PT1565209E - Percursor n-acetilgalactosamina-4-sulfatase, métodos de tratamento utilizando a dita enzima e métodos para produzir e purificar a dita enzima - Google Patents

Percursor n-acetilgalactosamina-4-sulfatase, métodos de tratamento utilizando a dita enzima e métodos para produzir e purificar a dita enzima Download PDF

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Publication number
PT1565209E
PT1565209E PT37832235T PT03783223T PT1565209E PT 1565209 E PT1565209 E PT 1565209E PT 37832235 T PT37832235 T PT 37832235T PT 03783223 T PT03783223 T PT 03783223T PT 1565209 E PT1565209 E PT 1565209E
Authority
PT
Portugal
Prior art keywords
enzyme
methods
sulfatase
acetylgalactosamine
purifying
Prior art date
Application number
PT37832235T
Other languages
English (en)
Inventor
Minmin Qin
John M Henstrand
Gary N Zecherle
Dan J Wendt
Wai-Pan Chan
Lin Chen
Paul A Fitzpatrick
Christopher M Starr
Stuart Swiedler
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of PT1565209E publication Critical patent/PT1565209E/pt

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06012—N-Acetylgalactosamine-4-sulfatase (3.1.6.12)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
PT37832235T 2002-11-07 2003-11-07 Percursor n-acetilgalactosamina-4-sulfatase, métodos de tratamento utilizando a dita enzima e métodos para produzir e purificar a dita enzima PT1565209E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/290,908 US6866844B2 (en) 2002-11-07 2002-11-07 Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme

Publications (1)

Publication Number Publication Date
PT1565209E true PT1565209E (pt) 2014-02-13

Family

ID=32312121

Family Applications (2)

Application Number Title Priority Date Filing Date
PT37832235T PT1565209E (pt) 2002-11-07 2003-11-07 Percursor n-acetilgalactosamina-4-sulfatase, métodos de tratamento utilizando a dita enzima e métodos para produzir e purificar a dita enzima
PT100114214T PT2327414E (pt) 2002-11-07 2003-11-07 Mecanismo de determinação da dose e dispositivo de injeção

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT100114214T PT2327414E (pt) 2002-11-07 2003-11-07 Mecanismo de determinação da dose e dispositivo de injeção

Country Status (18)

Country Link
US (1) US6866844B2 (pt)
EP (2) EP2327414B1 (pt)
JP (1) JP4459059B2 (pt)
CN (1) CN100374157C (pt)
AR (1) AR042019A1 (pt)
AU (1) AU2003290642B2 (pt)
BR (1) BRPI0316039B1 (pt)
CA (1) CA2502928C (pt)
CY (1) CY1116164T1 (pt)
DK (1) DK2327414T3 (pt)
ES (2) ES2445028T3 (pt)
HK (1) HK1157215A1 (pt)
IL (1) IL168435A (pt)
MX (1) MXPA05004880A (pt)
PT (2) PT1565209E (pt)
SI (1) SI2327414T1 (pt)
TW (1) TWI327919B (pt)
WO (1) WO2004043373A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972124B2 (en) * 2000-05-01 2005-12-06 Biomarin Pharmaceuticals Inc. Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
ATE511645T1 (de) * 2006-03-17 2011-06-15 Biomarin Pharm Inc Testverfahren zum nachweis von antikörpern gegen lysosomenenzyme
CN101539550B (zh) * 2009-04-28 2012-05-23 李绍平 用于多糖的定性与定量分析方法
WO2011163650A2 (en) 2010-06-25 2011-12-29 Shire Human Genetic Therapies, Inc. Methods and compositions for cns delivery of arylsulfatase a
PE20170938A1 (es) 2010-06-25 2017-07-13 Shire Human Genetic Therapies Suministro al sistema nervioso central de agentes terapeuticos
CN103068999A (zh) * 2010-08-20 2013-04-24 贝林格尔.英格海姆国际有限公司 通过在获自细胞培养物的液体中改变ph灭活蛋白酶的方法
WO2013094579A1 (ja) 2011-12-20 2013-06-27 日本ケミカルリサーチ株式会社 ホルミルグリシン残基の分析法
US20140377244A1 (en) 2011-12-23 2014-12-25 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
US20150093800A1 (en) * 2013-09-05 2015-04-02 Genentech, Inc. Method for chromatography reuse
FR3011468B1 (fr) * 2013-10-04 2015-12-04 Inventiva Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281225A (pt) 1961-07-20
US3472931A (en) 1969-01-17 1969-10-14 Foster Milburn Co Percutaneous absorption with lower alkyl amides
US3891757A (en) 1971-11-11 1975-06-24 Alza Corp Anaesthetic topical and percutaneous administration with selected promoters
SE387536B (sv) 1973-03-13 1976-09-13 Astra Laekemedel Ab Forfarande for framstellning av en lokalanestetisk beredning
AU2001255771B2 (en) 2000-05-01 2007-05-31 Biomarin Pharmaceutical Inc. Enzymes useful for treating and methods for treating MPS-VI and cell lines for producing such enzymes recombinantly

Also Published As

Publication number Publication date
CY1116164T1 (el) 2017-02-08
ES2533770T3 (es) 2015-04-15
HK1157215A1 (en) 2012-06-29
BR0316039A (pt) 2005-09-13
CA2502928A1 (en) 2004-05-27
TW200427459A (en) 2004-12-16
JP2006510356A (ja) 2006-03-30
CN100374157C (zh) 2008-03-12
AU2003290642B2 (en) 2008-07-10
MXPA05004880A (es) 2005-07-22
BRPI0316039B8 (pt) 2021-05-25
BRPI0316039B1 (pt) 2017-08-29
IL168435A (en) 2014-07-31
WO2004043373A2 (en) 2004-05-27
PT2327414E (pt) 2015-04-13
TWI327919B (en) 2010-08-01
US6866844B2 (en) 2005-03-15
ES2445028T3 (es) 2014-02-27
AU2003290642A1 (en) 2004-06-03
WO2004043373A3 (en) 2004-08-05
EP2327414A1 (en) 2011-06-01
EP1565209A4 (en) 2008-01-02
EP1565209A2 (en) 2005-08-24
EP2327414B1 (en) 2015-01-07
DK2327414T3 (en) 2015-04-13
CA2502928C (en) 2013-07-16
CN1726046A (zh) 2006-01-25
JP4459059B2 (ja) 2010-04-28
US20040101524A1 (en) 2004-05-27
EP1565209B1 (en) 2013-11-06
SI2327414T1 (sl) 2015-05-29
AR042019A1 (es) 2005-06-08

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