DK2332533T3 - Cannabinoidholdige planteekstrakter som neurobeskyttelsesmidler - Google Patents
Cannabinoidholdige planteekstrakter som neurobeskyttelsesmidler Download PDFInfo
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- DK2332533T3 DK2332533T3 DK10189019.2T DK10189019T DK2332533T3 DK 2332533 T3 DK2332533 T3 DK 2332533T3 DK 10189019 T DK10189019 T DK 10189019T DK 2332533 T3 DK2332533 T3 DK 2332533T3
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- cannabinoid
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- cbd
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
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- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (1)
1. Planteekstrakt af Cannabis sativa L, der enten omfatter: a) et ekstrakt, hvor et større cannabinoid er tetrahydrocannabinol (THC) og ekstraktet omfatter (vægt/vægt ekstrakt) i) 63,0 - 78,0 % THC, 0,1 - 2,5 % cannabidiol, 1,0 - 2,0 % cannabigerol, 0,8 - 2,2 % cannabichromen, 0,4 - 1,0 % tetrahydrocannabivarin, og < 2,0 % tetrahydrocannabinolsyre og ii) < 6,0 % terpener indbefattende monoterpener; di/tri-terpener; sesquiterpener; og andre terpener og 6,3 - 26,7 % steroler; triglycerider; alkaner; squalen; tocopherol og carotenoider eller b) et ekstrakt, hvor et større cannabinoid er cannabidiol (CBD) og ekstraktet omfatter (vægt/vægt ekstrakt) i) 57,0 - 72,0 % CBD, 2,0 - 6,5 % THC, 0,8 - 6,5 % cannabigerol, 3,0 - 6,5 % cannabichromen, 1,0 - 2,0 % cannabidivarin og < 2,0 % cannabidiolsyre og ii) <5,8% terpener indbefattende monoterpener; di/tri-terpener; sesquiterpener og andre terpener, og 1,7 - 28,4 % steroler; triglycerider; alkaner; squalen; tocopherol og carotenoider; og hvor forholdet mellem den cannabinoidholdige fraktion (i) og den ikke-cannabinoidholdige fraktion (ii) er mellem 60:40 og 90:10 af det totale ekstrakt.
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GB0601013A GB2434312B (en) | 2006-01-18 | 2006-01-18 | Cannabinoid-containing plant extracts as neuroprotective agents |
EP07704916.1A EP1976506B1 (en) | 2006-01-18 | 2007-01-17 | Cannabinoid-containing plant extracts as neuroprotective agents |
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DK07704916.1T DK1976506T3 (da) | 2006-01-18 | 2007-01-17 | Cannabinoid-holdige planteekstrakter som neuroprotektorer |
DK10189019.2T DK2332533T3 (da) | 2006-01-18 | 2007-01-17 | Cannabinoidholdige planteekstrakter som neurobeskyttelsesmidler |
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DK07704916.1T DK1976506T3 (da) | 2006-01-18 | 2007-01-17 | Cannabinoid-holdige planteekstrakter som neuroprotektorer |
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US (2) | US8673368B2 (da) |
EP (2) | EP1976506B1 (da) |
CA (1) | CA2636634C (da) |
CY (2) | CY1121136T1 (da) |
DK (2) | DK1976506T3 (da) |
ES (2) | ES2698370T3 (da) |
GB (1) | GB2434312B (da) |
HU (2) | HUE046388T2 (da) |
LT (2) | LT2332533T (da) |
PL (2) | PL2332533T3 (da) |
PT (2) | PT1976506T (da) |
SI (2) | SI1976506T1 (da) |
WO (1) | WO2007083098A1 (da) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2434312B (en) | 2006-01-18 | 2011-06-29 | Gw Pharma Ltd | Cannabinoid-containing plant extracts as neuroprotective agents |
GB2450753B (en) * | 2007-07-06 | 2012-07-18 | Gw Pharma Ltd | New Pharmaceutical formulation |
GB2451254A (en) * | 2007-07-24 | 2009-01-28 | Gw Pharma Ltd | Cannabidiol for use in the treatment of neurodegenerative conditions |
