DK2881128T3 - Ambulatory infusion system comprising a step switch mechanism for valve control - Google Patents
Ambulatory infusion system comprising a step switch mechanism for valve control Download PDFInfo
- Publication number
- DK2881128T3 DK2881128T3 DK13195599.9T DK13195599T DK2881128T3 DK 2881128 T3 DK2881128 T3 DK 2881128T3 DK 13195599 T DK13195599 T DK 13195599T DK 2881128 T3 DK2881128 T3 DK 2881128T3
- Authority
- DK
- Denmark
- Prior art keywords
- valve
- unit
- coupling
- pump
- metering
- Prior art date
Links
- 238000001802 infusion Methods 0.000 title claims description 33
- 230000007246 mechanism Effects 0.000 title claims description 27
- 238000010168 coupling process Methods 0.000 claims description 77
- 238000005859 coupling reaction Methods 0.000 claims description 77
- 230000008878 coupling Effects 0.000 claims description 76
- 229940079593 drug Drugs 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 16
- 238000006073 displacement reaction Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 229920001971 elastomer Polymers 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000007779 soft material Substances 0.000 claims description 2
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims 1
- 238000007789 sealing Methods 0.000 description 10
- 230000002093 peripheral effect Effects 0.000 description 9
- 230000002349 favourable effect Effects 0.000 description 7
- 230000009467 reduction Effects 0.000 description 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 238000004891 communication Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005360 mashing Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1413—Modular systems comprising interconnecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
- A61M5/14216—Reciprocating piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M2005/14573—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for quick connection/disconnection with a driving system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M2039/226—Spindles or actuating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13195599.9A EP2881128B1 (en) | 2013-12-04 | 2013-12-04 | Ambulatory infusion system including a step switching mechanism for valve control |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2881128T3 true DK2881128T3 (en) | 2019-01-28 |
Family
ID=49725017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13195599.9T DK2881128T3 (en) | 2013-12-04 | 2013-12-04 | Ambulatory infusion system comprising a step switch mechanism for valve control |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10183113B2 (https=) |
| EP (1) | EP2881128B1 (https=) |
| JP (1) | JP6517205B2 (https=) |
| KR (1) | KR101852695B1 (https=) |
| CN (1) | CN105764543B (https=) |
| DK (1) | DK2881128T3 (https=) |
| ES (1) | ES2698603T3 (https=) |
| MX (1) | MX372976B (https=) |
| PL (1) | PL2881128T3 (https=) |
| RU (1) | RU2673861C2 (https=) |
| SI (1) | SI2881128T1 (https=) |
| WO (1) | WO2015082305A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE067982T2 (hu) | 2012-03-30 | 2024-12-28 | Insulet Corp | Folyadékadagoló készülék transzkután beviteli eszközzel, behelyezõ mechanizmussal és vércukor monitorozással |
| EP2881128B1 (en) | 2013-12-04 | 2018-10-24 | F. Hoffmann-La Roche AG | Ambulatory infusion system including a step switching mechanism for valve control |
| DK2921189T3 (da) | 2014-03-17 | 2017-11-13 | Hoffmann La Roche | Initialisering af en doseringsenhed til lægemiddelsinfusion |
| US10363374B2 (en) | 2016-05-26 | 2019-07-30 | Insulet Corporation | Multi-dose drug delivery device |
