DK2512502T3 - Fremgangsmåder og sammensætninger til opløsning af tumorer - Google Patents
Fremgangsmåder og sammensætninger til opløsning af tumorer Download PDFInfo
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- DK2512502T3 DK2512502T3 DK10842519.0T DK10842519T DK2512502T3 DK 2512502 T3 DK2512502 T3 DK 2512502T3 DK 10842519 T DK10842519 T DK 10842519T DK 2512502 T3 DK2512502 T3 DK 2512502T3
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Claims (1)
1. Terapeutisk sammensætning til anvendelse i opløsning af en progressiv metastatisk stadie IV-cancer refraktær til mindst én runde af kemoterapi, hvilken sammensætning omfatter allogene Th1-celler konjugerede med anti-CD3/anti-CD28 monoklonale antistof-coatede mikrokugler, hvor sammensætningen er til administration til en patient i henhold til den følgende doseringsplan: a) tre eller flere intradermale injektioner med en dosis på mellem 1 x 107 og 4 x 107 celler med ikke mindre end 2 dage imellem og med ikke mere end 8 dage imellem, b) mellem 2 dage og 8 dage efter fuldendelsen af trin a), intratumoral injektion af 1 x 107 til 6 x 107 celler inden for en time af ablation af tumoren, og c) inden for 8 dage af ablation, en eller flere intravenøse infusioner med en dosis på 1 x 107 til 1 x 108 celler med ikke mindre end to dage imellem, hvor administration af sammensætningen resulterer i en forøgelse i størrelse af tumoren, der bliver hypodens eller mørk sammenlignet med et udgangspunkt forud for behandling som vist på en CT-scanning efter 30 dage.
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| US8420078B2 (en) * | 2005-03-10 | 2013-04-16 | Yeda Research And Development Co. Ltd. | Methods and immunogenic cell preparations for treating antigen-associated diseases |
| US20080112963A1 (en) * | 2006-11-13 | 2008-05-15 | Immunovative Therapies, Ltd. | Ablative immunotherapy |
| US20120128656A1 (en) * | 2008-05-02 | 2012-05-24 | Immunovative Therapies, Ltd. | Vaccine compositions and methods |
| WO2010037395A2 (en) * | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
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2010
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- 2010-12-15 CN CN2010800575066A patent/CN102740874A/zh active Pending
- 2010-12-15 EP EP10842519.0A patent/EP2512502B1/en active Active
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- 2010-12-15 PL PL10842519T patent/PL2512502T3/pl unknown
- 2010-12-15 PT PT108425190T patent/PT2512502T/pt unknown
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- 2010-12-15 DK DK10842519.0T patent/DK2512502T3/da active
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- 2010-12-15 HU HUE10842519A patent/HUE037105T2/hu unknown
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2012
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2013
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2014
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| JP6553219B2 (ja) | 2019-07-31 |
| HK1222804A1 (zh) | 2017-07-14 |
| EP2512502A4 (en) | 2013-05-08 |
| CA2786585C (en) | 2019-11-26 |
| WO2011084451A2 (en) | 2011-07-14 |
| KR20120095418A (ko) | 2012-08-28 |
| HUE037105T2 (hu) | 2018-08-28 |
| EP2512502A2 (en) | 2012-10-24 |
| ES2667295T3 (es) | 2018-05-10 |
| JP2016121164A (ja) | 2016-07-07 |
| NO2512502T3 (da) | 2018-08-18 |
| BR112012014569A2 (pt) | 2016-08-16 |
| US20140178334A1 (en) | 2014-06-26 |
| JP2013514365A (ja) | 2013-04-25 |
| KR101837561B1 (ko) | 2018-04-26 |
| IL220386B (en) | 2020-04-30 |
| PL2512502T3 (pl) | 2018-08-31 |
| CN105457020A (zh) | 2016-04-06 |
| CN102740874A (zh) | 2012-10-17 |
| JP6278597B2 (ja) | 2018-02-14 |
| EP2512502B1 (en) | 2018-03-21 |
| BR112012014569A8 (pt) | 2017-12-26 |
| US20220273784A1 (en) | 2022-09-01 |
| JP2018090605A (ja) | 2018-06-14 |
| CA2786585A1 (en) | 2011-07-14 |
| PT2512502T (pt) | 2018-05-02 |
| US20110142887A1 (en) | 2011-06-16 |
| WO2011084451A3 (en) | 2011-10-27 |
| US20160206718A1 (en) | 2016-07-21 |
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