EP2341903A1 (en) * | 2008-07-31 | 2011-07-13 | Bionorica Research GmbH | Cannabinoids for use in treating or preventing cognitive impairment and dementia |
GB2471523A (en) | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
GB2478595B (en) * | 2010-03-12 | 2018-04-04 | Gw Pharma Ltd | Phytocannabinoids in the treatment of glioma |
GB2487183B (en) * | 2011-01-04 | 2018-10-03 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy |
TWI583374B (zh) | 2010-03-30 | 2017-05-21 | Gw伐瑪有限公司 | 使用植物大麻素次大麻二酚(cbdv)來治療癲癇之用途 |
GB2479153B (en) * | 2010-03-30 | 2014-03-19 | Gw Pharma Ltd | The phytocannabinoid cannabidivarin (CBDV) for use in the treatment of epilepsy |
US8445034B1 (en) | 2010-11-02 | 2013-05-21 | Albert L Coles, Jr. | Systems and methods for producing organic cannabis tincture |
GB201111261D0 (en) * | 2011-07-01 | 2011-08-17 | Gw Pharma Ltd | Cannabinoids for use in the treatment of neuro-degenerative diseases or disorders |
GB2514054A (en) | 2011-09-29 | 2014-11-12 | Gw Pharma Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
GB2504263B (en) | 2012-06-08 | 2015-09-16 | Gw Pharma Ltd | Synergistic therapies for neuroprotection |
US20150313868A1 (en) | 2012-12-18 | 2015-11-05 | Kotzker Consulting Llc | Use of cannabinoids and terpenes for treatment of organophosphate and carbamate toxicity |
AU2014223458A1 (en) | 2013-02-28 | 2015-10-15 | Full Spectrum Laboratories Limited | Biosynthesis of cannabinoids |
EP4137142A1 (en) * | 2013-03-14 | 2023-02-22 | Purple Mundo, Inc. | Bioactive concentrates and uses thereof |
US9380813B2 (en) | 2014-02-11 | 2016-07-05 | Timothy McCullough | Drug delivery system and method |
US10821240B2 (en) | 2014-02-11 | 2020-11-03 | Vapor Cartridge Technology Llc | Methods and drug delivery devices using cannabis |
US9220294B2 (en) | 2014-02-11 | 2015-12-29 | Timothy McCullough | Methods and devices using cannabis vapors |
GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
GB2527599A (en) | 2014-06-27 | 2015-12-30 | Gw Pharma Ltd | Use of 7-OH-Cannabidiol (7-OH-CBD) and/or 7-OH-Cannabidivarin (7-OH-CBDV) in the treatment of epilepsy |
US11293038B2 (en) | 2014-07-14 | 2022-04-05 | Librede Inc. | Production of cannabinoids in yeast |
US9822384B2 (en) | 2014-07-14 | 2017-11-21 | Librede Inc. | Production of cannabinoids in yeast |
US9394510B2 (en) | 2014-08-25 | 2016-07-19 | Full Spectrum Laboratories Limited | Apparatus and methods for the simultaneous production of compounds |
GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
CA3135893C (en) | 2014-10-21 | 2023-11-14 | United Cannabis Corp. | Cannabis extracts and methods of preparing and using same |
GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
GB2541191A (en) | 2015-08-10 | 2017-02-15 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
RU2701565C1 (ru) * | 2015-10-16 | 2019-09-30 | Импакт Биосайенсес Корп. | Способы и композиции для лечения черепно-мозговой травмы |
WO2017093986A1 (en) * | 2015-12-05 | 2017-06-08 | Canabuzz-Med | Veterinary composition and methods for production and use |
US11191794B1 (en) | 2016-02-08 | 2021-12-07 | Jeff Nordahl | Packaged hemp products formed from raw cannabis |
US9956173B1 (en) | 2016-02-08 | 2018-05-01 | Jeff Nordahl | Packaged frozen cubes of cannabis juice purée that are non-psychoactive |
US11172698B1 (en) | 2016-02-08 | 2021-11-16 | Jeff Nordahl | Pasteurized juice formed from raw cannabis |
