DK246984A - Dihydrobenzopyrrolobenzodiazepiner en fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler - Google Patents

Dihydrobenzopyrrolobenzodiazepiner en fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler Download PDF

Info

Publication number
DK246984A
DK246984A DK246984A DK246984A DK246984A DK 246984 A DK246984 A DK 246984A DK 246984 A DK246984 A DK 246984A DK 246984 A DK246984 A DK 246984A DK 246984 A DK246984 A DK 246984A
Authority
DK
Denmark
Prior art keywords
dihydrobenzopyrrolobenzodiazepines
medicines
procedure
preparation
Prior art date
Application number
DK246984A
Other languages
Danish (da)
English (en)
Other versions
DK246984D0 (da
Inventor
Edward J Glamkowski
Yulin Chiang
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK246984D0 publication Critical patent/DK246984D0/da
Publication of DK246984A publication Critical patent/DK246984A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DK246984A 1983-05-18 1984-05-17 Dihydrobenzopyrrolobenzodiazepiner en fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler DK246984A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/495,569 US4761411A (en) 1983-05-18 1983-05-18 Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses

Publications (2)

Publication Number Publication Date
DK246984D0 DK246984D0 (da) 1984-05-17
DK246984A true DK246984A (da) 1984-11-19

Family

ID=23969143

Family Applications (1)

Application Number Title Priority Date Filing Date
DK246984A DK246984A (da) 1983-05-18 1984-05-17 Dihydrobenzopyrrolobenzodiazepiner en fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler

Country Status (16)

Country Link
US (1) US4761411A (fr)
EP (1) EP0129692A3 (fr)
JP (1) JPS59219285A (fr)
KR (1) KR840009310A (fr)
AU (1) AU575830B2 (fr)
CA (1) CA1244414A (fr)
DK (1) DK246984A (fr)
ES (1) ES532509A0 (fr)
FI (1) FI77865C (fr)
GR (1) GR82273B (fr)
HU (1) HU193010B (fr)
IL (1) IL71856A0 (fr)
NZ (1) NZ208180A (fr)
PH (1) PH21087A (fr)
PT (1) PT78599B (fr)
ZA (1) ZA843722B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
US4751223A (en) * 1986-10-14 1988-06-14 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines
US5008262A (en) * 1988-04-19 1991-04-16 The United States Of America As Represented By The Department Of Health And Human Services Method of treating trichotillomania and onchyphagia
US4929615A (en) * 1989-06-12 1990-05-29 Hoechst-Roussel Pharmaceuticals Inc. 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines
US5312819A (en) * 1990-08-20 1994-05-17 Sandoz Ltd. Pharmaceutical compositions comprising clozapine and a radical scavenger
WO1997016430A1 (fr) * 1995-11-01 1997-05-09 Merck & Co., Inc. Derives de l'hexahydro-5-imino-1,4-heteroazepine inhibiteurs des synthases de l'oxyde nitrique
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
KR20070100894A (ko) 2005-01-19 2007-10-12 브리스톨-마이어스 스큅 컴퍼니 혈전색전성 장애 치료용 p2y1 수용체 억제제로서의2-페녹시-n-(1,3,4-티아디졸-2-일)피리딘-3-아민 유도체및 관련 화합물
DE602006017694D1 (de) 2005-06-27 2010-12-02 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
TW200726764A (en) * 2005-06-27 2007-07-16 Bristol Myers Squibb Co N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
DE602006020871D1 (de) 2005-06-27 2011-05-05 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden
WO2007002634A1 (fr) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Antagonistes carbocycliques et heherocycliques du recepteur p2y1, utiles pour traiter des etats pathologiques thrombotiques
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2012153796A1 (fr) * 2011-05-10 2012-11-15 協和発酵キリン株式会社 Composé pyrimido-diazépinone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2733371A (en) * 1970-04-14 1972-10-12 A. H. Robins Company, Incorporated 5, 7-DISUBSTITUTED-l, 9-ALKYLENE-l, 4-BENZODIAZEPIN-2 ONES
GB1451389A (en) * 1974-07-03 1976-09-29 Pierrel Spa Indolobenzazepines
US4186199A (en) * 1978-11-02 1980-01-29 American Hoechst Corporation Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines
US4192874A (en) * 1978-11-02 1980-03-11 American Hoechst Corporation Substituted 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines
GB8333581D0 (en) * 1983-12-16 1984-01-25 Wyeth John & Brother Ltd Heterocyclic compounds
IE57646B1 (en) * 1983-12-16 1993-02-10 Wyeth John & Brother Ltd Derivatives of imidazoquinolines and analogues thereof

