DK2961741T3 - Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases - Google Patents
Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases Download PDFInfo
- Publication number
- DK2961741T3 DK2961741T3 DK14707155.9T DK14707155T DK2961741T3 DK 2961741 T3 DK2961741 T3 DK 2961741T3 DK 14707155 T DK14707155 T DK 14707155T DK 2961741 T3 DK2961741 T3 DK 2961741T3
- Authority
- DK
- Denmark
- Prior art keywords
- mmol
- formula
- compound
- give
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13382065 | 2013-03-01 | ||
| PCT/EP2014/053877 WO2014131855A1 (en) | 2013-03-01 | 2014-02-27 | Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2961741T3 true DK2961741T3 (en) | 2017-07-03 |
Family
ID=47901928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14707155.9T DK2961741T3 (en) | 2013-03-01 | 2014-02-27 | Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9573956B2 (enExample) |
| EP (1) | EP2961741B1 (enExample) |
| JP (1) | JP6338601B2 (enExample) |
| CA (1) | CA2908482A1 (enExample) |
| DK (1) | DK2961741T3 (enExample) |
| ES (1) | ES2635016T3 (enExample) |
| WO (1) | WO2014131855A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2922925A1 (en) * | 2013-09-05 | 2015-03-12 | Genentech, Inc. | Antiproliferative compounds |
| JP6535007B2 (ja) * | 2013-12-20 | 2019-06-26 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ | 新規ピペリジンカルボキサミド化合物、その調製方法及び使用 |
| CA2987978C (en) * | 2014-06-16 | 2022-08-16 | Fundacion Para La Investigacion Medica Aplicada | Novel compounds as dual inhibitors of histone methyltransferases and dna methyltransferases |
| WO2016020307A1 (en) * | 2014-08-04 | 2016-02-11 | Fundación Para La Investigación Médica Aplicada | Novel compounds for use in cognition improvement |
| WO2016120432A1 (en) * | 2015-01-30 | 2016-08-04 | Fundación Para La Investigación Médica Aplicada | Compounds and methods for anticoagulation therapy |
| CN104610166B (zh) * | 2015-03-10 | 2017-06-13 | 山东大学 | 嘧啶苄基异羟肟酸类组蛋白去乙酰化酶抑制剂及制备方法和应用 |
| EP3932914A1 (en) | 2015-03-13 | 2022-01-05 | Valo Health, Inc. | Alpha-cinnamide compounds and compositions as hdac8 inhibitors |
| CA2987109C (en) | 2015-06-26 | 2020-07-07 | Chongqing University of Arts and Sciences | 6-(benzo[d][1,3]dioxol-5-yl)-2-substituted-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6h,7h)-dione derivatives as phosphodiesterase type-5 inhibitors |
| KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
| CN107163052B (zh) * | 2017-04-18 | 2020-08-11 | 华南农业大学 | 一种针对多种pde-5抑制剂药物的免疫检测方法 |
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| CN108912029B (zh) * | 2017-08-25 | 2021-10-01 | 广东东阳光药业有限公司 | 含氮杂环酰胺衍生物及其用途 |
| ES2902365T3 (es) | 2017-11-27 | 2022-03-28 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituidos como inhibidores de PDE1 |
| CN110054625B (zh) * | 2018-01-18 | 2022-01-07 | 山东大学 | N-酰基苯磺酰胺异羟肟酸类Bcl-2、HDAC双靶点抑制剂及制备方法和应用 |
| CN108558890A (zh) * | 2018-06-28 | 2018-09-21 | 重庆康刻尔制药有限公司 | 一种西地那非中间体合成方法 |
| CN109824516B (zh) * | 2019-03-14 | 2021-07-23 | 泰州精英化成医药科技有限公司 | 一种反式-4-羟基环已烷甲酸叔丁酯的制备方法 |
| CN109810108B (zh) * | 2019-03-20 | 2021-08-06 | 华东理工大学 | 2,8-二氮杂-螺-[4,5]-癸烷类嘧啶-异羟肟酸化合物及其用途 |
| TW202237615A (zh) | 2020-12-11 | 2022-10-01 | 南韓商日東製藥股份有限公司 | 作為雄激素受體及磷酸二酯酶雙重抑制劑的新穎化合物 |
| MX2024007904A (es) | 2021-12-22 | 2024-09-18 | Augustine Therapeutics | Compuestos y uso de estos como inhibidores de hdac6. |
| CN115417877B (zh) * | 2022-09-20 | 2024-05-14 | 杭州师范大学 | 组蛋白去乙酰化酶抑制剂及其制备和在制备抗癌症药物上的应用 |
| CN116375714A (zh) * | 2023-03-24 | 2023-07-04 | 苏州满元生物科技有限公司 | 卡巴地那非类药物关键中间体的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1638775A (zh) * | 2002-01-04 | 2005-07-13 | 亨利福尔德健康组织 | 治疗疾病和损伤用的氧化氮供体 |
| CN1548438A (zh) | 2003-05-16 | 2004-11-24 | 烟台开发区北方药物研究所 | 2-取代苯基-6,8-二烃基-3H-咪唑[1,5α][1,3,5]三嗪-4-酮衍生物,其制备方法及其药物用途 |
