DK2318062T3 - Nye biomaterialer, fremstilling af disse ved elektrospinning og deres anvendelse inden for området biomedicin og kirurgi - Google Patents

Nye biomaterialer, fremstilling af disse ved elektrospinning og deres anvendelse inden for området biomedicin og kirurgi Download PDF

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Publication number
DK2318062T3
DK2318062T3 DK09781012.1T DK09781012T DK2318062T3 DK 2318062 T3 DK2318062 T3 DK 2318062T3 DK 09781012 T DK09781012 T DK 09781012T DK 2318062 T3 DK2318062 T3 DK 2318062T3
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DK
Denmark
Prior art keywords
biomaterials
fibers
hyaluronic acid
acid
electrospinning
Prior art date
Application number
DK09781012.1T
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English (en)
Inventor
Davide Bellini
Lanfranco Callegaro
Marie Astier
Fabio Giusti
Original Assignee
Anika Therapeutics S R L
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Publication date
Application filed by Anika Therapeutics S R L filed Critical Anika Therapeutics S R L
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Publication of DK2318062T3 publication Critical patent/DK2318062T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/30—Woven fabric [i.e., woven strand or strip material]
    • Y10T442/3065—Including strand which is of specific structural definition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/60—Nonwoven fabric [i.e., nonwoven strand or fiber material]
    • Y10T442/608—Including strand or fiber material which is of specific structural definition
    • Y10T442/614—Strand or fiber material specified as having microdimensions [i.e., microfiber]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/60—Nonwoven fabric [i.e., nonwoven strand or fiber material]
    • Y10T442/608—Including strand or fiber material which is of specific structural definition
    • Y10T442/614—Strand or fiber material specified as having microdimensions [i.e., microfiber]
    • Y10T442/626—Microfiber is synthetic polymer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)

Claims (17)

1. Biomaterialer i form af vævet eller ikke-vævet tekstil omfattende fibre med en diameter, der er mindre end en mikron hyaluronsyre og derivater fremstillet af hyaluronsyrebenzylester med en esterificeringsprocent i området 50 -100 % tilvejebragt ved en elektrospinningteknik.
2. Biomaterialer ifølge krav 1, hvor fibrene har en diameter, der ligger i området mellem 0,01 pm og 1,0 pm.
3. Biomaterialer ifølge krav 2, hvor fibrene har en diameter på 0,1 pm.
4. Biomaterialer ifølge krav 1, hvor derivaterne anvendes i kombination med eller associeret med estere af alginsyre eller andre naturlige, halvsyntetiske eller syntetiske polymerer.
5. Biomaterialer ifølge krav 1 til 4 bestående af en unik type fibre eller fibre bestående af diverse polymerer.
6. Biomaterialer ifølge krav 5 omfattende fibre bestående af i det mindste fibre af HA-benzylester med en esterificeringsprocent i området 50 - 100 % i kombination med en anden polymer eller fibre bestående af mindst 1 % HA-estere og for restens vedkommende af naturlige, halvsyntetiske eller syntetiske polymerer.
7. Biomaterialer ifølge krav 4 og 6, hvor de naturlige polymerer er valgt blandt: kollagen, hyaluronsyre, cellulose, chitin, chitosan, pektin, pektinsyre, agar, agarose, gellan, alginsyre, stivelser, naturlige gummiprodukter, poly-glycaner.
8. Biomaterialer ifølge krav 4 og 6, hvor de halvsyntetiske polymerer er valgt blandt: krydsbundet kollagen og hyaluronsyre og kemisk modificerede derivater af polymererne ifølge krav 6.
9. Biomaterialer ifølge krav 4 og 6, hvor de syntetiske polymerer er valgt blandt: polymælkesyre, polyglycolsyre, copolymerer af polymælke- og poly-glycolsyre, polycaprolacton og polyurethan.
10. Fibre med en diameter, der er mindre end en mikron af hyaluronsyrederi-vater fremstillet af HA-benzylester med en esterificeringsprocent i området 50 -100 % tilvejebragt ved elektrospinningteknik.
11. Biomaterialer og fibre ifølge krav 1 -10 til fremstilling af coatings, medicineringsværktøjer og/eller biosplejsede biomaterialer.
12. Biomaterialer og fibre ifølge krav 1 -10 til anvendelse ved en fremgangsmåde til absorption af det exsudat, der er til stede i forbrændinger og/eller i hudsår eller til væksten af fibroblaster ved regenerering af derma/hud.
13. Biomaterialer og fibre ifølge krav 11-12 til anvendelse inden for dermatologi, odontologi, stomatologi, otorhinolaryngologi, ortopædi, neurokirurgi og inden for kirurgi af indre organer.
14. Biomaterialer og fibre ifølge krav 11-12 til anvendelse som tamponer inden for kirurgisk behandling af næse og ører.
15. Biomaterialer ifølge krav 1, hvor esterificeringsprocenten ligger i området 50 - 75 %.
16. Biomaterialer ifølge krav 1, hvor esterificeringsprocenten ligger i området 80- 100%.
17. Fremgangsmåde til fremstilling ved elektospinning af biomaterialer og fibre, hvor: - en hyaluronsyrebenzylester med en esterificeringsprocent i området 50 - 75 % blandes med polyvinylpirrolidon (PVP) i et v/v-forhold på 80:20, fortrinsvis 87:13; - blandingen solubiliseres i det passende opløsningsmiddel; - opløsningen underkastes elektrospinning.
DK09781012.1T 2008-07-29 2009-07-24 Nye biomaterialer, fremstilling af disse ved elektrospinning og deres anvendelse inden for området biomedicin og kirurgi DK2318062T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI2008A000143A IT1391734B1 (it) 2008-07-29 2008-07-29 Nuovi biomateriali, loro preparazione per elettrospinning e loro uso in campo biomedico e chirurgico.
PCT/EP2009/059535 WO2010012653A2 (en) 2008-07-29 2009-07-24 New biomaterials, their preparation by electrospinning and their use in the biomedical and surgical field

