region, which generally has the result that the medications, because of the progressive movement of the packaging material web during the packaging, are arranged essentially one behind another, so that the volume of the medication pack created in the course of the blister packaging is only insufficiently utilized and it results as relatively long, in relation to the longitudinal direction of the packaging material web.

Because of the embodiment according to the invention of the folding and guiding unit, the medications are guided vertically spaced apart from the folded region into the packaging region, so that the medications firstly fall down, stopped by the vertical joining region of the preceding medication pack, onto the folded region and subsequent medications are optionally

C 578WO arranged over already supplied medications. The medications to be supplied no longer obstruct one another mutually, so that at uniform speed (compared to known packaging devices), the same number of medications can be packaged more rapidly and in a shorter medication pack, since the medications are arranged therein not only one behind another, but rather also one on top of another. Upon use of a folding and guiding unit according to the invention, the supply of the individual medications of the medication set is accordingly improved such that shorter medication packs can be created, which results, inter alia, in a material savings with regard to the packaging material. However, more rapid blister packaging is also possible simultaneously, since the device can be operated more rapidly because of the lesser obstruction of the individual medications among one another during the supply.

If known impact plates are used, it is possible in disadvantageous cases that circular-cylindrical medications will be supplied on their end face to the folded packaging material web region. If medications having a relatively large radius are to be packaged, it can thus occur that they are (should be) supplied and packaged vertically in relation to the movement direction of the packaging material web, with respect to their radius, which can result in problems in the following joining regions in dependence on the size of the medications and the filling of a folded packaging material web region to be closed. For example, if the folded packaging material web bulges out too strongly, it is possibly too flat to be joined together in the second joining unit in parallel to the longitudinal unit, since the packaging material web simply no longer reaches the actual joining region of the joining unit.

In a preferred embodiment of the packaging device according to the invention, it is therefore provided that the surface of the folding and guiding unit which provides the impact region is implemented as concave. This has the result, on the one hand, that the impact region has a steeper angle of inclination (in comparison to a surface without concave embodiment), but the medication supply section arranged in the tip of the triangular

C 578WO folding and guiding unit is implemented as flat or, in contrast, so that the surface of the folding and guiding unit represents a type of ski jump, via which the medications are guided particularly effectively and in an oriented manner (approximately parallel to the joining region) into the prefolded region of the packaging material web. A vertical joining region of the preceding medication pack forms a stop for the medications therein, from which they fall down to the folded region, so that an arrangement one on top of another is more probable .

During the impact of the medications in the impact region of the folding and guiding unit, extremely small medication particles regularly split off and contaminate the surface of the folding and guiding unit. Subsequent medications can entrain the contaminant particles, so that increasing contamination of the medications in the medication packs can take place over time. It is therefore necessary to regularly replace the folding and guiding unit, which is time-consuming and requires an undesired interruption of the blister packaging.

In a preferred embodiment of the packaging device according to the invention, it is therefore provided that the folding and guiding unit has a detachable medication supply component and a folding component, wherein the supply section is part of the detachable medication supply component and the folding section is part of the folding component. As soon as a certain level of contamination is reached, because of the embodiment according to the invention of the folding and guiding unit, only the detachable medication supply component, which comes into contact with the medications, must be replaced, the folding component, which ensures the guiding and folding of the packaging material web, can remain in the packaging device. The replacement can therefore be carried out substantially more rapidly, since it is no longer necessary to insert the entire folding and guiding unit in the guide path of the packaging material web.

As already described above, it is an essential advantage of the packaging device according to the invention that medications can also be arranged one on top of another in the packaging

C 578WO region. An optimal arrangement of the medications in the folded region of the packaging material web is dependent on the distance of the supply section to the folded region of the packaging material web, more precisely on the distance of the upper side of the supply section to the lower side of the folded section. To be able to set this distance ideally, it is provided in a preferred embodiment that the detachable medication supply component is mounted so it is pivotable.

