DK2363139T3 - Fremgangsmåde til at øge klasse I-præsentation af eksogene antigener gennem humane dendritiske celler - Google Patents
Fremgangsmåde til at øge klasse I-præsentation af eksogene antigener gennem humane dendritiske celler Download PDFInfo
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- DK2363139T3 DK2363139T3 DK10180857.4T DK10180857T DK2363139T3 DK 2363139 T3 DK2363139 T3 DK 2363139T3 DK 10180857 T DK10180857 T DK 10180857T DK 2363139 T3 DK2363139 T3 DK 2363139T3
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4648—Bacterial antigens
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
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- Developmental Biology & Embryology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Claims (5)
1. Fremgangsmåde til at fremme behandling med Major Histocompatability Complex (MHC) af klasse I af et opløseligt antigen gennem humane dendriti-ske celler (DC), hvor de nævnte DC udsættes, in vitro, for et virusantigen, et bakterieantigen, et vævsspecifikt antigen, eller antigenfragmenter deraf, i tilstedeværelse af bacillus Calmette Guerin (BCG) eller BCG med lipopo-lysaccharid (LPS) som en faktor eller et middel, der fremmer MHC-klasse I-behandling af antigenet.
2. Fremgangsmåde ifølge krav 1, i hvilken antigenet er et virusneutraliseringsantigen, eller et antigenfragment deraf.
3. Fremgangsmåde ifølge krav 1 og krav 2, i hvilken de humane DC blev opnået fra hudens epidermis, milt, knoglemarv, thymus, lymfeknude, navlesnorsblod eller perifert blod.
4. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 3, i hvilken de dendritiske celler er dendritiske celler med forlænget levetid.
5. Fremgangsmåde til fremstilling af en højere procentdel af aktiverede CD8+ T-celler in vitro ved (a) at tilvejebringe isolerede DC, som er blevet udsat for BCG eller BCG og LPS og et opløseligt antigen omfattende et virusantigen, et bakterieantigen, et vævsspecifikt antigen eller antigenfragmenter deraf, og (b) at inkubere ikke-primede T-celler in vitro med de nævnte DC, så der fremstilles en højere procentdel af CD8+ T-celler, end når ikke-primede T-celler inkuberes med DC, der alene har været udsat for antigen.
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| EP01933328A EP1292321B1 (en) | 2000-05-12 | 2001-05-11 | Method to increase class i presentation of exogenous antigens by human dendritic cells |
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| DK10180857.4T DK2363139T3 (da) | 2000-05-12 | 2001-05-11 | Fremgangsmåde til at øge klasse I-præsentation af eksogene antigener gennem humane dendritiske celler |
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| EP (2) | EP2363139B1 (da) |
| JP (4) | JP4841794B2 (da) |
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| AU2001259760B2 (en) * | 2000-05-12 | 2006-10-05 | Northwest Biotherapeutics, Inc. | Method to increase class I presentation of exogenous antigens by human dendritic cells |
| JP2005505270A (ja) * | 2001-09-06 | 2005-02-24 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法 |
| AU2013201707B2 (en) * | 2001-09-06 | 2017-04-27 | Northwest Biotherapeutics, Inc. | Compositions and methods for priming monocytic dendritic cells and T cells for Th-1 response |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| EP2360169B1 (en) | 2001-10-23 | 2015-10-14 | Psma Development Company, L.L.C. | PSMA antibodies |
| ES2337454T3 (es) * | 2001-11-30 | 2010-04-26 | The Government Of The Usa, As Represented By The Secretary Department Of Health And Human Services | Peptidos agonistas de antigenos especificos de la protasa, y usos de los mismos. |
| JP4624377B2 (ja) * | 2001-12-10 | 2011-02-02 | 株式会社グリーンペプタイド | 腫瘍抗原 |
| EP2189470A1 (en) * | 2001-12-10 | 2010-05-26 | Green Peptide Co., Ltd. | Tumor antigens |
| US20110189093A1 (en) * | 2008-04-14 | 2011-08-04 | Proscan Rx Pharma | Prostate specific membrane antigen antibodies and antigen binding fragments |
| WO2009155332A1 (en) * | 2008-06-17 | 2009-12-23 | Cedars-Sinai Medical Center | Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors |
| PT2326350E (pt) | 2008-09-08 | 2013-12-10 | Psma Dev Company L L C | Compostos para matar células cancerosas resistentes a taxano, que expressam psma |
| WO2010065876A2 (en) * | 2008-12-06 | 2010-06-10 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to th-1 dendritic cells |
| WO2010096693A2 (en) * | 2009-02-19 | 2010-08-26 | Mayo Foundation For Medical Education And Research | Methods and materials for generating t cells |
| WO2011084479A1 (en) * | 2009-12-15 | 2011-07-14 | Immuneregen Biosciences, Inc. | Substance p and analogs thereof as adjuvant therapy for adoptive cellular immunotherapy |