US11779622B1 (en) | 2016-02-08 | 2023-10-10 | Jeff Nordahl | Packaged raw cannabis powder |
IL307857A (en) * | 2016-03-16 | 2023-12-01 | Buzzelet Development And Technologies Ltd | Cannobinoid compounds are rich in terpenes |
GB2548873B (en) | 2016-03-31 | 2020-12-02 | Gw Res Ltd | Use of Cannabidiol in the Treatment of SturgeWeber Syndrome |
GB2549278B (en) | 2016-04-11 | 2021-02-17 | Gw Res Ltd | Use of cannabidivarin in the treatment of autism spectrum disorder |
GB2549277B (en) * | 2016-04-11 | 2021-02-17 | Gw Res Ltd | Cannabidiolic Acid for use in the Treatment of Autism Spectrum Disorder |
US10499584B2 (en) | 2016-05-27 | 2019-12-10 | New West Genetics | Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles |
WO2018000094A1 (en) | 2016-06-29 | 2018-01-04 | CannScience Innovations Inc. | Decarboxylated cannabis resins, uses thereof and methods of making same |
US9717683B1 (en) | 2016-06-29 | 2017-08-01 | Ep Pharma, Llc | Low-temperature inhalation administration of cannabinoid entities |
GB2551987A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Oral cannabinoid formulations |
GB2551986A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Parenteral formulations |
GB2553139A (en) | 2016-08-25 | 2018-02-28 | Gw Res Ltd | Use of cannabinoids in the treatment of multiple myeloma |
CA3077624A1 (en) | 2016-10-01 | 2018-04-05 | James Smeeding | Pharmaceutical compositions comprising a statin and a cannabinoid and uses thereof |
WO2018071452A1 (en) * | 2016-10-11 | 2018-04-19 | Growblox Life Sciences L.L.C. | Cannabinoid-containing complex mixtures for the treatment of neurodegenerative diseases |
US10239808B1 (en) * | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
GB2557921A (en) | 2016-12-16 | 2018-07-04 | Gw Res Ltd | Use of cannabinoids in the treatment of angelman syndrome |
AU2018215200B2 (en) | 2017-02-01 | 2022-12-15 | Gbs Global Biopharma, Inc. | Cannabinoid-containing complex mixtures for the treatment of mast cell-associated or basophil-mediated inflammatory disorders |
CA3053187A1 (en) * | 2017-02-09 | 2018-08-16 | Bodhi Research & Development Inc. | Cannabinoid-containing fatty acid formulations for treating disorders of the nervous system |
GB2559774B (en) | 2017-02-17 | 2021-09-29 | Gw Res Ltd | Oral cannabinoid formulations |
EP3600361A4 (en) | 2017-03-24 | 2021-01-06 | Trait Biosciences, Inc. | HIGH LEVEL IN VIVO BIOSYNTHESIS AND ISOLATION OF WATER-SOLUBLE CANNABINOIDS IN PLANT SYSTEMS |
CN107137605A (zh) * | 2017-03-27 | 2017-09-08 | 昭通天麻产业开发有限公司 | 一种由乌天麻提取物和植物大麻提取物及口服载体组成的组合物 |
WO2018205038A1 (en) * | 2017-05-12 | 2018-11-15 | Tetra Bio-Pharma Inc. | Compositions comprising cannabinoids and terpenes useful in the treatment of cancer and vascular ocular disorders via inhibition of hedgehog signalling |
US11946059B2 (en) | 2017-07-11 | 2024-04-02 | Trait Biosciences, Inc. | In vivo generation of water-soluble cannabinoids in plant cell suspension cultures |
US11905543B2 (en) | 2017-07-11 | 2024-02-20 | Trait Biosceinces, Inc. | In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures |
AU2018301674B2 (en) | 2017-07-11 | 2024-03-28 | Trait Biosciences, Inc. | Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter |
GB2564459B (en) | 2017-07-12 | 2022-03-09 | Gw Res Ltd | Use of cannabinoids in the treatment of a neurodegenerative disease or disorder |