| BR112018073547A2 (pt) * | 2016-06-07 | 2019-03-19 | F. Hoffmann-La Roche Ag | unidade de acionamento de válvula, unidade de acionamento, unidade de dosagem e bomba de infusão ambulatorial |
| US11446436B2 (en) | 2016-07-08 | 2022-09-20 | Roche Diabetes Care, Inc. | Flow detector |
| RU2745881C2 (ru) | 2016-08-09 | 2021-04-02 | Ф. Хоффманн-Ля Рош Аг | Амбулаторный инфузионный аппарат |
| EP3730169B1 (en) | 2016-08-14 | 2023-08-02 | Insulet Corporation | Drug delivery device with detection of position of the plunger |
| DK3335746T3 (da) * | 2016-12-14 | 2020-07-20 | Hoffmann La Roche | Ambulant infusionsenhed |
| DK3335745T3 (da) * | 2016-12-14 | 2020-02-17 | Hoffmann La Roche | Initialisering af ambulant infusionssystem |
| US10603440B2 (en) | 2017-01-19 | 2020-03-31 | Insulet Corporation | Cartridge hold-up volume reduction |
| CN109281855A (zh) * | 2017-07-19 | 2019-01-29 | 上海圣速电子科技股份有限公司 | 一种自动控制加液系统及其工艺方法 |
| EP4375504B1 (en) | 2017-08-03 | 2026-04-15 | Insulet Corporation | Micro piston pump |
| US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
| AU2019223659B2 (en) * | 2018-02-23 | 2024-09-05 | F. Hoffmann-La Roche Ag | Dosing unit refilling scheduling |
| US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
| US11229736B2 (en) | 2018-06-06 | 2022-01-25 | Insulet Corporation | Linear shuttle pump for drug delivery |
| DE102018118630A1 (de) | 2018-08-01 | 2020-02-06 | B. Braun Melsungen Ag | Infusionssystem mit Infusionspumpe und damit kuppelbaren Pumpmodul |
| AU2019390474B2 (en) | 2018-11-28 | 2023-03-30 | Insulet Corporation | Drug delivery shuttle pump system and valve assembly |
| US11698059B2 (en) | 2018-12-29 | 2023-07-11 | Biosense Webster (Israel) Ltd. | Disposable dual-action reciprocating pump assembly |
| US11730882B2 (en) * | 2018-12-29 | 2023-08-22 | Biosense Webster (Israel) Ltd. | Dual-action irrigation pump with variable speed to provide constant fluid flow |
| EP4004368A4 (en) * | 2019-07-25 | 2023-06-28 | Becton, Dickinson and Company | Rotational metering pump for insulin patch |
| US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
| EP4096755A4 (en) * | 2020-01-31 | 2024-01-24 | Becton, Dickinson and Company | Valve shaft pump with coordinated pumping and valving operations |
| EP4271446B1 (en) * | 2021-01-04 | 2026-04-22 | Becton Dickinson and Company | Discrete dose control and overdose prevention mechanism |
| EP4274640A1 (en) | 2021-01-08 | 2023-11-15 | Insulet Corporation | Single actuated precision dose intermediate pumping chamber |
| US12440617B2 (en) | 2021-01-11 | 2025-10-14 | Insulet Corporation | Linear activated drug dosing pump system |
| US12594376B2 (en) | 2021-05-21 | 2026-04-07 | Insulet Corporation | Compact positive displacement pump for wearable drug delivery device |
| US12359903B2 (en) | 2021-05-28 | 2025-07-15 | Insulet Corporation | Spring-based status sensors |
| CN116983504A (zh) * | 2022-04-26 | 2023-11-03 | 深圳硅基传感科技有限公司 | 用于输送流体的医疗装置及医疗系统 |
| CN116942951A (zh) * | 2022-04-26 | 2023-10-27 | 深圳硅基传感科技有限公司 | 医疗装置的限流结构 |
| CN119097791A (zh) * | 2023-06-08 | 2024-12-10 | 深圳硅基传感科技有限公司 | 基于脉冲控制多个阀门的流体输送装置 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5264022A (en) * | 1975-11-22 | 1977-05-27 | Shinryo Air Cond | Switch valve |
| US4396385A (en) * | 1980-12-05 | 1983-08-02 | Baxter Travenol Laboratories, Inc. | Flow metering apparatus for a fluid infusion system |
| US4850980A (en) * | 1987-12-04 | 1989-07-25 | Fisher Scientific Company | I.V. pump cassette |
