DK2674479T3 - Envejsbioreaktor og topplade samt fremgangsmåde til fremstilling - Google Patents

Envejsbioreaktor og topplade samt fremgangsmåde til fremstilling Download PDF

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Publication number
DK2674479T3
DK2674479T3 DK12172304.3T DK12172304T DK2674479T3 DK 2674479 T3 DK2674479 T3 DK 2674479T3 DK 12172304 T DK12172304 T DK 12172304T DK 2674479 T3 DK2674479 T3 DK 2674479T3
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DK
Denmark
Prior art keywords
top plate
head plate
bioreactor
magnetic
diving
Prior art date
Application number
DK12172304.3T
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English (en)
Inventor
Matthias Dr-Ing Arnold
Heinz-Gerhard Dr Rer Nat Köhn
Nico Dipl-Ing Gülzow
Sven Dipl-Ing Eikelmann
Jochen Beese
Eckhart Dr-Ing Kopowski
Christopher Dipl-Ing Günther
Sebastian Dipl-Ing Selzer
Original Assignee
Eppendorf Ag
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Publication date
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Application filed by Eppendorf Ag filed Critical Eppendorf Ag
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Publication of DK2674479T3 publication Critical patent/DK2674479T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Accessories For Mixers (AREA)

Claims (12)

1. Topplade (100) til en envejsbioreaktor (1), især til anvendelse i et, fortrinsvis parallelt, bioreaktorsystem (10), til anvendelse inden for cellekultur og/eller mikrobiologi, hvor toppladen (100) omfatter en inderside (101) og en yderside (102), der ligger over for indersiden (101), hvor ydersiden (102) har flere tilslutninger (120), og indersiden (101) har flere dykrør (110), som er udformet ud i et med hele toppladen (100).
2. Topplade (100) ifølge det foregående krav, kendetegnet ved, at dykrørene (110) har en længde på over 50 procent af en diameter af toppladen (100).
3. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at dykrørene (110) har en længde, der er større end en diameter af toppladen (100).
4. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at dykrørene (110) har en indvendig diameter på mindre end 5 millimeter og/eller en vægtykkelse på mindre end 3 millimeter.
5. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at mindst to af dykrørene (110) har forskellige indvendige diametre.
6. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at mindst to af dykrørene (110) har forskellige længder.
7. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at toppladen (100) er fremstillet ved sprøjtestøbning.
8. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at toppladen (100) har et indhak til optagelse af et leje (500) af et røreværk (300).
9. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at diameteren af mindst et af dykrørene (110) er tilspidset ved den ende, der vender bort fra toppladen (100).
10. Topplade (100) ifølge det foregående krav, kendetegnet ved, at det tilspidsede dykrør (110) og/eller et eller flere af de andre dykrør ved den ende, der vender bort fra toppladen (100), er lukket og fortrinsvis er forsynet med en åbning ved denne lukkede ende.
11. Topplade (100) ifølge mindst et af de foregående krav, kendetegnet ved, at mindst en af tilslutningerne (120) på toppladens (100) yderside har et indvendigt gevind.
12. Fremgangsmåde til fremstilling af en topplade (100) til en envejsbioreak-tor (1), især til anvendelse i et, fortrinsvis parallelt, bioreaktorsystem (10), til anvendelse inden for cellekultur og/eller mikrobiologi, især en topplade ifølge et af kravene 1-11, omfattende de følgende trin: sprøjtestøbning af en topplade (100) omfattende en inderside (101) og en yderside (102), der ligger over for indersiden (101), hvor ydersiden (102) har flere tilslutninger (120), og indersiden (101) har flere dykrør (110), som er udformet ud i et med hele toppladen (100).
DK12172304.3T 2012-06-15 2012-06-15 Envejsbioreaktor og topplade samt fremgangsmåde til fremstilling DK2674479T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12172304.3A EP2674479B1 (de) 2012-06-15 2012-06-15 Einwegbioreaktor und Kopfplatte sowie Herstellungsverfahren

Publications (1)

Publication Number Publication Date
DK2674479T3 true DK2674479T3 (da) 2015-04-13

Family

ID=46319599

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12172304.3T DK2674479T3 (da) 2012-06-15 2012-06-15 Envejsbioreaktor og topplade samt fremgangsmåde til fremstilling
DK13730518.1T DK2861711T3 (da) 2012-06-15 2013-06-13 Engangsbioreaktor og hovedplade, og en fremgangsmåde til fremstilling deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK13730518.1T DK2861711T3 (da) 2012-06-15 2013-06-13 Engangsbioreaktor og hovedplade, og en fremgangsmåde til fremstilling deraf