US10272360B2 (en) | 2017-08-05 | 2019-04-30 | Priya Naturals, Inc. | Phytochemical extraction system and methods to extract phytochemicals from plants including plants of the family Cannabaceae sensu stricto |
EP3687527A4 (en) * | 2017-09-25 | 2021-05-26 | Canopy Health Innovations | COMPOSITIONS CONSISTING OF CANNABIDIOL, TETRAHYDROCANNABINOL, TERPENES AND FLAVONOIDS AND THEIR USE IN THE TREATMENT OF INSOMNIA |
US20190183849A1 (en) * | 2017-10-21 | 2019-06-20 | Alexander Kariman | Compound and method for treatment of diseases and disorders |
US10307392B2 (en) * | 2017-10-21 | 2019-06-04 | Alexander Kariman | Compound and method for treatment of diseases and disorders |
US10722545B2 (en) | 2018-01-01 | 2020-07-28 | Alexander Kariman | Compound and method for treatment of movement disorders |
GB2569961B (en) | 2018-01-03 | 2021-12-22 | Gw Res Ltd | Pharmaceutical |
CA3089994A1 (en) | 2018-01-31 | 2019-08-08 | Canopy Holdings, LLC | Hemp powder |
MX2020010284A (es) * | 2018-03-30 | 2021-02-18 | India Globalization Capital Inc | Método y composición para el tratamiento de los trastornos del snc. |
GB201806953D0 (en) | 2018-04-27 | 2018-06-13 | Gw Res Ltd | Cannabidiol Preparations |
US20200035118A1 (en) | 2018-07-27 | 2020-01-30 | Joseph Pandolfino | Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes |
US10897925B2 (en) | 2018-07-27 | 2021-01-26 | Joseph Pandolfino | Articles and formulations for smoking products and vaporizers |
EP3864000A4 (en) | 2018-10-10 | 2022-08-10 | Treehouse Biosciences, Inc. | CANNABIGEROL SYNTHESIS |
EP3876702A4 (en) * | 2018-11-09 | 2022-09-21 | Agriculture Victoria Services Pty Ltd | CANNABIS PLANTS WITH A CANNABINOID PROFILE ENRICHED WITH D-9-TETRAHYDROCANNABINOL AND CANNABIGEROL |
WO2020093170A1 (en) * | 2018-11-09 | 2020-05-14 | Cronos Group Inc. | Liquid composition for an electronic vapor device |
KR102445087B1 (ko) | 2019-05-03 | 2022-09-20 | 자이우스 라이프 사이언시스 아이엔씨. | 통증 관리용 제형 |
GB2584341B (en) | 2019-05-31 | 2023-03-01 | Gw Res Ltd | Cannabinoid formulations |
WO2021055079A1 (en) | 2019-09-16 | 2021-03-25 | Vapor Cartridge Technology Llc | Drug delivery system with stackable substrates |
US12016829B2 (en) | 2019-10-11 | 2024-06-25 | Pike Therapeutics Inc. | Pharmaceutical composition and method for treating seizure disorders |
CA3155181A1 (en) | 2019-10-14 | 2021-04-22 | Pike Therapeutics, Inc., 1219014 B.C. Ltd. | Transdermal delivery of cannabidiol |
GB202002754D0 (en) | 2020-02-27 | 2020-04-15 | Gw Res Ltd | Methods of treating tuberous sclerosis complex with cannabidiol and everolimus |
EP4121164A1 (en) * | 2020-03-17 | 2023-01-25 | Tauriga Sciences Inc. | Medicated cannabinoid compositions, methods of manufacturing, and methods of treatment |
US11160757B1 (en) | 2020-10-12 | 2021-11-02 | GW Research Limited | pH dependent release coated microparticle cannabinoid formulations |
KR20220084761A (ko) * | 2020-12-14 | 2022-06-21 | 강원대학교산학협력단 | 헴프 껍질 추출물을 포함하는 인지기능 개선용 조성물 |
CN113368086B (zh) * | 2021-08-11 | 2021-12-03 | 龙麻(上海)医药研发有限责任公司 | 一种大麻素组合物及其在制备治疗帕金森、阿尔茨海默等神经退行性疾病的药物中的应用 |
WO2023200906A1 (en) | 2022-04-12 | 2023-10-19 | Shackelford Pharma Inc. | Treatment of seizure disorders |
WO2024033521A1 (en) | 2022-08-12 | 2024-02-15 | GW Research Limited | Oral solid dosage forms comprising cannabinoids |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2337633B (en) | 1998-05-20 | 2003-04-02 | Mitel Corp | Method of forming capacitors in a semiconductor device |