| RU2022169C1 (ru) * | 1991-05-12 | 1994-10-30 | Центральный научно-исследовательский институт "Буревестник" | Дозирующий поршневой насос |
| CN103239773B (zh) * | 2006-03-30 | 2015-08-26 | 瓦莱里塔斯公司 | 多筒式流体递送器械 |
| ES2331546T3 (es) | 2007-03-15 | 2010-01-07 | F. Hoffmann-La Roche Ag | Sistema de infusion con un dispositivo de dosificacion. |
| EP2361646B1 (en) * | 2008-09-12 | 2013-03-20 | Roche Diagnostics GmbH | Dosing unit and ambulatory infusion device comprising dosing unit |
| AU2010274709B2 (en) * | 2009-07-23 | 2016-07-14 | Swissinnov Product Sarl | Fluid delivery system comprising a fluid pumping device and a drive system |
| US20110021990A1 (en) * | 2009-07-23 | 2011-01-27 | Thierry Navarro | Micropump and method for manufacturing thereof |
| EP2457602A1 (en) * | 2010-11-25 | 2012-05-30 | F. Hoffmann-La Roche AG | Infusion pump having dosing unit with safety valve |
| EP2881128B1 (en) | 2013-12-04 | 2018-10-24 | F. Hoffmann-La Roche AG | Ambulatory infusion system including a step switching mechanism for valve control |
-
2013
- 2013-12-04 EP EP13195599.9A patent/EP2881128B1/en active Active
- 2013-12-04 ES ES13195599T patent/ES2698603T3/es active Active
- 2013-12-04 PL PL13195599T patent/PL2881128T3/pl unknown
- 2013-12-04 SI SI201331280T patent/SI2881128T1/sl unknown
- 2013-12-04 DK DK13195599.9T patent/DK2881128T3/en active
-
2014
- 2014-11-27 JP JP2016536766A patent/JP6517205B2/ja active Active
- 2014-11-27 RU RU2016125555A patent/RU2673861C2/ru active
- 2014-11-27 CN CN201480066363.3A patent/CN105764543B/zh active Active
- 2014-11-27 KR KR1020167011608A patent/KR101852695B1/ko active Active
- 2014-11-27 MX MX2016005382A patent/MX372976B/es active IP Right Grant
- 2014-11-27 WO PCT/EP2014/075826 patent/WO2015082305A1/en not_active Ceased
-
2016
- 2016-06-01 US US15/170,875 patent/US10183113B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2881128B1 (en) | 2018-10-24 |
| PL2881128T3 (pl) | 2019-04-30 |
| SI2881128T1 (sl) | 2019-01-31 |
| US10183113B2 (en) | 2019-01-22 |
| KR101852695B1 (ko) | 2018-04-26 |
| CN105764543A (zh) | 2016-07-13 |
| ES2698603T3 (es) | 2019-02-05 |
| KR20160065186A (ko) | 2016-06-08 |
| WO2015082305A1 (en) | 2015-06-11 |
| EP2881128A1 (en) | 2015-06-10 |
| US20160317741A1 (en) | 2016-11-03 |
| MX2016005382A (es) | 2016-08-08 |
| MX372976B (es) | 2020-04-06 |
| RU2673861C2 (ru) | 2018-11-30 |
| JP2016538958A (ja) | 2016-12-15 |
| JP6517205B2 (ja) | 2019-05-22 |
| CN105764543B (zh) | 2019-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2881128T3 (en) | Ambulatory infusion system comprising a step switch mechanism for valve control | |
| US8500700B2 (en) | Dosing unit, ambulatory infusion device comprising dosing unit and method for operating a dosing unit | |
| EP3337534B1 (en) | Drive mechanism for infusion pump | |
| JP6649691B2 (ja) | 分離ピストン型定量ポンプ | |
| EP2457602A1 (en) | Infusion pump having dosing unit with safety valve | |
| EP3724500B1 (en) | Micropump with cam mechanism for axial displacement of rotor | |
| IL214359A (en) | Tiny pump | |
| KR20160033131A (ko) | 유체의 용적형 펌핑을 위한 회전-진동 서브어셈블리 및 회전-진동 용적형 펌핑 장치 | |
| JP2016026558A (ja) | 内部カム計量ポンプ | |
| ES2861505T3 (es) | Unidad de accionamiento de dispositivo de infusión con dispositivo de bloqueo | |
| US9095650B2 (en) | Precision fluid delivery systems | |
| US10912886B2 (en) | Valve clutch device and dosing unit with a valve clutch device | |
| KR20070108218A (ko) | 의료용 유체 전달 시스템 및 그와 관련된 방법 | |
| HK1226674A1 (en) | Ambulatory infusion system including a step switching mechanism for valve control | |
| HK1226674B (zh) | 包括用於阀控制的步进开关机构的便携式输注系统 |