As already mentioned, the contamination of the surface of the folding and guiding unit is problematic and requires a cleaned surface to be regularly provided. This can be performed, for example, in that the folding and guiding unit, or at least a component of this unit, is replaced. To lengthen the intervals between the provision of a cleaned surface, it is provided in a preferred embodiment of the packaging device according to the invention that the surface of the folding and guiding unit which provides the impact region is at least sectionally provided with an anti-adhesive coating, which makes it more difficult for medication particles which have split off to adhere. Medication particles which possibly split off are conducted with the medications into the folded packaging material web and do not remain on the surface.

Alternatively or additionally, it is provided in a further preferred embodiment that a cleaning unit, using which contaminants adhering to the surface of the folding and guiding unit can be removed, is assigned to the folding and guiding unit. This can be performed, for example, in that a fluid is applied to the surface of the folding and guiding unit, which flushes the adhering contaminants into the packaging material web. The contaminated region of the packaging material web is joined together as usual to form a pouch and subsequently disposed of. For example, a cleaning liquid can be used as the cleaning fluid. In the embodiment of the cleaning unit and the guiding of the cleaning fluid, it is to be ensured that the contaminant particles are not flushed into other regions of the packaging device.

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The packaging material web is provided to the folding and guiding unit via the packaging material supply, specifically typically from a storage roll, which can be arranged in a special section of the packaging device. In particular in large blister packaging centers, large quantities of medications are blister packaged, often in repeating sequence, so that the storage roll can have already finished printed or marked packaging material web regions. In such a case, a spontaneous change of the medication to be packaged is only possible if the storage roll having the already marked packaging material web is replaced. To be flexible with regard to the medication to be packaged, it is provided in a preferred embodiment of the packaging device according to the invention that it comprises a marking unit, using which the packaging material web is marked in accordance with the medications to be packed or the already packed medications. Corresponding markings are typically printed on the packaging material web, so that it is preferable for the marking unit to be arranged upstream of the folding and guiding unit, so that a packaging material web which is not yet folded can be printed.

An embodiment of the packaging device according to the invention will be described in greater detail hereafter with reference to the drawing, in which

Figure 1A shows a diagonal view of the packaging device according to the invention having packaging material web guided through the device;

Figure IB shows a diagonal view of the packaging device according to the invention without packaging material web;

Figures 2A - 2F show detail views of the packaging device according to the invention in the region of the folding and guiding unit;

Figures 3A and 3B show side views of the packaging device according to the invention in the region of the folding and guiding unit;

Figures 4A - 4C and 5A - 5C show schematic illustrations of the supply of medications into the folded packaging material web

C 578WO in the case of the use of a typical impact plate and a folding and guiding unit according to the invention; and

Figures 6A - 6F show various views of an embodiment of the folding and guiding unit.

Figures 1A and IB show diagonal views of one embodiment of the packaging device according to the invention. In Figure 1A, a packaging material web 2 guided through the device is shown in the upper region, which leaves the device as a blister tube 2d (only indicated). The blister tube is formed during the passage through the device; how this takes place precisely is explained with reference to the following figures. The packaging material web and the blister tube are left out in Figure IB, otherwise the figures are identical.

The illustrated embodiment of the packaging device according to the invention comprises a storage roll 11, on which a packaging material web 2 is stored, which is shaped into pouches and filled with medications as it passes through the packaging device. The packaging material web 2 is supplied from the storage roll 11 to a folding and guiding unit 20 using a packaging material supply 10, wherein a marking unit 60 is also arranged between storage roll and folding and guiding unit 20 in the embodiment shown, using which items of information can be applied to the packaging material web.

With the aid of a folding and guiding unit 20, which is triangular in this embodiment, and a following first joining unit 40, the packaging material web 2 is folded in the longitudinal direction to form a U-shaped double web, wherein the two legs of the double web are generally of equal width and/or height. The precise way in which the actual folding operation of the packaging material web and the filling of the folded packaging material web, which takes place in the same section of the packaging device, are carried out will be described in greater detail with reference to the following figures .

