DK2946007T3 - Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer - Google Patents

Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer Download PDF

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DK2946007T3
DK2946007T3 DK14740745.6T DK14740745T DK2946007T3 DK 2946007 T3 DK2946007 T3 DK 2946007T3 DK 14740745 T DK14740745 T DK 14740745T DK 2946007 T3 DK2946007 T3 DK 2946007T3
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hematopoytic
multiline
stamps
defined factors
reprogramming human
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DK14740745.6T
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Vladislav M Sandler
Shahin Rafii
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Univ Cornell
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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DK14740745.6T 2013-01-15 2014-01-15 Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer DK2946007T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361752688P 2013-01-15 2013-01-15
PCT/US2014/011575 WO2014113415A1 (en) 2013-01-15 2014-01-15 Reprogramming of human endothelium into hematopoietic multi-lineage progenitors by defined factors

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DK2946007T3 true DK2946007T3 (da) 2019-07-15

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DK14740745.6T DK2946007T3 (da) 2013-01-15 2014-01-15 Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer

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Country Link
US (1) US10113149B2 (da)
EP (1) EP2946007B1 (da)
JP (1) JP6581906B2 (da)
CN (1) CN105051184B (da)
AU (1) AU2014207627B2 (da)
CA (1) CA2898180C (da)
DK (1) DK2946007T3 (da)
ES (1) ES2733909T3 (da)
RU (1) RU2691062C2 (da)
WO (1) WO2014113415A1 (da)

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GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
CN105051061B (zh) 2013-01-30 2020-02-21 康奈尔大学 用于扩增干细胞的组合物和方法
EP3584312A1 (en) 2014-06-27 2019-12-25 Angiocrine Bioscience, Inc. Neural cells expressing adenovirus e4orf1, and methods of making and using the same
WO2016138025A2 (en) 2015-02-23 2016-09-01 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
WO2016187820A1 (zh) * 2015-05-26 2016-12-01 中国科学院广州生物医药与健康研究院 一种人原代细胞培养基及其应用
EP3307873A4 (en) * 2015-06-09 2018-12-05 The Regents of The University of California Hematopoietic cells and methods of using and generating the same
CN108291196B (zh) 2015-07-20 2021-08-27 安吉克莱茵生物科学有限公司 表达ets转录因子的工程化的内皮细胞
JP7089282B2 (ja) * 2015-07-20 2022-06-22 アンジオクライン・バイオサイエンス・インコーポレイテッド 幹細胞移植のための方法および組成物
EP3383182B1 (en) * 2015-12-03 2023-06-07 The Brigham and Women's Hospital, Inc. Methods for generating functional hematopoietic stem cells
CA3009225A1 (en) * 2015-12-23 2017-06-29 Monash University Cell reprogramming
WO2017181168A1 (en) * 2016-04-15 2017-10-19 Angiocrine Bioscience, Inc. Enhanced gene delivery methods
US11261430B2 (en) 2016-05-03 2022-03-01 The Children's Medical Center Corporation Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells
RU2753441C2 (ru) 2016-09-13 2021-08-16 Ангиокрин Биосайенс, Инк. Гематоэнцефалический барьер, содержащий сконструированные эндотелиальные клетки
JP7265988B2 (ja) * 2017-02-03 2023-04-27 コーネル ユニヴァーシティー 安定な３次元血管およびそれを形成するための方法
EP3621630A4 (en) 2017-06-14 2021-03-10 The Children's Medical Center HEMATOPOIETIC STEM AND PRECURSOR CELLS FROM HEMOGENIC ENDOTHELIAL CELLS BY EPISOMAL PLASMID GENERAL TRANSFER
US12146165B2 (en) 2018-03-23 2024-11-19 The Children's Medical Center Corporation Endothelial cell factors and methods thereof
CN108676777A (zh) * 2018-04-03 2018-10-19 华南生物医药研究院 胎肝窦内皮细胞株在造血干细胞扩增和分化中的应用
CN110577967A (zh) * 2018-05-22 2019-12-17 中国人民解放军军事科学院军事医学研究院 诱导性多能干细胞及其制备方法
US20220228096A1 (en) * 2019-06-27 2022-07-21 Showa Denko Materials Co., Ltd. Cell Scaffold Material, Cell Culture Support, and Cell Culture Method
EP3993812A4 (en) 2019-07-03 2023-08-09 Cornell University PROCEDURE FOR FUNCTIONAL VASCULARISATION OF PANCREA ISLANDS AND BETA CELL ORGANOIDS
WO2021263189A1 (en) * 2020-06-25 2021-12-30 Angiocrine Bioscience, Inc. Endothelial cells for mitigation of chemotherapy-induced toxicity
IL311903A (en) * 2021-10-12 2024-06-01 Wisconsin Alumni Res Found Production of hepatocytes and hematopoietic progenitor cells from human embryonic stem cells

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CA2556018A1 (en) * 2004-02-11 2005-09-09 Aldagen, Inc. Stem cell populations and methods of use
WO2005100549A1 (ja) 2004-04-14 2005-10-27 Kanazawa University Technology Licensing Organization Ltd. 臓器特異的幹細胞の増殖方法及び増殖装置
RU2359030C1 (ru) * 2008-03-19 2009-06-20 Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты)
JP5725394B2 (ja) 2009-03-25 2015-05-27 公立大学法人大阪府立大学 造血幹細胞の培養方法
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Also Published As

Publication number Publication date
ES2733909T3 (es) 2019-12-03
CN105051184B (zh) 2018-08-10
CA2898180C (en) 2023-09-26
JP6581906B2 (ja) 2019-09-25
JP2016505266A (ja) 2016-02-25
AU2014207627B2 (en) 2019-09-12
RU2691062C2 (ru) 2019-06-10
AU2014207627A1 (en) 2015-08-06
RU2015134394A (ru) 2017-02-21
US10113149B2 (en) 2018-10-30
EP2946007A1 (en) 2015-11-25
CN105051184A (zh) 2015-11-11
EP2946007A4 (en) 2016-06-08
EP2946007B1 (en) 2019-04-10
US20150361398A1 (en) 2015-12-17
WO2014113415A1 (en) 2014-07-24
CA2898180A1 (en) 2014-07-24

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