DK2727588T3 - Baclofen- og acamprosat-baseret terapi af neurologiske lidelser - Google Patents

Baclofen- og acamprosat-baseret terapi af neurologiske lidelser Download PDF

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DK2727588T3
DK2727588T3 DK13196461.1T DK13196461T DK2727588T3 DK 2727588 T3 DK2727588 T3 DK 2727588T3 DK 13196461 T DK13196461 T DK 13196461T DK 2727588 T3 DK2727588 T3 DK 2727588T3
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baclofen
acamprosate
composition
drug
combination
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DK13196461.1T
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Daniel Cohen
Ilya Chumakov
Serguei Nabirochkin
Emmanuel Vial
Mickaël Guedj
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Pharnext
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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Claims (12)

1. Sammensætning omfattende (i) baclofen eller et farmaceutisk acceptabelt salt deraf, eller arbaclofen placarbil eller 3-(p-chlorphenyl)-4-hydroxysmørsyre, og (ii) acamprosat eller et farmaceutisk acceptabelt salt deraf, eller homotaurin eller ethyldimethyl-ammonio-propansulfonat eller taurin, til anvendelse i behandlingen af multipel sklerose hos et individ med behov deraf.
2. Sammensætningen til anvendelse ifølge krav 1, yderligere omfattende mindst én forbindelse valgt fra sulfisoxazol, methimazol, prilocain, dyphyllin, quinacrin, carbenoxolon, aminocapronsyre, cabergolin, diethylcarbamazin, cinacalcet, cinnarizin, eplerenon, fenoldopam, leflunomid, levosimendan, sulodexid, terbinafin, zonisamid, etomidat, phenformin, trimetazidin, mexiletin, ifenprodil, moxifloxacin, bromocriptin eller torasemid, eller farmaceutisk acceptable salte deraf.
3. Sammensætningen til anvendelse ifølge krav 1 eller 2, hvor nævnte sammensætning omfatter mindst én af de følgende kombinationer af forbindelser: - baclofen og acamprosat, - baclofen og acamprosat og diethylcarbamazin, - baclofen og acamprosat og cinacalcet, - baclofen og acamprosat og sulfisoxazol, - baclofen og acamprosat og torasemid, - baclofen og acamprosat og ifenprodil, - baclofen og acamprosat og mexiletin, - baclofen og acamprosat og eplerenon, - baclofen og acamprosat og levosimendan, - baclofen og acamprosat og terbinafin, eller - baclofen og acamprosat og leflunomid, eller farmaceutisk acceptable salte deraf.
4. Sammensætningen til anvendelse ifølge krav 1, hvor nævnte sammensætning omfatter mindst én af de følgende kombinationer af forbindelser: - baclofen, acamprosat og donepezil, - baclofen, acamprosat og rivastigmin, - baclofen, acamprosat og memantin, - baclofen, acamprosat og gabapentin, eller farmaceutisk acceptable salte deraf.
5. Sammensætningen til anvendelse ifølge krav 1, omfattende (i) baclofen eller et farmaceutisk acceptabelt salt deraf, eller arbaclofen placarbil eller 3-(p-chlorphenyl)-4-hydroxysmørsyre, og (ii) acamprosat eller et farmaceutisk acceptabelt salt deraf, eller homotaurin eller ethyldimethyl-ammonio-propansulfonat eller taurin, som de eneste aktive midler.
6. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvilken yderligere omfatter en farmaceutisk acceptabel bærer eller excipiens.
7. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor forbindelserne i nævnte sammensætning formuleres eller administreres sammen, separat eller sekventielt.
8. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor nævnte sammensætning administreres gentagne gange til individet.
9. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor forholdet acamprosat/baclofen (W:W) er omfattet mellem 0,05 og 1000.
10. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor dosen af baclofen er mindre end 100 mg/dag.
11. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor dosen af acamprosat er mindre end 1000 mg/dag.
12. Sammensætningen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor et calciumsalt af acamprosat anvendes.
DK13196461.1T 2011-03-01 2012-03-01 Baclofen- og acamprosat-baseret terapi af neurologiske lidelser DK2727588T3 (da)

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EP11305217 2011-03-01
US201161468658P 2011-03-29 2011-03-29
US201161493606P 2011-06-06 2011-06-06
EP11305687 2011-06-06
EP12708113.1A EP2560631B1 (en) 2011-03-01 2012-03-01 Baclofen and acamprosate based therapy of neurogical disorders

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