DK2437747T3 - Kombinationspræparat, der omfatter et exosom og et kortikosteroid - Google Patents
Kombinationspræparat, der omfatter et exosom og et kortikosteroid Download PDFInfo
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- DK2437747T3 DK2437747T3 DK10800713.9T DK10800713T DK2437747T3 DK 2437747 T3 DK2437747 T3 DK 2437747T3 DK 10800713 T DK10800713 T DK 10800713T DK 2437747 T3 DK2437747 T3 DK 2437747T3
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- Prior art keywords
- exosomes
- pharmaceutical composition
- corticosteroid
- disease
- joint
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Claims (25)
1. Farmaceutisk sammensætning, der indeholder et kortikosteroid sammen med exosomer i nærvær eller fravær af en cytokinantagonist og/eller en vækstfaktor, hvor exosomeme kan fremstilles ved hjælp af en fremgangsmåde, der omfatter følgende trin: tilvejebringelse af en blodprøve, der indeholder exosomer, og fortrinsvis øgning af koncentrationen af exosomeme.
2. Farmaceutisk sammensætning, der indeholder exosomer i nærvær eller fravær af en cytokinantagonist og/eller en vækstfaktor til anvendelse i en kombinationsterapi sammen med et kortikosteroid til behandling af en sygdom, der er udvalgt fra gmppen bestående af ledsygdomme, såsom artrose, artritis, ledinflammation og inflammatorisk brusktab, degenerative hvirvelsøjlesygdomme, ledsmerter og autoimmune sygdomme, hvor sygdommen er forskellig fra rheumatoid artritis, og exosomeme kan fremstilles ved hjælp af en fremgangsmåde, der omfatter følgende trin: tilvejebringelse af en blodprøve, der indeholder exosomer, og fortrinsvis øgning af koncentrationen af exosomeme.
3. Farmaceutisk sammensætning, der indeholder et kortikosteroid i nærvær eller fravær af en cytokinantagonist og/eller en vækstfaktor til anvendelse i en kombinationsterapi sammen med exosomer til behandling af en sygdom, der er udvalgt fra gmppen bestående af ledsygdomme, såsom artrose, artritis, ledinflammation og inflammatorisk bmsktab, degenerative hvirvelsøjlesygdomme, ledsmerter og autoimmune sygdomme, hvor sygdommen er forskellig fra rheumatoid artritis, og exosomeme er opnået fra en blodprøve.
4. Farmaceutisk sammensætning, der indeholder en cytokinantagonist og/eller en vækstfaktor til anvendelse i en kombinationsterapi sammen med et kortikosteroid og exosomer til behandling af en sygdom, der er udvalgt fra gruppen bestående af ledsygdomme, såsom artrose, artritis, ledinflammation og inflammatorisk brusktab, degenerative hvirvelsøjlesygdomme, ledsmerter og autoimmune sygdomme, hvor sygdommen er forskellig fra rheumatoid artritis, og exosomeme er opnået fra en blodprøve.
5. Kit, der indeholder (i) en farmaceutisk sammensætning, der indeholder exosomer i nærvær eller fravær af en cytokinantagonist og/eller en vækstfaktor, og (ii) en farmaceutisk sammensætning, der indeholder et kortikosteroid i nærvær eller fravær af en cytokinantagonist og/eller en vækstfaktor, hvor exosomeme kan fremstilles ved hjælp af en fremgangsmåde, der omfatter følgende trin: tilvejebringelse af en blodprøve, der indeholder exosomer, og fortrinsvis øgning af koncentrationen af exosomeme.
6. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 2 eller 3 eller kit ifølge krav 5, hvor de farmaceutiske sammensætninger er bestemt til en simultan eller sekventiel administration af exosomeme og kortikosteroidet.
7. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 1 til 6, hvor kortikosteroidet er (a) et glucokortikoid, såsom kortison, hydrokortison, prednison, prednisolon, cloprednol, deflazacort, fluocortin, triamcinolon, dexamethason, methylprednisolon, fluprednisolon, clocortolon, clobetason, alclomethason, flumethason, flupredniden, flurandrenolon, betamethason, beclomethason, fluocortolon, mometason, fluticason, halomethason, fluocinolon, diflorason, desoximethason, fluocinonid, amcinonid, halcinonid, diflucortolon, clobetasol, paramethason; (b) et mineralokortikoid, såsom aldosteron, desoxycorticosteron og fludrocortison; eller (c) et androgen, såsom dehydroepiandrosteron (DHEA) og østrogener; eller et salt, en ester eller et prodrug deraf.
8. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 1,3,5,6 eller 7, hvor kortikosteroidet er til stede i en koncentration fra 1 til 80 mg/dosis i den kortikosteroidholdige farmaceutiske sammensætning.
9. Farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 3, 4, 6, 7 eller 8, hvor exosomeme er auto loge eller allogene i forhold til den patient, der skal behandles.
10. Farmaceutisk sammensætning eller kit ifølge et hvilket som helst af kravene 1 eller 5 til 9 til anvendelse til behandling af ledsygdomme, såsom artrose, artritis, ledinflammation og inflammatorisk brusktab, degenerative hvirvelsøjlesygdomme og/eller ledsmerter.
11. Farmaceutisk sammensætning eller kit til anvendelse ifølge et hvilket som helst af kravene 2 til 4 eller 6 til 10, hvor artrosen er en aktiveret artrose eller en inflammatorisk artrose.
12. Farmaceutisk sammensætning eller kit til anvendelse ifølge et hvilket som helst af kravene 2 til 4 eller 6 til 10, hvor artritis er en infektiøs artritis, såsom bakteriel artritis eller en ikke-infektiøs artritis.
13. Farmaceutisk sammensætning eller kit til anvendelse ifølge et hvilket som helst af kravene 2 til 4 eller 6 til 10, hvor den degenerative hvirvelsøjlesygdom er en diskusprolaps.
14. Farmaceutisk sammensætning eller kit ifølge et hvilket som helst af kravene 1 eller 5 til 9 til anvendelse til behandling af en autoimmun sygdom.
15. Farmaceutisk sammensætning eller kit til anvendelse ifølge et hvilket som helst af kravene 2 til 4, 6 til 9 til 14, hvor den autoimmune sygdom er neurodermatitis eller alopecia areata.
16. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 1 til 15, hvor de farmaceutiske sammensætninger er egnede til lokal administration.
17. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse eller kit ifølge krav 16, hvor den lokale administration er udvalgt fra gruppen bestående af injektion ind i det ramte kropsområde, i særdeleshed ind i det ramte led, ved den ramte nerverod eller ind i den ramte diskus, eller ind i det lokale område heraf; intra-artikulær injektion og topisk administration.
18. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 1 til 17, hvor de farmaceutiske sammensætninger endvidere indeholder en bærer og/eller en excipiens.
19. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 1 til 18, hvor en cytokinantagonist er til stede, og cytokinantagonisten er udvalgt fra gruppen bestående af interleukin-antagonister, i særdeleshed IL-1-antagonister, såsom IL-IRa, tumor-nekrose-faktor (TNF)-antagonister, i særdeleshed en TNF-a-antagonist, såsom et anti-TNF-a-antistof, interferonantagonister og chemokinantagonister.
20. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge krav 19, hvor cytokinantagonisten er naturligt forekommende eller rekombinant IL-lRa-protein, navnlig orthokin eller anakinra.
21. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 19 eller 20, hvor cytokinantagonisten er til stede i en koncentration fra 0,5 til 150 mg/dosis i den cytokin-antagonist-holdige farmaceutiske sammensætning.
22. Farmaceutisk sammensætning, farmaceutisk sammensætning til anvendelse, eller kit ifølge et hvilket som helst af kravene 1 til 21, hvor en vækstfaktor er til stede, og vækstfaktoren er udvalgt fra gruppen bestående af TGF-β, IGF, BMP, HGF og VEGF.
23. Anvendelse af exosomer i nærvær eller fravær af en cytokinantagonist og/eller en vækstfaktor til fremstilling af en farmaceutisk sammensætning til anvendelse i en kombinationsterapi sammen med et kortikosteroid til behandling af en sygdom, der er udvalgt fra gruppen bestående af ledsygdomme, såsom artrose, artritis, ledinflammation og inflammatorisk brusktab, degenerative hvirvelsøjlesygdomme, ledsmerter og autoimmune sygdomme, hvor sygdommen er forskellig fra rheumatoid artritis, og exosomeme kan fremstilles ved hjælp af en fremgangsmåde, der omfatter følgende trin: tilvejebringelse af en blodprøve, der indeholder exosomer, og fortrinsvis øgning af koncentrationen af exosomeme.
