DK3004080T3 - Triazolforbindelser og deres anvendelse som gamma-sekretase-modulatorer - Google Patents
Triazolforbindelser og deres anvendelse som gamma-sekretase-modulatorer Download PDFInfo
- Publication number
- DK3004080T3 DK3004080T3 DK14728533.2T DK14728533T DK3004080T3 DK 3004080 T3 DK3004080 T3 DK 3004080T3 DK 14728533 T DK14728533 T DK 14728533T DK 3004080 T3 DK3004080 T3 DK 3004080T3
- Authority
- DK
- Denmark
- Prior art keywords
- gamma secretase
- secretase modulators
- triazol compounds
- triazol
- compounds
- Prior art date
Links
- VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical compound C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 title 1
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical class C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 title 1
- 229940124648 γ-Secretase Modulator Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1350684 | 2013-06-04 | ||
| PCT/EP2014/061501 WO2014195322A1 (en) | 2013-06-04 | 2014-06-03 | Triazole compounds and their use as gamma secretase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3004080T3 true DK3004080T3 (da) | 2019-01-02 |
Family
ID=50896282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14728533.2T DK3004080T3 (da) | 2013-06-04 | 2014-06-03 | Triazolforbindelser og deres anvendelse som gamma-sekretase-modulatorer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9718805B2 (enExample) |
| EP (1) | EP3004080B1 (enExample) |
| JP (1) | JP6396438B2 (enExample) |
| CN (1) | CN105263922B (enExample) |
| DK (1) | DK3004080T3 (enExample) |
| ES (1) | ES2701810T3 (enExample) |
| WO (1) | WO2014195322A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE060353T2 (hu) * | 2015-02-25 | 2023-02-28 | Prilenia Neurotherapeutics Ltd | Pridopidin alkalmazása memória javítására |
| US11471449B2 (en) | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
| JP2019537582A (ja) * | 2016-10-31 | 2019-12-26 | ハフ イアー インスティテュート | シナプス形成および神経突起形成を増強するための方法 |
| CN121202886A (zh) * | 2024-06-26 | 2025-12-26 | 浙江养生堂天然药物研究所有限公司 | 杂环类化合物及其用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20030312A1 (it) | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer. |
| CA2534240A1 (en) | 2003-08-07 | 2005-02-17 | Merck Sharp & Dohme Limited | Treatment for alzheimer's disease and related conditions |
| JP2007513128A (ja) | 2003-12-03 | 2007-05-24 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病および関連状態の治療に有用な１−アルキル−３−チオ置換インドール−２−アルキン酸 |
| CN101723900B (zh) | 2004-05-26 | 2012-08-22 | 卫材R&D管理有限公司 | 肉桂酰胺类化合物 |
| US8389547B2 (en) | 2006-04-26 | 2013-03-05 | Yudith Garcia | Piperidines and related compounds for the treatment of Alzheimer's disease |
| JPWO2007135969A1 (ja) | 2006-05-19 | 2009-10-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウレア系−シンナミド誘導体 |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| JP2010518080A (ja) | 2007-02-08 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | 治療薬 |
| EP2121633A2 (en) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| EP2120573A4 (en) | 2007-02-12 | 2011-05-25 | Merck Sharp & Dohme | piperidine |
| US8242150B2 (en) | 2007-06-13 | 2012-08-14 | Merck Sharp & Dohme Corp. | Triazole derivatives for treating alzheimer'S disease and related conditions |
| CA2695543A1 (en) | 2007-08-06 | 2009-02-12 | Schering Corporation | Gamma secretase modulators |
| CA2698341A1 (en) * | 2007-09-06 | 2009-03-12 | Schering Corporation | Gamma secretase modulators |
| WO2009087127A1 (en) | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| JP5328816B2 (ja) | 2008-02-22 | 2013-10-30 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβの調節薬 |
