DK2946007T3 - Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer - Google Patents

Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer Download PDF

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Publication number
DK2946007T3
DK2946007T3 DK14740745.6T DK14740745T DK2946007T3 DK 2946007 T3 DK2946007 T3 DK 2946007T3 DK 14740745 T DK14740745 T DK 14740745T DK 2946007 T3 DK2946007 T3 DK 2946007T3
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hematopoytic
multiline
stamps
defined factors
reprogramming human
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DK14740745.6T
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English (en)
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Vladislav M Sandler
Shahin Rafii
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Univ Cornell
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells

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  • Chemical Kinetics & Catalysis (AREA)
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  • Vascular Medicine (AREA)
  • Diabetes (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK14740745.6T 2013-01-15 2014-01-15 Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer DK2946007T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361752688P 2013-01-15 2013-01-15
PCT/US2014/011575 WO2014113415A1 (en) 2013-01-15 2014-01-15 Reprogramming of human endothelium into hematopoietic multi-lineage progenitors by defined factors

Publications (1)

Publication Number Publication Date
DK2946007T3 true DK2946007T3 (da) 2019-07-15

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DK14740745.6T DK2946007T3 (da) 2013-01-15 2014-01-15 Reprogrammering af humant endothelium til hematopoietiske multilinje-stamceller af definerede faktorer

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Country Link
US (1) US10113149B2 (da)
EP (1) EP2946007B1 (da)
JP (1) JP6581906B2 (da)
CN (1) CN105051184B (da)
AU (1) AU2014207627B2 (da)
CA (1) CA2898180C (da)
DK (1) DK2946007T3 (da)
ES (1) ES2733909T3 (da)
RU (1) RU2691062C2 (da)
WO (1) WO2014113415A1 (da)

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GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
CN114558032B (zh) 2012-12-21 2025-07-29 安斯泰来再生医药协会 由多能干细胞制备血小板的方法及其组合物
WO2014120714A1 (en) 2013-01-30 2014-08-07 Cornell University Compositions and methods for the expansion of stem cells
AU2015279552B2 (en) 2014-06-27 2021-01-21 Angiocrine Bioscience, Inc. Neural cells expressing adenovirus E4ORF1, and methods of making and using the same
US20160243288A1 (en) 2015-02-23 2016-08-25 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
CN105517672B (zh) * 2015-05-26 2019-06-21 中国科学院广州生物医药与健康研究院 一种人原代细胞培养基及其应用
WO2016201133A2 (en) * 2015-06-09 2016-12-15 The Regents Of The University Of California Hematopoietic cells and methods of using and generating the same
HK1258452A1 (zh) 2015-07-20 2019-11-15 Angiocrine Bioscience, Inc. 表达ets转录因子的工程化的内皮细胞
SG10201913752PA (en) * 2015-07-20 2020-03-30 Angiocrine Bioscience Inc Methods and compositions for stem cell transplantation
US11162073B2 (en) 2015-12-03 2021-11-02 The Brigham And Women's Hospital, Inc. Methods for generating functional hematopoietic stem cells
WO2017106932A1 (en) * 2015-12-23 2017-06-29 Monash University Cell reprogramming
AU2017248848B2 (en) * 2016-04-15 2022-12-08 Angiocrine Bioscience, Inc. Enhanced gene delivery methods
US11261430B2 (en) 2016-05-03 2022-03-01 The Children's Medical Center Corporation Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells
AU2017326174B2 (en) 2016-09-13 2024-02-22 Angiocrine Bioscience, Inc. Blood-brain barrier comprising engineered endothelial cells
EP3576756A4 (en) * 2017-02-03 2020-12-16 Cornell University STABLE THREE-DIMENSIONAL BLOOD VESSELS AND THEIR FORMATION PROCESSES
WO2018232079A1 (en) * 2017-06-14 2018-12-20 Daley George Q Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells by episomal plasmid gene transfer
CN112105721A (zh) * 2018-03-23 2020-12-18 儿童医疗中心公司 内皮细胞因子及其方法
CN108676777A (zh) * 2018-04-03 2018-10-19 华南生物医药研究院 胎肝窦内皮细胞株在造血干细胞扩增和分化中的应用
CN110577967A (zh) * 2018-05-22 2019-12-17 中国人民解放军军事科学院军事医学研究院 诱导性多能干细胞及其制备方法
EP3992276A4 (en) * 2019-06-27 2022-09-07 Showa Denko Materials Co., Ltd. CELL SCAFFOLD MATERIAL, SUPPORT AND METHOD FOR CELL CULTURE
US12576114B2 (en) 2019-07-03 2026-03-17 Cornell University Methods of functional vascularization of pancreatic islets and beta-cell organoids
CA3183395A1 (en) * 2020-06-25 2021-12-30 Paul William FINNEGAN Endothelial cells for mitigation of chemotherapy-induced toxicity
US20230113074A1 (en) * 2021-10-12 2023-04-13 Wisconsin Alumni Research Foundation Derivation of hepatocytes and hematopoietic progenitors from human embryonic stem cells

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CA2556018A1 (en) * 2004-02-11 2005-09-09 Aldagen, Inc. Stem cell populations and methods of use
WO2005100549A1 (ja) 2004-04-14 2005-10-27 Kanazawa University Technology Licensing Organization Ltd. 臓器特異的幹細胞の増殖方法及び増殖装置
RU2359030C1 (ru) * 2008-03-19 2009-06-20 Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты)
JP5725394B2 (ja) 2009-03-25 2015-05-27 公立大学法人大阪府立大学 造血幹細胞の培養方法
US9732128B2 (en) * 2010-10-22 2017-08-15 Biotime, Inc. Methods of modifying transcriptional regulatory networks in stem cells
WO2012109208A2 (en) * 2011-02-08 2012-08-16 Cellular Dynamics International, Inc. Hematopoietic precursor cell production by programming

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Publication number Publication date
CA2898180C (en) 2023-09-26
US10113149B2 (en) 2018-10-30
CN105051184B (zh) 2018-08-10
RU2015134394A (ru) 2017-02-21
JP2016505266A (ja) 2016-02-25
AU2014207627B2 (en) 2019-09-12
RU2691062C2 (ru) 2019-06-10
CN105051184A (zh) 2015-11-11
EP2946007A1 (en) 2015-11-25
CA2898180A1 (en) 2014-07-24
AU2014207627A1 (en) 2015-08-06
JP6581906B2 (ja) 2019-09-25
EP2946007A4 (en) 2016-06-08
ES2733909T3 (es) 2019-12-03
WO2014113415A1 (en) 2014-07-24
US20150361398A1 (en) 2015-12-17
EP2946007B1 (en) 2019-04-10

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