DK2821138T3 - Flydecelle med integreret tørstof - Google Patents

Flydecelle med integreret tørstof Download PDF

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Publication number
DK2821138T3
DK2821138T3 DK13175335.2T DK13175335T DK2821138T3 DK 2821138 T3 DK2821138 T3 DK 2821138T3 DK 13175335 T DK13175335 T DK 13175335T DK 2821138 T3 DK2821138 T3 DK 2821138T3
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DK
Denmark
Prior art keywords
cavity
support
support element
passage
cell according
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DK13175335.2T
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English (en)
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DK2821138T4 (da
Inventor
Tina Röser
Weber Lutz
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Thinxxs Microtechnology Ag
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/163—Biocompatibility

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Secondary Cells (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (13)

1. Mikroflydende flydecelle omfattende et tørstof (5), der er arrangeret indeni flyde-cellen i et hulrum (3) og som sørger for integration med en væske placeret i hulheden (3), hvor hulheden (3) er afgrænset af en udsparing (2) i stoffet (1) og et dække (4), der lukker af for udsparingen (2), og hvor flydecellen omfatter et separat støtteelement (8) med en støtteflade (13) for tørstoffet (5), hvilken flade er tilvejebragt for et arrangement nær ved udsparingen (3), kendetegnet ved, at en udadtil åben passage (10), der leder til en ydre flade af flydecellen åbner op indtil udsparingen (3), og at det separate støtteelement (8) er i stand til at blive indført i passagen (10) fra ydersiden, således at hulheden (3) er aflukket, og således at støttefladen (13) er arrangeret nær ved hulheden (3).
2. Flydecelle ifølge krav 1, kendetegnet ved, at hulheden (3) danner et kanalnetværk (9) for transport, analyse og/eller syntese af en væske, og ved at hvis hensigtsmæssigt flere af sådanne støtteelementer (8) er i stand til at blive indført i en flerhed af passager (10).
3. Flydecelle ifølge krav 1 eller 2, kendetegnet ved, at udsparingen (2) er udformet i et pladeformet stof (1) og er aflukket af en filmtype dække (4), og ved at passagen (10) er udformet i det pladeformede stof.
4. Flydecelle ifølge krav 3, kendetegnet ved, at passagen (10) ledes til en pladeoverflade af det pladeformede stof (1).
5. Flydecelle ifølge ethvert af kravene 1-4, kendetegnet ved, at støtteelementet (8) er i stand til at blive forbundet til flydecellen på en aftagelig måde, og/eller på en ikke-aftagelig måde, således at hulheden (3) afdækkes på væsketæt måde.
6. Flydecelle ifølge ethvert af kravene 1-5, kendetegnet ved, at støtteelementet (8) i det mindste i tværsnit komplet fylder passagen (10), hvor fortrinsvis støtteelementet (8) og passagen (10) har cirkulært tværsnit og støtteelementet (8) snævrer sig ind imod hulheden (3) og passagen (10) bliver snæver imod hulheden.
7. Flydecelle ifølge ethvert af kravene 1-6, kendetegnet ved, at støtteelementet (8) har en del (12; 15; 17) der rager udad fra flydecellen, hvor hvis hensigtsmæssigt delen griber ind bagved flydecellen på ydersiden på en måde som en krave (15).
8. Flydecelle ifølge ethvert af kravene 1-7, kendetegnet ved, at støttefladen (13) af støtteelementet (8) er arrangeret således at det flugter med eller således at det rager bagud fra en nærliggende vægflade (14) af hulheden (3) eller ved at støtteelementet (8) rager ind i hulheden (3) fra den nærliggende vægflade (14) af hulheden.
9. Flydecelle ifølge ethvert af kravene 1-8, kendetegnet ved, at det tørre stof klæber til støttefladen (13), og at støttefladen (13) fortrinsvis har en strukturering (19-21), belægning (22) og/eller overflademodifikationer der fremmer vedhæftningen.
10. Flydecelle ifølge ethvert af kravene 1-9, kendetegnet ved, at støttefladen (13) for tørstoffet (5) er dannet af en separat komponent (21; 26). der er forbundet til resten af støtteelementet (8), og som materialemæssigt adskiller sig fra resten af støtteelementet (8).
11. Flydecelle ifølge ethvert af kravene 1-10, kendetegnet ved, at støttefladen (13) for tørstoffet (5) er dannet af en membran (27), der aflukker en passageåbning (28) i støtteelementet (8) imod hulheden (3), hvor membranen (27) fortrinsvis er transparent og/eller er i stand til at blive elastisk deformeret ved at blive påvirket via passageåbningen (18).
12. Fremgangsmåde til indføring af tørstof (5), der er tilvejebragt for at samvirke med en væske, ind i en mikro flydende flydecelle ifølge ethvert af kravene 1-11, kendetegnet ved, at tørstoffet (5) påføres en støtteflade (13) af et separat støtteelement (8), og støtteelementet (8) med tørstoffet (5) indføres i en passage (10), der åbner sig imod hulheden (3), hvor støttefladen (13) afgrænser hulheden (3) og hulheden (3) er aflukket på væsketæt måde.
13. Fremgangsmåde ifølge krav 12, kendetegnet ved, at der for at forme tørstoffet (5) en væske (7) tilføres til støttefladen (13), og støtteelementet (8) med væsken (7) ud sættes for en tørringsbehandling, hvor fortrinsvis en flerhed af sådanne støtteelementer behandles på samme tid.
DK13175335.2T 2013-07-05 2013-07-05 Flydecelle med integreret tørstof DK2821138T4 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13175335.2A EP2821138B2 (de) 2013-07-05 2013-07-05 Flusszelle mit integrierter Trockensubstanz

Publications (2)

Publication Number Publication Date
DK2821138T3 true DK2821138T3 (da) 2019-02-11
DK2821138T4 DK2821138T4 (da) 2022-05-16

Family

ID=48745809

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13175335.2T DK2821138T4 (da) 2013-07-05 2013-07-05 Flydecelle med integreret tørstof

Country Status (6)

Country Link
US (1) US10232367B2 (da)
EP (1) EP2821138B2 (da)
CN (1) CN105517710B (da)
DK (1) DK2821138T4 (da)
ES (1) ES2704424T5 (da)
WO (1) WO2015001070A1 (da)

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Also Published As

Publication number Publication date
US20160167047A1 (en) 2016-06-16
ES2704424T5 (es) 2022-05-20
CN105517710A (zh) 2016-04-20
DK2821138T4 (da) 2022-05-16
EP2821138A1 (de) 2015-01-07
WO2015001070A1 (de) 2015-01-08
ES2704424T3 (es) 2019-03-18
EP2821138B1 (de) 2018-10-24
US10232367B2 (en) 2019-03-19
EP2821138B2 (de) 2022-02-09
CN105517710B (zh) 2017-04-05
EP2821138B8 (de) 2019-03-06

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