DK2946007T3 - Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer - Google Patents

Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer Download PDF

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DK2946007T3
DK2946007T3 DK14740745.6T DK14740745T DK2946007T3 DK 2946007 T3 DK2946007 T3 DK 2946007T3 DK 14740745 T DK14740745 T DK 14740745T DK 2946007 T3 DK2946007 T3 DK 2946007T3
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hematopoytic
multiline
stamps
defined factors
reprogramming human
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DK14740745.6T
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Vladislav M Sandler
Shahin Rafii
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Univ Cornell
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells

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DK14740745.6T 2013-01-15 2014-01-15 Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer DK2946007T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361752688P 2013-01-15 2013-01-15
PCT/US2014/011575 WO2014113415A1 (en) 2013-01-15 2014-01-15 Reprogramming of human endothelium into hematopoietic multi-lineage progenitors by defined factors

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DK2946007T3 true DK2946007T3 (da) 2019-07-15

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DK14740745.6T DK2946007T3 (da) 2013-01-15 2014-01-15 Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer

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Country Link
US (1) US10113149B2 (da)
EP (1) EP2946007B1 (da)
JP (1) JP6581906B2 (da)
CN (1) CN105051184B (da)
AU (1) AU2014207627B2 (da)
CA (1) CA2898180C (da)
DK (1) DK2946007T3 (da)
ES (1) ES2733909T3 (da)
RU (1) RU2691062C2 (da)
WO (1) WO2014113415A1 (da)

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GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
ES2896354T3 (es) 2012-12-21 2022-02-24 Astellas Inst For Regenerative Medicine Métodos para la producción de plaquetas a partir de células madre pluripotentes
CN105051061B (zh) 2013-01-30 2020-02-21 康奈尔大学 用于扩增干细胞的组合物和方法
AU2015279552B2 (en) 2014-06-27 2021-01-21 Angiocrine Bioscience, Inc. Neural cells expressing adenovirus E4ORF1, and methods of making and using the same
WO2016187820A1 (zh) * 2015-05-26 2016-12-01 中国科学院广州生物医药与健康研究院 一种人原代细胞培养基及其应用
US20210040452A1 (en) * 2015-06-09 2021-02-11 The Regents Of The University Of California Hematopoietic cells and methods of using and generating the same
ES2939635T3 (es) * 2015-07-20 2023-04-25 Angiocrine Bioscience Inc Métodos y composiciones para el trasplante de células madre
JP6861438B2 (ja) 2015-07-20 2021-04-21 アンジオクライン・バイオサイエンス・インコーポレイテッドＡｎｇｉｏｃｒｉｎｅ Ｂｉｏｓｃｉｅｎｃｅ， Ｉｎｃ． Ｅｔｓ転写因子を発現する改変内皮細胞
AU2016362508B2 (en) * 2015-12-03 2021-07-01 Children's Medical Center Corporation Methods for generating functional hematopoietic stem cells
EP3394250A4 (en) * 2015-12-23 2019-11-27 Monash University ZELLENNEUPROGRAMMIERUNG
JP7080184B2 (ja) * 2016-04-15 2022-06-03 アンジオクライン・バイオサイエンス・インコーポレイテッド 遺伝子送達の増強方法
WO2017192708A1 (en) * 2016-05-03 2017-11-09 The Children's Medical Center Corporation Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells
IL265352B2 (en) 2016-09-13 2024-05-01 Angiocrine Bioscience Inc Blood brain barrier containing engineered endothelial cells
US11932876B2 (en) 2017-02-03 2024-03-19 Cornell University Stable three-dimensional blood vessels and methods for forming the same
EP3621630A4 (en) * 2017-06-14 2021-03-10 The Children's Medical Center HEMATOPOIETIC STEM AND PRECURSOR CELLS FROM HEMOGENIC ENDOTHELIAL CELLS BY EPISOMAL PLASMID GENERAL TRANSFER
WO2019183508A1 (en) * 2018-03-23 2019-09-26 The Children's Medical Center Corporation Endothelial cell factors and methods thereof
CN108676777A (zh) * 2018-04-03 2018-10-19 华南生物医药研究院 胎肝窦内皮细胞株在造血干细胞扩增和分化中的应用
CN110577967A (zh) * 2018-05-22 2019-12-17 中国人民解放军军事科学院军事医学研究院 诱导性多能干细胞及其制备方法
CN114051530A (zh) * 2019-06-27 2022-02-15 昭和电工材料株式会社 细胞支架材料、细胞培养支撑体、以及细胞的培养方法
US20220354901A1 (en) * 2019-07-03 2022-11-10 Cornell University Methods of functional vascularization of pancreatic islets and beta-cell organoids
WO2023064284A1 (en) * 2021-10-12 2023-04-20 Wisconsin Alumni Research Foundation Derivation of hepatocytes and hematopoietic progenitors from human embryonic stem cells

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CA2556018A1 (en) * 2004-02-11 2005-09-09 Aldagen, Inc. Stem cell populations and methods of use
WO2005100549A1 (ja) * 2004-04-14 2005-10-27 Kanazawa University Technology Licensing Organization Ltd. 臓器特異的幹細胞の増殖方法及び増殖装置
RU2359030C1 (ru) * 2008-03-19 2009-06-20 Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты)
JP5725394B2 (ja) * 2009-03-25 2015-05-27 公立大学法人大阪府立大学 造血幹細胞の培養方法
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Publication number Publication date
EP2946007A4 (en) 2016-06-08
CN105051184A (zh) 2015-11-11
CN105051184B (zh) 2018-08-10
RU2691062C2 (ru) 2019-06-10
US10113149B2 (en) 2018-10-30
CA2898180C (en) 2023-09-26
AU2014207627B2 (en) 2019-09-12
RU2015134394A (ru) 2017-02-21
CA2898180A1 (en) 2014-07-24
US20150361398A1 (en) 2015-12-17
WO2014113415A1 (en) 2014-07-24
JP2016505266A (ja) 2016-02-25
EP2946007B1 (en) 2019-04-10
AU2014207627A1 (en) 2015-08-06
ES2733909T3 (es) 2019-12-03
JP6581906B2 (ja) 2019-09-25
EP2946007A1 (en) 2015-11-25

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