Publications (1)

Publication Number Publication Date
DK2318062T3 true DK2318062T3 (da) 2017-06-19

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DK09781012.1T DK2318062T3 (da) 2008-07-29 2009-07-24 Nye biomaterialer, fremstilling af disse ved elektrospinning og deres anvendelse inden for området biomedicin og kirurgi

Country Status (8)

Country Link
US (1) US8865964B2 (da)
EP (1) EP2318062B1 (da)
DK (1) DK2318062T3 (da)
ES (1) ES2630039T3 (da)
HU (1) HUE033846T2 (da)
IT (1) IT1391734B1 (da)
PL (1) PL2318062T3 (da)
WO (1) WO2010012653A2 (da)

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CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
WO2017192776A1 (en) 2016-05-03 2017-11-09 The Trustees Of Columbia University In The City Of New York Method for improving expansion of t cells from patients
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
BR112019002171B1 (pt) 2016-08-02 2023-01-17 Fitesa Simpsonville, Inc. Sistema e processo para preparar um tecido não tecido de ácido poliláctico (pla) por fiação contínua
US11441251B2 (en) 2016-08-16 2022-09-13 Fitesa Germany Gmbh Nonwoven fabrics comprising polylactic acid having improved strength and toughness
CN107412881B (zh) * 2017-08-01 2020-10-16 浙江理工大学 一种复合增强人工皮肤感受器的制备方法
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Also Published As

Publication number Publication date
US20110196328A1 (en) 2011-08-11
EP2318062A2 (en) 2011-05-11
US8865964B2 (en) 2014-10-21
ES2630039T3 (es) 2017-08-17
ITFI20080143A1 (it) 2010-01-30
WO2010012653A2 (en) 2010-02-04
HUE033846T2 (en) 2018-01-29
EP2318062B1 (en) 2017-04-05
PL2318062T3 (pl) 2017-09-29
IT1391734B1 (it) 2012-01-27
WO2010012653A3 (en) 2010-06-24

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