DK2460823T3 - Modificeret sekretionssystem til øget ekspression af polypeptider ibakterier - Google Patents
Modificeret sekretionssystem til øget ekspression af polypeptider ibakterierInfo
- Publication number
- DK2460823T3 DK2460823T3 DK12157805.8T DK12157805T DK2460823T3 DK 2460823 T3 DK2460823 T3 DK 2460823T3 DK 12157805 T DK12157805 T DK 12157805T DK 2460823 T3 DK2460823 T3 DK 2460823T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptides
- bacteria
- increased expression
- secretion system
- host cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92887507P | 2007-05-10 | 2007-05-10 | |
| EP08780652A EP2152732B1 (en) | 2007-05-10 | 2008-05-12 | A modified secretion system to increase expression of polypeptides in bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2460823T3 true DK2460823T3 (da) | 2014-05-05 |
Family
ID=39791456
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12157805.8T DK2460823T3 (da) | 2007-05-10 | 2008-05-12 | Modificeret sekretionssystem til øget ekspression af polypeptider ibakterier |
| DK08780652.7T DK2152732T3 (da) | 2007-05-10 | 2008-05-12 | Modificeret sekretionssystem til at øge ekspression af polypeptider i bakterier |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08780652.7T DK2152732T3 (da) | 2007-05-10 | 2008-05-12 | Modificeret sekretionssystem til at øge ekspression af polypeptider i bakterier |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8343735B2 (da) |
| EP (2) | EP2460823B1 (da) |
| CN (1) | CN101679489B (da) |
| AT (1) | ATE550348T1 (da) |
| DK (2) | DK2460823T3 (da) |
| WO (1) | WO2008141281A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2100947A1 (en) | 2008-03-14 | 2009-09-16 | The Procter and Gamble Company | Automatic dishwashing detergent composition |
| CN105238801A (zh) | 2009-04-24 | 2016-01-13 | 丹尼斯科美国公司 | 具有修饰的原区的蛋白酶 |
| US9265819B2 (en) * | 2011-09-21 | 2016-02-23 | St. Jude Children's Research Hospital | Live, attenuated Streptococcus pneumoniae strain and vaccine for protection against pneumococcal disease |
| CN103013960A (zh) * | 2012-12-21 | 2013-04-03 | 青岛蔚蓝生物集团有限公司 | 一种碱性蛋白酶及其重组表达工程菌 |
| CN114395577A (zh) * | 2022-01-06 | 2022-04-26 | 上海应用技术大学 | 一种基因工程菌的制备方法、基因工程菌及重组壳聚糖酶 |
| WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302544A (en) | 1979-10-15 | 1981-11-24 | University Of Rochester | Asporogenous mutant of B. subtilis for use as host component of HV1 system |
| US4450235A (en) | 1982-04-21 | 1984-05-22 | Cpc International Inc. | Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system |
| US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5310675A (en) | 1983-06-24 | 1994-05-10 | Genencor, Inc. | Procaryotic carbonyl hydrolases |
| EP0134048B2 (en) | 1983-07-06 | 1996-08-14 | Gist-Brocades N.V. | Molecular cloning and expression in industrial microorganism species |
| US5700676A (en) | 1984-05-29 | 1997-12-23 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
| EP0254735B2 (en) | 1986-01-15 | 1998-06-17 | Amgen Inc. | METHOD FOR PRODUCTION OF THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS |
| US4980288A (en) | 1986-02-12 | 1990-12-25 | Genex Corporation | Subtilisin with increased thermal stability |
| GB8608194D0 (en) | 1986-04-03 | 1986-05-08 | Massey Ferguson Services Nv | Valve control system |
| HU213220B (en) | 1987-02-27 | 1997-03-28 | Gist Brocades Nv | Method for enhanced production of serine protease in transformed bacillus cells and production of the transformed cells |
| US4914031A (en) | 1987-04-10 | 1990-04-03 | Amgen, Inc. | Subtilisin analogs |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| CN1056187C (zh) | 1988-02-11 | 2000-09-06 | 金克克国际有限公司 | 新的蛋白水解酶及其在洗涤剂中的应用 |
| US5665587A (en) | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| DK97190D0 (da) | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
| US5482849A (en) | 1990-12-21 | 1996-01-09 | Novo Nordisk A/S | Subtilisin mutants |
| ATE168130T1 (de) | 1991-05-01 | 1998-07-15 | Novo Nordisk As | Stabilisierte enzyme und waschmittelzusammensetzungen |
| DE4411223A1 (de) | 1994-03-31 | 1995-10-05 | Solvay Enzymes Gmbh & Co Kg | Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren |
| US20030157642A1 (en) | 1997-07-15 | 2003-08-21 | Caldwell Robert M. | Increasing production of proteins in gram-positive microorganisms |
| AR015977A1 (es) | 1997-10-23 | 2001-05-30 | Genencor Int | Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes |
| AU2207099A (en) | 1997-12-24 | 1999-07-19 | Genencor International, Inc. | An improved method of assaying for a preferred enzyme and/or preferred detergentcomposition |
| US6835550B1 (en) | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| US6376450B1 (en) | 1998-10-23 | 2002-04-23 | Chanchal Kumar Ghosh | Cleaning compositions containing multiply-substituted protease variants |
| US6509185B1 (en) | 2000-01-07 | 2003-01-21 | Genencor International, Inc. | Mutant aprE promotor |
| AU2003215062B2 (en) * | 2002-02-08 | 2008-06-19 | Genencor International, Inc. | Secretion, transcription and sporulation genes in Bacillus clausii |
-
2008
- 2008-05-12 EP EP12157805.8A patent/EP2460823B1/en active Active
- 2008-05-12 US US12/598,182 patent/US8343735B2/en active Active
- 2008-05-12 CN CN200880014188.8A patent/CN101679489B/zh active Active
- 2008-05-12 DK DK12157805.8T patent/DK2460823T3/da active
- 2008-05-12 AT AT08780652T patent/ATE550348T1/de active
- 2008-05-12 WO PCT/US2008/063418 patent/WO2008141281A1/en active Application Filing
- 2008-05-12 DK DK08780652.7T patent/DK2152732T3/da active
- 2008-05-12 EP EP08780652A patent/EP2152732B1/en active Active
-
2012
- 2012-10-15 US US13/652,107 patent/US8623630B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2460823A1 (en) | 2012-06-06 |
| EP2152732A1 (en) | 2010-02-17 |
| CN101679489B (zh) | 2014-05-28 |
| DK2152732T3 (da) | 2012-06-04 |
| CN101679489A (zh) | 2010-03-24 |
| US8623630B2 (en) | 2014-01-07 |
| WO2008141281A1 (en) | 2008-11-20 |
| ATE550348T1 (de) | 2012-04-15 |
| US20100184137A1 (en) | 2010-07-22 |
| US20130102052A1 (en) | 2013-04-25 |
| US8343735B2 (en) | 2013-01-01 |
| EP2460823B1 (en) | 2014-02-26 |
| EP2152732B1 (en) | 2012-03-21 |
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