DK2521555T3 - Methods and compositions for increasing the sensitivity to tyrosine kinase inhibitors - Google Patents

Methods and compositions for increasing the sensitivity to tyrosine kinase inhibitors Download PDF

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Publication number
DK2521555T3
DK2521555T3 DK10832418.7T DK10832418T DK2521555T3 DK 2521555 T3 DK2521555 T3 DK 2521555T3 DK 10832418 T DK10832418 T DK 10832418T DK 2521555 T3 DK2521555 T3 DK 2521555T3
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DK
Denmark
Prior art keywords
mir
egfr
cancer
mirna
tyrosine kinase
Prior art date
Application number
DK10832418.7T
Other languages
Danish (da)
English (en)
Inventor
Peter Jeffery Leedman
Keith Michael Giles
Felicity Caris Kalinowski
Original Assignee
Univ Western Australia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2009905758A external-priority patent/AU2009905758A0/en
Application filed by Univ Western Australia filed Critical Univ Western Australia
Application granted granted Critical
Publication of DK2521555T3 publication Critical patent/DK2521555T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK10832418.7T 2009-11-24 2010-11-24 Methods and compositions for increasing the sensitivity to tyrosine kinase inhibitors DK2521555T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2009905758A AU2009905758A0 (en) 2009-11-24 Method of Modulating Epidermal Growth Factor (EGF) Ligands
PCT/AU2010/001578 WO2011063456A1 (en) 2009-11-24 2010-11-24 Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
DK2521555T3 true DK2521555T3 (en) 2017-01-09

Family

ID=44065735

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10832418.7T DK2521555T3 (en) 2009-11-24 2010-11-24 Methods and compositions for increasing the sensitivity to tyrosine kinase inhibitors

Country Status (9)

Country Link
US (2) US20130090366A1 (enExample)
EP (2) EP2504014A4 (enExample)
JP (2) JP2013511560A (enExample)
CN (2) CN102762213A (enExample)
AU (2) AU2010324529A1 (enExample)
CA (2) CA2781572A1 (enExample)
DK (1) DK2521555T3 (enExample)
ES (1) ES2608923T3 (enExample)
WO (2) WO2011063456A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2314688B1 (en) 2004-11-12 2014-07-16 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
WO2012005572A1 (en) * 2010-07-06 2012-01-12 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
CA2856594A1 (en) * 2011-11-25 2013-05-30 Integragen A method for predicting responsiveness to a treatment with an egfr inhibitor
FR2984168B1 (fr) * 2011-12-19 2019-07-05 Chanel Parfums Beaute Micro-rna pour leur utilisation dans la pigmentation
WO2013173500A2 (en) * 2012-05-15 2013-11-21 New York University Method for predicting recurrence of melanoma using mirna alterations
EP2908830A4 (en) 2012-10-18 2016-11-30 Univ Western Australia CANCER THERAPY WITH MIRNAS
CA2903882A1 (en) * 2013-03-15 2014-09-18 Mirna Therapeutics, Inc. Combination cancer treatments utilizing micrornas and egfr-tki inhibitors
US20140308274A1 (en) * 2013-03-15 2014-10-16 Mirna Therapeutics, Inc. Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors
US20160175401A1 (en) 2013-07-31 2016-06-23 Dana-Farber Cancer Institute Inc. Compoitions and methods for modulating thermogenesis using pth-related and egf-related compounds
CN108537001B (zh) * 2018-04-12 2021-06-01 华中科技大学鄂州工业技术研究院 一种预测用于治疗肝癌的特异性治疗药物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893034B2 (en) * 2004-09-02 2011-02-22 Yale University Regulation of oncogenes by microRNAs
EP2314688B1 (en) * 2004-11-12 2014-07-16 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
DK2061482T3 (en) * 2006-08-28 2015-04-20 Univ Western Australia PROCEDURE FOR MODULATING EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) CONCERNING MIRNA
CA2671299A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
JP2010516692A (ja) * 2007-01-19 2010-05-20 バイエル・ヘルスケア・エルエルシー 化学療法剤に対し抵抗性を有する癌の処置

Also Published As

Publication number Publication date
EP2504014A4 (en) 2013-04-17
EP2521555B1 (en) 2016-09-28
AU2010324530B2 (en) 2016-12-15
CA2781572A1 (en) 2011-06-03
CN102762213A (zh) 2012-10-31
CN102762214A (zh) 2012-10-31
EP2504014A1 (en) 2012-10-03
JP2013511559A (ja) 2013-04-04
AU2010324529A1 (en) 2012-07-19
JP2013511560A (ja) 2013-04-04
AU2010324530A1 (en) 2012-07-19
EP2521555A1 (en) 2012-11-14
CA2781571A1 (en) 2011-06-03
US20130090366A1 (en) 2013-04-11
WO2011063456A1 (en) 2011-06-03
EP2521555A4 (en) 2013-08-07
US9051551B2 (en) 2015-06-09
ES2608923T3 (es) 2017-04-17
US20130116299A1 (en) 2013-05-09
WO2011063455A1 (en) 2011-06-03

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