24. Anvendelse af et kortikosteroid i nærvær eller fravær af en cytokinantagonist og/eller en vækstfaktor til fremstilling af en farmaceutisk sammensætning til anvendelse i en kombinationsterapi sammen med exosomer til behandling af en sygdom, der er udvalgt fra gruppen bestående af ledsygdomme, såsom artrose, artritis, ledinflammation og inflammatorisk brusktab, degenerative hvirvelsøjlesygdomme, ledsmerter og autoimmune sygdomme, hvor sygdommen er forskellig fra rheumatoid artritis, og exosomeme er opnået fra en blodprøve.
25. Fremgangsmåde til fremstilling af et kortikosteroid og farmaceutisk sammensætning, der indeholder exosomer, hvilken fremgangsmåde omfatter følgende trin: tilvejebringelse af en blodprøve, der indeholder exosomer, fortrinsvis øgning af koncentrationen af exosomeme og blanding med et kortikosteroid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009057495 | 2009-12-10 | ||
| PCT/EP2010/069426 WO2011082950A1 (de) | 2009-12-10 | 2010-12-10 | Kombinationspräparate mit exosomen und corticosteroid |
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| Publication Number | Publication Date |
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| DK2437747T3 true DK2437747T3 (da) | 2016-10-24 |
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| DK10800714.7T DK2437748T5 (da) | 2009-12-10 | 2010-12-10 | Kombinationspræparat, der omfatter en cytokinantagonist og et kortikosteroid |
| DK10800713.9T DK2437747T3 (da) | 2009-12-10 | 2010-12-10 | Kombinationspræparat, der omfatter et exosom og et kortikosteroid |
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| DK10800714.7T DK2437748T5 (da) | 2009-12-10 | 2010-12-10 | Kombinationspræparat, der omfatter en cytokinantagonist og et kortikosteroid |
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| US20170189475A9 (en) * | 2009-12-10 | 2017-07-06 | Orthogen Ag | Combination preparation comprising a cytokine antagonist and corticosteroid |
| DE102012019088A1 (de) | 2012-09-28 | 2014-04-03 | Orthogen Ag | Antibakterielle Arzneimittelpräparate |
| CN104673749B (zh) * | 2015-02-12 | 2017-10-20 | 江苏大学 | 一种粒细胞样髓源性抑制细胞来源exosomes及其应用 |
| TW201722443A (zh) * | 2015-11-13 | 2017-07-01 | 奧爾托金公司 | 對老化相關病症有效之醫藥製劑 |
| EA201890841A1 (ru) * | 2016-08-17 | 2018-09-28 | Ортоген Аг | Фармацевтический препарат против старения |
| KR20190055086A (ko) | 2016-08-19 | 2019-05-22 | 칼리뮨, 인코포레이티드 | 재조합 자기-상보적인 아데노-부속 바이러스를 이용한 병태의 치료 방법 및 조성물 |
| WO2018056481A1 (ko) * | 2016-09-23 | 2018-03-29 | ㈜프로스테믹스 | 면역 억제 및 항염증성 조성물 |
| US11958886B2 (en) | 2016-12-07 | 2024-04-16 | University Of Florida Research Foundation, Incorporated | IL-1RA cDNAs |
| CN108175759B (zh) * | 2016-12-08 | 2021-03-19 | 暨南大学 | 一种抗肿瘤靶向给药系统及其制备方法与应用 |
| EA038300B1 (ru) * | 2017-04-18 | 2021-08-06 | Юниверсити Оф Флорида Рисерч Фаундейшен, Инкорпорейтед | Кднк il-1ra |
| CN108619114B (zh) * | 2018-05-02 | 2020-08-11 | 东南大学 | 一种负载地塞米松的巨噬细胞源微囊泡及其制备方法和应用 |
| CN109078171A (zh) * | 2018-09-10 | 2018-12-25 | 因之彩生物科技（武汉）有限公司 | 一种外用组合物及其应用以及外用治疗剂 |
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