| CN102272133A (zh) | 2008-11-06 | 2011-12-07 | 阿斯利康(瑞典)有限公司 | 淀粉样β的调节剂 |
| WO2010052199A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| UY32622A (es) | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| KR20120050450A (ko) * | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
| TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β－類澱粉生成之化合物 |
| EP2523955B1 (en) * | 2010-01-15 | 2014-07-16 | Janssen Pharmaceuticals, Inc. | Novel substituted bicyclic triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| TW201206946A (en) | 2010-07-15 | 2012-02-16 | Bristol Myers Squibb Co | Compounds for the reduction of beta-amyloid production |
-
2014
- 2014-06-03 US US14/895,519 patent/US9718805B2/en not_active Expired - Fee Related
- 2014-06-03 JP JP2016517274A patent/JP6396438B2/ja not_active Expired - Fee Related
- 2014-06-03 EP EP14728533.2A patent/EP3004080B1/en not_active Not-in-force
- 2014-06-03 DK DK14728533.2T patent/DK3004080T3/da active
- 2014-06-03 WO PCT/EP2014/061501 patent/WO2014195322A1/en not_active Ceased
- 2014-06-03 CN CN201480031629.0A patent/CN105263922B/zh not_active Expired - Fee Related
- 2014-06-03 ES ES14728533T patent/ES2701810T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9718805B2 (en) | 2017-08-01 |
| US20160108022A1 (en) | 2016-04-21 |
| CN105263922B (zh) | 2018-08-17 |
| WO2014195322A1 (en) | 2014-12-11 |
| ES2701810T3 (es) | 2019-02-26 |
| EP3004080A1 (en) | 2016-04-13 |
| JP6396438B2 (ja) | 2018-09-26 |
| CN105263922A (zh) | 2016-01-20 |
| JP2016520636A (ja) | 2016-07-14 |
| EP3004080B1 (en) | 2018-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUE057734T2 (hu) | Heterociklusos vegyületek és alkalmazásuk | |
| HRP20181392T1 (hr) | Heterociklični spojevi i njihova uporaba | |
| DK3277681T3 (da) | Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer | |
| DK3363438T3 (da) | Substituerede 2-azabicykler og deres anvendelse som orexinreceptormodulatorer | |
| HRP20190483T1 (hr) | Ror gama (rory) modulatori | |
| DK3381917T3 (da) | Imidazopyridinforbindelser og anvendelser deraf | |
| DK3149001T3 (da) | Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere | |
| DK3608325T3 (da) | Polycykliske-carbamoylpyridonforbindelser og deres farmaceutiske anvendelse | |
| DK2763112T3 (da) | Dynamisk nødhjælp | |
| DK2968173T3 (da) | Heterocykliske forbindelser og anvendelser deraf | |
| HUE054009T2 (hu) | Szubsztituált tetrahidrokinolinon vegyületek ROR gamma modulátorként | |
| DK3143011T3 (da) | Deutererede heterocykliske forbindelser og deres anvendelse som billeddannende stoffer | |
| IL249970B (en) | Gamma delta t cells and uses thereof | |
| DK3063144T3 (da) | Antiparasitære og pesticid-isoxazolinforbindelser | |
| EP2967969C0 (en) | IMPLANT | |
| HUE048902T2 (hu) | Új ROR gamma modulátor vegyületek | |
| DK3030549T3 (da) | Pyridazinonforbindelser og anvendelser deraf | |
| DK3077467T3 (da) | Sikkativsammensætning og anvendelse deraf | |
| DK2958926T5 (da) | Epidithiodioxopiperazinforbindelse eller derivater deraf og anvendelse deraf | |
| DK3126361T3 (da) | Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer | |
| LT2991633T (lt) | Terapija bakteriografu | |
| IL251851A0 (en) | Thiazoles as modulators of ror gamma t | |
| EP2985099A4 (en) | HYDRAULIC CHUCK | |
| DK3066089T3 (da) | Substituerede n-acetyl-l-cysteinderivater og relaterede forbindelser | |
| PL3004079T3 (pl) | Związki pirymidyny i ich zastosowanie jako modulatorów sekretazy gamma |