DK299587A - Fremgangsmaade til fremstilling af netilmicin - Google Patents

Fremgangsmaade til fremstilling af netilmicin

Info

Publication number
DK299587A
DK299587A DK299587A DK299587A DK299587A DK 299587 A DK299587 A DK 299587A DK 299587 A DK299587 A DK 299587A DK 299587 A DK299587 A DK 299587A DK 299587 A DK299587 A DK 299587A
Authority
DK
Denmark
Prior art keywords
netilmicin
converting
manufacturing
imino
substituent
Prior art date
Application number
DK299587A
Other languages
English (en)
Other versions
DK299587D0 (da
DK169343B1 (da
Inventor
Chou-Hong Tann
Tiruvettipuram K Thiruvengadam
John Sze-Hung Chiu
Cesar Colon
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DK299587A publication Critical patent/DK299587A/da
Publication of DK299587D0 publication Critical patent/DK299587D0/da
Application granted granted Critical
Publication of DK169343B1 publication Critical patent/DK169343B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK299587A 1985-10-15 1987-06-12 Fremgangsmåde til fremstilling af netilmicin samt selektivt blokerede sisomicin-derivater DK169343B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78719385A 1985-10-15 1985-10-15
US78719385 1985-10-15
US8602122 1986-10-14
PCT/US1986/002122 WO1987002365A2 (en) 1985-10-15 1986-10-14 Process for preparing netilmicin

Publications (3)

Publication Number Publication Date
DK299587A true DK299587A (da) 1987-06-12
DK299587D0 DK299587D0 (da) 1987-06-12
DK169343B1 DK169343B1 (da) 1994-10-10

Family

ID=25140700

Family Applications (1)

Application Number Title Priority Date Filing Date
DK299587A DK169343B1 (da) 1985-10-15 1987-06-12 Fremgangsmåde til fremstilling af netilmicin samt selektivt blokerede sisomicin-derivater

Country Status (21)

Country Link
EP (2) EP0242385B1 (da)
JP (2) JPH0649716B2 (da)
KR (1) KR930003493B1 (da)
AR (1) AR242396A1 (da)
AU (1) AU597285B2 (da)
BG (1) BG51252A3 (da)
CA (1) CA1290751C (da)
DK (1) DK169343B1 (da)
ES (1) ES2030395T3 (da)
FI (1) FI84486C (da)
GR (1) GR3002670T3 (da)
HU (1) HU199498B (da)
IE (1) IE59481B1 (da)
IL (1) IL80299A (da)
NZ (1) NZ217918A (da)
PH (1) PH24737A (da)
PL (1) PL149511B1 (da)
PT (1) PT83533B (da)
SU (1) SU1630614A3 (da)
WO (1) WO1987002365A2 (da)
ZA (1) ZA867785B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0139021B1 (ko) * 1995-02-09 1998-04-30 김은영 1-엔(n)-에틸시소마이신의 제조방법
GB2478990A (en) 2010-03-26 2011-09-28 E2V Tech Magnetron with high gfrequency cathode heater power supply
CN102796150A (zh) * 2012-08-31 2012-11-28 无锡福祈制药有限公司 一种高纯度西索霉素的分离纯化方法
CN105503972B (zh) * 2015-12-09 2018-05-29 无锡济民可信山禾药业股份有限公司 一种以杂多酸为催化剂合成1-N-乙基庆大霉素C1a的方法
CN106866756A (zh) * 2017-01-10 2017-06-20 苏利制药科技江阴有限公司 一种合成1‑n‑乙基西索米星的方法
CN110885350A (zh) * 2019-08-28 2020-03-17 山东安信制药有限公司 一种普拉佐米星的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1034573A (en) * 1974-08-01 1978-07-11 Peter J.L. Daniels Preparation of 1-n-substituted 4,6-di-(aminoglycosyl)-1,3-diaminocyclitols
US4230847A (en) * 1976-06-17 1980-10-28 Schering Corporation Aminoglycoside antibiotic compounds
DE2712160A1 (de) * 1977-03-19 1978-09-28 Bayer Ag Pseudotrisaccharide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2924659A1 (de) * 1979-06-19 1981-01-22 Bayer Ag Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
JPH06316589A (ja) 1994-11-15
PT83533B (pt) 1989-05-31
WO1987002365A2 (en) 1987-04-23
ZA867785B (en) 1988-05-25
NZ217918A (en) 1990-11-27
ES2030395T3 (es) 1992-11-01
SU1630614A3 (ru) 1991-02-23
EP0219093A3 (en) 1987-11-25
IL80299A (en) 1991-06-10
FI872621A0 (fi) 1987-06-12
AR242396A1 (es) 1994-08-31
HUT43613A (en) 1987-11-30
JPS63501079A (ja) 1988-04-21
HU199498B (en) 1990-02-28
PH24737A (en) 1990-10-01
CA1290751C (en) 1991-10-15
PL261846A1 (en) 1988-06-23
PL149511B1 (en) 1990-02-28
EP0219093A2 (en) 1987-04-22
FI84486C (fi) 1991-12-10
FI872621A (fi) 1987-06-12
AU6474486A (en) 1987-05-05
EP0242385A1 (en) 1987-10-28
IE862706L (en) 1987-04-15
KR870700632A (ko) 1987-12-30
PT83533A (en) 1986-11-01
JPH0649716B2 (ja) 1994-06-29
EP0242385B1 (en) 1991-06-12
IL80299A0 (en) 1987-01-30
JPH0735394B2 (ja) 1995-04-19
AU597285B2 (en) 1990-05-31
BG51252A3 (en) 1993-03-15
WO1987002365A3 (en) 1987-08-27
KR930003493B1 (ko) 1993-05-01
DK299587D0 (da) 1987-06-12
FI84486B (fi) 1991-08-30
DK169343B1 (da) 1994-10-10
GR3002670T3 (en) 1993-01-25
IE59481B1 (en) 1994-03-09

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

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