Using the first joining unit 40, which is arranged downstream of the folding and guiding unit 20, the folded packaging material web, which is filled with medications, is

C 578WO joined together vertically in relation to the longitudinal direction or movement direction X of the packaging material web (see Figure 1), wherein a joining region simultaneously represents the beginning of a new (not yet closed) blister pack and the end of the preceding blister pack. In the embodiment shown, the first joining unit 40 is implemented by a welding unit, using which the folded double web is welded vertically in relation to the longitudinal direction. A cleaning unit 29 is fastened on the first joining unit 40, using which a cleaning fluid can be applied to the surface of the folding and guiding unit 20, to remove contaminants from the surface.

A second joining unit 50 is arranged downstream of the first joining unit 40, using which the folded double web, which is filled with medications and is already provided with vertical joining regions, is joined together in parallel to the longitudinal direction and spaced apart from the fold of the packaging material web, wherein this is again implemented by welding in the embodiment shown. The finished blister tube 2d is guided out of the automatic blister packaging machine and supplied to inspection and separation (for example, patientrelated) .

Figures 2A - 2E show detail views of one embodiment of the packaging device according to the invention in the region of the folding and guiding unit 20. As can already be seen in Figure 2A, the packaging material web 2 is folded with the aid of the folding and guiding unit 20 and the first joining unit 40 to form a double web 2c.

For this purpose, the unfolded packaging material web 2 is guided at a packaging material web receiving region 21 under the triangular folding and guiding unit 20. Sections 2a, 2b of the packaging material web 2 protrude at the lateral regions of the folding and guiding unit. At the tip of the folding and guiding unit 20 (not shown in Figure 2A), the folding region is established, i.e., the region in which the actual folding of the packaging material web takes place. The fold of the double web is maintained in this case by the first joining unit 40 downstream from the folding and guiding unit 20.

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Figure 2A also shows several details of the first joining unit 40, specifically two welding rollers 41, 42, which are aligned vertically in relation to the longitudinal direction or movement direction of the packaging material web (or double web), and using which welded regions or joining regions oriented vertically in relation to the longitudinal direction of the packaging material web are implemented.

During the blister packaging, the welding rollers 41, 42 rotate, wherein the rotational velocity is adapted to the pouch length and the movement velocity of the packaging material web. In the illustrated embodiment, each welding roller comprises two opposing welding sections 41a, 41b, 42a, 42b (see Figure 2B in this regard) and the welding rollers only have contact in these regions with the double web guided between them during the rotation. The welding sections are adapted to one another, so that during the progression of the double web and rotation of the welding rollers, these come into contact with the double web every X centimeters and implement a joining region 4. The path length of the noncontact between welding sections and double web defines the length of the blister pack.

The illustration according to Figure 2B is only used to illustrate the rollers/contact regions. As is apparent, the joining region is at the height of the axes of the welding rollers in the movement direction of the packaging material web, i.e., the joining region 4 was just introduced; the rollers would have to be shown rotated by 90°C to reproduce this welding which has just taken place. However, this illustration was selected for reasons of comprehensibility.

As already indicated, the folding and guiding unit 20 can be embodied in multiple parts and can have a detachable pharmaceutical supply component and a folding component. In Figure 2C, the detachable pharmaceutical supply component 26 is omitted and only the flatly implemented, triangular folding component 27 can be seen. It can also be seen in this figure that the packaging material web 2, after it was guided at the packaging material receiving region 21 under the folding and guiding unit 20, protrudes at the two other lateral regions of

C 578WO the folding and guiding unit 20, the so-called packaging material web folding regions, of which only the right packaging material web folding region 22a in the movement direction can be seen.

