DK2739646T3 - COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES - Google Patents

COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES Download PDF

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Publication number
DK2739646T3
DK2739646T3 DK12721415.3T DK12721415T DK2739646T3 DK 2739646 T3 DK2739646 T3 DK 2739646T3 DK 12721415 T DK12721415 T DK 12721415T DK 2739646 T3 DK2739646 T3 DK 2739646T3
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DK
Denmark
Prior art keywords
proinsulin
buffer
concentration
pka
substance
Prior art date
Application number
DK12721415.3T
Other languages
Danish (da)
English (en)
Inventor
Kelvin Eckert
Janina Noack
Stefan Hermann
Matthias Schwede
Original Assignee
Stefan Hermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stefan Hermann filed Critical Stefan Hermann
Application granted granted Critical
Publication of DK2739646T3 publication Critical patent/DK2739646T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK12721415.3T 2011-05-10 2012-05-09 COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES DK2739646T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11003823 2011-05-10
PCT/EP2012/001992 WO2012152439A1 (fr) 2011-05-10 2012-05-09 Système tampon complet pour la renaturation de la pro-insuline humaine ou de dérivés de pro-insuline humaine

Publications (1)

Publication Number Publication Date
DK2739646T3 true DK2739646T3 (en) 2018-02-26

Family

ID=46085882

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12721415.3T DK2739646T3 (en) 2011-05-10 2012-05-09 COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES

Country Status (4)

Country Link
EP (1) EP2739646B1 (fr)
DK (1) DK2739646T3 (fr)
PL (1) PL2739646T3 (fr)
WO (1) WO2012152439A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10155799B2 (en) 2014-07-21 2018-12-18 Merck Sharp & Dohme Corp. Chromatography process for purification of insulin and insulin analogs
US20220299532A1 (en) * 2019-06-10 2022-09-22 Sanford Burnham Prebys Medical Discovery Institute Correcting protein misfolding in diabetes

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US425A (en) 1837-10-12 James bogardus
US76459A (en) 1868-04-07 hubbard
NZ199391A (en) 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4605513A (en) 1984-08-08 1986-08-12 Eli Lilly And Company Process for inhibiting peptide carbamylation
DE3501641A1 (de) 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
EP0347781B1 (fr) 1988-06-23 1994-02-16 Hoechst Aktiengesellschaft Mini-proinsuline et sa production et utilisation
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
GR1005153B (el) 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
WO2005051979A1 (fr) 2003-02-21 2005-06-09 Akzo Nobel N.V. Prevention et/ou retard d'une carbamylation de peptides/proteines dans une solution d'uree au moyen de composes de type non ethylene diamine
EP2274318B1 (fr) * 2008-04-30 2014-08-13 Wockhardt Limited Procedes de repliement de l'insuline
UA91281C2 (ru) * 2008-11-26 2010-07-12 Общество С Ограниченной Ответственностью «Мако» Способ получения рекомбинантного инсулина человека

Also Published As

Publication number Publication date
EP2739646B1 (fr) 2018-01-24
EP2739646A1 (fr) 2014-06-11
PL2739646T3 (pl) 2018-05-30
WO2012152439A1 (fr) 2012-11-15

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