DK251478A - PROCEDURE FOR THE PREPARATION OF PENCILLANIC ACID-1,1-DIOXIDES - Google Patents

PROCEDURE FOR THE PREPARATION OF PENCILLANIC ACID-1,1-DIOXIDES

Info

Publication number
DK251478A
DK251478A DK251478A DK251478A DK251478A DK 251478 A DK251478 A DK 251478A DK 251478 A DK251478 A DK 251478A DK 251478 A DK251478 A DK 251478A DK 251478 A DK251478 A DK 251478A
Authority
DK
Denmark
Prior art keywords
dioxides
procedure
preparation
pencillanic acid
pencillanic
Prior art date
Application number
DK251478A
Other languages
Danish (da)
Other versions
DK155740C (en
DK155740B (en
Inventor
W E Barth
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27122691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK251478(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of DK251478A publication Critical patent/DK251478A/en
Priority to DK428682A priority Critical patent/DK156480C/en
Publication of DK155740B publication Critical patent/DK155740B/en
Application granted granted Critical
Publication of DK155740C publication Critical patent/DK155740C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK251478A 1977-06-07 1978-06-06 METHOD OF ANALOGUE FOR PREPARATION OF PENICILLANIC ACID-1,1-DIOXIDE, CERTAIN ESTERS AND PHYSIOLOGICALLY ACCEPTABLE SALTS DK155740C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK428682A DK156480C (en) 1977-06-07 1982-09-27 PENICILLANIC ACID-1 OXIDES USED AS INTERMEDIATES IN THE PREPARATION OF THERAPEUTIC ACTIVE PENICILLANIC ACID-1,1-DIOXIDE DERIVATIVES

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80432077A 1977-06-07 1977-06-07
US80432077 1977-06-07
US87938178A 1978-02-21 1978-02-21
US87938178 1978-02-21

Publications (3)

Publication Number Publication Date
DK251478A true DK251478A (en) 1978-12-08
DK155740B DK155740B (en) 1989-05-08
DK155740C DK155740C (en) 1989-10-23

Family

ID=27122691

Family Applications (1)

Application Number Title Priority Date Filing Date
DK251478A DK155740C (en) 1977-06-07 1978-06-06 METHOD OF ANALOGUE FOR PREPARATION OF PENICILLANIC ACID-1,1-DIOXIDE, CERTAIN ESTERS AND PHYSIOLOGICALLY ACCEPTABLE SALTS

Country Status (35)

Country Link
AR (1) AR224111A1 (en)
AT (2) AT360649B (en)
AU (1) AU513636B2 (en)
BE (1) BE867859A (en)
BG (2) BG34615A3 (en)
CH (1) CH634073A5 (en)
CS (1) CS208472B2 (en)
DD (2) DD148585A5 (en)
DE (2) DE2824535C3 (en)
DK (1) DK155740C (en)
EG (1) EG13869A (en)
FI (1) FI66003C (en)
FR (2) FR2393804A1 (en)
GB (1) GB2000138B (en)
GR (1) GR72255B (en)
HK (1) HK13184A (en)
HU (1) HU180042B (en)
IE (1) IE47079B1 (en)
IL (2) IL54867A (en)
IN (1) IN149747B (en)
IT (1) IT1096381B (en)
KE (1) KE3355A (en)
LU (1) LU79774A1 (en)
MY (1) MY8500092A (en)
NL (2) NL180009C (en)
NO (2) NO151746C (en)
NZ (1) NZ187476A (en)
OA (1) OA05964A (en)
PH (3) PH26810A (en)
PL (1) PL114501B1 (en)
PT (1) PT68146A (en)
SE (2) SE436206B (en)
SG (1) SG65383G (en)
SU (1) SU860706A1 (en)
YU (1) YU41829B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77306A1 (en) * 1977-05-09 1979-01-18
DE2912511C2 (en) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmaceutical composition containing penicillanic acid
DK155942C (en) * 1977-12-23 1989-10-23 Pfizer METHOD OF ANALOGUE FOR THE PREPARATION OF 6-AMINOPENICILLANIC ACID-1,1-DIOXIDE AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION AND BASIS SALTS.
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
US4241050A (en) * 1978-09-01 1980-12-23 Pfizer Inc. Penam 1,1-dioxides as beta-lactamase inhibitors
CA1158639A (en) * 1978-12-11 1983-12-13 Eric M. Gordon 6-bromopenicillanic acid sulfone
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
SE449103B (en) * 1979-03-05 1987-04-06 Pfizer SET TO PENICILLANIC ACID-1,1-DIOXIDE AND ESSERS THEREOF
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
IL59948A0 (en) * 1979-05-21 1980-06-30 Rech Applications Therap Penicillanic acid derivatives,their production and pharmaceutical compositions containing them
DE3051044C2 (en) * 1979-06-19 1989-03-30 Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4256733A (en) * 1979-09-26 1981-03-17 Pfizer Inc. Acetoxymethyl penam compounds as β-lactamase inhibitors
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4432903A (en) * 1980-09-08 1984-02-21 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
DE3261759D1 (en) * 1981-07-15 1985-02-14 Kanebo Ltd Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
PT76526B (en) * 1982-04-19 1986-01-21 Gist Brocades Nv Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides
US4502988A (en) * 1983-08-08 1985-03-05 Eli Lilly And Company Oxidation process
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4647457A (en) * 1983-12-16 1987-03-03 Hoffmann-La Roche Inc. Penicillanic acid derivatives
WO1987006230A1 (en) * 1986-04-10 1987-10-22 Leo Pharmaceutical Products Ltd. A/S Method for preparing penicillanic acid derivatives
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
CN102977120B (en) * 2012-12-14 2015-05-27 江西富祥药业股份有限公司 Method for preparing and crystallizing sulbactam pivoxyl