| US7666872B2 (en) * | 2004-03-05 | 2010-02-23 | Nycomed Gmbh | Use for PDE5 inhibitors |
| ES2548759T3 (es) | 2006-08-24 | 2015-10-20 | Surface Logix, Inc. | Compuestos farmacocinéticamente mejorados |
| US20080221132A1 (en) * | 2006-09-11 | 2008-09-11 | Xiong Cai | Multi-Functional Small Molecules as Anti-Proliferative Agents |
| JP2010527928A (ja) * | 2007-05-18 | 2010-08-19 | ヴィヴァス・インコーポレイテッド | ホスホジエステラーゼ−５阻害剤を含む新規の組み合わせおよびそれらの使用 |
| UA110347C2 (uk) | 2010-08-12 | 2015-12-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | ПОХІДНІ 6-ЦИКЛОАЛКІЛ-1,5-ДИГІДРОПІРАЗОЛО[3,4-d]ПІРИМІДИН-4-ОНУ І ЇХ ЗАСТОСУВАННЯ ЯК ІНГІБІТОРІВ PDE9A |
| EP2535049A1 (en) | 2011-06-17 | 2012-12-19 | Proyecto de Biomedicina Cima, S.L. | Tadalafil for the treatment of dementia |
-
2014
- 2014-02-27 CA CA2908482A patent/CA2908482A1/en not_active Abandoned
- 2014-02-27 ES ES14707155.9T patent/ES2635016T3/es active Active
- 2014-02-27 US US14/770,065 patent/US9573956B2/en not_active Expired - Fee Related
- 2014-02-27 DK DK14707155.9T patent/DK2961741T3/en active
- 2014-02-27 WO PCT/EP2014/053877 patent/WO2014131855A1/en not_active Ceased
- 2014-02-27 EP EP14707155.9A patent/EP2961741B1/en not_active Not-in-force
- 2014-02-27 JP JP2015559501A patent/JP6338601B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014131855A9 (en) | 2014-11-13 |
| EP2961741A1 (en) | 2016-01-06 |
| WO2014131855A1 (en) | 2014-09-04 |
| US20160002246A1 (en) | 2016-01-07 |
| JP2016513130A (ja) | 2016-05-12 |
| US9573956B2 (en) | 2017-02-21 |
| EP2961741B1 (en) | 2017-04-05 |
| ES2635016T3 (es) | 2017-10-02 |
| JP6338601B2 (ja) | 2018-06-06 |
| CA2908482A1 (en) | 2014-09-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2961741B1 (en) | Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases | |
| AU2015299161A1 (en) | Novel compounds for use in cognition improvement | |
| TWI543974B (zh) | 苯基－３－氮雜－雙環［３．１．０］己－３－基－甲酮及其作為藥物之用途 | |
| CN101679279B (zh) | 作为5-ht6拮抗剂的磺酰吡唑啉甲脒衍生物 | |
| AU2017319430A1 (en) | N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease | |
| AU2014318178B2 (en) | Substituted 2, 3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis | |
| US20230010299A1 (en) | Heterocyclic trpml1 agonists | |
| JP6229717B2 (ja) | ガンマセクレターゼモジュレーターとしての縮合トリアゾール誘導体 | |
| CA3145868A1 (en) | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxi n (atx) modulators for the treatment of inflammatory airway or fibrotic diseases | |
| CN120712253A (zh) | 用于治疗疾病或障碍的氢喹唑啉衍生物 | |
| CA3146439A1 (en) | 1-(6-(methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide derivatives as autotaxin (atx) modulators for the treatment of inflammatory airway diseases | |
| JP2015520218A (ja) | シクロヘキサン−１，２’−インデン−１’，２’’−イミダゾール化合物およびｂａｃｅ阻害物質としてのその使用 | |
| TW201002716A (en) | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases | |
| US20130029983A1 (en) | Aminothienopyridazine inhibitors of tau assembly | |
| AU2017376444A1 (en) | Thiazine derivatives as beta-secretase inhibitors and methods of use | |
| JP6167465B2 (ja) | イミダゾ−オキサジアゾール及びイミダゾ−チアジアゾール誘導体 | |
| CA3247233A1 (en) | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND THEIR METHODS OF USE | |
| US20240368092A1 (en) | 2,4-Dihydro-3H-1,2,4-Triazol-3-One P2X7 Antagonists | |
| AU2020316643B2 (en) | N-methyl, N-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases | |
| CN113015736B (zh) | 用于诱导软骨发生以治疗关节损害的6-羟基-8-氧杂三环[3.2.1.02,4]辛烷-2-甲酰胺衍生物 | |
| JP2007517855A (ja) | セロトニン及びノルアドレナリン再取込み阻害剤としての活性を示すピペラジン誘導体 | |
| CN119585241A (zh) | At2r拮抗剂及其用途 | |
| EA052613B1 (ru) | Антагонисты at2r и их применение | |
| CN115784986A (zh) | 一种hdac6抑制剂及其制备方法和应用 | |
| EA046174B1 (ru) | Производные n-метил, n-(6-(метокси)пиридазин-3-ил)амина в качестве модуляторов аутотаксина (atx) для лечения воспалительных заболеваний дыхательных путей или фиброзных заболеваний |