DK2855665T3 - Tilvejebringelse af funktionelle og bestandige endotele celler fra humane amnionvæske-afledte celler - Google Patents
Tilvejebringelse af funktionelle og bestandige endotele celler fra humane amnionvæske-afledte celler Download PDFInfo
- Publication number
- DK2855665T3 DK2855665T3 DK13797778T DK13797778T DK2855665T3 DK 2855665 T3 DK2855665 T3 DK 2855665T3 DK 13797778 T DK13797778 T DK 13797778T DK 13797778 T DK13797778 T DK 13797778T DK 2855665 T3 DK2855665 T3 DK 2855665T3
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- Prior art keywords
- cells
- endotel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
- C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Display Devices Of Pinball Game Machines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261653185P | 2012-05-30 | 2012-05-30 | |
US201261709431P | 2012-10-04 | 2012-10-04 | |
PCT/US2013/043236 WO2013181326A1 (en) | 2012-05-30 | 2013-05-30 | Generation of functional and durable endothelial cells from human amniotic fluid-derived cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2855665T3 true DK2855665T3 (da) | 2019-11-04 |
Family
ID=49673886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13797778T DK2855665T3 (da) | 2012-05-30 | 2013-05-30 | Tilvejebringelse af funktionelle og bestandige endotele celler fra humane amnionvæske-afledte celler |
Country Status (10)
Country | Link |
---|---|
US (1) | US9637723B2 (da) |
EP (1) | EP2855665B8 (da) |
JP (1) | JP6445971B2 (da) |
CN (1) | CN104520422B (da) |
AU (1) | AU2013267422B2 (da) |
CA (1) | CA2874764C (da) |
DK (1) | DK2855665T3 (da) |
HK (1) | HK1209155A1 (da) |
SG (1) | SG11201407635XA (da) |
WO (1) | WO2013181326A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3117839A4 (en) * | 2014-03-03 | 2017-12-20 | UNIST (Ulsan National Institute of Science and Technology) | Composition for inducing direct transdifferentiation of somatic cell into vascular progenitor cell, and use thereof |
RU2745300C2 (ru) | 2014-06-27 | 2021-03-23 | Анджиокрин Биосайенс, Инк. | Клетки нервной системы, экспрессирующие e4orf1 аденовируса, и способы их получения и применения |
CN106282238A (zh) * | 2015-06-08 | 2017-01-04 | 深圳市伊思科生物科技有限公司 | 细胞的转分化方法 |
CN105012969B (zh) * | 2015-07-17 | 2018-10-23 | 中国人民解放军第二军医大学 | 一种保护和促进斑秃处毛发再生的药物及其应用 |
AU2016297524B2 (en) * | 2015-07-20 | 2022-03-17 | Angiocrine Bioscience, Inc. | Engineered endothelial cells expressing an ets transcription factor |
FI3325612T3 (fi) * | 2015-07-20 | 2023-03-20 | Angiocrine Bioscience Inc | Menetelmiä ja kompositioita kantasolutransplantaatiota varten |
AU2017326174B2 (en) | 2016-09-13 | 2024-02-22 | Angiocrine Bioscience, Inc. | Blood-brain barrier comprising engineered endothelial cells |
EP3550013A4 (en) * | 2016-12-02 | 2020-06-24 | Takara Bio Inc. | PROCESS FOR PRODUCING ENDOTHELIAL CELLS |
BR112019012997A2 (pt) | 2016-12-22 | 2019-12-10 | Ohio State Innovation Foundation | composições e métodos para reprogramar células somáticas para células vasculogênicas induzidas |
JP7265988B2 (ja) * | 2017-02-03 | 2023-04-27 | コーネル ユニヴァーシティー | 安定な3次元血管およびそれを形成するための方法 |
CN108939092B (zh) * | 2017-05-19 | 2021-12-17 | 四川大学 | 肌肉细胞etv2基因表达促进剂在制备治疗肢端缺血性疾病的药物中的用途 |
AU2020350442A1 (en) * | 2019-09-20 | 2022-03-31 | Emory University | Endothelial and smooth muscle like tissue produced from urine cells and uses related thereto |