Country Status (6)

Country Link
US (1) US10030220B2 (da)
EP (2) EP2674479B1 (da)
JP (2) JP6227636B2 (da)
CN (1) CN104379722B (da)
DK (2) DK2674479T3 (da)
WO (1) WO2013186294A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9745547B2 (en) 2011-10-10 2017-08-29 Dasgip Information And Technology Gmbh Method for controlled operation of a biotechnological apparatus and bioreactor system
CN103975055B (zh) 2011-10-10 2016-05-04 德国达斯其普信息与程序技术有限公司 包括生物反应器的生物技术装置、用于生物反应器的排出气体温度控制装置以及用于处理生物技术装置中的排出气流的方法
DE102015109148B3 (de) * 2015-06-10 2016-05-04 Human Med Ag Vorrichtung zum Separieren von regenerativen und adulten Stammzellen
WO2017025210A1 (en) 2015-08-08 2017-02-16 Stobbe Pharma Tech Gmbh Disposable bioprocess system supporting biological activity
US10836989B2 (en) * 2015-10-16 2020-11-17 Global Life Sciences Solutions Usa Llc Disposable container, mixing system and packaging
US11613724B2 (en) * 2015-12-10 2023-03-28 Rosemount Inc. Single-use bioreactor sensor interface
EP3199616A1 (de) 2016-01-29 2017-08-02 Eppendorf Ag Einweg-anschlusseinrichtung
DE102016120699B3 (de) 2016-10-28 2018-03-08 Trace Analytics Gmbh Sonde mit zwei Entnahmeöffnungen
CN108018204A (zh) 2016-11-03 2018-05-11 浙江金仪盛世生物工程有限公司 一种平行生物反应器系统
US11136541B2 (en) 2016-12-28 2021-10-05 Zhejiang Jinyishengshi Bioengineering Co., Ltd. Parallel bioreactor system
WO2019097500A1 (en) * 2017-11-20 2019-05-23 Willis Michael Jared Photoreactor for cell assay and array chemical and biochemical reactions
GB201719769D0 (en) * 2017-11-28 2018-01-10 Cronin 3D Ltd Analytical device and methods of use
EP3514223A1 (de) * 2018-01-17 2019-07-24 Eppendorf AG Multisensor für einen bioreaktor, bioreaktor, verfahren zur herstellung eines multisensors und zur messung von parametern
NL2021470B1 (en) 2018-08-15 2020-02-24 Applikon Biotechnology B V Lid configuration for a bioreactor
WO2020167676A1 (en) 2019-02-11 2020-08-20 Culture Biosciences, Inc. Bioreactor vessel for automated fermentation system
EP3763807A1 (de) * 2019-07-12 2021-01-13 Eppendorf AG Multi-connector-port
EP3839035A1 (de) * 2019-12-18 2021-06-23 Eppendorf AG Bioreaktor, kopfplatte für einen bioreaktor und datenübertragungseinheit für eine kopfplatte
CN111534420A (zh) * 2020-04-07 2020-08-14 天津大学 一种生物反应器

