DK2621468T3 - Farmaceutisk carbetocin-sammensætning - Google Patents
Farmaceutisk carbetocin-sammensætning Download PDFInfo
- Publication number
- DK2621468T3 DK2621468T3 DK11776530.5T DK11776530T DK2621468T3 DK 2621468 T3 DK2621468 T3 DK 2621468T3 DK 11776530 T DK11776530 T DK 11776530T DK 2621468 T3 DK2621468 T3 DK 2621468T3
- Authority
- DK
- Denmark
- Prior art keywords
- composition
- carbetocin
- methionine
- buffer
- formulation
- Prior art date
Links
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Claims (9)
1. Vandig sammensætning omfattende carbetocin eller et farmaceutisk aktivt salt deraf, hvor sammensætningen omfatter fra 0,05 mg/ml til 0,5 mg/ml carbetocin eller et farmaceutisk aktivt salt deraf, og pH-værdien af sammensætningen er fra 5,2 til 5,65, og hvor sammensætningen yderligere omfatter en antioxidant udvalgt fra gruppen bestående af methionin, EDTA og en kombination af methionin og EDTA.
2. Sammensætning ifølge krav 1, hvor pH-værdien af sammensætningen er fra 5,26 til 5,65.
3. Sammensætning ifølge krav 1 eller krav 2 yderligere omfattende et buffermiddel, for eksempel ravsyre.
4. Sammensætning ifølge krav 1 eller krav 2 yderligere omfattende en buffer, for eksempel en succinat- eller citrat/phosphat-buffer.
5. Sammensætning ifølge krav 3 eller krav 4, hvor kun én buffer eller buffermiddel er til stede.
6. Sammensætning ifølge et hvilket som helst af de foregående krav, hvor koncentrationen af carbetocin eller farmaceutisk aktivt salt deraf er fra 0,05 mg/ml til 0,1 mg/ml.
7. Sammensætning ifølge et hvilket som helst af de foregående krav, yderligere omfattende et isotonimiddel.
8. Sammensætning ifølge et hvilket som helst af kravene 1 til 7 til anvendelse i behandling eller forebyggelse af livmoderatoni, for eksempel efter vaginal fødsel, fødsel ved kejsersnit, eller til anvendelse i behandling eller forebyggelse af livmoderatoni hos en patient med risiko for at udvikle blødning i efterbyrdsperioden; og/eller til anvendelse i behandling eller forebyggelse af for kraftig blødning efter vaginal fødsel.
9. Sæt af dele omfattende: en vandig farmaceutisk sammensætning omfattende fra 0,05 mg/ml til 0,5 mg/ml carbetocin eller et farmaceutisk aktivt salt deraf og en antioxidant udvalgt fra gruppen bestående af methionin, EDTA og en kombination af methionin og EDTA, hvor pH-værdien af sammensætningen er fra 5,2 til 5,65; og en beholder til sammensætningen, eventuelt med særskilte injektionsmidler; eventuelt yderligere omfattende et isotonimiddel, foreksempel NaCI.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP10251690 | 2010-09-30 | ||
PCT/IB2011/002394 WO2012042371A2 (en) | 2010-09-30 | 2011-09-29 | Pharmaceutical composition |
Publications (1)
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DK2621468T3 true DK2621468T3 (da) | 2017-09-11 |
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ID=43478408
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DK17169301.3T DK3246018T3 (da) | 2010-09-30 | 2011-09-29 | Farmaceutisk sammensætning |
DK11776530.5T DK2621468T3 (da) | 2010-09-30 | 2011-09-29 | Farmaceutisk carbetocin-sammensætning |
DK17169328.6T DK3222272T3 (da) | 2010-09-30 | 2011-09-29 | Farmaceutisk sammensætning med carbetocin |
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DK17169301.3T DK3246018T3 (da) | 2010-09-30 | 2011-09-29 | Farmaceutisk sammensætning |
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DK17169328.6T DK3222272T3 (da) | 2010-09-30 | 2011-09-29 | Farmaceutisk sammensætning med carbetocin |
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JP (2) | JP6038797B2 (da) |
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CN (4) | CN107412728A (da) |
AU (1) | AU2011309762B2 (da) |
BR (2) | BR112013007362B1 (da) |
CA (1) | CA2812510A1 (da) |
CY (2) | CY1119245T1 (da) |
DK (3) | DK3246018T3 (da) |
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HK (1) | HK1246170A1 (da) |
HR (2) | HRP20211969T1 (da) |
HU (3) | HUE056835T2 (da) |
IL (3) | IL225238B (da) |
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RU (2) | RU2604690C2 (da) |
SI (3) | SI3222272T1 (da) |
TW (6) | TWI650134B (da) |
WO (1) | WO2012042371A2 (da) |
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EP2846810A4 (en) * | 2012-05-08 | 2016-04-13 | Dilafor Ab | TREATMENT OF AFTERBREAD BLOOMING WITH CHEMICALLY MODIFIED HEPARIN OR HEPARANSULFATE AND ONE UTEROTONIC AGENT |
PL3666258T3 (pl) * | 2014-09-19 | 2024-04-08 | Ferring Bv | Sposób leczenia zespołu Pradera-Williego |
CN107106640B (zh) * | 2014-10-01 | 2021-06-15 | 奥克希托恩生物科学公司 | 含有分娩控制物质的口服崩解固体药物剂量单元 |
RU2701199C2 (ru) | 2014-10-01 | 2019-09-25 | Окситон Байосайенс Б.В. | Перорально распадающаяся твердая фармацевтическая единица дозирования, содержащая контролирующее родовую деятельность вещество |
PT3242676T (pt) | 2015-01-07 | 2023-12-06 | TONIX Pharmaceuticals Holding Corp | Formulações de ocitocina que contém magnésio e métodos de uso |
WO2016162819A1 (en) * | 2015-04-07 | 2016-10-13 | Lupin Limited | Stable aqueous pharmaceutical composition of anti-tnf alpha antibody |
MX2018012351A (es) | 2016-04-12 | 2019-02-07 | Trigemina Inc | Formulaciones de oxitocina que contienen magnesio y metodos de uso. |
CN107773531B (zh) * | 2016-08-31 | 2021-05-04 | 成都倍特药业股份有限公司 | 一种马来酸麦角新碱注射液 |
CN108236601B (zh) * | 2016-12-23 | 2020-04-17 | 深圳翰宇药业股份有限公司 | 一种稳定的含卡贝缩宫素的阴道给药的药用组合物及其制备方法 |
BR112020001832A2 (pt) * | 2017-08-11 | 2020-07-28 | Ferring B.V. | método de produção de uma composição farmacêuti-ca |
GB201721846D0 (en) * | 2017-12-22 | 2018-02-07 | Arecor Ltd | Novel composition |
JP2021515005A (ja) | 2018-03-01 | 2021-06-17 | トライジェミナ, インコーポレイテッド | 標識オキシトシンならびに製造および使用の方法 |
CN108721598B (zh) * | 2018-07-03 | 2020-06-05 | 北京市新里程医药科技有限公司 | 一种缩宫素原料的制备方法及其药物组合物和制剂 |
WO2020061414A1 (en) * | 2018-09-20 | 2020-03-26 | Levo Therapeutics, Inc. | Stable intranasal formulations of carbetocin |
CN112969450B (zh) | 2018-09-20 | 2023-05-30 | 阿卡蒂亚药品公司 | 卡贝缩宫素药物产品及用于制备其的方法 |
US20220080023A1 (en) * | 2018-12-21 | 2022-03-17 | Arecor Limited | Novel composition |
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