DK2921489T3 - 2-pyridone-RELATED - Google Patents
2-pyridone-RELATED Download PDFInfo
- Publication number
- DK2921489T3 DK2921489T3 DK13855534.7T DK13855534T DK2921489T3 DK 2921489 T3 DK2921489 T3 DK 2921489T3 DK 13855534 T DK13855534 T DK 13855534T DK 2921489 T3 DK2921489 T3 DK 2921489T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- cyclopropyl
- compounds
- crystal
- difluoroethyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims description 166
- 238000000034 method Methods 0.000 claims description 61
- 239000002904 solvent Substances 0.000 claims description 44
- 239000013078 crystal Substances 0.000 claims description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- -1 2-pyridone compound Chemical class 0.000 claims description 33
- 239000003814 drug Substances 0.000 claims description 32
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- 238000000634 powder X-ray diffraction Methods 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
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- ABERLDAQFUZISG-SJLPKXTDSA-N 3-cyclopropyl-6-[(1r)-1-[4-(1,1-difluoroethyl)phenyl]-2-[(2r)-5-oxopyrrolidin-2-yl]ethyl]-1h-pyridin-2-one Chemical compound C1=CC(C(F)(F)C)=CC=C1[C@H](C=1NC(=O)C(C2CC2)=CC=1)C[C@@H]1NC(=O)CC1 ABERLDAQFUZISG-SJLPKXTDSA-N 0.000 claims description 9
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- APOYTRAZFJURPB-UHFFFAOYSA-N 2-methoxy-n-(2-methoxyethyl)-n-(trifluoro-$l^{4}-sulfanyl)ethanamine Chemical compound COCCN(S(F)(F)F)CCOC APOYTRAZFJURPB-UHFFFAOYSA-N 0.000 description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012249792 | 2012-11-13 | ||
| PCT/JP2013/080517 WO2014077235A1 (ja) | 2012-11-13 | 2013-11-12 | ２－ピリドン化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2921489T3 true DK2921489T3 (en) | 2017-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13855534.7T DK2921489T3 (en) | 2012-11-13 | 2013-11-12 | 2-pyridone-RELATED |
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|---|---|
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| MY (1) | MY173812A (enExample) |
| NO (1) | NO2921489T3 (enExample) |
| NZ (1) | NZ707832A (enExample) |
| PH (1) | PH12015501056A1 (enExample) |
| PL (1) | PL2921489T3 (enExample) |
| PT (1) | PT2921489T (enExample) |
| RU (1) | RU2662157C2 (enExample) |
| SG (1) | SG11201503716RA (enExample) |
| TW (1) | TWI591064B (enExample) |
| WO (1) | WO2014077235A1 (enExample) |
| ZA (1) | ZA201503323B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6048533B2 (ja) * | 2014-05-12 | 2016-12-21 | 日産化学工業株式会社 | ２−ピリドン化合物を含有する医薬 |
| CN106573909A (zh) * | 2014-05-13 | 2017-04-19 | 日产化学工业株式会社 | 2‑吡啶酮化合物的制造方法 |
| KR102695130B1 (ko) | 2018-05-31 | 2024-08-16 | 후아 메디슨 (상하이) 엘티디. | 글루코키나제 활성화제 및 ppar 수용체 활성화제를 함유하는 약제학적 병용물, 조성물, 및 병용 제제, 및 이의 제조 방법 및 용도 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4275069A (en) | 1979-01-22 | 1981-06-23 | The Upjohn Company | Anti-diabetic 1,2-dihydro-2-oxo-6-alkyl-nicotinic acids |
| DE60014610T2 (de) | 1999-03-29 | 2006-03-09 | F. Hoffmann-La Roche Ag | Glukokinase aktivatoren |
| US6353111B1 (en) | 1999-12-15 | 2002-03-05 | Hoffmann-La Roche Inc. | Trans olefinic glucokinase activators |
| CA2652074C (en) | 2006-06-08 | 2013-08-06 | Eli Lilly And Company | Substituted carboxamides as group 1 metabotropic receptor antagonists |
| WO2008079787A2 (en) | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
| AU2008276055B2 (en) * | 2007-07-17 | 2013-01-31 | Bristol-Myers Squibb Company | Pyridone GPR119 G protein-coupled receptor agonists |
| US20110130365A1 (en) | 2008-07-29 | 2011-06-02 | Benbow John W | Fluorinated Heteroaryls |
| BR112012013195A2 (pt) * | 2009-12-04 | 2016-08-09 | Nissan Chemical Ind Ltd | compostos de 2-piridona. |
| JP2013010750A (ja) * | 2011-06-02 | 2013-01-17 | Taisho Pharmaceutical Co Ltd | ２−ピリドン化合物を含有する医薬 |
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- 2013-11-12 AU AU2013345930A patent/AU2013345930B2/en not_active Ceased
- 2013-11-12 KR KR1020157012117A patent/KR102160841B1/ko not_active Expired - Fee Related
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2015
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- 2015-05-12 PH PH12015501056A patent/PH12015501056A1/en unknown
- 2015-05-13 ZA ZA2015/03323A patent/ZA201503323B/en unknown
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