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS643482Y2 (da) * 1984-12-19 1989-01-30
US6670171B2 (en) * 2001-07-09 2003-12-30 Wheaton Usa, Inc. Disposable vessel
CN1171989C (zh) 2002-07-13 2004-10-20 华中科技大学 一种生物反应器
DE102006020461B3 (de) 2006-04-28 2007-10-04 Sartorius Biotech Gmbh Behälter mit flexiblen Wänden
DE102006021984B4 (de) 2006-05-10 2013-05-08 Sartorius Stedim Biotech Gmbh Bioreaktor
DE102006022306B4 (de) 2006-05-11 2009-06-25 Sartorius Stedim Biotech Gmbh Vibrationsmischer
SG176507A1 (en) * 2006-05-13 2011-12-29 Advanced Tech Materials Disposable bioreactor
US7819934B2 (en) 2006-07-14 2010-10-26 Xcellerex, Inc. Environmental containment systems
US8057092B2 (en) * 2006-11-30 2011-11-15 Corning Incorporated Disposable spinner flask
WO2008101124A1 (en) 2007-02-15 2008-08-21 Broadley-James Corporation Sterile bioreactor bag with integrated drive unit
US8822209B2 (en) * 2007-07-12 2014-09-02 Brooks Automation, Inc. Disposable spinner flask
US9109193B2 (en) * 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
US7832922B2 (en) * 2007-11-30 2010-11-16 Levitronix Gmbh Mixing apparatus and container for such
TWI325401B (en) * 2007-12-17 2010-06-01 Duen Gang Mou Vessel structure
DE102008010427B4 (de) 2008-02-21 2010-05-12 Sartorius Stedim Biotech Gmbh Bioreaktor
US8690418B2 (en) 2008-03-19 2014-04-08 Sartorius Stedim Biotech Gmbh Method of mixing
DE102008025508A1 (de) 2008-05-28 2009-12-03 Sartorius Stedim Biotech Gmbh Mischsystem
DE102008025507A1 (de) 2008-05-28 2009-12-03 Sartorius Stedim Biotech Gmbh Mischsystem
DE102008027638A1 (de) * 2008-06-06 2009-12-10 Sann, Heiner, Dr. Disposable Vorrichtung und Verfahren zur Abluftkühlung, Luftfeuchtereduzierung und Schaumreduzierung
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
DE102008060773A1 (de) * 2008-12-05 2010-06-10 Sartorius Stedim Biotech Gmbh Verschluss für einen Behälter
FR2943355B1 (fr) 2009-03-18 2011-04-08 Sartorius Stedim Biotech Sa Recipient-melangeur avec palier d'arbre en partie superieure
EP2409130B1 (en) 2009-03-20 2013-12-04 Pbs Biotech, Inc. Automatable aseptic sample withdrawal system
CN201419084Y (zh) * 2009-04-07 2010-03-10 上海森松制药设备工程有限公司 用于生物反应器的磁力搅拌装置
EP2251407B1 (en) 2009-05-12 2016-06-29 Eppendorf AG Disposable bioreactor and method for its production
DE202010007640U1 (de) 2009-06-16 2010-08-19 Sartorius Stedim Biotech Gmbh Behälter mit einem Sensoradapter
JP2011098259A (ja) * 2009-11-04 2011-05-19 Fox Kagaku:Kk 微小型攪拌造粒装置
DE102009056468A1 (de) * 2009-12-01 2011-06-09 Technische Universität München Rührorgan für Milliliter-Bioreaktoren
CN201565273U (zh) * 2009-12-02 2010-09-01 上海化工研究院 一种磁力搅拌反应釜
US20110151552A1 (en) 2009-12-23 2011-06-23 Ge Healthcare Bio-Sciences Corp. Bioreactors
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
JP5570913B2 (ja) * 2010-08-27 2014-08-13 株式会社日立製作所 生体細胞の培養容器及び培養装置
US9005959B2 (en) * 2011-05-01 2015-04-14 Therapeutic Proteins International, LLC Bioreactor exhaust
DE102011054363B4 (de) 2011-10-10 2015-07-09 DASGIP Information and Process Technology GmbH Verfahren zum geregelten Betreiben einer biotechnologischen Vorrichtung und biotechnologische Vorrichtung
DE102011054365B4 (de) 2011-10-10 2014-01-02 DASGIP Information and Process Technology GmbH Biotechnologische Vorrichtung, Bioreaktorsystem mit mehreren biotechnologischen Vorrichtungen, Verfahren zum Temperieren eines Kultivierungsraumes in einer biotechnologischen Vorrichtung sowie Verfahren zum Temperieren von Kultivierungsräumen in einem Bioreaktorsystem

Also Published As

Publication number Publication date
WO2013186294A1 (en) 2013-12-19
JP2015525073A (ja) 2015-09-03
EP2674479A1 (de) 2013-12-18
CN104379722B (zh) 2018-11-09
EP2861711A1 (en) 2015-04-22
JP6227636B2 (ja) 2017-11-08
US10030220B2 (en) 2018-07-24
EP2674479B1 (de) 2015-03-18
JP6527919B2 (ja) 2019-06-12
DK2861711T3 (da) 2022-08-01
JP2017225454A (ja) 2017-12-28
US20150132840A1 (en) 2015-05-14
EP2861711B1 (en) 2022-07-20
CN104379722A (zh) 2015-02-25

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