DK2327414T3 - Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme - Google Patents

Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme Download PDF

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Publication number
DK2327414T3
DK2327414T3 DK10011421.4T DK10011421T DK2327414T3 DK 2327414 T3 DK2327414 T3 DK 2327414T3 DK 10011421 T DK10011421 T DK 10011421T DK 2327414 T3 DK2327414 T3 DK 2327414T3
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Prior art keywords
sulfatase
acetylgalactosamine
precursor
human
purity
Prior art date
Application number
DK10011421.4T
Other languages
Danish (da)
English (en)
Inventor
Minmin Qin
Wai-Pan Chan
Lin Chen
Stuart Swiedler
John M Henstrand
Gary N Zecherle
Dan J Wendt
Paul A Fitzpatrick
Christopher M Starr
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Application granted granted Critical
Publication of DK2327414T3 publication Critical patent/DK2327414T3/en

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • B01D15/327Reversed phase with hydrophobic interaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • B01D15/3828Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/06Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06012N-Acetylgalactosamine-4-sulfatase (3.1.6.12)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
DK10011421.4T 2002-11-07 2003-11-07 Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme DK2327414T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/290,908 US6866844B2 (en) 2002-11-07 2002-11-07 Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
EP03783223.5A EP1565209B1 (en) 2002-11-07 2003-11-07 Precursor n-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme

Publications (1)

Publication Number Publication Date
DK2327414T3 true DK2327414T3 (en) 2015-04-13

Family

ID=32312121

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10011421.4T DK2327414T3 (en) 2002-11-07 2003-11-07 Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme

Country Status (17)

Country Link
US (1) US6866844B2 (cg-RX-API-DMAC7.html)
EP (2) EP2327414B1 (cg-RX-API-DMAC7.html)
JP (1) JP4459059B2 (cg-RX-API-DMAC7.html)
CN (1) CN100374157C (cg-RX-API-DMAC7.html)
AR (1) AR042019A1 (cg-RX-API-DMAC7.html)
AU (1) AU2003290642B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0316039B1 (cg-RX-API-DMAC7.html)
CA (1) CA2502928C (cg-RX-API-DMAC7.html)
CY (1) CY1116164T1 (cg-RX-API-DMAC7.html)
DK (1) DK2327414T3 (cg-RX-API-DMAC7.html)
ES (2) ES2533770T3 (cg-RX-API-DMAC7.html)
IL (1) IL168435A (cg-RX-API-DMAC7.html)
MX (1) MXPA05004880A (cg-RX-API-DMAC7.html)
PT (2) PT2327414E (cg-RX-API-DMAC7.html)
SI (1) SI2327414T1 (cg-RX-API-DMAC7.html)
TW (1) TWI327919B (cg-RX-API-DMAC7.html)
WO (1) WO2004043373A2 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972124B2 (en) * 2000-05-01 2005-12-06 Biomarin Pharmaceuticals Inc. Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
JP2009529885A (ja) * 2006-03-17 2009-08-27 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム酵素に対する抗体の検出のためのアッセイ
CN101539550B (zh) * 2009-04-28 2012-05-23 李绍平 用于多糖的定性与定量分析方法
CN103282046B (zh) 2010-06-25 2015-05-13 夏尔人类遗传性治疗公司 芳基硫酸酯酶 a cns 递送的方法和组合物
UA129740C2 (uk) 2010-06-25 2025-07-23 Такеда Фармасьютікал Компані Лімітед Застосування композиції, що включає білок арилсульфатази а (аса)
WO2012022688A1 (de) * 2010-08-20 2012-02-23 Boehringer Ingelheim International Gmbh Verfahren zur inaktivierung von proteasen in einer aus einer zellkultur gewonnen flüssigkeit durch ph änderung
WO2013094579A1 (ja) 2011-12-20 2013-06-27 日本ケミカルリサーチ株式会社 ホルミルグリシン残基の分析法
WO2013096899A2 (en) 2011-12-23 2013-06-27 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
WO2015035180A1 (en) 2013-09-05 2015-03-12 Genentech, Inc. Method for chromatography reuse
FR3011468B1 (fr) * 2013-10-04 2015-12-04 Inventiva Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose
KR102286260B1 (ko) 2017-08-31 2021-08-05 주식회사 녹십자 설파타아제 단백질을 정제하는 방법
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281225A (cg-RX-API-DMAC7.html) 1961-07-20
US3472931A (en) 1969-01-17 1969-10-14 Foster Milburn Co Percutaneous absorption with lower alkyl amides
US3891757A (en) 1971-11-11 1975-06-24 Alza Corp Anaesthetic topical and percutaneous administration with selected promoters
SE387536B (sv) 1973-03-13 1976-09-13 Astra Laekemedel Ab Forfarande for framstellning av en lokalanestetisk beredning
WO2001083722A2 (en) 2000-05-01 2001-11-08 Biomarin Pharmaceuticals Enzymes useful for treating and methods for treating mps-vi and cells lines for producing such enzymes recombinantly

Also Published As

Publication number Publication date
CA2502928C (en) 2013-07-16
AU2003290642B2 (en) 2008-07-10
CN1726046A (zh) 2006-01-25
CN100374157C (zh) 2008-03-12
WO2004043373A3 (en) 2004-08-05
CA2502928A1 (en) 2004-05-27
TWI327919B (en) 2010-08-01
US6866844B2 (en) 2005-03-15
BRPI0316039B1 (pt) 2017-08-29
JP2006510356A (ja) 2006-03-30
HK1157215A1 (en) 2012-06-29
EP1565209B1 (en) 2013-11-06
TW200427459A (en) 2004-12-16
WO2004043373A2 (en) 2004-05-27
JP4459059B2 (ja) 2010-04-28
US20040101524A1 (en) 2004-05-27
AU2003290642A1 (en) 2004-06-03
ES2533770T3 (es) 2015-04-15
EP1565209A4 (en) 2008-01-02
AR042019A1 (es) 2005-06-08
PT2327414E (pt) 2015-04-13
PT1565209E (pt) 2014-02-13
BRPI0316039B8 (cg-RX-API-DMAC7.html) 2021-05-25
EP1565209A2 (en) 2005-08-24
EP2327414B1 (en) 2015-01-07
ES2445028T3 (es) 2014-02-27
CY1116164T1 (el) 2017-02-08
IL168435A (en) 2014-07-31
EP2327414A1 (en) 2011-06-01
MXPA05004880A (es) 2005-07-22
BR0316039A (pt) 2005-09-13
SI2327414T1 (sl) 2015-05-29

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