DE10051427C1 (de) | 2000-10-17 | 2002-06-13 | Adam Mueller | Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte |
EP1361864B9 (en) | 2001-02-14 | 2014-07-09 | GW Pharma Limited | Liquid spray formulations for buccal delivery of cannabinoids |
CH695661A5 (de) * | 2001-03-06 | 2006-07-31 | Forsch Hiscia Ver Fuer Krebsfo | Pharmazeutische Zusammensetzung. |
GB2377218A (en) | 2001-05-04 | 2003-01-08 | Gw Pharmaceuticals Ltd | Process and apparatus for extraction of active substances and enriched extracts from natural products |
GB2381450B (en) * | 2001-10-31 | 2006-05-31 | Gw Pharma Ltd | Compositions for administration of natural or synthetic cannabinoids by vaporisation |
DE10226494A1 (de) | 2002-06-14 | 2004-01-08 | Lts Lohmann Therapie-Systeme Ag | Filmförmige mucoadhäsive Darreichungsformen zur Verabreichung von Cannabis-Wirkstoffen |
AU2003253005B2 (en) * | 2002-08-14 | 2009-03-19 | GW Research Limited | Cannabinoid liquid formulations for mucosal administration |
GB2391865B (en) | 2002-08-14 | 2005-06-01 | Gw Pharma Ltd | Improvements in the extraction of pharmaceutically active components from plant materials |
US6946150B2 (en) | 2002-08-14 | 2005-09-20 | Gw Pharma Limited | Pharmaceutical formulation |
GB2392093B (en) * | 2002-08-14 | 2006-03-08 | Gw Pharma Ltd | Pharmaceutical formulations |
WO2004100893A2 (en) * | 2003-05-12 | 2004-11-25 | Indevus Pharmaceuticals, Inc. | Methods for treatment of inflammatory diseases using ct-3 or analogs thereof |
AU2005305675B2 (en) * | 2004-11-16 | 2012-12-13 | Gw Pharma Limited | New use for cannabinoid |
GB2434312B (en) | 2006-01-18 | 2011-06-29 | Gw Pharma Ltd | Cannabinoid-containing plant extracts as neuroprotective agents |
WO2008024490A2 (en) | 2006-08-24 | 2008-02-28 | Theraquest Biosciences, Inc. | Oral pharmaceutical formulations of abuse deterrent cannabinoids and method of use |
GB2450493A (en) | 2007-06-25 | 2008-12-31 | Gw Pharma Ltd | Cannabigerol for use in treatment of diseases benefiting from agonism of CB1 and CB2 cannabinoid receptors |
GB2479153B (en) | 2010-03-30 | 2014-03-19 | Gw Pharma Ltd | The phytocannabinoid cannabidivarin (CBDV) for use in the treatment of epilepsy |
GB201111261D0 (en) | 2011-07-01 | 2011-08-17 | Gw Pharma Ltd | Cannabinoids for use in the treatment of neuro-degenerative diseases or disorders |
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Publication number | Publication date |
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PT1976506T (pt) | 2019-10-15 |
GB0601013D0 (en) | 2006-03-01 |
EP2332533B1 (en) | 2018-08-22 |
CA2636634A1 (en) | 2007-07-26 |
ES2746973T3 (es) | 2020-03-09 |
SI2332533T1 (sl) | 2019-02-28 |
EP1976506B1 (en) | 2019-06-26 |
CA2636634C (en) | 2017-07-11 |
EP1976506A1 (en) | 2008-10-08 |
EP2332533A1 (en) | 2011-06-15 |
SI1976506T1 (sl) | 2019-11-29 |
LT2332533T (lt) | 2018-12-27 |
GB2434312B (en) | 2011-06-29 |
CY1122076T1 (el) | 2020-11-25 |
US9205063B2 (en) | 2015-12-08 |
WO2007083098A1 (en) | 2007-07-26 |
HUE046388T2 (hu) | 2020-03-30 |
CY1121136T1 (el) | 2020-05-29 |
ES2698370T3 (es) | 2019-02-04 |
PL1976506T3 (pl) | 2020-01-31 |
GB2434312A (en) | 2007-07-25 |
US20140377382A1 (en) | 2014-12-25 |
HUE041959T2 (hu) | 2019-06-28 |
US8673368B2 (en) | 2014-03-18 |
US20100239693A1 (en) | 2010-09-23 |
DK1976506T3 (da) | 2019-10-07 |
PT2332533T (pt) | 2018-11-29 |
LT1976506T (lt) | 2019-10-10 |
PL2332533T3 (pl) | 2019-02-28 |
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