In Figure 2D, the complete folding and guiding unit 20 is shown, however, the packaging material web 2 is omitted, and the left packaging material web folding region 22b is visible in this illustration.

In Figure 2E, the first joining unit is omitted to illustrate the fold, in order to illustrate the region at which the folded packaging material web regions 2a, 2b come together, wherein this region 6 is only schematically illustrated. For example, it is indicated that the packaging material web regions 2a, 2b run together to a point in the region 6, which is not entirely accurate in practice, since the region is continuously filled with medications, which deform the region.

The packaging material web/double web is moved during the blister packaging through the packaging device, and the joining region also moves further (in the direction of the arrow) with the web. The folded packaging material web and the folding and guiding unit 20 form a type of funnel, and medications to be blister packaged are conducted into this funnel via the folding and guiding unit (see also Figure 3B in this regard).

In the illustration shown in Figure 2F, both the first joining unit and also the packaging material web/double web are omitted, and the folding and guiding unit 20 embodied according to the invention can be seen. In the embodiment shown, the folding and guiding unit 20 is constructed in two parts, having a lower folding component 27 and an upper medication supply component 26, wherein the medication supply component is detachably fastened on the folding component. In the embodiment shown, the medication supply component 26 provides an impact region 24, from which medications to be packaged are supplied to the packaging region.

As can be seen in Figure 2F, the two packaging material web folding regions 22a, 22b, which are provided in the present case by the folding component 27, run together in the folding section

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23, which defines the folded region of the packaging material web. The medication supply component 26 has, in the region of the tip, the medication supply section 25, which is implemented spaced apart vertically (upward) from the folding section 23. Furthermore, it can already be inferred in Figure 2F that the surface of the medication supply component 26 is implemented as concave .

Figures 3A and 3B show side views of the packaging device according to the invention in the region of the folding and guiding unit 20. In Figure 3A, the first joining unit is omitted, to illustrate the course of the folding of the packaging material web 2 from the side. It can be seen in this illustration that the folding and guiding unit itself is arranged inclined in the packaging device, and the folded packaging material web 2c is also guided further in an inclined manner after the folding.

Figure 3B shows a further side view of the packaging device according to the invention, wherein in this illustration, a part of the folded packaging material web, the region 2b from Figure 3A, is omitted, so that the folding and guiding unit 20 can be seen. In the illustration according to Figure 3B, a plurality of medications 7 are also shown, in order, on the one hand, to illustrate the supply of the medications 7 into the packaging region 6 and the arrangement of individual medications in a blister pack (still to be finished) (delimited by joining regions 4a, 4b).

The provided medication set is supplied via a supply 5 to the folding and guiding unit 20, on which it is incident in the impact region 24. The concave embodiment of the surface of the folding and guiding unit 20, which is formed in the embodiment shown from the medication supply component 26 and the folding component 27, causes the angle in the impact region to be steeper in comparison to a surface which is not implemented as concave, so that the medications are accelerated more strongly. The medication supply section 25 is implemented in the region of the tip of the folding and guiding unit 20, specifically vertically spaced apart from the folding section 23. The

C 578WO embodiment according to the invention of the folding and guiding unit 20 has the effect that the medications 7 are not supplied to the packaging region 6 in the region of the fold 3, but rather vertically spaced apart from the folded region 3 in relation to the movement direction of the packaging material web. The folding and guiding unit according to the invention forms a type of ski jump (this effect is reinforced by the concave embodiment of the surface), which has the result that the medications 7 are not simply deposited one after another in the folded region 3, but rather jump into the packaging region

6. They impact in the packaging region, in the snapshot shown in the present case against the vertical joining region 4a, and then fall in the direction of the folded region 3. In this manner, medications can be arranged not only one after another (in the movement direction of the packaging material web), but rather also one on top of another, which has the result that the same number of medications can be packaged in a smaller blister pack. A correspondingly produced blister pack is shown in Figure 3B left from the joining region 4a. It can also be seen that a joining region 4a for the blister pack which was just produced represents the beginning and represents the pack end for the preceding blister pack.

