DK299587A - Fremgangsmaade til fremstilling af netilmicin - Google Patents
Fremgangsmaade til fremstilling af netilmicinInfo
- Publication number
- DK299587A DK299587A DK299587A DK299587A DK299587A DK 299587 A DK299587 A DK 299587A DK 299587 A DK299587 A DK 299587A DK 299587 A DK299587 A DK 299587A DK 299587 A DK299587 A DK 299587A
- Authority
- DK
- Denmark
- Prior art keywords
- netilmicin
- converting
- manufacturing
- imino
- substituent
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229960000808 netilmicin Drugs 0.000 title abstract 3
- ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78719385A | 1985-10-15 | 1985-10-15 | |
| US78719385 | 1985-10-15 | ||
| US8602122 | 1986-10-14 | ||
| PCT/US1986/002122 WO1987002365A2 (en) | 1985-10-15 | 1986-10-14 | Process for preparing netilmicin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK299587A true DK299587A (da) | 1987-06-12 |
| DK299587D0 DK299587D0 (da) | 1987-06-12 |
| DK169343B1 DK169343B1 (da) | 1994-10-10 |
Family
ID=25140700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK299587A DK169343B1 (da) | 1985-10-15 | 1987-06-12 | Fremgangsmåde til fremstilling af netilmicin samt selektivt blokerede sisomicin-derivater |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP0242385B1 (da) |
| JP (2) | JPH0649716B2 (da) |
| KR (1) | KR930003493B1 (da) |
| AR (1) | AR242396A1 (da) |
| AU (1) | AU597285B2 (da) |
| BG (1) | BG51252A3 (da) |
| CA (1) | CA1290751C (da) |
| DK (1) | DK169343B1 (da) |
| ES (1) | ES2030395T3 (da) |
| FI (1) | FI84486C (da) |
| GR (1) | GR3002670T3 (da) |
| HU (1) | HU199498B (da) |
| IE (1) | IE59481B1 (da) |
| IL (1) | IL80299A (da) |
| NZ (1) | NZ217918A (da) |
| PH (1) | PH24737A (da) |
| PL (1) | PL149511B1 (da) |
| PT (1) | PT83533B (da) |
| SU (1) | SU1630614A3 (da) |
| WO (1) | WO1987002365A2 (da) |
| ZA (1) | ZA867785B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0139021B1 (ko) * | 1995-02-09 | 1998-04-30 | 김은영 | 1-엔(n)-에틸시소마이신의 제조방법 |
| GB2478990A (en) | 2010-03-26 | 2011-09-28 | E2V Tech | Magnetron with high gfrequency cathode heater power supply |
| CN102796150A (zh) * | 2012-08-31 | 2012-11-28 | 无锡福祈制药有限公司 | 一种高纯度西索霉素的分离纯化方法 |
| CN105503972B (zh) * | 2015-12-09 | 2018-05-29 | 无锡济民可信山禾药业股份有限公司 | 一种以杂多酸为催化剂合成1-N-乙基庆大霉素C1a的方法 |
| CN106866756A (zh) * | 2017-01-10 | 2017-06-20 | 苏利制药科技江阴有限公司 | 一种合成1‑n‑乙基西索米星的方法 |
| CN110885350A (zh) * | 2019-08-28 | 2020-03-17 | 山东安信制药有限公司 | 一种普拉佐米星的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1034573A (en) * | 1974-08-01 | 1978-07-11 | Peter J.L. Daniels | Preparation of 1-n-substituted 4,6-di-(aminoglycosyl)-1,3-diaminocyclitols |
| US4230847A (en) * | 1976-06-17 | 1980-10-28 | Schering Corporation | Aminoglycoside antibiotic compounds |
| DE2712160A1 (de) * | 1977-03-19 | 1978-09-28 | Bayer Ag | Pseudotrisaccharide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE2924659A1 (de) * | 1979-06-19 | 1981-01-22 | Bayer Ag | Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel |
-
1986
- 1986-10-14 EP EP86906216A patent/EP0242385B1/en not_active Expired - Lifetime
- 1986-10-14 ZA ZA867785A patent/ZA867785B/xx unknown
- 1986-10-14 PT PT83533A patent/PT83533B/pt not_active IP Right Cessation
- 1986-10-14 PL PL1986261846A patent/PL149511B1/pl unknown
- 1986-10-14 KR KR1019870700501A patent/KR930003493B1/ko not_active Expired - Fee Related
- 1986-10-14 HU HU865468A patent/HU199498B/hu not_active IP Right Cessation
- 1986-10-14 CA CA000520424A patent/CA1290751C/en not_active Expired - Lifetime
- 1986-10-14 NZ NZ217918A patent/NZ217918A/en unknown
- 1986-10-14 AU AU64744/86A patent/AU597285B2/en not_active Ceased
- 1986-10-14 JP JP61505496A patent/JPH0649716B2/ja not_active Expired - Fee Related
- 1986-10-14 AR AR86305570A patent/AR242396A1/es active
- 1986-10-14 IE IE270686A patent/IE59481B1/en not_active IP Right Cessation
- 1986-10-14 ES ES198686906216T patent/ES2030395T3/es not_active Expired - Lifetime
- 1986-10-14 EP EP86114196A patent/EP0219093A3/en active Pending
- 1986-10-14 PH PH34364A patent/PH24737A/en unknown
- 1986-10-14 WO PCT/US1986/002122 patent/WO1987002365A2/en not_active Ceased
- 1986-10-14 IL IL80299A patent/IL80299A/xx not_active IP Right Cessation
-
1987
- 1987-06-12 SU SU874202675A patent/SU1630614A3/ru active
- 1987-06-12 FI FI872621A patent/FI84486C/fi active IP Right Grant
- 1987-06-12 BG BG080149A patent/BG51252A3/bg unknown
- 1987-06-12 DK DK299587A patent/DK169343B1/da not_active IP Right Cessation
-
1991
- 1991-09-10 GR GR91401281T patent/GR3002670T3/el unknown
-
1993
- 1993-12-09 JP JP5309048A patent/JPH0735394B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
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