| RU2530523C2 (ru) * | 2012-03-29 | 2014-10-10 | Олег Борисович Егоров | Способ противоопухолевой иммунотерапии |
| KR101985769B1 (ko) | 2013-03-15 | 2019-06-04 | 동우 화인켐 주식회사 | 마스크리스 디지털 노광 방식을 통한 컬러 필터의 제조 방법 |
| GB201315321D0 (en) * | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
| EA035259B1 (ru) * | 2014-02-14 | 2020-05-21 | Иммьюн Дизайн Корп. | Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции |
| DE102015106810A1 (de) | 2015-04-30 | 2016-11-03 | Infineon Technologies Ag | Implantierbare Vorrichtung und implantierbares System mit dieser |
| CN114246942A (zh) * | 2020-09-24 | 2022-03-29 | 刘慧宁 | 肿瘤复合抗原、树突状细胞多价疫苗及其应用 |
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| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5162504A (en) | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
| CA2051092C (en) | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| US5227471A (en) | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
| ES2215991T3 (es) * | 1992-04-01 | 2004-10-16 | The Rockefeller University | Procedimiento para la proliferacion (in vitro) de precursores de celulas dendriticas y su uso para producir inmunogenos. |
| WO1994002156A1 (en) | 1992-07-16 | 1994-02-03 | The Board Of Trustees Of Leland Stanford Junior University | Methods for using dendritic cells to activate t cells |
| JP3908271B2 (ja) * | 1993-03-05 | 2007-04-25 | エピミューン，インコーポレイティド | Ｈｌａ−ａ２．１結合ペプチドおよびそれらの使用 |
| US5788963A (en) * | 1995-07-31 | 1998-08-04 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| US6130087A (en) | 1996-10-07 | 2000-10-10 | Fordham University | Methods for generating cytotoxic T cells in vitro |
| IL125608A0 (en) * | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
| JP2003535024A (ja) * | 1999-06-29 | 2003-11-25 | エピミューン インコーポレイテッド | Ｈｌａ結合ペプチドおよびそれらの使用 |
| AU2001259760B2 (en) * | 2000-05-12 | 2006-10-05 | Northwest Biotherapeutics, Inc. | Method to increase class I presentation of exogenous antigens by human dendritic cells |
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- 2001-05-11 NZ NZ522807A patent/NZ522807A/en not_active IP Right Cessation
- 2001-05-11 DK DK01933328.5T patent/DK1292321T3/da active
- 2001-05-11 IL IL15265501A patent/IL152655A0/xx unknown
- 2001-05-11 WO PCT/US2001/015428 patent/WO2001087325A1/en active Application Filing
- 2001-05-11 ES ES10180857T patent/ES2571979T3/es not_active Expired - Lifetime
- 2001-05-11 AT AT01933328T patent/ATE530193T1/de active
- 2001-05-11 EP EP10180857.4A patent/EP2363139B1/en not_active Expired - Lifetime
- 2001-05-11 DK DK10180857.4T patent/DK2363139T3/da active
- 2001-05-11 EP EP01933328A patent/EP1292321B1/en not_active Expired - Lifetime
- 2001-05-11 US US09/854,248 patent/US20030175247A1/en not_active Abandoned
- 2001-05-11 ES ES01933328T patent/ES2375948T3/es not_active Expired - Lifetime
- 2001-05-11 CA CA002407104A patent/CA2407104A1/en not_active Abandoned
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2002
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2007
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2008
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2011
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2012
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2013
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2014
- 2014-02-23 IL IL231081A patent/IL231081A/en not_active IP Right Cessation
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2015
- 2015-03-03 JP JP2015040909A patent/JP2015108018A/ja active Pending
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2016
- 2016-10-25 IL IL248493A patent/IL248493A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003533486A (ja) | 2003-11-11 |
| EP2363139B1 (en) | 2016-03-02 |
| US20030175247A1 (en) | 2003-09-18 |
| ATE530193T1 (de) | 2011-11-15 |
| IL152655A0 (en) | 2003-06-24 |
| ES2375948T3 (es) | 2012-03-07 |
| JP2015108018A (ja) | 2015-06-11 |
| JP2014001244A (ja) | 2014-01-09 |
| DK1292321T3 (da) | 2012-01-30 |
| EP1292321A4 (en) | 2005-09-21 |
| AU2001259760B2 (en) | 2006-10-05 |
| WO2001087325A1 (en) | 2001-11-22 |
| HK1161977A1 (zh) | 2012-08-17 |
| IL248493A0 (en) | 2016-11-30 |
| IL152655A (en) | 2014-03-31 |
| IL231081A0 (en) | 2014-03-31 |
| IL231081A (en) | 2016-11-30 |
| AU5976001A (en) | 2001-11-26 |
| CA2407104A1 (en) | 2001-11-22 |
| EP1292321A1 (en) | 2003-03-19 |
| EP1292321B1 (en) | 2011-10-26 |
| EP2363139A1 (en) | 2011-09-07 |
| AU2007200049A1 (en) | 2007-01-25 |
| JP4841794B2 (ja) | 2011-12-21 |
| US20080171023A1 (en) | 2008-07-17 |
| JP2011225628A (ja) | 2011-11-10 |
| NZ522807A (en) | 2004-11-26 |
| ES2571979T3 (es) | 2016-05-27 |
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