The precise manner of the depositing of the medications in the packaging region is dependent on the medications themselves and the length of the blister pack. In the state shown, the medications impact on the joining region and then fall down. During the progression of the packaging material web, during which the joining region 4a moves further to the left, it can also occur that the medications no longer impact on the joining region, but rather simply arrive in the packaging region spaced apart in the movement direction.

Figures 4A - 4C and 5A - 5C schematically show the difference in the production of blister packs using a known impact plate and a folding and guiding unit according to the invention, wherein Figures 4A - 4C show the production using a known impact plate 20'.

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Figures 6A - 6D show various views of an embodiment of a folding and guiding unit 20 according to the invention, wherein the embodiment shown has a medication supply component 26 and a folding component 27.

In the embodiment shown, the folding component 27 is implemented as a flat triangular plate. In particular the lower side of the folding component can also be implemented completely differently in other embodiments, however.

In the figures, in particular Figure 6C, the concave embodiment of the surface of the medication supply component 26 is well visible. Furthermore, the packaging material web receiving region 21 and the packaging material web folding regions 22a, 22b are well visible, which are provided in the embodiment shown by the folding component 27.

It is well visible in Figures 6E and 6F that the medication supply component can be implemented as pivotable in relation to the folding component, whereby an adaptation of the folding and guiding unit to the medications to be packaged or blister packaged is possible.

Claims

Claims

1. A packaging device (1) for medications, having a packaging material supply (10) for supplying a flexible, elongated packaging material web (2) from a storage roll (11), a folding and guiding unit (20), arranged downstream of the packaging material supply (10), having a packaging material web receiving region (21) and two packaging material web folding regions (22a, 22b), which run together in a folding section (23), wherein the folding and guiding unit (20) folds the packaging material web (2) in the longitudinal direction, in that the edges of the packaging material web are guided along the packaging material web folding regions (22a, 22b) and the folding section (23) establishes a folded region (3) in the packaging material web (2), and wherein the folding and guiding unit (20) has a impact region (24) for medications to be packaged, a first joining unit (40), arranged downstream of the folding and guiding unit (20), using which the folded packaging material web (2) is joined together vertically in relation to the longitudinal direction, a second joining unit (50), arranged downstream of the folding and guiding unit (20), using which the folded packaging material web (2) is joined together in parallel to the longitudinal direction, wherein the folding and guiding unit (20) has a medication supply section (25), spaced apart from the folding section (23), via which medications are guided, vertically spaced apart from the folded region (3), into the folded packaging material web (2) .
2. The packaging device (1) for medications according to Claim 1, characterized in that the surface of the folding and guiding unit (20) which provides the impact region (24) is implemented as concave.

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3. The packaging device (1) for medications according to Claim 1 or 2, characterized in that the folding and guiding unit (20) has a detachable medication supply component (26) and a folding component (27), wherein the supply section (25) is part of the detachable medication supply component (26) and the folding section (23) is part of the folding component (27).
4. The packaging device (1) for medications according to Claim 3, characterized in that the detachable medication supply component (26) is mounted so it is pivotable such that the supply section (25) of the medication supply component (26) is vertically adjustable in relation to the folding region (3).
5. The packaging device (1) for medications according to one of Claims 1-4, characterized in that the surface of the folding and guiding unit (20) which provides the impact region (24) is at least sectionally provided with an anti-adhesive coating (2 8) .
6. The packaging device (1) for medications according to one of Claims 1-5, characterized in that the folding and guiding unit (20) is assigned a cleaning unit (29), using which contaminants adhering to the surface of the folding and guiding unit (20) can be removed
7. The packaging device (1) for medications according to one of Claims 1-6, characterized in that the packaging device (1) comprises a marking unit (60), preferably arranged upstream of the folding and guiding unit (20).