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197466A (en) * 1961-10-30 1965-07-27 Smith Kline French Lab Penicillin sulfoxides and process
LU77306A1 (en) * 1977-05-09 1979-01-18
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones

Also Published As

Publication number Publication date
BG34615A3 (en) 1983-10-15
IT7824270A0 (en) 1978-06-06
GR72255B (en) 1983-10-06
NO152448B (en) 1985-06-24
EG13869A (en) 1983-03-31
BE867859A (en) 1978-12-06
PL207396A1 (en) 1979-06-04
NZ187476A (en) 1982-08-17
DE2824535B2 (en) 1980-05-14
FI66003B (en) 1984-04-30
FR2393804A1 (en) 1979-01-05
SE8305916D0 (en) 1983-10-27
HU180042B (en) 1983-01-28
DD148585A5 (en) 1981-06-03
GB2000138B (en) 1982-03-03
IL54867A0 (en) 1978-08-31
DK155740C (en) 1989-10-23
GB2000138A (en) 1979-01-04
NL7806126A (en) 1978-12-11
DK155740B (en) 1989-05-08
CS208472B2 (en) 1981-09-15
SE8305916L (en) 1983-10-27
IE781140L (en) 1978-12-07
MY8500092A (en) 1985-12-31
KE3355A (en) 1983-12-16
IN149747B (en) 1982-04-03
AU3683878A (en) 1979-12-06
IL54867A (en) 1981-11-30
DE2824535A1 (en) 1978-12-14
AT364084B (en) 1981-09-25
ATA128580A (en) 1981-02-15
BG34614A3 (en) 1983-10-15
PH16465A (en) 1983-10-20
NL930064I2 (en) 1994-04-18
NO151746C (en) 1985-06-05
FR2393805B1 (en) 1984-02-24
NO151746B (en) 1985-02-18
IE47079B1 (en) 1983-12-14
CH634073A5 (en) 1983-01-14
AU513636B2 (en) 1980-12-11
FI66003C (en) 1984-08-10
PH26810A (en) 1992-11-05
FI781800A (en) 1978-12-08
DD140888A5 (en) 1980-04-02
NL930064I1 (en) 1993-09-01
HK13184A (en) 1984-02-24
IT1096381B (en) 1985-08-26
FR2393805A1 (en) 1979-01-05
ATA411278A (en) 1980-06-15
SU860706A1 (en) 1981-08-30
LU79774A1 (en) 1980-01-22
OA05964A (en) 1981-06-30
NO823126L (en) 1978-12-08
SE447995B (en) 1987-01-12
IL62168A0 (en) 1981-03-31
FR2393804B1 (en) 1980-11-07
DE2824535C3 (en) 1981-01-22
YU41829B (en) 1988-02-29
YU117078A (en) 1983-01-21
NO152448C (en) 1985-10-02
NL180009C (en) 1986-12-16
AT360649B (en) 1981-01-26
DE2857263C3 (en) 1981-12-17
PL114501B1 (en) 1981-02-28
NO781970L (en) 1978-12-08
PT68146A (en) 1978-07-01
DE2857263B2 (en) 1981-04-23
PH21116A (en) 1987-07-16
AR224111A1 (en) 1981-10-30
SG65383G (en) 1985-03-29
SE7806628L (en) 1978-12-08
SE436206B (en) 1984-11-19

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Legal Events

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PUP Patent expired