DK2838548T3 - Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof - Google Patents

Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof Download PDF

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Publication number
DK2838548T3
DK2838548T3 DK13714128.9T DK13714128T DK2838548T3 DK 2838548 T3 DK2838548 T3 DK 2838548T3 DK 13714128 T DK13714128 T DK 13714128T DK 2838548 T3 DK2838548 T3 DK 2838548T3
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hla class
deficient cells
proteins
expressing
cells capable
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DK13714128.9T
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DK2838548T5 (en
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David W Russell
Roli K Hirata
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Univ Washington Through Its Center For Commercialization
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
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    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/4643—Vertebrate antigens
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
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    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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DK13714128.9T 2012-04-17 2013-03-15 Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof DK2838548T5 (en)

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US201261625314P 2012-04-17 2012-04-17
PCT/US2013/032058 WO2013158292A1 (en) 2012-04-17 2013-03-15 Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof

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DK2838548T3 true DK2838548T3 (en) 2023-08-21
DK2838548T5 DK2838548T5 (en) 2024-08-05

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US (2) US20150056225A1 (da)
EP (2) EP4253409A3 (da)
JP (3) JP2015514421A (da)
AU (1) AU2013249820C1 (da)
CA (2) CA2870571A1 (da)
DK (1) DK2838548T5 (da)
ES (1) ES2959382T3 (da)
FI (1) FI2838548T3 (da)
HU (1) HUE063231T2 (da)
PL (1) PL2838548T3 (da)
PT (1) PT2838548T (da)
WO (1) WO2013158292A1 (da)

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EP4253409A2 (en) 2023-10-04
FI2838548T3 (fi) 2023-10-02
US20190365876A1 (en) 2019-12-05
EP4253409A3 (en) 2023-12-06
JP7531925B2 (ja) 2024-08-13
EP2838548B1 (en) 2023-07-19
ES2959382T3 (es) 2024-02-26
JP2019068856A (ja) 2019-05-09
DK2838548T5 (en) 2024-08-05
WO2013158292A1 (en) 2013-10-24
EP2838548A1 (en) 2015-02-25
JP2015514421A (ja) 2015-05-21
CA2870571A1 (en) 2013-10-24
US20150056225A1 (en) 2015-02-26
PL2838548T3 (pl) 2024-02-05
CA3085032A1 (en) 2013-10-24
AU2013249820A1 (en) 2014-10-23
AU2013249820B2 (en) 2017-07-20
HUE063231T2 (hu) 2024-01-28
PT2838548T (pt) 2023-10-13
JP7130571B2 (ja) 2022-09-05
JP2022162047A (ja) 2022-10-21
AU2013249820C1 (en) 2018-10-25

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