KR20230024268A (ko) * | 2020-06-12 | 2023-02-20 | 에모리 유니버시티 | 내피 세포 및 혈관 형성을 위한 전사 인자 etv2 유전자를 사용한 직접 생체 내 재프로그래밍 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
ATE231143T1 (de) | 1999-04-09 | 2003-02-15 | Smithkline Beecham Corp | Triarylimidazole |
AR029803A1 (es) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
WO2002040468A1 (en) | 2000-11-16 | 2002-05-23 | Smithkline Beecham Corporation | Compounds |
GB0027987D0 (en) | 2000-11-16 | 2001-01-03 | Smithkline Beecham Plc | Compounds |
GB0102668D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
GB0127433D0 (en) | 2001-11-15 | 2002-01-09 | Smithkline Beecham Corp | Compounds |
GB0127430D0 (en) | 2001-11-15 | 2002-01-09 | Smithkline Beecham Corp | Compounds |
KR20030062788A (ko) | 2002-01-19 | 2003-07-28 | 포휴먼텍(주) | 생체분자 전달 펩타이드 mph1-btm 및 이것을포함하는 생명공학제품 |
KR20030062789A (ko) | 2002-01-19 | 2003-07-28 | 포휴먼텍(주) | 생체분자 전달 펩타이드 sim2-btm 및 이것을포함하는 생명공학제품 |
WO2003097639A1 (en) | 2002-05-15 | 2003-11-27 | Smithkline Beecham Corporation | Benzoxazine and benzoxazinone substituted triazoles |
PA8595001A1 (es) | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
GB0326963D0 (en) | 2003-11-19 | 2003-12-24 | Glaxo Group Ltd | Compounds |
BRPI0508397A (pt) | 2004-03-05 | 2007-08-07 | Taisho Pharmaceutical Co Ltd | derivado de tiazol ou um sal farmaceuticamente aceitável do mesmo, inibidor de alk5, estimulador de proliferação de folìculo capilar, e, estimulador do crescimento capilar ou um agente de crescimento capilar |
US8465732B2 (en) * | 2007-01-19 | 2013-06-18 | Cornell Research Foundation, Inc. | Endothelial cells expressing adenovirus E4ORF1 and methods of use thereof |
AU2010343137B2 (en) * | 2009-12-29 | 2017-08-03 | Cornell University | Methods for developing endothelial cells from pluripotent cells and endothelial cells derived |
US8785192B2 (en) * | 2010-07-07 | 2014-07-22 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
ES2788300T3 (es) * | 2010-11-09 | 2020-10-21 | Univ Cornell | Regeneración hepática |
-
2013
- 2013-05-30 EP EP13797778.1A patent/EP2855665B8/en active Active
- 2013-05-30 JP JP2015515169A patent/JP6445971B2/ja active Active
- 2013-05-30 US US14/404,739 patent/US9637723B2/en active Active
- 2013-05-30 SG SG11201407635XA patent/SG11201407635XA/en unknown
- 2013-05-30 DK DK13797778T patent/DK2855665T3/da active
- 2013-05-30 CA CA2874764A patent/CA2874764C/en active Active
- 2013-05-30 AU AU2013267422A patent/AU2013267422B2/en active Active
- 2013-05-30 WO PCT/US2013/043236 patent/WO2013181326A1/en active Application Filing
- 2013-05-30 CN CN201380037915.3A patent/CN104520422B/zh active Active
-
2015
- 2015-10-05 HK HK15109719.4A patent/HK1209155A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SG11201407635XA (en) | 2014-12-30 |
HK1209155A1 (en) | 2016-03-24 |
US20150147299A1 (en) | 2015-05-28 |
CN104520422A (zh) | 2015-04-15 |
AU2013267422B2 (en) | 2018-07-26 |
EP2855665B1 (en) | 2019-07-31 |
CN104520422B (zh) | 2019-08-23 |
EP2855665A4 (en) | 2015-11-04 |
CA2874764C (en) | 2022-11-01 |
JP6445971B2 (ja) | 2018-12-26 |
CA2874764A1 (en) | 2013-12-05 |
AU2013267422A1 (en) | 2014-12-18 |
JP2015519066A (ja) | 2015-07-09 |
US9637723B2 (en) | 2017-05-02 |
EP2855665B8 (en) | 2019-09-25 |
WO2013181326A1 (en) | 2013-12-05 |
EP2855665A1 (en) | 2015-04-08 |
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