Also Published As

Publication number Publication date
GR82273B (fr) 1984-12-13
FI77865C (fi) 1989-05-10
AU575830B2 (en) 1988-08-11
AU2834784A (en) 1984-11-22
PT78599A (en) 1984-06-01
PH21087A (en) 1987-07-16
ES8506652A1 (es) 1985-08-01
NZ208180A (en) 1988-01-08
PT78599B (en) 1986-07-17
FI841965A (fi) 1984-11-19
US4761411A (en) 1988-08-02
EP0129692A3 (fr) 1987-07-29
CA1244414A (fr) 1988-11-08
HU193010B (en) 1987-08-28
IL71856A0 (en) 1984-09-30
FI841965A0 (fi) 1984-05-16
HUT37432A (en) 1985-12-28
ZA843722B (en) 1985-01-30
ES532509A0 (es) 1985-08-01
EP0129692A2 (fr) 1985-01-02
JPS59219285A (ja) 1984-12-10
KR840009310A (ko) 1984-12-26
FI77865B (fi) 1989-01-31
DK246984D0 (da) 1984-05-17

Similar Documents

Publication Publication Date Title
DK310383A (da) 14-fluormorphinaner, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
DK418985D0 (da) Indkapslede pyrethroider samt fremgangsmaade til fremstilling deraf oganvendelse som insecticid
DK647087D0 (da) Substituerede basiske tetraliner, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK49283D0 (da) Pyrazoloxaziner, -thiaziner og - quinoliner, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler
DK222382A (da) Benzezepinderivater fremgangsmaade til deres fremstilling samt deres anvendelse
DK398583D0 (da) Spergualin-beslaegtede forbindelser, fremgangsmader til fremstilling deraf samt deres anvendelse som laegemidler
DK246984A (da) Dihydrobenzopyrrolobenzodiazepiner en fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK426083A (da) Pteriner, fremgangsmaader til deres fremstilling samt deres anvendelse
DK539087D0 (da) 4,5-dihydro- og 4,5,6,7-tetrahydro-pyrazolooe1,5-aaapyrimidiner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK303688A (da) Polyoxygenerede labdanderivater, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK55188A (da) Alkylsubstituerede n-benzopyranyllactamer, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK16982A (da) Sisomicin-derivater fremgangsmaade til fremstilling heraf samt deres anvendelse som laegemidler
DK166210C (da) Krystallinske cephalosporin-hydrohalogenidsalte, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
DK393788A (da) Substituerede thienoimidazolderivater, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK382283D0 (da) Thiazol-derivater, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler
DK548086A (da) Nitroanthracycliner, fremgangsmaade til deres fremstilling samt deres anvendelse
DK231089D0 (da) Substituerede azolthioethere, fremgangsmaade til fremstilling deraf samt deres anvendelse som skadedyrsbekaempelsesmiddel
DK403585A (da) Histargin-beslaegtede forbindelser, en fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
DK225189A (da) Hydrazinocarbonyloxylabdaner, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK329882A (da) Oxothienobenzoxepiner,fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
NO830814L (no) 7-alfa-aminoacyl-3-klorcefalosporiner, fremgangsmaate til deres fremstilling samt deres anvendelse som legemiddel
DK547289D0 (da) Benzoisothiazoler og fremgangsmaade til fremstilling deraf samt deres anvendelse som skadedyrsbekaempelsesmiddel
DK144784A (da) Optiske antipoder af 8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemiddel
DK321387A (da) Cytorhodin s-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK259984A (da) Alkylen-bis-heterocyclyl-biguanider, en fremgangsmaade til deres fremstilling samt deres anvendelse

Legal Events

Date Code Title Description
ATS Application withdrawn